Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
92
Gene name Gene Name - the full gene name approved by the HGNC.
Activin A receptor type 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACVR2A
Synonyms (NCBI Gene) Gene synonyms aliases
ACTRII, ACVR2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q22.3-q23.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000536 hsa-miR-16-5p Review, Luciferase reporter assay, Western blot 20216554
MIRT021134 hsa-miR-186-5p Sequencing 20371350
MIRT025616 hsa-miR-10a-5p Sequencing 20371350
MIRT026448 hsa-miR-192-5p Microarray 19074876
MIRT568636 hsa-miR-561-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001702 Process Gastrulation with mouth forming second IEA
GO:0001934 Process Positive regulation of protein phosphorylation IMP 17472960
GO:0004674 Function Protein serine/threonine kinase activity EXP 8622651, 8721982
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004675 Function Transmembrane receptor protein serine/threonine kinase activity TAS 1314589
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
102581 173 ENSG00000121989
Protein
UniProt ID P27037
Protein name Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Protein function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD trans
PDB 3Q4T , 3SOC , 4ASX , 5NH3 , 7U5P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01064 Activin_recp 23 114 Activin types I and II receptor domain Domain
PF00069 Pkinase 196 481 Protein kinase domain Domain
Sequence
Sequence length 513
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
Fluid shear stress and atherosclerosis
  Signaling by Activin
Signaling by BMP
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Gastric Adenocarcinoma rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Gout Gout GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 31589790
Adenocarcinoma Associate 25478808, 29522538
Adenocarcinoma of Lung Associate 34036102
Adenoma Associate 34843512
Anodontia Associate 16380996, 17258738
Anxiety Associate 32652377
Brain Neoplasms Associate 7670558
Breast Neoplasms Associate 29114882, 35589867
Bronchiectasis Associate 40536885
Carcinogenesis Associate 14691305, 18941508, 19820113, 34843512