WDR20 (WD repeat domain 20)

Gene

• Entrez ID: 91833
• Gene name: WD repeat domain 20
• Gene symbol: WDR20
• Synonyms (NCBI Gene): Bun107, DMR
• Chromosome: 14
• Chromosome location: 14q32.31
• Summary: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT697672	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT697671	hsa-miR-4537	HITS-CLIP	23313552
MIRT069290	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT069291	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT697672	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT697671	hsa-miR-4537	HITS-CLIP	23313552
MIRT1489836	hsa-miR-181a	CLIP-seq
MIRT1489837	hsa-miR-181b	CLIP-seq
MIRT1489838	hsa-miR-181c	CLIP-seq
MIRT1489839	hsa-miR-181d	CLIP-seq
MIRT1489840	hsa-miR-23a	CLIP-seq
MIRT1489841	hsa-miR-23b	CLIP-seq
MIRT1489842	hsa-miR-23c	CLIP-seq
MIRT1489843	hsa-miR-4262	CLIP-seq
MIRT1489844	hsa-miR-4289	CLIP-seq
MIRT1489845	hsa-miR-616	CLIP-seq
MIRT1489846	hsa-miR-664	CLIP-seq
MIRT1489847	hsa-miR-101	CLIP-seq
MIRT1489848	hsa-miR-1264	CLIP-seq
MIRT1489849	hsa-miR-1297	CLIP-seq
MIRT1489850	hsa-miR-132	CLIP-seq
MIRT1489851	hsa-miR-153	CLIP-seq
MIRT1489852	hsa-miR-194	CLIP-seq
MIRT1489853	hsa-miR-212	CLIP-seq
MIRT1489854	hsa-miR-26a	CLIP-seq
MIRT1489855	hsa-miR-26b	CLIP-seq
MIRT1489856	hsa-miR-3150a-3p	CLIP-seq
MIRT1489857	hsa-miR-3175	CLIP-seq
MIRT1489858	hsa-miR-3668	CLIP-seq
MIRT1489859	hsa-miR-3928	CLIP-seq
MIRT1489860	hsa-miR-4323	CLIP-seq
MIRT1489861	hsa-miR-4465	CLIP-seq
MIRT1489862	hsa-miR-448	CLIP-seq
MIRT1489863	hsa-miR-4667-5p	CLIP-seq
MIRT1489864	hsa-miR-4700-5p	CLIP-seq
MIRT1489865	hsa-miR-4758-3p	CLIP-seq
MIRT1489866	hsa-miR-4795-5p	CLIP-seq
MIRT1489867	hsa-miR-4797-5p	CLIP-seq
MIRT1489868	hsa-miR-520f	CLIP-seq
MIRT1489869	hsa-miR-539	CLIP-seq
MIRT1489870	hsa-miR-548ag	CLIP-seq
MIRT1489871	hsa-miR-548ai	CLIP-seq
MIRT1489872	hsa-miR-765	CLIP-seq
MIRT1489873	hsa-miR-939	CLIP-seq
MIRT1489874	hsa-miR-130a	CLIP-seq
MIRT1489875	hsa-miR-130b	CLIP-seq
MIRT1489876	hsa-miR-19a	CLIP-seq
MIRT1489877	hsa-miR-19b	CLIP-seq
MIRT1489878	hsa-miR-301a	CLIP-seq
MIRT1489879	hsa-miR-301b	CLIP-seq
MIRT1489880	hsa-miR-302a	CLIP-seq
MIRT1489881	hsa-miR-302b	CLIP-seq
MIRT1489882	hsa-miR-302c	CLIP-seq
MIRT1489883	hsa-miR-302d	CLIP-seq
MIRT1489884	hsa-miR-302e	CLIP-seq
MIRT1489885	hsa-miR-3666	CLIP-seq
MIRT1489886	hsa-miR-372	CLIP-seq
MIRT1489887	hsa-miR-373	CLIP-seq
MIRT1489888	hsa-miR-4295	CLIP-seq
MIRT1489889	hsa-miR-454	CLIP-seq
MIRT1489890	hsa-miR-519a	CLIP-seq
MIRT1489891	hsa-miR-519b-3p	CLIP-seq
MIRT1489892	hsa-miR-519c-3p	CLIP-seq
MIRT1489893	hsa-miR-520a-3p	CLIP-seq
MIRT1489894	hsa-miR-520b	CLIP-seq
MIRT1489895	hsa-miR-520c-3p	CLIP-seq
MIRT1489896	hsa-miR-520d-3p	CLIP-seq
MIRT1489897	hsa-miR-520e	CLIP-seq
MIRT1489836	hsa-miR-181a	CLIP-seq
MIRT1489837	hsa-miR-181b	CLIP-seq
MIRT1489838	hsa-miR-181c	CLIP-seq
MIRT1489839	hsa-miR-181d	CLIP-seq
MIRT1489840	hsa-miR-23a	CLIP-seq
MIRT1489841	hsa-miR-23b	CLIP-seq
MIRT1489842	hsa-miR-23c	CLIP-seq
MIRT1489898	hsa-miR-3128	CLIP-seq
MIRT1489899	hsa-miR-3652	CLIP-seq
MIRT1489843	hsa-miR-4262	CLIP-seq
MIRT1489844	hsa-miR-4289	CLIP-seq
MIRT1489900	hsa-miR-4430	CLIP-seq
MIRT1489901	hsa-miR-4505	CLIP-seq
MIRT1489902	hsa-miR-532-3p	CLIP-seq
MIRT1489903	hsa-miR-647	CLIP-seq
MIRT1489904	hsa-miR-662	CLIP-seq
MIRT1489846	hsa-miR-664	CLIP-seq
MIRT1489905	hsa-miR-1184	CLIP-seq
MIRT1489906	hsa-miR-217	CLIP-seq
MIRT1489860	hsa-miR-4323	CLIP-seq
MIRT1489907	hsa-miR-4418	CLIP-seq
MIRT1489908	hsa-miR-509-3-5p	CLIP-seq
MIRT1489909	hsa-miR-509-5p	CLIP-seq
MIRT2368105	hsa-miR-1302	CLIP-seq
MIRT2368106	hsa-miR-203	CLIP-seq
MIRT2368107	hsa-miR-3122	CLIP-seq
MIRT1489898	hsa-miR-3128	CLIP-seq
MIRT2368108	hsa-miR-3136-5p	CLIP-seq
MIRT2368109	hsa-miR-3189-3p	CLIP-seq
MIRT2368110	hsa-miR-3199	CLIP-seq
MIRT1489899	hsa-miR-3652	CLIP-seq
MIRT2368111	hsa-miR-374c	CLIP-seq
MIRT2368112	hsa-miR-3913-5p	CLIP-seq
MIRT2368113	hsa-miR-4298	CLIP-seq
MIRT1489900	hsa-miR-4430	CLIP-seq
MIRT2368114	hsa-miR-4439	CLIP-seq
MIRT1489901	hsa-miR-4505	CLIP-seq
MIRT2368115	hsa-miR-4513	CLIP-seq
MIRT2368116	hsa-miR-4700-3p	CLIP-seq
MIRT1489903	hsa-miR-647	CLIP-seq
MIRT2368117	hsa-miR-655	CLIP-seq
MIRT1489856	hsa-miR-3150a-3p	CLIP-seq
MIRT1489857	hsa-miR-3175	CLIP-seq
MIRT2396934	hsa-miR-3646	CLIP-seq
MIRT2396935	hsa-miR-3662	CLIP-seq
MIRT2396936	hsa-miR-3925-3p	CLIP-seq
MIRT1489859	hsa-miR-3928	CLIP-seq
MIRT1489863	hsa-miR-4667-5p	CLIP-seq
MIRT2396937	hsa-miR-4691-3p	CLIP-seq
MIRT1489864	hsa-miR-4700-5p	CLIP-seq
MIRT1489866	hsa-miR-4795-5p	CLIP-seq
MIRT1489869	hsa-miR-539	CLIP-seq
MIRT1489872	hsa-miR-765	CLIP-seq
MIRT2396938	hsa-miR-766	CLIP-seq
MIRT1489873	hsa-miR-939	CLIP-seq
MIRT2441661	hsa-miR-188-5p	CLIP-seq
MIRT2441662	hsa-miR-3940-5p	CLIP-seq
MIRT2441663	hsa-miR-4507	CLIP-seq
MIRT2441664	hsa-miR-629	CLIP-seq
MIRT2661635	hsa-miR-1179	CLIP-seq
MIRT2661636	hsa-miR-1200	CLIP-seq
MIRT2661637	hsa-miR-1226	CLIP-seq
MIRT2661638	hsa-miR-1301	CLIP-seq
MIRT1489874	hsa-miR-130a	CLIP-seq
MIRT1489875	hsa-miR-130b	CLIP-seq
MIRT1489850	hsa-miR-132	CLIP-seq
MIRT1489852	hsa-miR-194	CLIP-seq
MIRT1489876	hsa-miR-19a	CLIP-seq
MIRT1489877	hsa-miR-19b	CLIP-seq
MIRT1489853	hsa-miR-212	CLIP-seq
MIRT2661639	hsa-miR-2276	CLIP-seq
MIRT2661640	hsa-miR-24	CLIP-seq
MIRT1489878	hsa-miR-301a	CLIP-seq
MIRT1489879	hsa-miR-301b	CLIP-seq
MIRT1489880	hsa-miR-302a	CLIP-seq
MIRT1489881	hsa-miR-302b	CLIP-seq
MIRT1489882	hsa-miR-302c	CLIP-seq
MIRT1489883	hsa-miR-302d	CLIP-seq
MIRT1489884	hsa-miR-302e	CLIP-seq
MIRT2661641	hsa-miR-3120-5p	CLIP-seq
MIRT2661642	hsa-miR-3140-5p	CLIP-seq
MIRT2661643	hsa-miR-3177-3p	CLIP-seq
MIRT2661644	hsa-miR-323-3p	CLIP-seq
MIRT2661645	hsa-miR-338-3p	CLIP-seq
MIRT1489885	hsa-miR-3666	CLIP-seq
MIRT2661646	hsa-miR-3691-3p	CLIP-seq
MIRT2661647	hsa-miR-3692	CLIP-seq
MIRT1489886	hsa-miR-372	CLIP-seq
MIRT1489887	hsa-miR-373	CLIP-seq
MIRT2661648	hsa-miR-3937	CLIP-seq
MIRT2661649	hsa-miR-3973	CLIP-seq
MIRT2661650	hsa-miR-4268	CLIP-seq
MIRT2661651	hsa-miR-4272	CLIP-seq
MIRT1489888	hsa-miR-4295	CLIP-seq
MIRT2661652	hsa-miR-4310	CLIP-seq
MIRT2661653	hsa-miR-4328	CLIP-seq
MIRT2661654	hsa-miR-4449	CLIP-seq
MIRT2661655	hsa-miR-4469	CLIP-seq
MIRT2661656	hsa-miR-4519	CLIP-seq
MIRT2661657	hsa-miR-4532	CLIP-seq
MIRT1489889	hsa-miR-454	CLIP-seq
MIRT2661658	hsa-miR-4655-3p	CLIP-seq
MIRT2661659	hsa-miR-4660	CLIP-seq
MIRT2661660	hsa-miR-4668-3p	CLIP-seq
MIRT2661661	hsa-miR-4677-3p	CLIP-seq
MIRT2661662	hsa-miR-4679	CLIP-seq
MIRT2661663	hsa-miR-4680-3p	CLIP-seq
MIRT2661664	hsa-miR-4684-5p	CLIP-seq
MIRT2661665	hsa-miR-4768-5p	CLIP-seq
MIRT2661666	hsa-miR-4772-3p	CLIP-seq
MIRT2661667	hsa-miR-4783-5p	CLIP-seq
MIRT2661668	hsa-miR-483-3p	CLIP-seq
MIRT2661669	hsa-miR-5047	CLIP-seq
MIRT2661670	hsa-miR-518a-5p	CLIP-seq
MIRT1489890	hsa-miR-519a	CLIP-seq
MIRT1489891	hsa-miR-519b-3p	CLIP-seq
MIRT1489892	hsa-miR-519c-3p	CLIP-seq
MIRT1489893	hsa-miR-520a-3p	CLIP-seq
MIRT1489894	hsa-miR-520b	CLIP-seq
MIRT1489895	hsa-miR-520c-3p	CLIP-seq
MIRT1489896	hsa-miR-520d-3p	CLIP-seq
MIRT1489897	hsa-miR-520e	CLIP-seq
MIRT2661671	hsa-miR-527	CLIP-seq
MIRT2661672	hsa-miR-548a-5p	CLIP-seq
MIRT2661673	hsa-miR-548ab	CLIP-seq
MIRT2661674	hsa-miR-548ak	CLIP-seq
MIRT2661675	hsa-miR-548b-5p	CLIP-seq
MIRT2661676	hsa-miR-548c-5p	CLIP-seq
MIRT2661677	hsa-miR-548d-5p	CLIP-seq
MIRT2661678	hsa-miR-548h	CLIP-seq
MIRT2661679	hsa-miR-548i	CLIP-seq
MIRT2661680	hsa-miR-548j	CLIP-seq
MIRT2661681	hsa-miR-548w	CLIP-seq
MIRT2661682	hsa-miR-548y	CLIP-seq
MIRT2661683	hsa-miR-559	CLIP-seq
MIRT2661684	hsa-miR-564	CLIP-seq
MIRT2661685	hsa-miR-598	CLIP-seq
MIRT2661686	hsa-miR-634	CLIP-seq
MIRT2661687	hsa-miR-668	CLIP-seq
MIRT2661688	hsa-miR-802	CLIP-seq
MIRT2661689	hsa-miR-933	CLIP-seq
MIRT2661635	hsa-miR-1179	CLIP-seq
MIRT2661636	hsa-miR-1200	CLIP-seq
MIRT2661637	hsa-miR-1226	CLIP-seq
MIRT2661638	hsa-miR-1301	CLIP-seq
MIRT1489874	hsa-miR-130a	CLIP-seq
MIRT1489875	hsa-miR-130b	CLIP-seq
MIRT1489876	hsa-miR-19a	CLIP-seq
MIRT1489877	hsa-miR-19b	CLIP-seq
MIRT2661639	hsa-miR-2276	CLIP-seq
MIRT2661640	hsa-miR-24	CLIP-seq
MIRT1489878	hsa-miR-301a	CLIP-seq
MIRT1489879	hsa-miR-301b	CLIP-seq
MIRT1489880	hsa-miR-302a	CLIP-seq
MIRT1489881	hsa-miR-302b	CLIP-seq
MIRT1489882	hsa-miR-302c	CLIP-seq
MIRT1489883	hsa-miR-302d	CLIP-seq
MIRT1489884	hsa-miR-302e	CLIP-seq
MIRT2661641	hsa-miR-3120-5p	CLIP-seq
MIRT2661642	hsa-miR-3140-5p	CLIP-seq
MIRT2661643	hsa-miR-3177-3p	CLIP-seq
MIRT2661645	hsa-miR-338-3p	CLIP-seq
MIRT1489885	hsa-miR-3666	CLIP-seq
MIRT2661646	hsa-miR-3691-3p	CLIP-seq
MIRT2661647	hsa-miR-3692	CLIP-seq
MIRT1489886	hsa-miR-372	CLIP-seq
MIRT1489887	hsa-miR-373	CLIP-seq
MIRT2661648	hsa-miR-3937	CLIP-seq
MIRT2661649	hsa-miR-3973	CLIP-seq
MIRT2661650	hsa-miR-4268	CLIP-seq
MIRT2661651	hsa-miR-4272	CLIP-seq
MIRT1489888	hsa-miR-4295	CLIP-seq
MIRT2661652	hsa-miR-4310	CLIP-seq
MIRT2661654	hsa-miR-4449	CLIP-seq
MIRT2661655	hsa-miR-4469	CLIP-seq
MIRT2661657	hsa-miR-4532	CLIP-seq
MIRT1489889	hsa-miR-454	CLIP-seq
MIRT2661658	hsa-miR-4655-3p	CLIP-seq
MIRT2661659	hsa-miR-4660	CLIP-seq
MIRT2661660	hsa-miR-4668-3p	CLIP-seq
MIRT2661661	hsa-miR-4677-3p	CLIP-seq
MIRT2661662	hsa-miR-4679	CLIP-seq
MIRT2661666	hsa-miR-4772-3p	CLIP-seq
MIRT2661667	hsa-miR-4783-5p	CLIP-seq
MIRT2661668	hsa-miR-483-3p	CLIP-seq
MIRT2661669	hsa-miR-5047	CLIP-seq
MIRT2661670	hsa-miR-518a-5p	CLIP-seq
MIRT1489890	hsa-miR-519a	CLIP-seq
MIRT1489891	hsa-miR-519b-3p	CLIP-seq
MIRT1489892	hsa-miR-519c-3p	CLIP-seq
MIRT1489893	hsa-miR-520a-3p	CLIP-seq
MIRT1489894	hsa-miR-520b	CLIP-seq
MIRT1489895	hsa-miR-520c-3p	CLIP-seq
MIRT1489896	hsa-miR-520d-3p	CLIP-seq
MIRT1489897	hsa-miR-520e	CLIP-seq
MIRT2661671	hsa-miR-527	CLIP-seq
MIRT2661672	hsa-miR-548a-5p	CLIP-seq
MIRT2661673	hsa-miR-548ab	CLIP-seq
MIRT2661674	hsa-miR-548ak	CLIP-seq
MIRT2661675	hsa-miR-548b-5p	CLIP-seq
MIRT2661676	hsa-miR-548c-5p	CLIP-seq
MIRT2661677	hsa-miR-548d-5p	CLIP-seq
MIRT2661678	hsa-miR-548h	CLIP-seq
MIRT2661679	hsa-miR-548i	CLIP-seq
MIRT2661680	hsa-miR-548j	CLIP-seq
MIRT2661681	hsa-miR-548w	CLIP-seq
MIRT2661682	hsa-miR-548y	CLIP-seq
MIRT2661683	hsa-miR-559	CLIP-seq
MIRT2661684	hsa-miR-564	CLIP-seq
MIRT2661686	hsa-miR-634	CLIP-seq
MIRT2661687	hsa-miR-668	CLIP-seq
MIRT2661689	hsa-miR-933	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19615732, 20147737, 25814554, 27373336, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	30466959, 33844468
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	30466959, 33844468
GO:0005737	Component	Cytoplasm	IEA
GO:0035800	Function	Deubiquitinase activator activity	IDA	20147737, 27373336

Other IDs

• MIM: 617741
• HGNC: 19667
• e!Ensembl: ENSG00000140153

Protein

• UniProt ID: Q8TBZ3
• Protein name: WD repeat-containing protein 20 (Protein DMR)
• Protein function: Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic cen
• PDB: 5K19, 5K1C, 6JLQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	210 → 248	WD domain, G-beta repeat	Repeat
  PF00400	WD40	253 → 290	WD domain, G-beta repeat	Repeat

• Sequence:

  MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
  NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV
  GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
  HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
  DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
  HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
  RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
  PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
  NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
  FLEDCIVTACQEGFICTWGRPGKVVSFNP

• Sequence length: 569

Pathways

Reactome:

Ub-specific processing proteases

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Clear cell carcinoma of kidney	Uncertain significance	rs768943158	RCV005927221

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Renal Cell	Associate	26790128
Myotonic Dystrophy	Associate	33844468
Neoplasms	Associate	33844468
Prostatic Neoplasms	Associate	26462181