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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UBH6 |
| Protein name |
Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1) |
| Protein function |
Inorganic ion transporter that mediates phosphate ion export across plasma membrane (PubMed:23791524, PubMed:25938945, PubMed:27080106, PubMed:31043717, PubMed:39169184, PubMed:39325866, PubMed:39747008, PubMed:39814721). Plays a major role in p |
| PDB |
5IJH
, 8TYU
, 8TYV
, 8X5B
, 8X5E
, 8X5F
, 8YET
, 8YEX
, 8YF4
, 8YFD
, 8YFU
, 8YFW
, 8YFX
, 9IJY
, 9IJZ
, 9IWS
, 9J4X
, 9J51
, 9J52
, 9J53
, 9J97
, 9J98
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF03105 |
SPX |
1 → 50 |
SPX domain |
Domain |
| PF03105 |
SPX |
34 → 102 |
SPX domain |
Domain |
| PF03105 |
SPX |
93 → 172 |
SPX domain |
Domain |
| PF03124 |
EXS |
268 → 617 |
EXS family |
Family |
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| Tissue specificity |
TISSUE SPECIFICITY: Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. {ECO:0000269|PubMed:9927670, ECO:0000269|PubMed:9990033}. |
| Sequence |
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| Sequence length |
696 |
| Interactions |
View interactions |
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| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| Acute myeloid leukemia |
Benign |
rs6697358, rs12088430, rs12075809 |
RCV005915605 RCV005921786 RCV005924860 |
| Cervical cancer |
Benign |
rs6697358, rs12088430, rs12075809 |
RCV005915607 RCV005921788 RCV005924862 |
| Familial pancreatic carcinoma |
Benign |
rs6697358 |
RCV005915608 |
| Lung cancer |
Benign |
rs6697358, rs12088430, rs12075809 |
RCV005915611 RCV005921791 RCV005924864 |
| Malignant tumor of esophagus |
Benign |
rs6697358, rs12088430, rs12075809 |
RCV005915606 RCV005921787 RCV005924861 |
| Ovarian serous cystadenocarcinoma |
Benign |
rs6697358, rs12075809 |
RCV005915609 RCV005924863 |
| Sarcoma |
Benign |
rs12088430 |
RCV005921789 |
| See cases |
Conflicting classifications of pathogenicity |
rs200954931 |
RCV002252772 |
| Thymoma |
Benign |
rs6697358 |
RCV005915610 |
| Uterine carcinosarcoma |
Benign |
rs12088430 |
RCV005921790 |
| Uterine corpus endometrial carcinoma |
Uncertain significance |
rs370177151 |
RCV005930610 |
| XPR1-related disorder |
Benign; Likely benign |
rs372023037, rs749737707, rs781372172, rs147941113, rs191427425 |
RCV003966264 RCV003901352 RCV003927218 RCV004757340 RCV003936001 |
| XPR1-related primary familial brain calcification |
Uncertain significance |
rs2102226595 |
RCV001563609 |
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