Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	915
Gene name Gene Name - the full gene name approved by the HGNC.	CD3 delta subunit of T-cell receptor complex
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CD3D
Synonyms (NCBI Gene) Gene synonyms aliases	CD3-DELTA, CD3DELTA, IMD19, T3D
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four

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SNP ID	Visualize variation	Clinical significance	Consequence
rs111033580	G>A,T	Pathogenic, likely-benign	Synonymous variant, coding sequence variant, stop gained
rs111033581	G>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs730880296	C>T	Pathogenic	Intron variant
rs1591278347	C>T	Pathogenic	Coding sequence variant, stop gained

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miRTarBase ID	miRNA	Experiments	Reference
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT624398	hsa-miR-339-5p	PAR-CLIP	27292025
MIRT624397	hsa-miR-4421	PAR-CLIP	27292025
MIRT624396	hsa-miR-5699-3p	PAR-CLIP	27292025
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT875233	hsa-miR-1185	CLIP-seq
MIRT875234	hsa-miR-3679-5p	CLIP-seq
MIRT875235	hsa-miR-4765	CLIP-seq
MIRT875236	hsa-miR-583	CLIP-seq
MIRT2196484	hsa-miR-3154	CLIP-seq
MIRT2196485	hsa-miR-451b	CLIP-seq
MIRT2196486	hsa-miR-4663	CLIP-seq
MIRT2196487	hsa-miR-647	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	NAS	29789755
GO:0002376	Process	Immune system process	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IC	9485181
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	NAS	1831653
GO:0005886	Component	Plasma membrane	IDA	31461748
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IC	9485181
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0042101	Component	T cell receptor complex	IDA	8176201
GO:0042105	Component	Alpha-beta T cell receptor complex	IBA
GO:0042105	Component	Alpha-beta T cell receptor complex	IDA	9485181
GO:0042105	Component	Alpha-beta T cell receptor complex	IEA
GO:0042105	Component	Alpha-beta T cell receptor complex	IPI	31461748
GO:0042105	Component	Alpha-beta T cell receptor complex	ISS
GO:0042802	Function	Identical protein binding	IDA	14967045
GO:0045059	Process	Positive thymic T cell selection	IBA
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0045059	Process	Positive thymic T cell selection	ISS
GO:0046631	Process	Alpha-beta T cell activation	NAS	29789755
GO:0050852	Process	T cell receptor signaling pathway	NAS	29789755

MIM	HGNC	e!Ensembl
186790	1673	ENSG00000167286

Protein

UniProt ID

P04234

Protein name

T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

Protein function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell

PDB

1XIW , 6JXR , 7FJD , 7FJE , 7FJF , 7PHR , 8ES7 , 8ES8 , 8ES9 , 8JC0 , 8JCB , 8TW4 , 8TW6 , 8WXE , 8WY0 , 8WYI , 8YC0 , 9BBC , 9C3E , 9CI8 , 9CIA , 9CQ4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16680	Ig_4	30 → 104	T-cell surface glycoprotein CD3 delta chain	Domain
PF02189	ITAM	146 → 165	Immunoreceptor tyrosine-based activation motif	Motif

Tissue specificity

TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells. {ECO:0000269|PubMed:1372642}.

Sequence

MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDL
GKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLAL
GVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Sequence length

171

Interactions

View interactions

	KEGG		Reactome
	Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Chagas disease Measles Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Primary immunodeficiency		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Immunodeficiency	immunodeficiency 19	rs730880296, rs1591278347, rs111033580, rs111033581	N/A

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Severe combined immunodeficiency disease	T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta	N/A	N/A	GenCC
severe combined immunodeficiency disease	Severe combined immunodeficiency disease	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (47)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	32509861
Anemia Aplastic	Stimulate	22401598
Arthritis Rheumatoid	Associate	36311761
Brain Diseases	Associate	29484035
Breast Neoplasms	Associate	33350431, 34572592
Carcinoma Hepatocellular	Inhibit	28258914
Carcinoma Hepatocellular	Associate	37386390
Carcinoma Non Small Cell Lung	Associate	26462029, 28587298
Cardiomyopathies	Associate	21422001
Cardiomyopathy Dilated	Associate	21422001, 36733486
Cerebral Infarction	Associate	36802116
Cerebral Palsy	Associate	29484035
Colonic Neoplasms	Associate	31914842
Colorectal Neoplasms	Associate	31914842, 34975867
Common Variable Immunodeficiency	Associate	31921117
COVID 19	Associate	39377750
Cross Infection	Associate	27015534
Death	Associate	26462029
Diabetes Mellitus	Associate	36187128
Epilepsy	Associate	34555062
Epilepsy	Inhibit	40697415
Epstein Barr Virus Infections	Associate	37420238
Exudative vitreoretinopathy 1	Associate	1415220
Fatigue Syndrome Chronic	Associate	36284352
Head and Neck Neoplasms	Associate	35090306
Immune System Diseases	Associate	35712757
Inflammatory Bowel Diseases	Associate	31921117
Leukemia Lymphoma Adult T Cell	Associate	35905535, 8381310
Lymphoma Large B Cell Diffuse	Associate	32042095
Lymphoma T Cell	Associate	2456698, 35905535
Lymphoma T Cell Peripheral	Associate	35905535
Multiple Myeloma	Associate	21669053
Nasopharyngeal Carcinoma	Associate	37274867
Neoplasms	Associate	31842801, 32081834, 35712757, 37841886
Non Muscle Invasive Bladder Neoplasms	Associate	32096345
Ovarian Neoplasms	Associate	37841886
Papillomavirus Infections	Associate	35090306
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	39453390
Respiratory Distress Syndrome	Associate	24288697
Sepsis	Associate	39377750
Severe Combined Immunodeficiency	Associate	15546002, 24288697, 35303369
Sjogren's Syndrome	Associate	15880807, 34367157
Squamous Cell Carcinoma of Head and Neck	Associate	32831060, 35712757
Subarachnoid Hemorrhage	Associate	36214715
Thyroiditis Autoimmune	Associate	31921117
Uterine Cervical Neoplasms	Associate	33901225, 35090306
X Linked Combined Immunodeficiency Diseases	Associate	31921117

CD3D (CD3 delta subunit of T-cell receptor complex)