CD80 (CD80 molecule)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
941
Gene name Gene Name - the full gene name approved by the HGNC.
CD80 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD80
Synonyms (NCBI Gene) Gene synonyms aliases
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may pl
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(34)
miRTarBase ID miRNA Experiments Reference
MIRT021278 hsa-miR-146a-5p Other 20375304
MIRT021278 hsa-miR-146a-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 26505653
MIRT021278 hsa-miR-146a-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 26505653
MIRT876186 hsa-let-7a CLIP-seq
MIRT876187 hsa-let-7b CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
BCL6 Repression 12860928
IRF7 Activation 16237059
NFKB1 Activation 11359799;12860928
RELA Activation 11359799;12860928
TRERF1 Repression 18652845
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(34)
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IEA
GO:0002376 Process Immune system process IEA
GO:0002682 Process Regulation of immune system process IEA
GO:0002710 Process Negative regulation of T cell mediated immunity IDA 11015443
GO:0005515 Function Protein binding IPI 9915850, 11279502, 18585785, 20587542, 21982860, 23417675, 31000591
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
112203 1700 ENSG00000121594
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P33681
Protein name T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
Protein function Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with th
PDB 1DR9 , 1I8L , 7TPS , 8FXW , 8FXZ , 8HXA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 36 → 135 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 141 → 227 CD80-like C2-set immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on activated B-cells, macrophages and dendritic cells.
Sequence
Sequence length 288
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Virion - Adenovirus
Cell adhesion molecules
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis 		  PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma N/A N/A GWAS
Breast cancer Lobular breast cancer (menopausal hormone therapy interaction) N/A N/A GWAS
Hypothyroidism Hypothyroidism N/A N/A GWAS
Systemic lupus erythematosus Systemic lupus erythematosus N/A N/A GWAS
Show/Hide Text Mining Associations (221)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Achondroplasia and Swiss type agammaglobulinemia Associate 12823285
Acute Coronary Syndrome Stimulate 24107715
Acute On Chronic Liver Failure Associate 36505417
Adenocarcinoma of Lung Associate 19799608, 26264617, 35948079, 36892747, 36922519
Alzheimer Disease Stimulate 23891730
Arthritis Associate 34691053
Arthritis Psoriatic Associate 16507115
Arthritis Psoriatic Stimulate 35095831
Arthritis Rheumatoid Associate 11037875, 12417058, 26980135, 32048307, 32228715
Arthritis Rheumatoid Stimulate 17328044