L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4)

Gene

• Entrez ID: 91133
• Gene name: L3MBTL histone methyl-lysine binding protein 4
• Gene symbol: L3MBTL4
• Synonyms (NCBI Gene): HsT1031
• Chromosome: 18
• Chromosome location: 18p11.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051988	hsa-let-7b-5p	CLASH	23622248
MIRT1102971	hsa-miR-125a-5p	CLIP-seq
MIRT1102972	hsa-miR-125b	CLIP-seq
MIRT1102973	hsa-miR-1323	CLIP-seq
MIRT1102974	hsa-miR-197	CLIP-seq
MIRT1102975	hsa-miR-216a	CLIP-seq
MIRT1102976	hsa-miR-3165	CLIP-seq
MIRT1102977	hsa-miR-3199	CLIP-seq
MIRT1102978	hsa-miR-331-3p	CLIP-seq
MIRT1102979	hsa-miR-3619-3p	CLIP-seq
MIRT1102980	hsa-miR-3654	CLIP-seq
MIRT1102981	hsa-miR-3659	CLIP-seq
MIRT1102982	hsa-miR-3692	CLIP-seq
MIRT1102983	hsa-miR-4286	CLIP-seq
MIRT1102984	hsa-miR-4287	CLIP-seq
MIRT1102985	hsa-miR-4318	CLIP-seq
MIRT1102986	hsa-miR-4319	CLIP-seq
MIRT1102987	hsa-miR-4469	CLIP-seq
MIRT1102988	hsa-miR-4648	CLIP-seq
MIRT1102989	hsa-miR-4649-3p	CLIP-seq
MIRT1102990	hsa-miR-4654	CLIP-seq
MIRT1102991	hsa-miR-4668-3p	CLIP-seq
MIRT1102992	hsa-miR-4685-3p	CLIP-seq
MIRT1102993	hsa-miR-4693-3p	CLIP-seq
MIRT1102994	hsa-miR-4698	CLIP-seq
MIRT1102995	hsa-miR-4713-5p	CLIP-seq
MIRT1102996	hsa-miR-4719	CLIP-seq
MIRT1102997	hsa-miR-4731-3p	CLIP-seq
MIRT1102998	hsa-miR-4740-5p	CLIP-seq
MIRT1102999	hsa-miR-4769-5p	CLIP-seq
MIRT1103000	hsa-miR-4776-5p	CLIP-seq
MIRT1103001	hsa-miR-4801	CLIP-seq
MIRT1103002	hsa-miR-495	CLIP-seq
MIRT1103003	hsa-miR-5096	CLIP-seq
MIRT1103004	hsa-miR-544b	CLIP-seq
MIRT1103005	hsa-miR-548a-5p	CLIP-seq
MIRT1103006	hsa-miR-548ab	CLIP-seq
MIRT1103007	hsa-miR-548ak	CLIP-seq
MIRT1103008	hsa-miR-548b-5p	CLIP-seq
MIRT1103009	hsa-miR-548c-3p	CLIP-seq
MIRT1103010	hsa-miR-548c-5p	CLIP-seq
MIRT1103011	hsa-miR-548d-5p	CLIP-seq
MIRT1103012	hsa-miR-548h	CLIP-seq
MIRT1103013	hsa-miR-548i	CLIP-seq
MIRT1103014	hsa-miR-548j	CLIP-seq
MIRT1103015	hsa-miR-548k	CLIP-seq
MIRT1103016	hsa-miR-548l	CLIP-seq
MIRT1103017	hsa-miR-548o	CLIP-seq
MIRT1103018	hsa-miR-548w	CLIP-seq
MIRT1103019	hsa-miR-548y	CLIP-seq
MIRT1103020	hsa-miR-559	CLIP-seq
MIRT1103021	hsa-miR-642a	CLIP-seq
MIRT2028175	hsa-miR-1305	CLIP-seq
MIRT2028176	hsa-miR-511	CLIP-seq
MIRT2559718	hsa-miR-1251	CLIP-seq
MIRT2559719	hsa-miR-151-3p	CLIP-seq
MIRT2559720	hsa-miR-4661-5p	CLIP-seq
MIRT2559721	hsa-miR-4757-5p	CLIP-seq
MIRT2559718	hsa-miR-1251	CLIP-seq
MIRT2559719	hsa-miR-151-3p	CLIP-seq
MIRT2559720	hsa-miR-4661-5p	CLIP-seq
MIRT2559721	hsa-miR-4757-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0042393	Function	Histone binding	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0060255	Process	Regulation of macromolecule metabolic process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA

Other IDs

• MIM: 617135
• HGNC: 26677
• e!Ensembl: ENSG00000154655

Protein

• UniProt ID: Q8NA19
• Protein name: Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4)
• Protein function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02820	MBT	88 → 156	mbt repeat	Domain
  PF02820	MBT	196 → 264	mbt repeat	Domain
  PF02820	MBT	300 → 368	mbt repeat	Domain
  PF01530	zf-C2HC	378 → 407	Zinc finger, C2HC type	Family
  PF00536	SAM_1	541 → 605	SAM domain (Sterile alpha motif)	Domain

• Sequence:

  MKQPNRKRKLNMDSKERLDQDGRLEQAEEEKKPKDSTTPLSHVPSAAAQGAWSWEWYLKE
  QKAVAAPVELFSKDQSFPEHENGFQIGMRLEGIDPRHPSVFCVLSVAEVCGYRLRLHFDG
  YLSCYDFWTNAGSPDIHPVGWCEKTKHELHIPKGYRKDKFVWMDYLKACKLQNAPKKLFR
  NRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVN
  SPYVQPVGWCQENGRTLIAPQGYPNPENFSWTEYLEATQTNAVPAKVFKMRLPHGFLPNM
  KLEVVDKRNPRLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHP
  LEVPQRTNDLKILPGQAVCPTPGCRGIGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDR
  LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLF
  RVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQV
  ARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS
  ILMFRHSQELPEEDIASGQEVRG

• Sequence length: 623

Pathways

KEGG:

Polycomb repressive complex