CD3D (CD3 delta subunit of T-cell receptor complex)

Gene

• Entrez ID: 915
• Gene name: CD3 delta subunit of T-cell receptor complex
• Gene symbol: CD3D
• Synonyms (NCBI Gene): CD3-DELTA, CD3DELTA, IMD19, T3D
• Disease Acronyms (UniProt): IMD19
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs111033580	G>A,T	Pathogenic, likely-benign	Synonymous variant, coding sequence variant, stop gained
rs111033581	G>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs730880296	C>T	Pathogenic	Intron variant
rs1591278347	C>T	Pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT624398	hsa-miR-339-5p	PAR-CLIP	27292025
MIRT624397	hsa-miR-4421	PAR-CLIP	27292025
MIRT624396	hsa-miR-5699-3p	PAR-CLIP	27292025
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT875233	hsa-miR-1185	CLIP-seq
MIRT875234	hsa-miR-3679-5p	CLIP-seq
MIRT875235	hsa-miR-4765	CLIP-seq
MIRT875236	hsa-miR-583	CLIP-seq
MIRT2196484	hsa-miR-3154	CLIP-seq
MIRT2196485	hsa-miR-451b	CLIP-seq
MIRT2196486	hsa-miR-4663	CLIP-seq
MIRT2196487	hsa-miR-647	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IBA	21873635
GO:0004888	Function	Transmembrane signaling receptor activity	IC	9485181
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	NAS	1831653
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	IC	9485181
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0042101	Component	T cell receptor complex	IDA	8176201
GO:0042101	Component	T cell receptor complex	NAS	9485181
GO:0042105	Component	Alpha-beta T cell receptor complex	IBA	21873635
GO:0042802	Function	Identical protein binding	IDA	14967045
GO:0045059	Process	Positive thymic T cell selection	IBA	21873635
GO:0045059	Process	Positive thymic T cell selection	ISS
GO:0046982	Function	Protein heterodimerization activity	IPI	9485181
GO:0050776	Process	Regulation of immune response	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0061024	Process	Membrane organization	TAS

Other IDs

• MIM: 186790
• HGNC: 1673
• e!Ensembl: ENSG00000167286

Protein

• UniProt ID: P04234
• Protein name: T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
• Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell
• PDB: 1XIW, 6JXR, 7FJD, 7FJE, 7FJF, 7PHR, 8ES7, 8ES8, 8ES9, 8JC0, 8JCB, 8TW4, 8TW6, 8WXE, 8WY0, 8WYI, 8YC0, 9BBC, 9C3E, 9CI8, 9CIA, 9CQ4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16680	Ig_4	30 → 104	T-cell surface glycoprotein CD3 delta chain	Domain
  PF02189	ITAM	146 → 165	Immunoreceptor tyrosine-based activation motif	Motif

• Tissue specificity: TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells. {ECO:0000269|PubMed:1372642}.
• Sequence:

  MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDL
  GKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLAL
  GVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

• Sequence length: 171

Pathways

KEGG:

Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Chagas disease
Measles
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Primary immunodeficiency

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	17597826
Immunodeficiency	IMMUNODEFICIENCY 19	rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866, rs483352928, rs121918659, rs111033580, rs111033581, rs74315290, rs193922740, rs193922741, rs104894199, rs483352927, rs104894286, rs1571865049, rs886041032, rs2069709, rs587776822, rs74315444, rs587776823, rs1315265916, rs104893893, rs104893894, rs121434560, rs387906572, rs587776853, rs104893973, rs587776854, rs587776855, rs587776857, rs104893974, rs121912715, rs1393707607, rs113994136, rs387906593, rs587776870, rs387906763, rs387906913, rs199469663, rs199469662, rs199469664, rs193922640, rs193922641, rs193922645, rs398122890, rs387907316, rs397514710, rs398122383, rs397515453, rs397514332, rs398123058, rs397518423, rs587777075, rs199676861, rs77563738, rs587777337, rs28730670, rs587777389, rs587777390, rs587777413, rs587777414, rs587777415, rs587777416, rs267608260, rs267608261, rs587778405, rs587777446, rs587777562, rs587777564, rs587777565, rs869320745, rs587777709, rs606231305, rs672601318, rs727503779, rs727503780, rs730880296, rs786200953, rs375323253, rs794729666, rs886041037, rs886041038, rs796051887, rs796051888, rs749956849, rs199641706, rs775739391, rs869312886, rs869312857, rs879253731, rs879253732, rs201025290, rs770927552, rs878853275, rs878853276, rs878853277, rs878853278, rs1567506566, rs886037920, rs886037921, rs750610248, rs200044623, rs886043118, rs886060531, rs1057519074, rs1057519075, rs1057518744, rs1057519079, rs1057518745, rs1057518746, rs1057518747, rs782178147, rs55729925, rs1064795762, rs1064794957, rs1085307649, rs745463649, rs773694113, rs1192554889, rs779575307, rs1554051075, rs1554051067, rs1554051033, rs1554067182, rs1555167566, rs1555169270, rs1555908409, rs1555719963, rs1404084330, rs144104577, rs1553238837, rs1553243550, rs1554020278, rs1554066684, rs762678772, rs570768621, rs1443126481, rs1553721236, rs121434258, rs888230251, rs1759915032, rs1759514836, rs138156467, rs1560914625, rs755373718, rs1561423197, rs1560938296, rs200803157, rs766555082, rs201543770, rs114951157, rs775578531, rs201128237, rs778624945, rs1563340753, rs1561772403, rs1484948342, rs777878144, rs1562364898, rs1561254290, rs1569296295, rs1568815169, rs1568822574, rs1571880832, rs934523851, rs1922072844, rs1266114717, rs137869655, rs869320689, rs1571880941, rs1580875488, rs1581303476, rs1448018291, rs1390410878, rs774803573, rs1591278347, rs1602300615, rs1601340933, rs757598952, rs1181595292, rs1408683294, rs1595843113, rs1595848141, rs779560450, rs1595816926, rs1581401865, rs1236009877, rs753213766, rs778993919, rs1602878106, rs141698985, rs1264504989, rs1580974401, rs2093571190, rs530286781, rs2086875746, rs2089298923, rs1206185362, rs1581573705, rs1596718225, rs1004337827, rs1573613529, rs1574636674, rs1574657735, rs1574657762, rs1574672718, rs1581573640, rs1553657429, rs200666300, rs1578735747, rs1578771211, rs1578793312, rs1578795536, rs1578809101, rs1578811073, rs1578811245, rs1171694504, rs1578971328, rs140800288, rs374333820, rs1584926133, rs1585040113, rs1584409386, rs1379376784, rs1586940273, rs1587143342, rs748910652, rs1592117677, rs758555433, rs1596712783, rs34019455, rs147766868, rs751386365, rs1600631294, rs1489114116, rs1057520578, rs1603007888, rs1603008329, rs1574450161, rs1578735709, rs1403833564, rs1580262965, rs570910902, rs1589866171, rs1578999313, rs1582635229, rs1582637044, rs1580851910, rs1750760771, rs745453685, rs1249197356, rs201840561, rs1940921909, rs1941410085, rs1941465194, rs1321690789, rs1302362911, rs1730552437, rs2052705192, rs1941856970	27807805, 25344390, 15546002, 23336327, 14602880, 22039266, 21926461, 24290291, 21883749
Severe combined immunodeficiency disease	Severe Combined Immunodeficiency, T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta	rs886037607, rs118203993, rs121908714, rs121908739, rs121908740, rs121908735, rs121908721, rs121908722, rs121908156, rs1564414523, rs1564418254, rs1564446526, rs786205074, rs121908157, rs121908159, rs786200884, rs397515357, rs104894562, rs137852624, rs137852625, rs137852626, rs137852627, rs137852507, rs137852509, rs111033619, rs111033620, rs1569480018, rs111033621, rs137852510, rs587776729, rs111033622, rs111033617, rs111033618, rs121917894, rs121917896, rs2133313409, rs121917897, rs28933392, rs104894282, rs104894283, rs104894285, rs121918570, rs121918572, rs730880318, rs104893674, rs730880319, rs104894453, rs104894454, rs104894451, rs137853206, rs777503956, rs267606645, rs267606648, rs397515390, rs193922346, rs193922347, rs193922348, rs193922349, rs193922350, rs137852508, rs193922640, rs193922641, rs193922643, rs193922645, rs193922361, rs193922364, rs193922464, rs148508754, rs193922574, rs113994174, rs606231246, rs397514671, rs397514686, rs397514755, rs199474679, rs199474685, rs199474686, rs199474681, rs150739647, rs267605358, rs886041036, rs587777335, rs587778405, rs145092287, rs587777562, rs606231256, rs200296680, rs786205456, rs786205517, rs774202259, rs786205615, rs878853261, rs786205890, rs782753385, rs746052951, rs869025224, rs869312857, rs869320660, rs869320659, rs869320658, rs879253742, rs886037924, rs886037925, rs750610248, rs886039394, rs761242509, rs886039387, rs886041043, rs886041044, rs886042051, rs886041333, rs749481781, rs1057517747, rs1057519506, rs1057523762, rs1057521062, rs1057520644, rs761583890, rs751635016, rs55729925, rs1064793248, rs1064793347, rs1064794027, rs781410769, rs1555524788, rs1486760100, rs769633203, rs1556330713, rs1555322558, rs1556330234, rs1556330755, rs1556329779, rs1556330552, rs1556329822, rs1556330286, rs1556331272, rs2146178281, rs376610445, rs757797994, rs775704953, rs1555743321, rs1564995660, rs1564995662, rs1556330249, rs144104577, rs886041796, rs1026474882, rs570768621, rs1556330562, rs1556330568, rs780014431, rs778343059, rs1555844617, rs1567629968, rs1567628757, rs1567629943, rs1567632864, rs1567632829, rs1567626023, rs1559328006, rs1561423197, rs1452483770, rs1568400897, rs1569479913, rs1568404443, rs1569480047, rs1563340753, rs368303189, rs1568431262, rs1568431102, rs1561424886, rs1602289943, rs1241698978, rs1569479994, rs1569480082, rs1602289649, rs1573261820, rs770985198, rs1589050343, rs1340132582, rs1589064324, rs1589070600, rs1213680890, rs149316157, rs1599873591, rs755706305, rs1602288051, rs1602289411, rs1602289183, rs1583513256, rs1589136659, rs1380154594, rs1011307501, rs1599876167, rs1569967422, rs1602289631, rs1573262398, rs760191638, rs1592117677, rs1640406042, rs372597855, rs1839558393, rs1839622622, rs1839957089, rs777008519, rs1233957241, rs2092261618, rs1839255008, rs1677695565, rs936493226, rs1162344514, rs991089005	15546002

Unknown
Disease term	Disease name	Evidence	References	Source
Otitis media	Otitis Media, Recurrent otitis media			ClinVar
Coronary artery disease	Coronary artery disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	32509861
Anemia Aplastic	Stimulate	22401598
Arthritis Rheumatoid	Associate	36311761
Brain Diseases	Associate	29484035
Breast Neoplasms	Associate	33350431, 34572592
Carcinoma Hepatocellular	Inhibit	28258914
Carcinoma Hepatocellular	Associate	37386390
Carcinoma Non Small Cell Lung	Associate	26462029, 28587298
Cardiomyopathies	Associate	21422001
Cardiomyopathy Dilated	Associate	21422001, 36733486
Cerebral Infarction	Associate	36802116
Cerebral Palsy	Associate	29484035
Colonic Neoplasms	Associate	31914842
Colorectal Neoplasms	Associate	31914842, 34975867
Common Variable Immunodeficiency	Associate	31921117
COVID 19	Associate	39377750
Cross Infection	Associate	27015534
Death	Associate	26462029
Diabetes Mellitus	Associate	36187128
Epilepsy	Associate	34555062
Epilepsy	Inhibit	40697415
Epstein Barr Virus Infections	Associate	37420238
Exudative vitreoretinopathy 1	Associate	1415220
Fatigue Syndrome Chronic	Associate	36284352
Head and Neck Neoplasms	Associate	35090306
Immune System Diseases	Associate	35712757
Inflammatory Bowel Diseases	Associate	31921117
Leukemia Lymphoma Adult T Cell	Associate	35905535, 8381310
Lymphoma Large B Cell Diffuse	Associate	32042095
Lymphoma T Cell	Associate	2456698, 35905535
Lymphoma T Cell Peripheral	Associate	35905535
Multiple Myeloma	Associate	21669053
Nasopharyngeal Carcinoma	Associate	37274867
Neoplasms	Associate	31842801, 32081834, 35712757, 37841886
Non Muscle Invasive Bladder Neoplasms	Associate	32096345
Ovarian Neoplasms	Associate	37841886
Papillomavirus Infections	Associate	35090306
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	39453390
Respiratory Distress Syndrome	Associate	24288697
Sepsis	Associate	39377750
Severe Combined Immunodeficiency	Associate	15546002, 24288697, 35303369
Sjogren's Syndrome	Associate	15880807, 34367157
Squamous Cell Carcinoma of Head and Neck	Associate	32831060, 35712757
Subarachnoid Hemorrhage	Associate	36214715
Thyroiditis Autoimmune	Associate	31921117
Uterine Cervical Neoplasms	Associate	33901225, 35090306
X Linked Combined Immunodeficiency Diseases	Associate	31921117