Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9332
Gene name Gene Name - the full gene name approved by the HGNC.	CD163 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CD163
Synonyms (NCBI Gene) Gene synonyms aliases	M130, MM130, SCARI1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis

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miRTarBase ID	miRNA	Experiments
MIRT873739	hsa-miR-15a	CLIP-seq
MIRT873740	hsa-miR-15b	CLIP-seq
MIRT873741	hsa-miR-16	CLIP-seq
MIRT873742	hsa-miR-195	CLIP-seq
MIRT873743	hsa-miR-214	CLIP-seq
MIRT873744	hsa-miR-340	CLIP-seq
MIRT873745	hsa-miR-3619-5p	CLIP-seq
MIRT873746	hsa-miR-3680	CLIP-seq
MIRT873747	hsa-miR-3929	CLIP-seq
MIRT873748	hsa-miR-424	CLIP-seq
MIRT873749	hsa-miR-4274	CLIP-seq
MIRT873750	hsa-miR-4291	CLIP-seq
MIRT873751	hsa-miR-4419b	CLIP-seq
MIRT873752	hsa-miR-4478	CLIP-seq
MIRT873753	hsa-miR-4484	CLIP-seq
MIRT873754	hsa-miR-4539	CLIP-seq
MIRT873755	hsa-miR-4680-5p	CLIP-seq
MIRT873756	hsa-miR-497	CLIP-seq
MIRT873757	hsa-miR-548an	CLIP-seq
MIRT873758	hsa-miR-761	CLIP-seq
MIRT873759	hsa-miR-922	CLIP-seq
MIRT1959186	hsa-miR-562	CLIP-seq
MIRT2196125	hsa-miR-101	CLIP-seq
MIRT2196126	hsa-miR-144	CLIP-seq
MIRT2196127	hsa-miR-3606	CLIP-seq
MIRT2196128	hsa-miR-4761-5p	CLIP-seq
MIRT2196129	hsa-miR-495	CLIP-seq
MIRT2196130	hsa-miR-582-5p	CLIP-seq
MIRT2196131	hsa-miR-802	CLIP-seq
MIRT2436172	hsa-miR-513a-3p	CLIP-seq
MIRT2436173	hsa-miR-548a-5p	CLIP-seq
MIRT2436174	hsa-miR-548ab	CLIP-seq
MIRT2436175	hsa-miR-548ak	CLIP-seq
MIRT2436176	hsa-miR-548b-5p	CLIP-seq
MIRT2436177	hsa-miR-548c-3p	CLIP-seq
MIRT2436178	hsa-miR-548c-5p	CLIP-seq
MIRT2436179	hsa-miR-548d-5p	CLIP-seq
MIRT2436180	hsa-miR-548h	CLIP-seq
MIRT2436181	hsa-miR-548i	CLIP-seq
MIRT2436182	hsa-miR-548j	CLIP-seq
MIRT2436183	hsa-miR-548k	CLIP-seq
MIRT2436184	hsa-miR-548l	CLIP-seq
MIRT2436185	hsa-miR-548w	CLIP-seq
MIRT2436186	hsa-miR-548y	CLIP-seq
MIRT2436187	hsa-miR-559	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
CEBPA	Unknown	10725797
ETS2	Unknown	10725797
SP1	Unknown	10725797
SPI1	Unknown	10725797

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005044	Function	Scavenger receptor activity	NAS	8370408
GO:0005044	Function	Scavenger receptor activity	TAS	8370408
GO:0005515	Function	Protein binding	IPI	15479433, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8370408
GO:0006953	Process	Acute-phase response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	24942581
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0097110	Function	Scaffold protein binding	IPI	23555801

MIM	HGNC	e!Ensembl
605545	1631	ENSG00000177575

Protein

UniProt ID

Q86VB7

Protein name

Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]

Protein function

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling o

PDB

8XMK , 8XMP , 8XMQ , 8XMW , 9FHB , 9FMU , 9FNO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00530	SRCR	54 → 152	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	162 → 259	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	269 → 366	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	376 → 473	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	481 → 578	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	586 → 683	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	722 → 819	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	829 → 926	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	932 → 1029	Scavenger receptor cysteine-rich domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous

Sequence

MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC
SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC
RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRW
GTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKH
QGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDA
AVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNED
AGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSAL
KTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRL
VGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQI
WAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKT
LGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMG
DCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLR
LVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGP
IWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLE
VFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPD
TLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDL
DDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGH
KEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQR
LAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENSHESADFSAAELISVSKFLPISGM
EKEAILSHTEKENGNL

Sequence length

1156

Interactions

View interactions

	Reactome
			Scavenging of heme from plasma CD163 mediating an anti-inflammatory response

CD163 (CD163 molecule)