Gene Gene information from NCBI Gene database.
Entrez ID 9318
Gene name COP9 signalosome subunit 2
Gene symbol COPS2
Synonyms (NCBI Gene)
ALIENCSN2SGN2TRIP15
Chromosome 15
Chromosome location 15q21.1
miRNA miRNA information provided by mirtarbase database.
550
miRTarBase ID miRNA Experiments Reference
MIRT025181 hsa-miR-181a-5p Microarray 17612493
MIRT032402 hsa-let-7b-5p Proteomics 18668040
MIRT440910 hsa-miR-218-5p HITS-CLIP 23212916
MIRT440910 hsa-miR-218-5p HITS-CLIP 23212916
MIRT903898 hsa-miR-106a CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000338 Process Protein deneddylation IBA
GO:0000338 Process Protein deneddylation IDA 19141280
GO:0001833 Process Inner cell mass cell proliferation IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604508 30747 ENSG00000166200
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61201
Protein name COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Protein function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of
PDB 4D10 , 4D18 , 4WSN , 6A73 , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 8H38 , 8H3A , 8H3F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01399 PCI 309 413 PCI domain Domain
Sequence
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
TSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQ
TDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIREC
GGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAK
PYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLI
KLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
QKRGGAR
YTALDKWTNQLNSLNQAVVSKLA
Sequence length 443
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation