UBE4A (ubiquitination factor E4A)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9354 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Ubiquitination factor E4A |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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UBE4A |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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E4, NEDHMS, UBOX2, UFD2 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q23.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q14139 | |||||||||||||||
| Protein name | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | |||||||||||||||
| Protein function | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin | |||||||||||||||
| PDB | 1WGM | |||||||||||||||
| Family and domains |
Pfam
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| Sequence | ||||||||||||||||
| Sequence length | 1066 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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