Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	940
Gene name	CD28 molecule
Gene symbol	CD28
Synonyms (NCBI Gene)	IMD123Tp44
Chromosome	2
Chromosome location	2q33.2
Summary	The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provide

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Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029645	hsa-miR-26b-5p	Microarray	19088304
MIRT438542	hsa-miR-145-5p	Luciferase reporter assay	24043548
MIRT438542	hsa-miR-145-5p	Luciferase reporter assay	24043548
MIRT684938	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684937	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684936	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684935	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684934	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684933	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684932	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684931	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684930	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684929	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684928	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684927	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684926	hsa-miR-302e	HITS-CLIP	23313552
MIRT684925	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684924	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684923	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684922	hsa-miR-520b	HITS-CLIP	23313552
MIRT684921	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684920	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684919	hsa-miR-520e	HITS-CLIP	23313552
MIRT684918	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684917	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684916	hsa-miR-520h	HITS-CLIP	23313552
MIRT684915	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT684914	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684913	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684912	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684910	hsa-miR-4252	HITS-CLIP	23313552
MIRT684911	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684909	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684908	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT684907	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT669127	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT669126	hsa-miR-7107-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT659689	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT659688	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659687	hsa-miR-4287	HITS-CLIP	23824327
MIRT659686	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT659685	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT659684	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659683	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620145	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620145	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620145	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT669127	hsa-miR-6753-3p	HITS-CLIP	27418678
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT669126	hsa-miR-7107-3p	HITS-CLIP	27418678
MIRT684938	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684937	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684936	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684935	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684934	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684933	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684932	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684931	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684930	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684929	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684928	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684927	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684926	hsa-miR-302e	HITS-CLIP	23313552
MIRT684925	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684924	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684923	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684922	hsa-miR-520b	HITS-CLIP	23313552
MIRT684921	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684920	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684919	hsa-miR-520e	HITS-CLIP	23313552
MIRT684918	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684917	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684916	hsa-miR-520h	HITS-CLIP	23313552
MIRT684915	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT684914	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684913	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684912	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684910	hsa-miR-4252	HITS-CLIP	23313552
MIRT684911	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684909	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684908	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT684907	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT669127	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT669126	hsa-miR-7107-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT659689	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT659688	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659687	hsa-miR-4287	HITS-CLIP	23824327
MIRT659686	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT659685	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT659684	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659683	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620147	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT620146	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620145	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT874585	hsa-miR-106a	CLIP-seq
MIRT874586	hsa-miR-106b	CLIP-seq
MIRT874587	hsa-miR-1224-3p	CLIP-seq
MIRT874588	hsa-miR-1234	CLIP-seq
MIRT874589	hsa-miR-1245	CLIP-seq
MIRT874590	hsa-miR-1273e	CLIP-seq
MIRT874591	hsa-miR-1273f	CLIP-seq
MIRT874592	hsa-miR-1289	CLIP-seq
MIRT874593	hsa-miR-1305	CLIP-seq
MIRT874594	hsa-miR-143	CLIP-seq
MIRT874595	hsa-miR-150	CLIP-seq
MIRT874596	hsa-miR-17	CLIP-seq
MIRT874597	hsa-miR-185	CLIP-seq
MIRT874598	hsa-miR-1913	CLIP-seq
MIRT874599	hsa-miR-20a	CLIP-seq
MIRT874600	hsa-miR-20b	CLIP-seq
MIRT874601	hsa-miR-302a	CLIP-seq
MIRT874602	hsa-miR-302b	CLIP-seq
MIRT874603	hsa-miR-302c	CLIP-seq
MIRT874604	hsa-miR-302d	CLIP-seq
MIRT874605	hsa-miR-3135b	CLIP-seq
MIRT874606	hsa-miR-3136-5p	CLIP-seq
MIRT874607	hsa-miR-3198	CLIP-seq
MIRT874608	hsa-miR-324-3p	CLIP-seq
MIRT874609	hsa-miR-3652	CLIP-seq
MIRT874610	hsa-miR-3664-5p	CLIP-seq
MIRT874611	hsa-miR-3671	CLIP-seq
MIRT874612	hsa-miR-3691-3p	CLIP-seq
MIRT874613	hsa-miR-372	CLIP-seq
MIRT874614	hsa-miR-373	CLIP-seq
MIRT874615	hsa-miR-3925-3p	CLIP-seq
MIRT874616	hsa-miR-3944-5p	CLIP-seq
MIRT874617	hsa-miR-4267	CLIP-seq
MIRT874618	hsa-miR-4294	CLIP-seq
MIRT874619	hsa-miR-4306	CLIP-seq
MIRT874620	hsa-miR-4309	CLIP-seq
MIRT874621	hsa-miR-4430	CLIP-seq
MIRT874622	hsa-miR-4439	CLIP-seq
MIRT874623	hsa-miR-4513	CLIP-seq
MIRT874624	hsa-miR-4534	CLIP-seq
MIRT874625	hsa-miR-4639-3p	CLIP-seq
MIRT874626	hsa-miR-4644	CLIP-seq
MIRT874627	hsa-miR-4695-3p	CLIP-seq
MIRT874628	hsa-miR-4708-5p	CLIP-seq
MIRT874629	hsa-miR-4770	CLIP-seq
MIRT874630	hsa-miR-513c	CLIP-seq
MIRT874631	hsa-miR-514b-5p	CLIP-seq
MIRT874632	hsa-miR-519d	CLIP-seq
MIRT874633	hsa-miR-520g	CLIP-seq
MIRT874634	hsa-miR-576-3p	CLIP-seq
MIRT874635	hsa-miR-607	CLIP-seq
MIRT874636	hsa-miR-616	CLIP-seq
MIRT874637	hsa-miR-766	CLIP-seq
MIRT874638	hsa-miR-93	CLIP-seq
MIRT874639	hsa-miR-943	CLIP-seq
MIRT1959284	hsa-miR-27a	CLIP-seq
MIRT1959285	hsa-miR-27b	CLIP-seq
MIRT1959286	hsa-miR-4659a-3p	CLIP-seq
MIRT1959287	hsa-miR-4659b-3p	CLIP-seq
MIRT1959288	hsa-miR-4753-3p	CLIP-seq
MIRT1959289	hsa-miR-498	CLIP-seq
MIRT1959290	hsa-miR-513a-5p	CLIP-seq
MIRT874591	hsa-miR-1273f	CLIP-seq
MIRT2196312	hsa-miR-1278	CLIP-seq
MIRT874592	hsa-miR-1289	CLIP-seq
MIRT874594	hsa-miR-143	CLIP-seq
MIRT2196313	hsa-miR-155	CLIP-seq
MIRT874597	hsa-miR-185	CLIP-seq
MIRT2196314	hsa-miR-219-5p	CLIP-seq
MIRT874605	hsa-miR-3135b	CLIP-seq
MIRT874607	hsa-miR-3198	CLIP-seq
MIRT874609	hsa-miR-3652	CLIP-seq
MIRT874610	hsa-miR-3664-5p	CLIP-seq
MIRT874618	hsa-miR-4294	CLIP-seq
MIRT874619	hsa-miR-4306	CLIP-seq
MIRT874620	hsa-miR-4309	CLIP-seq
MIRT874621	hsa-miR-4430	CLIP-seq
MIRT874624	hsa-miR-4534	CLIP-seq
MIRT874625	hsa-miR-4639-3p	CLIP-seq
MIRT874626	hsa-miR-4644	CLIP-seq
MIRT874628	hsa-miR-4708-5p	CLIP-seq
MIRT874629	hsa-miR-4770	CLIP-seq
MIRT2196315	hsa-miR-4782-3p	CLIP-seq
MIRT2196316	hsa-miR-4794	CLIP-seq
MIRT1959289	hsa-miR-498	CLIP-seq
MIRT2385729	hsa-miR-1270	CLIP-seq
MIRT874591	hsa-miR-1273f	CLIP-seq
MIRT874605	hsa-miR-3135b	CLIP-seq
MIRT874609	hsa-miR-3652	CLIP-seq
MIRT874621	hsa-miR-4430	CLIP-seq
MIRT2385730	hsa-miR-4683	CLIP-seq
MIRT2385731	hsa-miR-4743	CLIP-seq
MIRT2385732	hsa-miR-620	CLIP-seq
MIRT1959289	hsa-miR-498	CLIP-seq
MIRT2446560	hsa-miR-577	CLIP-seq
MIRT874585	hsa-miR-106a	CLIP-seq
MIRT874586	hsa-miR-106b	CLIP-seq
MIRT874587	hsa-miR-1224-3p	CLIP-seq
MIRT874588	hsa-miR-1234	CLIP-seq
MIRT874589	hsa-miR-1245	CLIP-seq
MIRT874595	hsa-miR-150	CLIP-seq
MIRT874596	hsa-miR-17	CLIP-seq
MIRT874598	hsa-miR-1913	CLIP-seq
MIRT874599	hsa-miR-20a	CLIP-seq
MIRT874600	hsa-miR-20b	CLIP-seq
MIRT874601	hsa-miR-302a	CLIP-seq
MIRT874602	hsa-miR-302b	CLIP-seq
MIRT874603	hsa-miR-302c	CLIP-seq
MIRT874604	hsa-miR-302d	CLIP-seq
MIRT874608	hsa-miR-324-3p	CLIP-seq
MIRT874613	hsa-miR-372	CLIP-seq
MIRT874614	hsa-miR-373	CLIP-seq
MIRT874627	hsa-miR-4695-3p	CLIP-seq
MIRT874630	hsa-miR-513c	CLIP-seq
MIRT874631	hsa-miR-514b-5p	CLIP-seq
MIRT874632	hsa-miR-519d	CLIP-seq
MIRT874633	hsa-miR-520g	CLIP-seq
MIRT874638	hsa-miR-93	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
EGR1	Unknown	10510368
NFKB1	Unknown	16365455
RELA	Unknown	16365455
SP1	Unknown	10510368

Show/Hide all (60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001772	Component	Immunological synapse	IEA
GO:0001819	Process	Positive regulation of cytokine production	TAS	8717514
GO:0002376	Process	Immune system process	IEA
GO:0002863	Process	Positive regulation of inflammatory response to antigenic stimulus	IEA
GO:0005515	Function	Protein binding	IPI	7568038, 7584133, 7807015, 8146197, 8183372, 9417079, 9784967, 10820259, 11285224, 15067037, 15554700, 18641334, 21931534
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	11390434
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9784967
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006955	Process	Immune response	IEA
GO:0006959	Process	Humoral immune response	TAS	8717514
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9784967
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	11390434
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IDA	15067037
GO:0009986	Component	Cell surface	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	23817958
GO:0010629	Process	Negative regulation of gene expression	IMP	23817958
GO:0015026	Function	Coreceptor activity	TAS	9784967
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0031295	Process	T cell costimulation	IBA
GO:0031295	Process	T cell costimulation	IDA	8484124
GO:0031295	Process	T cell costimulation	IEA
GO:0031295	Process	T cell costimulation	TAS	8617933
GO:0032733	Process	Positive regulation of interleukin-10 production	IDA	8617933
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	3875683
GO:0032743	Process	Positive regulation of interleukin-2 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IDA	8617933
GO:0035739	Process	CD4-positive, alpha-beta T cell proliferation	IEA
GO:0042098	Process	T cell proliferation	IEA
GO:0042102	Process	Positive regulation of T cell proliferation	IBA
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	3159820, 8617933
GO:0042102	Process	Positive regulation of T cell proliferation	IEA
GO:0042102	Process	Positive regulation of T cell proliferation	TAS	9784967
GO:0042110	Process	T cell activation	IBA
GO:0042110	Process	T cell activation	IDA	7568038, 7737275
GO:0042110	Process	T cell activation	IDA	23918985
GO:0042110	Process	T cell activation	IGI	18337562
GO:0042129	Process	Regulation of T cell proliferation	IEA
GO:0042802	Function	Identical protein binding	NAS	3159820
GO:0043066	Process	Negative regulation of apoptotic process	TAS	8717514
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0045060	Process	Negative thymic T cell selection	IEA
GO:0045066	Process	Regulatory T cell differentiation	IDA	18641304
GO:0045070	Process	Positive regulation of viral genome replication	NAS	7492435
GO:0045589	Process	Regulation of regulatory T cell differentiation	IEA
GO:0045727	Process	Positive regulation of translation	NAS	12028592
GO:0045840	Process	Positive regulation of mitotic nuclear division	IDA	3159820
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048304	Process	Positive regulation of isotype switching to IgG isotypes	IEA
GO:0050852	Process	T cell receptor signaling pathway	IBA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050870	Process	Positive regulation of T cell activation	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:0098636	Component	Protein complex involved in cell adhesion	IDA	7544393
GO:2000563	Process	Positive regulation of CD4-positive, alpha-beta T cell proliferation	IEA

MIM	HGNC	e!Ensembl
186760	1653	ENSG00000178562

P10747

Protein name

T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)

Protein function

Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intra

PDB

1YJD , 3WA4 , 5AUL , 5GJH , 5GJI , 6O8D , 7PPN , 7VU5 , 8S6Z , 8W2V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15910	V-set_2	23 → 139	ICOS V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in T-cells and plasma cells, but not in less mature B-cells.

Sequence

MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLD
SAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPP
PYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVR
SKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS

Sequence length

220

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production Type I diabetes mellitus Measles PD-L1 expression and PD-1 checkpoint pathway in cancer Autoimmune thyroid disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

CD28 (CD28 molecule)