Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	92675
Gene name Gene Name - the full gene name approved by the HGNC.	D-aminoacyl-tRNA deacylase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DTD1
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf88, DTD, DUE-B, DUEB, HARS2, pqn-68
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p11.23
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA rep

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021511	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT031804	hsa-miR-16-5p	Proteomics	18668040
MIRT152457	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT152457	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT946545	hsa-miR-3120-3p	CLIP-seq
MIRT946546	hsa-miR-4280	CLIP-seq
MIRT946547	hsa-miR-4452	CLIP-seq
MIRT946548	hsa-miR-4635	CLIP-seq
MIRT946549	hsa-miR-483-3p	CLIP-seq
MIRT946550	hsa-miR-548a-5p	CLIP-seq
MIRT946551	hsa-miR-548ab	CLIP-seq
MIRT946552	hsa-miR-548ak	CLIP-seq
MIRT946553	hsa-miR-548b-5p	CLIP-seq
MIRT946554	hsa-miR-548c-5p	CLIP-seq
MIRT946555	hsa-miR-548d-5p	CLIP-seq
MIRT946556	hsa-miR-548h	CLIP-seq
MIRT946557	hsa-miR-548i	CLIP-seq
MIRT946558	hsa-miR-548j	CLIP-seq
MIRT946559	hsa-miR-548k	CLIP-seq
MIRT946560	hsa-miR-548l	CLIP-seq
MIRT946561	hsa-miR-548w	CLIP-seq
MIRT946562	hsa-miR-548y	CLIP-seq
MIRT946563	hsa-miR-559	CLIP-seq
MIRT1980368	hsa-miR-1280	CLIP-seq
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT1980369	hsa-miR-3117-5p	CLIP-seq
MIRT1980370	hsa-miR-34a	CLIP-seq
MIRT1980371	hsa-miR-34c-5p	CLIP-seq
MIRT1980372	hsa-miR-371b-3p	CLIP-seq
MIRT1980373	hsa-miR-421	CLIP-seq
MIRT1980374	hsa-miR-449a	CLIP-seq
MIRT1980375	hsa-miR-449b	CLIP-seq
MIRT1980376	hsa-miR-602	CLIP-seq
MIRT2215381	hsa-miR-145	CLIP-seq
MIRT2215382	hsa-miR-1913	CLIP-seq
MIRT1980369	hsa-miR-3117-5p	CLIP-seq
MIRT2215383	hsa-miR-3194-5p	CLIP-seq
MIRT2215384	hsa-miR-324-3p	CLIP-seq
MIRT1980373	hsa-miR-421	CLIP-seq
MIRT2215385	hsa-miR-4277	CLIP-seq
MIRT2215386	hsa-miR-4640-5p	CLIP-seq
MIRT2215387	hsa-miR-4661-3p	CLIP-seq
MIRT2215388	hsa-miR-4726-5p	CLIP-seq
MIRT2215389	hsa-miR-4727-5p	CLIP-seq
MIRT2215390	hsa-miR-514	CLIP-seq
MIRT2215391	hsa-miR-514b-3p	CLIP-seq
MIRT1980376	hsa-miR-602	CLIP-seq
MIRT2448559	hsa-miR-1228	CLIP-seq
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT2448559	hsa-miR-1228	CLIP-seq
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT2448559	hsa-miR-1228	CLIP-seq
MIRT2519810	hsa-miR-1270	CLIP-seq
MIRT2519811	hsa-miR-128	CLIP-seq
MIRT2519812	hsa-miR-1291	CLIP-seq
MIRT2519813	hsa-miR-129-5p	CLIP-seq
MIRT2519814	hsa-miR-1322	CLIP-seq
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT2519815	hsa-miR-217	CLIP-seq
MIRT2519816	hsa-miR-2467-3p	CLIP-seq
MIRT1980369	hsa-miR-3117-5p	CLIP-seq
MIRT946545	hsa-miR-3120-3p	CLIP-seq
MIRT2519817	hsa-miR-3120-5p	CLIP-seq
MIRT2519818	hsa-miR-3121-5p	CLIP-seq
MIRT2519819	hsa-miR-3128	CLIP-seq
MIRT2519820	hsa-miR-3133	CLIP-seq
MIRT1980370	hsa-miR-34a	CLIP-seq
MIRT1980371	hsa-miR-34c-5p	CLIP-seq
MIRT2519821	hsa-miR-3659	CLIP-seq
MIRT2519822	hsa-miR-3678-3p	CLIP-seq
MIRT1980372	hsa-miR-371b-3p	CLIP-seq
MIRT1980373	hsa-miR-421	CLIP-seq
MIRT2519823	hsa-miR-4258	CLIP-seq
MIRT2519824	hsa-miR-4302	CLIP-seq
MIRT2519825	hsa-miR-4434	CLIP-seq
MIRT1980374	hsa-miR-449a	CLIP-seq
MIRT1980375	hsa-miR-449b	CLIP-seq
MIRT2519826	hsa-miR-450b-5p	CLIP-seq
MIRT2519827	hsa-miR-4516	CLIP-seq
MIRT2519828	hsa-miR-4520a-3p	CLIP-seq
MIRT2519829	hsa-miR-4531	CLIP-seq
MIRT2215386	hsa-miR-4640-5p	CLIP-seq
MIRT2519830	hsa-miR-4652-3p	CLIP-seq
MIRT2519831	hsa-miR-4658	CLIP-seq
MIRT2519832	hsa-miR-4694-5p	CLIP-seq
MIRT2519833	hsa-miR-4711-5p	CLIP-seq
MIRT2215388	hsa-miR-4726-5p	CLIP-seq
MIRT2519834	hsa-miR-4731-5p	CLIP-seq
MIRT2519835	hsa-miR-4802-3p	CLIP-seq
MIRT946549	hsa-miR-483-3p	CLIP-seq
MIRT2519836	hsa-miR-507	CLIP-seq
MIRT2519837	hsa-miR-548ad	CLIP-seq
MIRT2519838	hsa-miR-553	CLIP-seq
MIRT2519839	hsa-miR-557	CLIP-seq
MIRT2519840	hsa-miR-574-5p	CLIP-seq
MIRT2519841	hsa-miR-589	CLIP-seq
MIRT1980376	hsa-miR-602	CLIP-seq
MIRT2519842	hsa-miR-620	CLIP-seq
MIRT2519843	hsa-miR-9	CLIP-seq
MIRT2448559	hsa-miR-1228	CLIP-seq
MIRT2519810	hsa-miR-1270	CLIP-seq
MIRT2519811	hsa-miR-128	CLIP-seq
MIRT2519812	hsa-miR-1291	CLIP-seq
MIRT2519813	hsa-miR-129-5p	CLIP-seq
MIRT2519814	hsa-miR-1322	CLIP-seq
MIRT946544	hsa-miR-140-3p	CLIP-seq
MIRT2519815	hsa-miR-217	CLIP-seq
MIRT2519816	hsa-miR-2467-3p	CLIP-seq
MIRT1980369	hsa-miR-3117-5p	CLIP-seq
MIRT946545	hsa-miR-3120-3p	CLIP-seq
MIRT2519818	hsa-miR-3121-5p	CLIP-seq
MIRT2519819	hsa-miR-3128	CLIP-seq
MIRT2519820	hsa-miR-3133	CLIP-seq
MIRT1980370	hsa-miR-34a	CLIP-seq
MIRT1980371	hsa-miR-34c-5p	CLIP-seq
MIRT2519821	hsa-miR-3659	CLIP-seq
MIRT2519822	hsa-miR-3678-3p	CLIP-seq
MIRT1980372	hsa-miR-371b-3p	CLIP-seq
MIRT1980373	hsa-miR-421	CLIP-seq
MIRT2519823	hsa-miR-4258	CLIP-seq
MIRT2519824	hsa-miR-4302	CLIP-seq
MIRT2519825	hsa-miR-4434	CLIP-seq
MIRT1980374	hsa-miR-449a	CLIP-seq
MIRT1980375	hsa-miR-449b	CLIP-seq
MIRT2519826	hsa-miR-450b-5p	CLIP-seq
MIRT2519827	hsa-miR-4516	CLIP-seq
MIRT2519828	hsa-miR-4520a-3p	CLIP-seq
MIRT2519829	hsa-miR-4531	CLIP-seq
MIRT2519831	hsa-miR-4658	CLIP-seq
MIRT2519832	hsa-miR-4694-5p	CLIP-seq
MIRT2519833	hsa-miR-4711-5p	CLIP-seq
MIRT2519834	hsa-miR-4731-5p	CLIP-seq
MIRT2519835	hsa-miR-4802-3p	CLIP-seq
MIRT946549	hsa-miR-483-3p	CLIP-seq
MIRT2519836	hsa-miR-507	CLIP-seq
MIRT2519837	hsa-miR-548ad	CLIP-seq
MIRT2519838	hsa-miR-553	CLIP-seq
MIRT2519839	hsa-miR-557	CLIP-seq
MIRT2519840	hsa-miR-574-5p	CLIP-seq
MIRT2519841	hsa-miR-589	CLIP-seq
MIRT1980376	hsa-miR-602	CLIP-seq
MIRT2519842	hsa-miR-620	CLIP-seq
MIRT2519843	hsa-miR-9	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0002161	Function	Aminoacyl-tRNA deacylase activity	IEA
GO:0003677	Function	DNA binding	EXP	17264083
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006260	Process	DNA replication	IEA
GO:0006399	Process	TRNA metabolic process	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051499	Function	D-aminoacyl-tRNA deacylase activity	IEA
GO:0051500	Function	D-tyrosyl-tRNA(Tyr) deacylase activity	IBA
GO:0106026	Function	Gly-tRNA(Ala) deacylase activity	IEA
GO:0106074	Process	Aminoacyl-tRNA metabolism involved in translational fidelity	IEA

MIM	HGNC	e!Ensembl
610996	16219	ENSG00000125821

Protein

UniProt ID

Q8TEA8

Protein name

D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related)

Protein function

Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). ; An aminoacyl-tRNA editing enz

PDB

2OKV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02580	Tyr_Deacylase	2 → 146	D-Tyr-tRNA(Tyr) deacylase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. {ECO:0000269|PubMed:12392168}.

Sequence

MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESG
KHWSKSVMDKQYEILCVSQFTLQCVLKGNKPDFHLAMPTEQAEGFYNSFLEQLRKTYRPE
LIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQLSKLEKQQQRKEKTRAKGPSE
SSKERNTPRKEDRSASSGAEGDVSSEREP

Sequence length

209

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

DTD1 (D-aminoacyl-tRNA deacylase 1)