Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9203
Gene name	Zinc finger MYM-type containing 3
Gene symbol	ZMYM3
Synonyms (NCBI Gene)	DXS6673EMYMXFIMXLID112ZNF198L2ZNF261
Chromosome	X
Chromosome location	Xq13.1
Summary	This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that f

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SNP ID	Visualize variation	Clinical significance	Consequence
rs142437272	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant, genic downstream transcript variant

174

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052466	hsa-let-7a-5p	CLASH	23622248
MIRT050706	hsa-miR-18a-5p	CLASH	23622248
MIRT043846	hsa-miR-330-3p	CLASH	23622248
MIRT037684	hsa-miR-744-5p	CLASH	23622248
MIRT1514929	hsa-miR-1179	CLIP-seq
MIRT1514930	hsa-miR-1193	CLIP-seq
MIRT1514931	hsa-miR-1207-5p	CLIP-seq
MIRT1514932	hsa-miR-1226	CLIP-seq
MIRT1514933	hsa-miR-1246	CLIP-seq
MIRT1514934	hsa-miR-1253	CLIP-seq
MIRT1514935	hsa-miR-1262	CLIP-seq
MIRT1514936	hsa-miR-1343	CLIP-seq
MIRT1514937	hsa-miR-141	CLIP-seq
MIRT1514938	hsa-miR-1912	CLIP-seq
MIRT1514939	hsa-miR-200a	CLIP-seq
MIRT1514940	hsa-miR-24	CLIP-seq
MIRT1514941	hsa-miR-2682	CLIP-seq
MIRT1514942	hsa-miR-2861	CLIP-seq
MIRT1514943	hsa-miR-3123	CLIP-seq
MIRT1514944	hsa-miR-3127-5p	CLIP-seq
MIRT1514945	hsa-miR-3130-3p	CLIP-seq
MIRT1514946	hsa-miR-3134	CLIP-seq
MIRT1514947	hsa-miR-3148	CLIP-seq
MIRT1514948	hsa-miR-3173-3p	CLIP-seq
MIRT1514949	hsa-miR-3201	CLIP-seq
MIRT1514950	hsa-miR-34a	CLIP-seq
MIRT1514951	hsa-miR-34c-5p	CLIP-seq
MIRT1514952	hsa-miR-3714	CLIP-seq
MIRT1514953	hsa-miR-378	CLIP-seq
MIRT1514954	hsa-miR-378b	CLIP-seq
MIRT1514955	hsa-miR-378c	CLIP-seq
MIRT1514956	hsa-miR-378d	CLIP-seq
MIRT1514957	hsa-miR-378e	CLIP-seq
MIRT1514958	hsa-miR-378f	CLIP-seq
MIRT1514959	hsa-miR-378h	CLIP-seq
MIRT1514960	hsa-miR-378i	CLIP-seq
MIRT1514961	hsa-miR-384	CLIP-seq
MIRT1514962	hsa-miR-3910	CLIP-seq
MIRT1514963	hsa-miR-3915	CLIP-seq
MIRT1514964	hsa-miR-3918	CLIP-seq
MIRT1514965	hsa-miR-3921	CLIP-seq
MIRT1514966	hsa-miR-3925-5p	CLIP-seq
MIRT1514967	hsa-miR-3928	CLIP-seq
MIRT1514968	hsa-miR-422a	CLIP-seq
MIRT1514969	hsa-miR-4274	CLIP-seq
MIRT1514970	hsa-miR-4284	CLIP-seq
MIRT1514971	hsa-miR-4294	CLIP-seq
MIRT1514972	hsa-miR-4426	CLIP-seq
MIRT1514973	hsa-miR-4433	CLIP-seq
MIRT1514974	hsa-miR-4436a	CLIP-seq
MIRT1514975	hsa-miR-449a	CLIP-seq
MIRT1514976	hsa-miR-449b	CLIP-seq
MIRT1514977	hsa-miR-449c	CLIP-seq
MIRT1514978	hsa-miR-4506	CLIP-seq
MIRT1514979	hsa-miR-4638-3p	CLIP-seq
MIRT1514980	hsa-miR-4647	CLIP-seq
MIRT1514981	hsa-miR-4649-3p	CLIP-seq
MIRT1514982	hsa-miR-4653-5p	CLIP-seq
MIRT1514983	hsa-miR-4662b	CLIP-seq
MIRT1514984	hsa-miR-4700-3p	CLIP-seq
MIRT1514985	hsa-miR-4701-3p	CLIP-seq
MIRT1514986	hsa-miR-4701-5p	CLIP-seq
MIRT1514987	hsa-miR-4714-3p	CLIP-seq
MIRT1514988	hsa-miR-4733-3p	CLIP-seq
MIRT1514989	hsa-miR-4763-3p	CLIP-seq
MIRT1514990	hsa-miR-4779	CLIP-seq
MIRT1514991	hsa-miR-4791	CLIP-seq
MIRT1514992	hsa-miR-4792	CLIP-seq
MIRT1514993	hsa-miR-4793-3p	CLIP-seq
MIRT1514994	hsa-miR-548an	CLIP-seq
MIRT1514995	hsa-miR-588	CLIP-seq
MIRT1514996	hsa-miR-659	CLIP-seq
MIRT1514997	hsa-miR-7	CLIP-seq
MIRT1514998	hsa-miR-711	CLIP-seq
MIRT1514999	hsa-miR-940	CLIP-seq
MIRT1515000	hsa-miR-129-5p	CLIP-seq
MIRT1515001	hsa-miR-1321	CLIP-seq
MIRT1515002	hsa-miR-1827	CLIP-seq
MIRT1515003	hsa-miR-1972	CLIP-seq
MIRT1514940	hsa-miR-24	CLIP-seq
MIRT1514941	hsa-miR-2682	CLIP-seq
MIRT1515004	hsa-miR-300	CLIP-seq
MIRT1515005	hsa-miR-3152-5p	CLIP-seq
MIRT1515006	hsa-miR-3179	CLIP-seq
MIRT1515007	hsa-miR-3189-3p	CLIP-seq
MIRT1515008	hsa-miR-338-5p	CLIP-seq
MIRT1515009	hsa-miR-3545-3p	CLIP-seq
MIRT1515010	hsa-miR-3612	CLIP-seq
MIRT1515011	hsa-miR-3689a-3p	CLIP-seq
MIRT1515012	hsa-miR-3689c	CLIP-seq
MIRT1515013	hsa-miR-381	CLIP-seq
MIRT1514970	hsa-miR-4284	CLIP-seq
MIRT1515014	hsa-miR-4312	CLIP-seq
MIRT1515015	hsa-miR-4420	CLIP-seq
MIRT1515016	hsa-miR-4475	CLIP-seq
MIRT1514977	hsa-miR-449c	CLIP-seq
MIRT1515017	hsa-miR-4509	CLIP-seq
MIRT1515018	hsa-miR-4666-3p	CLIP-seq
MIRT1515019	hsa-miR-4728-5p	CLIP-seq
MIRT1515020	hsa-miR-4739	CLIP-seq
MIRT1515021	hsa-miR-4755-3p	CLIP-seq
MIRT1515022	hsa-miR-4756-5p	CLIP-seq
MIRT1515023	hsa-miR-4774-3p	CLIP-seq
MIRT1515024	hsa-miR-4797-5p	CLIP-seq
MIRT1515025	hsa-miR-566	CLIP-seq
MIRT1515026	hsa-miR-650	CLIP-seq
MIRT1515027	hsa-miR-935	CLIP-seq
MIRT1514930	hsa-miR-1193	CLIP-seq
MIRT2155443	hsa-miR-1207-3p	CLIP-seq
MIRT2155444	hsa-miR-1229	CLIP-seq
MIRT1514933	hsa-miR-1246	CLIP-seq
MIRT1515001	hsa-miR-1321	CLIP-seq
MIRT1515002	hsa-miR-1827	CLIP-seq
MIRT1514940	hsa-miR-24	CLIP-seq
MIRT2155445	hsa-miR-2467-5p	CLIP-seq
MIRT1514941	hsa-miR-2682	CLIP-seq
MIRT2155446	hsa-miR-3126-5p	CLIP-seq
MIRT1514944	hsa-miR-3127-5p	CLIP-seq
MIRT1514945	hsa-miR-3130-3p	CLIP-seq
MIRT1514946	hsa-miR-3134	CLIP-seq
MIRT2155447	hsa-miR-3135	CLIP-seq
MIRT1514949	hsa-miR-3201	CLIP-seq
MIRT1515010	hsa-miR-3612	CLIP-seq
MIRT2155448	hsa-miR-3622b-5p	CLIP-seq
MIRT1514952	hsa-miR-3714	CLIP-seq
MIRT2155449	hsa-miR-3914	CLIP-seq
MIRT1514964	hsa-miR-3918	CLIP-seq
MIRT2155450	hsa-miR-3945	CLIP-seq
MIRT2155451	hsa-miR-4253	CLIP-seq
MIRT1514969	hsa-miR-4274	CLIP-seq
MIRT1514970	hsa-miR-4284	CLIP-seq
MIRT1514971	hsa-miR-4294	CLIP-seq
MIRT1514972	hsa-miR-4426	CLIP-seq
MIRT1514973	hsa-miR-4433	CLIP-seq
MIRT1514974	hsa-miR-4436a	CLIP-seq
MIRT2155452	hsa-miR-4446-5p	CLIP-seq
MIRT2155453	hsa-miR-4457	CLIP-seq
MIRT2155454	hsa-miR-4489	CLIP-seq
MIRT2155455	hsa-miR-4496	CLIP-seq
MIRT1514977	hsa-miR-449c	CLIP-seq
MIRT2155456	hsa-miR-4504	CLIP-seq
MIRT1514978	hsa-miR-4506	CLIP-seq
MIRT1515017	hsa-miR-4509	CLIP-seq
MIRT1514980	hsa-miR-4647	CLIP-seq
MIRT1514983	hsa-miR-4662b	CLIP-seq
MIRT1514984	hsa-miR-4700-3p	CLIP-seq
MIRT1514986	hsa-miR-4701-5p	CLIP-seq
MIRT1514987	hsa-miR-4714-3p	CLIP-seq
MIRT2155457	hsa-miR-4731-3p	CLIP-seq
MIRT1515020	hsa-miR-4739	CLIP-seq
MIRT2155458	hsa-miR-4755-5p	CLIP-seq
MIRT1515022	hsa-miR-4756-5p	CLIP-seq
MIRT1514991	hsa-miR-4791	CLIP-seq
MIRT1514993	hsa-miR-4793-3p	CLIP-seq
MIRT1515024	hsa-miR-4797-5p	CLIP-seq
MIRT2155459	hsa-miR-4801	CLIP-seq
MIRT2155460	hsa-miR-541	CLIP-seq
MIRT2155461	hsa-miR-549	CLIP-seq
MIRT1514995	hsa-miR-588	CLIP-seq
MIRT2155462	hsa-miR-629	CLIP-seq
MIRT1515026	hsa-miR-650	CLIP-seq
MIRT2155463	hsa-miR-654-5p	CLIP-seq
MIRT2155464	hsa-miR-767-3p	CLIP-seq
MIRT2155465	hsa-miR-873	CLIP-seq
MIRT1515027	hsa-miR-935	CLIP-seq
MIRT1514972	hsa-miR-4426	CLIP-seq
MIRT1514980	hsa-miR-4647	CLIP-seq
MIRT1514983	hsa-miR-4662b	CLIP-seq
MIRT1514945	hsa-miR-3130-3p	CLIP-seq
MIRT2667699	hsa-miR-3691-3p	CLIP-seq
MIRT1514971	hsa-miR-4294	CLIP-seq
MIRT1514973	hsa-miR-4433	CLIP-seq
MIRT2667700	hsa-miR-4761-5p	CLIP-seq
MIRT1514993	hsa-miR-4793-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	TAS	10486218
GO:0005515	Function	Protein binding	IPI	30021884, 30889214, 32814053, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	36586412
GO:0005654	Component	Nucleoplasm	IDA
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0008270	Function	Zinc ion binding	IEA
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
300061	13054	ENSG00000147130

Q14202

Protein name

Zinc finger MYM-type protein 3 (Zinc finger protein 261)

Protein function

Plays a role in the regulation of cell morphology and cytoskeletal organization.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06467	zf-FCS	348 → 389	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	404 → 440	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	446 → 488	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	493 → 532	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	541 → 578	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	586 → 623	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	628 → 664	MYM-type Zinc finger with FCS sequence motif	Domain
PF06467	zf-FCS	715 → 751	MYM-type Zinc finger with FCS sequence motif	Domain
PF12012	DUF3504	1185 → 1353	Domain of unknown function (DUF3504)	Family

Tissue specificity

TISSUE SPECIFICITY: Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.

Sequence

MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLL
DTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQT
PEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELP
QGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERKRS
ERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRA
GRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEI
WNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLH
EVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFC
NTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLT
GPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSG
KPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGC
VLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARC
HACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQ
TPSQTKVENSNTVRTPEENGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQ
NRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPM
FLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQS
AEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLV
GPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYA
NGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCL
GIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQL
GVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAP
VRQRKGRDTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYL
QPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD

Sequence length

1370

Interactions

View interactions

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal facial shape	Likely pathogenic	rs2147988068	RCV002291086
Global developmental delay	Likely pathogenic	rs2147988068	RCV002291086
Hyporeflexia	Likely pathogenic	rs2147988068	RCV002291086
Intellectual developmental disorder, X-linked 112	Pathogenic; Likely pathogenic	rs2519835731, rs2519822410	RCV003313747 RCV004595279
Neonatal hypotonia	Likely pathogenic	rs2147988068	RCV002291086

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Intellectual disability	Uncertain significance	rs746982292	RCV001260796
Neurodevelopmental disorder	Uncertain significance	rs2519844077	RCV003994754
ZMYM3-related disorder	Uncertain significance; Likely benign; Benign	rs2147982186, rs894482055, rs1338083779, rs2519837951, rs1221460658, rs141256730, rs150144367, rs752294993, rs201097988, rs765146259, rs148915559, rs140177072, rs369768301, rs761169958, rs151152741, rs140663879 View all (1 more)	RCV003405725 RCV003400194 RCV003404587 RCV003410862 RCV003412209 RCV003908970 RCV003914690 RCV003899338 RCV003949544 RCV003936867 RCV003949218 RCV003947033 RCV003947310 RCV003969541 RCV003978272 RCV003940463

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	33173136
Aortic Valve Stenosis	Associate	24721225
Azoospermia Nonobstructive	Associate	36017582
Bipolar Disorder	Associate	33173136
Cognition Disorders	Associate	33173136
Developmental Disabilities	Associate	36586412
Hypersensitivity Delayed	Associate	36586412
Hypospadias	Associate	24721225
Infertility	Associate	36017582
Infertility Male	Associate	39267058
Intellectual Disability	Associate	23871722
Leukemia Lymphocytic Chronic B Cell	Associate	27060156
Medulloblastoma	Associate	25030029
Neoplasms	Associate	24571310, 24710217, 25030029, 33115829
Neurocognitive Disorders	Associate	33173136
Prostatic Neoplasms	Associate	33115829
Sarcoma Ewing	Associate	25223734
Schizophrenia	Associate	33173136

ZMYM3 (zinc finger MYM-type containing 3)