SESTD1 (SEC14 and spectrin domain containing 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 91404
Gene name SEC14 and spectrin domain containing 1
Gene symbol SESTD1
Synonyms (NCBI Gene)
Solo
Chromosome 2
Chromosome location 2q31.2
miRNA miRNA information provided by mirtarbase database.
846
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (846)
miRTarBase ID miRNA Experiments Reference
MIRT019309 hsa-miR-148b-3p Microarray 17612493
MIRT020137 hsa-miR-130b-3p Sequencing 20371350
MIRT026016 hsa-miR-148a-3p Sequencing 20371350
MIRT030699 hsa-miR-21-5p Microarray 18591254
MIRT031094 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0001786 Function Phosphatidylserine binding IDA 20164195
GO:0005515 Function Protein binding IPI 20164195, 25416956, 31515488, 32296183
GO:0005545 Function 1-phosphatidylinositol binding IDA 20164195
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IBA
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IDA 20164195
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
621011 18379 ENSG00000187231
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VW0
Protein name SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo)
Protein function May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13716 CRAL_TRIO_2 28 → 154 Divergent CRAL/TRIO domain Domain
Tissue specificity TISSUE SPECIFICITY: Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature. {ECO:0000269|PubMed:20164195}.
Sequence 
MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKA
RGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRL
GFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI
NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDE
LLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQW
GIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLS
DVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLL
EEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQ
RCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEK
HRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHR
LEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFG
SPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES
Sequence length 696
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Thymoma Uncertain significance rs140312284 RCV005932293
Show/Hide Text Mining Associations (3)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Bipolar Disorder Associate 26503763
Carcinoma Non Small Cell Lung Associate 34496260
Tuberculosis Pulmonary Associate 36787336