CYTH3 (cytohesin 3)

Gene

• Entrez ID: 9265
• Gene name: Cytohesin 3
• Gene symbol: CYTH3
• Synonyms (NCBI Gene): ARNO3, GRP1, PSCD3, cytohesin-3
• Chromosome: 7
• Chromosome location: 7p22.1
• Summary: This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckst

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018199	hsa-miR-335-5p	Microarray	18185580
MIRT044672	hsa-miR-320a	CLASH	23622248
MIRT488784	hsa-miR-1281	PAR-CLIP	23592263
MIRT488783	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488782	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT488781	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT488779	hsa-miR-449a	PAR-CLIP	23592263
MIRT488780	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT488778	hsa-miR-548au-3p	PAR-CLIP	23592263
MIRT488777	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT488776	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT488784	hsa-miR-1281	PAR-CLIP	23592263
MIRT488783	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488782	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT488781	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT488779	hsa-miR-449a	PAR-CLIP	23592263
MIRT488780	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT488778	hsa-miR-548au-3p	PAR-CLIP	23592263
MIRT488777	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT488776	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT922235	hsa-let-7a	CLIP-seq
MIRT922236	hsa-let-7b	CLIP-seq
MIRT922237	hsa-let-7c	CLIP-seq
MIRT922238	hsa-let-7d	CLIP-seq
MIRT922239	hsa-let-7e	CLIP-seq
MIRT922240	hsa-let-7f	CLIP-seq
MIRT922241	hsa-let-7g	CLIP-seq
MIRT922242	hsa-let-7i	CLIP-seq
MIRT922243	hsa-miR-1257	CLIP-seq
MIRT922244	hsa-miR-1271	CLIP-seq
MIRT922245	hsa-miR-1289	CLIP-seq
MIRT922246	hsa-miR-1304	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT922248	hsa-miR-144	CLIP-seq
MIRT922249	hsa-miR-182	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922251	hsa-miR-202	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT922253	hsa-miR-22	CLIP-seq
MIRT922254	hsa-miR-24	CLIP-seq
MIRT922255	hsa-miR-29a	CLIP-seq
MIRT922256	hsa-miR-29b	CLIP-seq
MIRT922257	hsa-miR-29c	CLIP-seq
MIRT922258	hsa-miR-3065-3p	CLIP-seq
MIRT922259	hsa-miR-3198	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT922261	hsa-miR-3619-3p	CLIP-seq
MIRT922262	hsa-miR-3622b-5p	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT922264	hsa-miR-3685	CLIP-seq
MIRT922265	hsa-miR-384	CLIP-seq
MIRT922266	hsa-miR-3973	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922268	hsa-miR-4254	CLIP-seq
MIRT922269	hsa-miR-4284	CLIP-seq
MIRT922270	hsa-miR-4294	CLIP-seq
MIRT922271	hsa-miR-4309	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT922275	hsa-miR-4458	CLIP-seq
MIRT922276	hsa-miR-4500	CLIP-seq
MIRT922277	hsa-miR-4642	CLIP-seq
MIRT922278	hsa-miR-4648	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922280	hsa-miR-4654	CLIP-seq
MIRT922281	hsa-miR-4659a-5p	CLIP-seq
MIRT922282	hsa-miR-4659b-5p	CLIP-seq
MIRT922283	hsa-miR-4668-5p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922285	hsa-miR-4685-5p	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922289	hsa-miR-4769-3p	CLIP-seq
MIRT922290	hsa-miR-4769-5p	CLIP-seq
MIRT922291	hsa-miR-4776-5p	CLIP-seq
MIRT922292	hsa-miR-4799-5p	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT922294	hsa-miR-495	CLIP-seq
MIRT922295	hsa-miR-499-3p	CLIP-seq
MIRT922296	hsa-miR-499a-3p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT922298	hsa-miR-512-5p	CLIP-seq
MIRT922299	hsa-miR-548k	CLIP-seq
MIRT922300	hsa-miR-581	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT922303	hsa-miR-619	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT922305	hsa-miR-802	CLIP-seq
MIRT922306	hsa-miR-96	CLIP-seq
MIRT922307	hsa-miR-98	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT738349	hsa-miR-1285	CLIP-seq
MIRT738348	hsa-miR-3187-5p	CLIP-seq
MIRT738350	hsa-miR-612	CLIP-seq
MIRT1973145	hsa-miR-1268	CLIP-seq
MIRT1973146	hsa-miR-1268b	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT1973147	hsa-miR-153	CLIP-seq
MIRT1973148	hsa-miR-1915	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT1973151	hsa-miR-3612	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT1973152	hsa-miR-3937	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT1973153	hsa-miR-4443	CLIP-seq
MIRT1973154	hsa-miR-4463	CLIP-seq
MIRT1973155	hsa-miR-448	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT1973157	hsa-miR-4508	CLIP-seq
MIRT1973158	hsa-miR-4514	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922285	hsa-miR-4685-5p	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT1973159	hsa-miR-4692	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT1973160	hsa-miR-4726-3p	CLIP-seq
MIRT1973161	hsa-miR-4767	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT1973162	hsa-miR-490-5p	CLIP-seq
MIRT922295	hsa-miR-499-3p	CLIP-seq
MIRT922296	hsa-miR-499a-3p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT1973163	hsa-miR-549	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT1973164	hsa-miR-650	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT1973165	hsa-miR-7	CLIP-seq
MIRT1973166	hsa-miR-744	CLIP-seq
MIRT922235	hsa-let-7a	CLIP-seq
MIRT922236	hsa-let-7b	CLIP-seq
MIRT922237	hsa-let-7c	CLIP-seq
MIRT922238	hsa-let-7d	CLIP-seq
MIRT922239	hsa-let-7e	CLIP-seq
MIRT922240	hsa-let-7f	CLIP-seq
MIRT922241	hsa-let-7g	CLIP-seq
MIRT922242	hsa-let-7i	CLIP-seq
MIRT2208846	hsa-miR-1254	CLIP-seq
MIRT922243	hsa-miR-1257	CLIP-seq
MIRT922244	hsa-miR-1271	CLIP-seq
MIRT922246	hsa-miR-1304	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT922248	hsa-miR-144	CLIP-seq
MIRT2208847	hsa-miR-148a	CLIP-seq
MIRT2208848	hsa-miR-148b	CLIP-seq
MIRT2208849	hsa-miR-152	CLIP-seq
MIRT2208850	hsa-miR-1539	CLIP-seq
MIRT2208851	hsa-miR-15a	CLIP-seq
MIRT2208852	hsa-miR-15b	CLIP-seq
MIRT2208853	hsa-miR-16	CLIP-seq
MIRT922249	hsa-miR-182	CLIP-seq
MIRT1973148	hsa-miR-1915	CLIP-seq
MIRT2208854	hsa-miR-195	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922251	hsa-miR-202	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT2208855	hsa-miR-3116	CLIP-seq
MIRT2208856	hsa-miR-3120-3p	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2208858	hsa-miR-3175	CLIP-seq
MIRT2208859	hsa-miR-3194-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT2208860	hsa-miR-3614-3p	CLIP-seq
MIRT922261	hsa-miR-3619-3p	CLIP-seq
MIRT922262	hsa-miR-3622b-5p	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT2208861	hsa-miR-3660	CLIP-seq
MIRT2208862	hsa-miR-3663-5p	CLIP-seq
MIRT2208863	hsa-miR-370	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT2208864	hsa-miR-424	CLIP-seq
MIRT922268	hsa-miR-4254	CLIP-seq
MIRT2208865	hsa-miR-4276	CLIP-seq
MIRT2208866	hsa-miR-4325	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT739460	hsa-miR-4327	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT922275	hsa-miR-4458	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT922276	hsa-miR-4500	CLIP-seq
MIRT2208867	hsa-miR-4526	CLIP-seq
MIRT2208868	hsa-miR-4633-3p	CLIP-seq
MIRT922277	hsa-miR-4642	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT2208869	hsa-miR-4716-3p	CLIP-seq
MIRT1973160	hsa-miR-4726-3p	CLIP-seq
MIRT922289	hsa-miR-4769-3p	CLIP-seq
MIRT922291	hsa-miR-4776-5p	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT2208870	hsa-miR-491-5p	CLIP-seq
MIRT2208871	hsa-miR-497	CLIP-seq
MIRT2208872	hsa-miR-502-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2208873	hsa-miR-516b	CLIP-seq
MIRT2208874	hsa-miR-545	CLIP-seq
MIRT2208875	hsa-miR-548a-3p	CLIP-seq
MIRT2208876	hsa-miR-548e	CLIP-seq
MIRT2208877	hsa-miR-548f	CLIP-seq
MIRT2208878	hsa-miR-574-3p	CLIP-seq
MIRT2208879	hsa-miR-579	CLIP-seq
MIRT922300	hsa-miR-581	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT2208880	hsa-miR-646	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT2208881	hsa-miR-888	CLIP-seq
MIRT2208882	hsa-miR-939	CLIP-seq
MIRT922306	hsa-miR-96	CLIP-seq
MIRT922307	hsa-miR-98	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT2208861	hsa-miR-3660	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT2208867	hsa-miR-4526	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT2436757	hsa-miR-3682-5p	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2436758	hsa-miR-550b	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2512640	hsa-miR-1245b-5p	CLIP-seq
MIRT2512641	hsa-miR-2110	CLIP-seq
MIRT2512642	hsa-miR-3142	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2512643	hsa-miR-3189-3p	CLIP-seq
MIRT2512644	hsa-miR-4450	CLIP-seq
MIRT2512640	hsa-miR-1245b-5p	CLIP-seq
MIRT2512641	hsa-miR-2110	CLIP-seq
MIRT2512642	hsa-miR-3142	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2512643	hsa-miR-3189-3p	CLIP-seq
MIRT2512644	hsa-miR-4450	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001726	Component	Ruffle	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	9707577, 23940353
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 32296183, 33961781
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	9742223, 23940353
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	9742223
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	17398095
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005912	Component	Adherens junction	ISS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0032012	Process	Regulation of ARF protein signal transduction	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IEA
GO:0048193	Process	Golgi vesicle transport	IMP	9707577
GO:0070161	Component	Anchoring junction	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	ISS

Other IDs

• MIM: 605081
• HGNC: 9504
• e!Ensembl: ENSG00000008256

Protein

• UniProt ID: O43739
• Protein name: Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)
• Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:239
• PDB: 4KAX, 6U3E, 6U3G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01369	Sec7	66 → 248	Sec7 domain	Domain
  PF00169	PH	265 → 381	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Almost absent from liver, thymus and peripheral blood lymphocytes.
• Sequence:

  MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE
  SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL
  GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN
  PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY
  ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYT
  TDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR
  ISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

• Sequence length: 400

Pathways

KEGG:

Phospholipase D signaling pathway
Endocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection

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