Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9113
Gene name	Large tumor suppressor kinase 1
Gene symbol	LATS1
Synonyms (NCBI Gene)	WARTSwts
Chromosome	6
Chromosome location	6q25.1
Summary	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1408705745	C>A,T	Likely-pathogenic	Stop gained, genic downstream transcript variant, non coding transcript variant, 3 prime UTR variant, missense variant, coding sequence variant
rs1582867955	C>T	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant

Show/Hide all (89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016931	hsa-miR-335-5p	Microarray	18185580
MIRT027020	hsa-miR-103a-3p	Sequencing	20371350
MIRT030710	hsa-miR-21-5p	Microarray	18591254
MIRT031514	hsa-miR-16-5p	Sequencing	20371350
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633521	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT633520	hsa-miR-4297	HITS-CLIP	23824327
MIRT633519	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631347	hsa-miR-5697	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT733925	hsa-miR-25-3p	qRT-PCR	33669647
MIRT735858	hsa-miR-1184	Western blottingqRT-PCR	32681581
MIRT735858	hsa-miR-1184	Western blottingImmunoprecipitaion (IP)qRT-PCR	32681581
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633521	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT633520	hsa-miR-4297	HITS-CLIP	23824327
MIRT633519	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631347	hsa-miR-5697	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT1105137	hsa-miR-1251	CLIP-seq
MIRT1105138	hsa-miR-200b	CLIP-seq
MIRT1105139	hsa-miR-200c	CLIP-seq
MIRT1105140	hsa-miR-21	CLIP-seq
MIRT1105141	hsa-miR-3121-3p	CLIP-seq
MIRT1105142	hsa-miR-330-3p	CLIP-seq
MIRT1105143	hsa-miR-4263	CLIP-seq
MIRT1105144	hsa-miR-429	CLIP-seq
MIRT1105145	hsa-miR-4684-5p	CLIP-seq
MIRT1105146	hsa-miR-4768-5p	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT1105148	hsa-miR-4799-5p	CLIP-seq
MIRT1105149	hsa-miR-553	CLIP-seq
MIRT1105150	hsa-miR-576-5p	CLIP-seq
MIRT1105151	hsa-miR-590-5p	CLIP-seq
MIRT2029028	hsa-miR-1279	CLIP-seq
MIRT2029029	hsa-miR-135a	CLIP-seq
MIRT2029030	hsa-miR-135b	CLIP-seq
MIRT2029031	hsa-miR-3135	CLIP-seq
MIRT2029032	hsa-miR-3914	CLIP-seq
MIRT2029033	hsa-miR-4277	CLIP-seq
MIRT2029034	hsa-miR-4699-3p	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT2260006	hsa-miR-4672	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT2260007	hsa-miR-4789-3p	CLIP-seq

Show/Hide all (69)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0000086	Process	G2/M transition of mitotic cell cycle	IDA	15122335
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	10518011
GO:0000819	Process	Sister chromatid segregation	IDA	15122335
GO:0000922	Component	Spindle pole	IBA
GO:0000922	Component	Spindle pole	IDA	10518011
GO:0000922	Component	Spindle pole	IEA
GO:0001827	Process	Inner cell mass cell fate commitment	IEA
GO:0001828	Process	Inner cell mass cellular morphogenesis	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10518011, 20412773, 35429439, 39173637
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	9988268, 10831611, 15220930, 18158288, 19739119, 19927127, 20303269, 20412773, 22078877, 22863277, 24012335, 24255178, 24362629, 24366813, 25026211, 25218637, 25283809, 25438054, 25751139, 28068668, 28087714, 28169360, 28514442, 32296183, 32661924, 33961781, 35044719, 35512704
GO:0005524	Function	ATP binding	IDA	10518011
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IDA	35429439
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IDA	39173637
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	IDA	10518011
GO:0008104	Process	Intracellular protein localization	IEA
GO:0009755	Process	Hormone-mediated signaling pathway	IEA
GO:0009755	Process	Hormone-mediated signaling pathway	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0019901	Function	Protein kinase binding	IPI	19927127
GO:0030216	Process	Keratinocyte differentiation	IEA
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	28068668
GO:0030496	Component	Midbody	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IDA	15220930
GO:0033146	Process	Regulation of intracellular estrogen receptor signaling pathway	IMP	28068668
GO:0035329	Process	Hippo signaling	IBA
GO:0035329	Process	Hippo signaling	IDA	35429439
GO:0035329	Process	Hippo signaling	IDA	20412773, 35429439
GO:0035329	Process	Hippo signaling	IEA
GO:0035329	Process	Hippo signaling	IEA
GO:0035329	Process	Hippo signaling	TAS
GO:0035332	Process	Positive regulation of hippo signaling	IDA	11118213
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043254	Process	Regulation of protein-containing complex assembly	IMP	20412773
GO:0044546	Process	NLRP3 inflammasome complex assembly	IDA	35114687, 35254907
GO:0044772	Process	Mitotic cell cycle phase transition	IEA
GO:0045736	Process	Negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	9988268
GO:0046620	Process	Regulation of organ growth	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0060644	Process	Mammary gland epithelial cell differentiation	IMP	28068668
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	20412773
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900181	Process	Negative regulation of protein localization to nucleus	IEA
GO:1900181	Process	Negative regulation of protein localization to nucleus	IMP	20412773
GO:1900181	Process	Negative regulation of protein localization to nucleus	ISS
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	31189953
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	39173637
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IEA
GO:2000058	Process	Regulation of ubiquitin-dependent protein catabolic process	IMP	28068668

MIM	HGNC	e!Ensembl
603473	6514	ENSG00000131023

O95835

Protein name

Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)

Protein function

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437

PDB

4ZRK , 5B5W , 5BRK , 7LWH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00627	UBA	101 → 138	UBA/TS-N domain	Domain
PF00069	Pkinase	705 → 1010	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269|PubMed:10518011}.

Sequence

MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE
DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI
QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG
SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP
QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY
PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ
NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME
LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ
PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV
TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV
DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR
KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC
LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF
VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG
HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR
QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM
KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR
QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF
RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV

Sequence length

1130

Interactions

View interactions

	KEGG		Reactome
	Hippo signaling pathway Hippo signaling pathway - multiple species		Signaling by Hippo

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Malignant peritoneal mesothelioma	Likely pathogenic	rs1408705745	RCV000758178
Multiple myeloma	Likely pathogenic	rs1582867955	RCV000984108
Myoepithelial tumor	Pathogenic	rs2483230018	RCV002463952

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Ependymoma	Uncertain significance	rs750318192	RCV000577865
Teratoma	Uncertain significance	rs2483086871	RCV003221370

Show/Hide Text Mining Associations (47)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35435136
Breast Neoplasms	Inhibit	26588988, 36443319
Breast Neoplasms	Associate	28232662, 28387539, 33247672, 34831091, 36609396, 38565950
Calcinosis Cutis	Associate	33897882
Carcinogenesis	Associate	36609396
Carcinoma Hepatocellular	Associate	25625370, 28076850, 28152516, 28815883, 29480061, 29901195, 30219064, 30999669, 33672268, 34565286
Carcinoma Hepatocellular	Inhibit	30308519
Carcinoma Non Small Cell Lung	Associate	28434174, 29286919
Carcinoma Pancreatic Ductal	Associate	35455997
Carcinoma Renal Cell	Associate	29850494, 36808829
Colitis Ulcerative	Associate	30604274
Colorectal Neoplasms	Associate	23885148, 30566960, 35798829
COVID 19	Associate	36346780
Crohn Disease	Stimulate	30604274
Death	Associate	28434174
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	25743838
Esophageal Neoplasms	Associate	40295580
Glioblastoma	Associate	31605013
Glioma	Inhibit	22909338
Hyperparathyroidism Primary	Associate	33670622
Hypoxia	Inhibit	34200497
Inflammatory Bowel Diseases	Associate	30604274
Leiomyosarcoma	Inhibit	12379777
Lupus Erythematosus Systemic	Associate	40057987
Lymphatic Metastasis	Associate	24175801
Melanoma	Associate	35941108
Melanoma Cutaneous Malignant	Associate	34542165
Mesothelioma Malignant	Associate	25902174
Migraine Disorders	Associate	39261750
Neoplasm Metastasis	Associate	33098447
Neoplasms	Inhibit	12379777, 17297610, 22909338, 25743838, 25902174, 28893265, 29480061, 30604274, 31028364, 31605013, 36443319, 36609396, 36808829
Neoplasms	Associate	20841485, 24175801, 26588988, 28387539, 29850494, 29901195, 33670622, 34267352, 34580349, 34831091
Nervous System Neoplasms	Associate	25041856
Neurilemmoma	Associate	25041856
Ovarian Neoplasms	Associate	12379777, 20841485, 31586262, 33875576, 37828220
Parathyroid Neoplasms	Inhibit	33670622
Peritonitis	Associate	30862609
Prostatic Neoplasms	Associate	33897882
Reperfusion Injury	Associate	30046369
Retinal Dysplasia	Associate	30604274
Sarcoma	Associate	12379777
Squamous Cell Carcinoma of Head and Neck	Associate	25743838, 29443735, 33773564
Stomach Neoplasms	Associate	24175801, 28893265, 29374493, 32423384, 36803368
Triple Negative Breast Neoplasms	Associate	28387539
Urinary Bladder Neoplasms	Associate	35798829
Uterine Cervical Neoplasms	Inhibit	28259899
Uterine Cervical Neoplasms	Associate	32975231

LATS1 (large tumor suppressor kinase 1)