Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	91133
Gene name Gene Name - the full gene name approved by the HGNC.	L3MBTL histone methyl-lysine binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	L3MBTL4
Synonyms (NCBI Gene) Gene synonyms aliases	HsT1031
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18p11.31

Show/Hide all(62)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051988	hsa-let-7b-5p	CLASH	23622248
MIRT1102971	hsa-miR-125a-5p	CLIP-seq
MIRT1102972	hsa-miR-125b	CLIP-seq
MIRT1102973	hsa-miR-1323	CLIP-seq
MIRT1102974	hsa-miR-197	CLIP-seq
MIRT1102975	hsa-miR-216a	CLIP-seq
MIRT1102976	hsa-miR-3165	CLIP-seq
MIRT1102977	hsa-miR-3199	CLIP-seq
MIRT1102978	hsa-miR-331-3p	CLIP-seq
MIRT1102979	hsa-miR-3619-3p	CLIP-seq
MIRT1102980	hsa-miR-3654	CLIP-seq
MIRT1102981	hsa-miR-3659	CLIP-seq
MIRT1102982	hsa-miR-3692	CLIP-seq
MIRT1102983	hsa-miR-4286	CLIP-seq
MIRT1102984	hsa-miR-4287	CLIP-seq
MIRT1102985	hsa-miR-4318	CLIP-seq
MIRT1102986	hsa-miR-4319	CLIP-seq
MIRT1102987	hsa-miR-4469	CLIP-seq
MIRT1102988	hsa-miR-4648	CLIP-seq
MIRT1102989	hsa-miR-4649-3p	CLIP-seq
MIRT1102990	hsa-miR-4654	CLIP-seq
MIRT1102991	hsa-miR-4668-3p	CLIP-seq
MIRT1102992	hsa-miR-4685-3p	CLIP-seq
MIRT1102993	hsa-miR-4693-3p	CLIP-seq
MIRT1102994	hsa-miR-4698	CLIP-seq
MIRT1102995	hsa-miR-4713-5p	CLIP-seq
MIRT1102996	hsa-miR-4719	CLIP-seq
MIRT1102997	hsa-miR-4731-3p	CLIP-seq
MIRT1102998	hsa-miR-4740-5p	CLIP-seq
MIRT1102999	hsa-miR-4769-5p	CLIP-seq
MIRT1103000	hsa-miR-4776-5p	CLIP-seq
MIRT1103001	hsa-miR-4801	CLIP-seq
MIRT1103002	hsa-miR-495	CLIP-seq
MIRT1103003	hsa-miR-5096	CLIP-seq
MIRT1103004	hsa-miR-544b	CLIP-seq
MIRT1103005	hsa-miR-548a-5p	CLIP-seq
MIRT1103006	hsa-miR-548ab	CLIP-seq
MIRT1103007	hsa-miR-548ak	CLIP-seq
MIRT1103008	hsa-miR-548b-5p	CLIP-seq
MIRT1103009	hsa-miR-548c-3p	CLIP-seq
MIRT1103010	hsa-miR-548c-5p	CLIP-seq
MIRT1103011	hsa-miR-548d-5p	CLIP-seq
MIRT1103012	hsa-miR-548h	CLIP-seq
MIRT1103013	hsa-miR-548i	CLIP-seq
MIRT1103014	hsa-miR-548j	CLIP-seq
MIRT1103015	hsa-miR-548k	CLIP-seq
MIRT1103016	hsa-miR-548l	CLIP-seq
MIRT1103017	hsa-miR-548o	CLIP-seq
MIRT1103018	hsa-miR-548w	CLIP-seq
MIRT1103019	hsa-miR-548y	CLIP-seq
MIRT1103020	hsa-miR-559	CLIP-seq
MIRT1103021	hsa-miR-642a	CLIP-seq
MIRT2028175	hsa-miR-1305	CLIP-seq
MIRT2028176	hsa-miR-511	CLIP-seq
MIRT2559718	hsa-miR-1251	CLIP-seq
MIRT2559719	hsa-miR-151-3p	CLIP-seq
MIRT2559720	hsa-miR-4661-5p	CLIP-seq
MIRT2559721	hsa-miR-4757-5p	CLIP-seq
MIRT2559718	hsa-miR-1251	CLIP-seq
MIRT2559719	hsa-miR-151-3p	CLIP-seq
MIRT2559720	hsa-miR-4661-5p	CLIP-seq
MIRT2559721	hsa-miR-4757-5p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006325	Process	Chromatin organization	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0042393	Function	Histone binding	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IBA	21873635

MIM	HGNC	e!Ensembl
617135	26677	ENSG00000154655

Protein

UniProt ID

Q8NA19

Protein name

Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4)

Protein function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02820	MBT	88 → 156	mbt repeat	Domain
PF02820	MBT	196 → 264	mbt repeat	Domain
PF02820	MBT	300 → 368	mbt repeat	Domain
PF01530	zf-C2HC	378 → 407	Zinc finger, C2HC type	Family
PF00536	SAM_1	541 → 605	SAM domain (Sterile alpha motif)	Domain

Sequence

MKQPNRKRKLNMDSKERLDQDGRLEQAEEEKKPKDSTTPLSHVPSAAAQGAWSWEWYLKE
QKAVAAPVELFSKDQSFPEHENGFQIGMRLEGIDPRHPSVFCVLSVAEVCGYRLRLHFDG
YLSCYDFWTNAGSPDIHPVGWCEKTKHELHIPKGYRKDKFVWMDYLKACKLQNAPKKLFR
NRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVN
SPYVQPVGWCQENGRTLIAPQGYPNPENFSWTEYLEATQTNAVPAKVFKMRLPHGFLPNM
KLEVVDKRNPRLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHP
LEVPQRTNDLKILPGQAVCPTPGCRGIGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLF
RVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQV
ARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS
ILMFRHSQELPEEDIASGQEVRG

Sequence length

623

Interactions

View interactions

	KEGG
	Polycomb repressive complex

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	26830138
Cholelithiasis	Cholelithiasis	rs121918440, rs72552778, rs387906528, rs759202962, rs377160065, rs1051861187, rs757693457, rs752563752	17632509
Hypertension	Hypertensive disease	rs13306026	27480026

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	20698951
Neoplasms	Inhibit	20698951

L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4)