SHKBP1 (SH3KBP1 binding protein 1)

Gene

• Entrez ID: 92799
• Gene name: SH3KBP1 binding protein 1
• Gene symbol: SHKBP1
• Synonyms (NCBI Gene): PP203, Sb1
• Chromosome: 19
• Chromosome location: 19q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040411	hsa-miR-615-3p	CLASH	23622248
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347419	hsa-miR-2110	CLIP-seq
MIRT1347420	hsa-miR-3150a-3p	CLIP-seq
MIRT1347421	hsa-miR-3164	CLIP-seq
MIRT1347422	hsa-miR-3175	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347427	hsa-miR-4728-5p	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT1347429	hsa-miR-939	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT2102856	hsa-miR-1291	CLIP-seq
MIRT1347419	hsa-miR-2110	CLIP-seq
MIRT2102857	hsa-miR-2115	CLIP-seq
MIRT2102858	hsa-miR-3144-5p	CLIP-seq
MIRT1347420	hsa-miR-3150a-3p	CLIP-seq
MIRT1347421	hsa-miR-3164	CLIP-seq
MIRT1347422	hsa-miR-3175	CLIP-seq
MIRT2102859	hsa-miR-3180-5p	CLIP-seq
MIRT2102860	hsa-miR-3191	CLIP-seq
MIRT2102861	hsa-miR-3649	CLIP-seq
MIRT2102862	hsa-miR-4652-5p	CLIP-seq
MIRT1347427	hsa-miR-4728-5p	CLIP-seq
MIRT2102863	hsa-miR-4747-5p	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT2102864	hsa-miR-491-5p	CLIP-seq
MIRT2102865	hsa-miR-520a-5p	CLIP-seq
MIRT2102866	hsa-miR-525-5p	CLIP-seq
MIRT2102867	hsa-miR-583	CLIP-seq
MIRT2102868	hsa-miR-628-3p	CLIP-seq
MIRT1347429	hsa-miR-939	CLIP-seq
MIRT2102856	hsa-miR-1291	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21145461, 21988832, 32296183, 34591642, 36931259
GO:0005764	Component	Lysosome	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IBA
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IEA
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	ISS
GO:0051260	Process	Protein homooligomerization	IEA

Other IDs

• MIM: 617322
• HGNC: 19214
• e!Ensembl: ENSG00000160410

Protein

• UniProt ID: Q8TBC3
• Protein name: SH3KBP1-binding protein 1 (SETA-binding protein 1)
• Protein function: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {
• PDB: 4CRH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02214	BTB_2	21 → 110	BTB/POZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16733801}.
• Sequence:

  MAAAATAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDET
  GAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLREELDRSS
  CGNVLFNGYLPPPVFPVKRRNRHSLVGPQQLGGRPAPVRRSNTMPPNLGNAGLLGRMLDE
  KTPPSPSGQPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIER
  LALTARVHGGALGEHDKMVAAATGSEILLWALQAEGGGSEIGVFHLGVPVEALFFVGNQL
  IATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKD
  NDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGP
  QLFQTFTVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKIL
  ALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGS
  PTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEQELME
  QLEHCELAPPAPSAPSWGCLPSPSPRISLTSLHSASSNTSLSGHRGSPSPPQAEARRRGG
  GSFVERCQELVRSGPDLRRPPTPAPWPSSGLGTPLTPPKMKLNETSF

• Sequence length: 707

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