PTTG1 (PTTG1 regulator of sister chromatid separation, securin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9232
Gene name Gene Name - the full gene name approved by the HGNC.
PTTG1 regulator of sister chromatid separation, securin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTTG1
Synonyms (NCBI Gene) Gene synonyms aliases
EAP1, ECRAR, HPTTG, PTTG, TUTR1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q33.3
Summary Summary of gene provided in NCBI Entrez Gene.
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT052149 hsa-let-7b-5p CLASH 23622248
MIRT050987 hsa-miR-17-5p CLASH 23622248
MIRT050118 hsa-miR-26a-5p CLASH 23622248
MIRT044923 hsa-miR-186-5p CLASH 23622248
MIRT044427 hsa-miR-320a CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
KLF6 Repression 20116377;23977008
SP1 Activation 18339849
SP1 Unknown 14644503
TP53 Activation 12355087
TP53 Repression 15016801
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004869 Function Cysteine-type endopeptidase inhibitor activity NAS 12194817
GO:0005515 Function Protein binding IPI 12194817
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 9811450
GO:0005737 Component Cytoplasm TAS 9811450
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604147 9690 ENSG00000164611
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95997
Protein name Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)
Protein function Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteoly
PDB 7NJ0 , 7NJ1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04856 Securin 1 → 191 Securin sister-chromatid separation inhibitor Family
Tissue specificity TISSUE SPECIFICITY: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. {ECO:0000269|PubMed:9
Sequence
Sequence length 202
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cell cycle
Oocyte meiosis
Human T-cell leukemia virus 1 infection 		  APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 20953187
Show/Hide Text Mining Associations (95)
Associations from Text Mining
Disease Name Relationship Type References
Acute Aortic Syndrome Associate 31721906
Adenocarcinoma of Lung Stimulate 25816405
Adenocarcinoma of Lung Associate 30353687, 34539658, 34996932, 37671160
Adrenal Cortex Neoplasms Associate 24238056
Adrenocortical Carcinoma Associate 24238056
Aneuploidy Stimulate 11013229
Aneuploidy Associate 12070128, 16799481, 31578227
Aortic Dissection Associate 31721906
Arthritis Psoriatic Stimulate 23677169
Arthritis Psoriatic Associate 25549700