Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	92799
Gene name Gene Name - the full gene name approved by the HGNC.	SH3KBP1 binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SHKBP1
Synonyms (NCBI Gene) Gene synonyms aliases	PP203, Sb1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040411	hsa-miR-615-3p	CLASH	23622248
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347419	hsa-miR-2110	CLIP-seq
MIRT1347420	hsa-miR-3150a-3p	CLIP-seq
MIRT1347421	hsa-miR-3164	CLIP-seq
MIRT1347422	hsa-miR-3175	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347427	hsa-miR-4728-5p	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT1347429	hsa-miR-939	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT2102856	hsa-miR-1291	CLIP-seq
MIRT1347419	hsa-miR-2110	CLIP-seq
MIRT2102857	hsa-miR-2115	CLIP-seq
MIRT2102858	hsa-miR-3144-5p	CLIP-seq
MIRT1347420	hsa-miR-3150a-3p	CLIP-seq
MIRT1347421	hsa-miR-3164	CLIP-seq
MIRT1347422	hsa-miR-3175	CLIP-seq
MIRT2102859	hsa-miR-3180-5p	CLIP-seq
MIRT2102860	hsa-miR-3191	CLIP-seq
MIRT2102861	hsa-miR-3649	CLIP-seq
MIRT2102862	hsa-miR-4652-5p	CLIP-seq
MIRT1347427	hsa-miR-4728-5p	CLIP-seq
MIRT2102863	hsa-miR-4747-5p	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT2102864	hsa-miR-491-5p	CLIP-seq
MIRT2102865	hsa-miR-520a-5p	CLIP-seq
MIRT2102866	hsa-miR-525-5p	CLIP-seq
MIRT2102867	hsa-miR-583	CLIP-seq
MIRT2102868	hsa-miR-628-3p	CLIP-seq
MIRT1347429	hsa-miR-939	CLIP-seq
MIRT2102856	hsa-miR-1291	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq
MIRT1347418	hsa-miR-1224-5p	CLIP-seq
MIRT1347423	hsa-miR-34a	CLIP-seq
MIRT1347424	hsa-miR-34c-5p	CLIP-seq
MIRT1347425	hsa-miR-449a	CLIP-seq
MIRT1347426	hsa-miR-449b	CLIP-seq
MIRT1347428	hsa-miR-4751	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21145461, 21988832, 32296183
GO:0005764	Component	Lysosome	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IBA	21873635
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	ISS
GO:0051260	Process	Protein homooligomerization	IEA

MIM	HGNC	e!Ensembl
617322	19214	ENSG00000160410

Protein

UniProt ID

Q8TBC3

Protein name

SH3KBP1-binding protein 1 (SETA-binding protein 1)

Protein function

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {

PDB

4CRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02214	BTB_2	21 → 110	BTB/POZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16733801}.

Sequence

MAAAATAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDET
GAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLREELDRSS
CGNVLFNGYLPPPVFPVKRRNRHSLVGPQQLGGRPAPVRRSNTMPPNLGNAGLLGRMLDE
KTPPSPSGQPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIER
LALTARVHGGALGEHDKMVAAATGSEILLWALQAEGGGSEIGVFHLGVPVEALFFVGNQL
IATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKD
NDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGP
QLFQTFTVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKIL
ALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGS
PTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEQELME
QLEHCELAPPAPSAPSWGCLPSPSPRISLTSLHSASSNTSLSGHRGSPSPPQAEARRRGG
GSFVERCQELVRSGPDLRRPPTPAPWPSSGLGTPLTPPKMKLNETSF

Sequence length

707

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Duchenne muscular dystrophy	Muscular Dystrophy, Duchenne	rs128625226, rs128625227, rs128625228, rs128625229, rs2147483647, rs104894787, rs128625230, rs128626234, rs201366610, rs267606770, rs128626235, rs128626231, rs146071084, rs128626232, rs104894788 View all (641 more)	30014611
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	35502885
Long QT Syndrome	Associate	30014611
Lymphatic Metastasis	Associate	35502885
Neoplasms	Associate	35502885
Squamous Cell Carcinoma of Head and Neck	Stimulate	35502885
Uterine Cervical Neoplasms	Associate	28112728

SHKBP1 (SH3KBP1 binding protein 1)