Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9318
Gene name Gene Name - the full gene name approved by the HGNC.
COP9 signalosome subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
COPS2
Synonyms (NCBI Gene) Gene synonyms aliases
ALIEN, CSN2, SGN2, TRIP15
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q21.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025181 hsa-miR-181a-5p Microarray 17612493
MIRT032402 hsa-let-7b-5p Proteomics 18668040
MIRT440910 hsa-miR-218-5p HITS-CLIP 23212916
MIRT440910 hsa-miR-218-5p HITS-CLIP 23212916
MIRT903898 hsa-miR-106a CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000338 Process Protein deneddylation IBA 21873635
GO:0000338 Process Protein deneddylation IDA 19141280
GO:0000715 Process Nucleotide-excision repair, DNA damage recognition TAS
GO:0001833 Process Inner cell mass cell proliferation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604508 30747 ENSG00000166200
Protein
UniProt ID P61201
Protein name COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Protein function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of
PDB 4D10 , 4D18 , 4WSN , 6A73 , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 8H38 , 8H3A , 8H3F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01399 PCI 309 413 PCI domain Domain
Sequence
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
TSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQ
TDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIREC
GGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAK
PYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLI
KLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
QKRGGAR
YTALDKWTNQLNSLNQAVVSKLA
Sequence length 443
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 22138541 ClinVar
Lung adenocarcinoma Lung adenocarcinoma Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Bipolar Disorder Associate 30503783
Colorectal Neoplasms Associate 26148070
Hypoadrenocorticism Familial Associate 10713076
Leukemia Lymphoma Adult T Cell Associate 35041720
Osteoporosis Associate 31432133
Polyposis Syndrome Hereditary Mixed 1 Associate 26148070