GPR55 (G protein-coupled receptor 55)

Gene

• Entrez ID: 9290
• Gene name: G protein-coupled receptor 55
• Gene symbol: GPR55
• Synonyms (NCBI Gene): LPIR1
• Chromosome: 2
• Chromosome location: 2q37.1
• Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051125	hsa-miR-16-5p	CLASH	23622248
MIRT040844	hsa-miR-18a-3p	CLASH	23622248
MIRT040546	hsa-miR-92b-3p	CLASH	23622248
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031513	hsa-miR-3140-3p	CLIP-seq
MIRT1031514	hsa-miR-3140-5p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT1031516	hsa-miR-3620	CLIP-seq
MIRT1031517	hsa-miR-3684	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1549368	hsa-miR-296-5p	CLIP-seq
MIRT1549369	hsa-miR-4731-5p	CLIP-seq
MIRT1549370	hsa-miR-4758-3p	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2005986	hsa-miR-498	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2238540	hsa-miR-3622a-3p	CLIP-seq
MIRT2238541	hsa-miR-3622b-3p	CLIP-seq
MIRT2238542	hsa-miR-3663-5p	CLIP-seq
MIRT2238543	hsa-miR-4276	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238544	hsa-miR-4527	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2238546	hsa-miR-4639-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2238547	hsa-miR-4753-3p	CLIP-seq
MIRT2238548	hsa-miR-499-3p	CLIP-seq
MIRT2238549	hsa-miR-499a-3p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238550	hsa-miR-767-3p	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT2388668	hsa-miR-214	CLIP-seq
MIRT2388669	hsa-miR-3619-5p	CLIP-seq
MIRT2388670	hsa-miR-4530	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2388671	hsa-miR-634	CLIP-seq
MIRT2388672	hsa-miR-761	CLIP-seq
MIRT2450637	hsa-miR-1248	CLIP-seq
MIRT2450638	hsa-miR-128	CLIP-seq
MIRT2450639	hsa-miR-129-3p	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT2450640	hsa-miR-150	CLIP-seq
MIRT2450641	hsa-miR-197	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT2450642	hsa-miR-3124-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT2450644	hsa-miR-3692	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004949	Function	Cannabinoid receptor activity	IBA	21873635
GO:0004949	Function	Cannabinoid receptor activity	IDA	19723626
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	18757503
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007202	Process	Activation of phospholipase C activity	IBA	21873635
GO:0007202	Process	Activation of phospholipase C activity	IDA	18757503
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA	21873635
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	18757503, 19805329
GO:0038171	Process	Cannabinoid signaling pathway	IEA
GO:0045453	Process	Bone resorption	IDA	19805329
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	19805329
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	19805329

Other IDs

• MIM: 604107
• HGNC: 4511
• e!Ensembl: ENSG00000135898

Protein

• UniProt ID: Q9Y2T6
• Protein name: G-protein coupled receptor 55
• Protein function: G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (P
• PDB: 8ZX4, 8ZX5, 9GE2, 9GE3, 9IY8, 9IYA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	37 → 288	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Higly expressed in macrophages and B-c
• Sequence:

  MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATS
  IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRF
  LAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAK
  VFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFL
  PVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIR
  AHRPSRVQLVLQDTTISRG

• Sequence length: 319

Pathways

Reactome:

Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29221444

Associations from Text Mining
Disease Name	Relationship Type	References
Anxiety	Associate	29435814
Atherosclerosis	Associate	25970609
Bone Diseases	Associate	25970609
Breast Neoplasms	Associate	20590578, 27340777, 37688769
Carcinoma Hepatocellular	Associate	37688769
Cardiovascular Diseases	Associate	25970609
Cholangiocarcinoma	Associate	37688769
Colorectal Neoplasms	Associate	33959968, 35562947
Depressive Disorder	Associate	29435814
Endometrial Neoplasms	Stimulate	34324032
Farber Lipogranulomatosis	Associate	27567474
Glioblastoma	Associate	40565152
Hepatitis C	Associate	31200545
Hereditary leiomyomatosis and renal cell cancer	Associate	30842391
HIV Infections	Associate	24562630
Inflammation	Associate	24562630, 35608548
Inflammation	Inhibit	31200545
Leiomyoma	Associate	30842391
Neoplasm Metastasis	Associate	27340777
Neoplasms	Associate	20590578, 25970609, 27340777, 27423937, 33959968, 34324032, 34948125, 35562947, 37688769, 40565152
Obesity	Associate	25970609
Osteolysis Essential	Associate	39940911
Pancreatic Neoplasms	Associate	37688769
Sarcoma Ewing	Associate	39940911
Skin Neoplasms	Associate	37688769
Triple Negative Breast Neoplasms	Associate	27340777
Tuberculosis Multidrug Resistant	Associate	27423937