Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9290
Gene name	G protein-coupled receptor 55
Gene symbol	GPR55
Synonyms (NCBI Gene)	LPIR1
Chromosome	2
Chromosome location	2q37.1
Summary	This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction

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Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051125	hsa-miR-16-5p	CLASH	23622248
MIRT040844	hsa-miR-18a-3p	CLASH	23622248
MIRT040546	hsa-miR-92b-3p	CLASH	23622248
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031513	hsa-miR-3140-3p	CLIP-seq
MIRT1031514	hsa-miR-3140-5p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT1031516	hsa-miR-3620	CLIP-seq
MIRT1031517	hsa-miR-3684	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1549368	hsa-miR-296-5p	CLIP-seq
MIRT1549369	hsa-miR-4731-5p	CLIP-seq
MIRT1549370	hsa-miR-4758-3p	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2005986	hsa-miR-498	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2238540	hsa-miR-3622a-3p	CLIP-seq
MIRT2238541	hsa-miR-3622b-3p	CLIP-seq
MIRT2238542	hsa-miR-3663-5p	CLIP-seq
MIRT2238543	hsa-miR-4276	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238544	hsa-miR-4527	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2238546	hsa-miR-4639-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2238547	hsa-miR-4753-3p	CLIP-seq
MIRT2238548	hsa-miR-499-3p	CLIP-seq
MIRT2238549	hsa-miR-499a-3p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238550	hsa-miR-767-3p	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT2388668	hsa-miR-214	CLIP-seq
MIRT2388669	hsa-miR-3619-5p	CLIP-seq
MIRT2388670	hsa-miR-4530	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2388671	hsa-miR-634	CLIP-seq
MIRT2388672	hsa-miR-761	CLIP-seq
MIRT2450637	hsa-miR-1248	CLIP-seq
MIRT2450638	hsa-miR-128	CLIP-seq
MIRT2450639	hsa-miR-129-3p	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT2450640	hsa-miR-150	CLIP-seq
MIRT2450641	hsa-miR-197	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT2450642	hsa-miR-3124-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT2450644	hsa-miR-3692	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9931487
GO:0004949	Function	Cannabinoid receptor activity	IBA
GO:0004949	Function	Cannabinoid receptor activity	IDA	19723626
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18757503
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9931487
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9931487
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	18757503
GO:0016020	Component	Membrane	IEA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	19805329
GO:0038171	Process	Cannabinoid signaling pathway	IEA
GO:0045453	Process	Bone resorption	IDA	19805329
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	19805329
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	19805329

MIM	HGNC	e!Ensembl
604107	4511	ENSG00000135898

Q9Y2T6

Protein name

G-protein coupled receptor 55

Protein function

G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (P

PDB

8ZX4 , 8ZX5 , 9GE2 , 9GE3 , 9IY8 , 9IYA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	37 → 288	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Higly expressed in macrophages and B-c

Sequence

MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATS
IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRF
LAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAK
VFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFL
PVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIR
AHRPSRVQLVLQDTTISRG

Sequence length

319

Interactions

View interactions

	Reactome
			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193920808	RCV000149174

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anxiety	Associate	29435814
Atherosclerosis	Associate	25970609
Bone Diseases	Associate	25970609
Breast Neoplasms	Associate	20590578, 27340777, 37688769
Carcinoma Hepatocellular	Associate	37688769
Cardiovascular Diseases	Associate	25970609
Cholangiocarcinoma	Associate	37688769
Colorectal Neoplasms	Associate	33959968, 35562947
Depressive Disorder	Associate	29435814
Endometrial Neoplasms	Stimulate	34324032
Farber Lipogranulomatosis	Associate	27567474
Glioblastoma	Associate	40565152
Hepatitis C	Associate	31200545
Hereditary leiomyomatosis and renal cell cancer	Associate	30842391
HIV Infections	Associate	24562630
Inflammation	Associate	24562630, 35608548
Inflammation	Inhibit	31200545
Leiomyoma	Associate	30842391
Neoplasm Metastasis	Associate	27340777
Neoplasms	Associate	20590578, 25970609, 27340777, 27423937, 33959968, 34324032, 34948125, 35562947, 37688769, 40565152
Obesity	Associate	25970609
Osteolysis Essential	Associate	39940911
Pancreatic Neoplasms	Associate	37688769
Sarcoma Ewing	Associate	39940911
Skin Neoplasms	Associate	37688769
Triple Negative Breast Neoplasms	Associate	27340777
Tuberculosis Multidrug Resistant	Associate	27423937

GPR55 (G protein-coupled receptor 55)