CD83 (CD83 molecule)

Gene

• Entrez ID: 9308
• Gene name: CD83 molecule
• Gene symbol: CD83
• Synonyms (NCBI Gene): BL11, HB15
• Chromosome: 6
• Chromosome location: 6p23
• Summary: The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002516	hsa-miR-373-3p	Microarray	15685193
MIRT002516	hsa-miR-373-3p	Microarray;Other	15685193
MIRT021231	hsa-miR-146a-5p	Other	20375304
MIRT023390	hsa-miR-122-5p	Microarray	17612493
MIRT024870	hsa-miR-215-5p	Microarray	19074876
MIRT026759	hsa-miR-192-5p	Microarray	19074876
MIRT876291	hsa-miR-1324	CLIP-seq
MIRT876292	hsa-miR-137	CLIP-seq
MIRT876293	hsa-miR-1825	CLIP-seq
MIRT876294	hsa-miR-194	CLIP-seq
MIRT876295	hsa-miR-198	CLIP-seq
MIRT876296	hsa-miR-199a-5p	CLIP-seq
MIRT876297	hsa-miR-199b-5p	CLIP-seq
MIRT876298	hsa-miR-22	CLIP-seq
MIRT876299	hsa-miR-3136-5p	CLIP-seq
MIRT876300	hsa-miR-3925-3p	CLIP-seq
MIRT876301	hsa-miR-3977	CLIP-seq
MIRT876302	hsa-miR-4279	CLIP-seq
MIRT876303	hsa-miR-4439	CLIP-seq
MIRT876304	hsa-miR-4459	CLIP-seq
MIRT876305	hsa-miR-4513	CLIP-seq
MIRT876306	hsa-miR-4659a-3p	CLIP-seq
MIRT876307	hsa-miR-4659b-3p	CLIP-seq
MIRT876308	hsa-miR-4691-5p	CLIP-seq
MIRT876309	hsa-miR-4768-5p	CLIP-seq
MIRT876310	hsa-miR-4778-3p	CLIP-seq
MIRT876311	hsa-miR-563	CLIP-seq
MIRT876312	hsa-miR-665	CLIP-seq
MIRT876313	hsa-miR-942	CLIP-seq
MIRT876314	hsa-miR-4700-3p	CLIP-seq
MIRT876315	hsa-miR-548v	CLIP-seq
MIRT876306	hsa-miR-4659a-3p	CLIP-seq
MIRT876307	hsa-miR-4659b-3p	CLIP-seq
MIRT1959689	hsa-miR-302a	CLIP-seq
MIRT1959690	hsa-miR-302b	CLIP-seq
MIRT1959691	hsa-miR-302c	CLIP-seq
MIRT1959692	hsa-miR-302d	CLIP-seq
MIRT1959693	hsa-miR-302e	CLIP-seq
MIRT1959694	hsa-miR-3665	CLIP-seq
MIRT1959695	hsa-miR-372	CLIP-seq
MIRT1959696	hsa-miR-373	CLIP-seq
MIRT1959697	hsa-miR-376c	CLIP-seq
MIRT1959698	hsa-miR-4464	CLIP-seq
MIRT1959699	hsa-miR-4748	CLIP-seq
MIRT1959700	hsa-miR-519a	CLIP-seq
MIRT1959701	hsa-miR-519b-3p	CLIP-seq
MIRT1959702	hsa-miR-519c-3p	CLIP-seq
MIRT1959703	hsa-miR-520a-3p	CLIP-seq
MIRT1959704	hsa-miR-520b	CLIP-seq
MIRT1959705	hsa-miR-520c-3p	CLIP-seq
MIRT1959706	hsa-miR-520d-3p	CLIP-seq
MIRT1959707	hsa-miR-520e	CLIP-seq
MIRT1959708	hsa-miR-657	CLIP-seq
MIRT2196703	hsa-miR-1207-3p	CLIP-seq
MIRT2196704	hsa-miR-15a	CLIP-seq
MIRT2196705	hsa-miR-15b	CLIP-seq
MIRT2196706	hsa-miR-16	CLIP-seq
MIRT2196707	hsa-miR-195	CLIP-seq
MIRT876295	hsa-miR-198	CLIP-seq
MIRT1959689	hsa-miR-302a	CLIP-seq
MIRT1959690	hsa-miR-302b	CLIP-seq
MIRT1959691	hsa-miR-302c	CLIP-seq
MIRT1959692	hsa-miR-302d	CLIP-seq
MIRT1959693	hsa-miR-302e	CLIP-seq
MIRT1959694	hsa-miR-3665	CLIP-seq
MIRT2196708	hsa-miR-3677-5p	CLIP-seq
MIRT1959695	hsa-miR-372	CLIP-seq
MIRT1959696	hsa-miR-373	CLIP-seq
MIRT1959697	hsa-miR-376c	CLIP-seq
MIRT2196709	hsa-miR-424	CLIP-seq
MIRT2196710	hsa-miR-4434	CLIP-seq
MIRT876304	hsa-miR-4459	CLIP-seq
MIRT1959698	hsa-miR-4464	CLIP-seq
MIRT2196711	hsa-miR-4488	CLIP-seq
MIRT2196712	hsa-miR-4516	CLIP-seq
MIRT2196713	hsa-miR-4519	CLIP-seq
MIRT2196714	hsa-miR-4531	CLIP-seq
MIRT2196715	hsa-miR-4640-5p	CLIP-seq
MIRT2196716	hsa-miR-4672	CLIP-seq
MIRT2196717	hsa-miR-4697-5p	CLIP-seq
MIRT2196718	hsa-miR-4726-5p	CLIP-seq
MIRT2196719	hsa-miR-4731-5p	CLIP-seq
MIRT1959699	hsa-miR-4748	CLIP-seq
MIRT2196720	hsa-miR-497	CLIP-seq
MIRT1959700	hsa-miR-519a	CLIP-seq
MIRT1959701	hsa-miR-519b-3p	CLIP-seq
MIRT1959702	hsa-miR-519c-3p	CLIP-seq
MIRT1959703	hsa-miR-520a-3p	CLIP-seq
MIRT1959704	hsa-miR-520b	CLIP-seq
MIRT1959705	hsa-miR-520c-3p	CLIP-seq
MIRT1959706	hsa-miR-520d-3p	CLIP-seq
MIRT1959707	hsa-miR-520e	CLIP-seq
MIRT876311	hsa-miR-563	CLIP-seq
MIRT2196721	hsa-miR-637	CLIP-seq
MIRT1959708	hsa-miR-657	CLIP-seq
MIRT876312	hsa-miR-665	CLIP-seq
MIRT2465072	hsa-miR-3163	CLIP-seq
MIRT2465073	hsa-miR-3688-5p	CLIP-seq
MIRT2465074	hsa-miR-548c-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Activation	19164127
NFKB1	Unknown	12182451
PPARG	Activation	15356156
RELA	Activation	19164127
SP1	Unknown	12182451
SP3	Unknown	12182451

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	20374249, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8422464, 9310491
GO:0006952	Process	Defense response	TAS	1378080
GO:0006959	Process	Humoral immune response	TAS	8422464
GO:0007165	Process	Signal transduction	TAS	9310491
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0032713	Process	Negative regulation of interleukin-4 production	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	IEA
GO:0032743	Process	Positive regulation of interleukin-2 production	IEA
GO:0043367	Process	CD4-positive, alpha-beta T cell differentiation	IEA
GO:0043372	Process	Positive regulation of CD4-positive, alpha-beta T cell differentiation	IEA

Other IDs

• MIM: 604534
• HGNC: 1703
• e!Ensembl: ENSG00000112149

Protein

• UniProt ID: Q01151
• Protein name: CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
• Protein function: Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation an
• PDB: 5MIX, 5MJ0, 5MJ1, 5MJ2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	19 → 127	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells. {ECO:0000269|PubMed:11922761}.
• Sequence:

  MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERM
  ETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSG
  KVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGM
  ERAFLPVTSPNKHLGLVTPHKTELV

• Sequence length: 205