Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
90627
Gene name Gene Name - the full gene name approved by the HGNC.
StAR related lipid transfer domain containing 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STARD13
Synonyms (NCBI Gene) Gene synonyms aliases
ARHGAP37, DLC2, GT650, LINC00464
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q13.1-q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domai
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006849 hsa-miR-125b-5p Luciferase reporter assay 22693547
MIRT006849 hsa-miR-125b-5p Luciferase reporter assay 22693547
MIRT023222 hsa-miR-122-5p Microarray 17612493
MIRT500925 hsa-miR-4295 PAR-CLIP 20371350
MIRT500924 hsa-miR-130a-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IBA 21873635
GO:0005515 Function Protein binding IPI 14697242
GO:0005811 Component Lipid droplet IEA
GO:0005829 Component Cytosol TAS
GO:0007165 Process Signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609866 19164 ENSG00000133121
Protein
UniProt ID Q9Y3M8
Protein name StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)
Protein function GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:1469724
PDB 2H80 , 2JW2 , 2PSO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07647 SAM_2 59 120 SAM domain (Sterile alpha motif) Domain
PF00620 RhoGAP 677 826 RhoGAP domain Domain
PF01852 START 908 1103 START domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. {ECO:0000269|PubMed:12531887, ECO:0000269|PubMed:14697242}.
Sequence
MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEA
KEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK

LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMRNT
TSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRDVL
NHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESFKA
MQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKCHEANKRG
GMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDS
SNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEKD
DLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEGNS
VSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAP
ASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAV
FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPEN
VNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLAD
ENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKK
ESSPRVIQKKYATG
KPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLE
ESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVE
APPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKT
DLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPE
WYSKGFGHLCAAEVARIRNSFQP
LIAEGPETKI
Sequence length 1113
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Intracranial aneurysm Intracranial Aneurysm rs1594095223 20364137
Unknown
Disease term Disease name Evidence References Source
Intracranial Aneurysm Intracranial Aneurysm GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 32900380
Adenocarcinoma of Lung Associate 34281560, 34335864
Astrocytoma Associate 24333506
Breast Neoplasms Inhibit 24627003
Carcinoma Hepatocellular Associate 18651974, 30827083
Carcinoma Non Small Cell Lung Associate 31059015, 33580150
Carcinoma Pancreatic Ductal Associate 25184537
Carcinoma Renal Cell Associate 36747492
Cardiovascular Diseases Associate 30423812
Colorectal Neoplasms Associate 25286763, 33411955