Gene Gene information from NCBI Gene database.
Entrez ID 9052
Gene name G protein-coupled receptor class C group 5 member A
Gene symbol GPRC5A
Synonyms (NCBI Gene)
GPCR5APEIG-1RAI3RAIG1TIG1
Chromosome 12
Chromosome location 12p13.1
Summary This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic
miRNA miRNA information provided by mirtarbase database.
1105
miRTarBase ID miRNA Experiments Reference
MIRT028489 hsa-miR-30a-5p Proteomics 18668040
MIRT029415 hsa-miR-26b-5p Microarray 19088304
MIRT703132 hsa-miR-34b-3p HITS-CLIP 23313552
MIRT703131 hsa-miR-4499 HITS-CLIP 23313552
MIRT703130 hsa-miR-6808-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 9857033
GO:0005515 Function Protein binding IPI 25311788
GO:0005730 Component Nucleolus IDA
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604138 9836 ENSG00000013588
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFJ5
Protein name Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)
Protein function Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Fu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00003 7tm_3 39 267 7 transmembrane sweet-taste receptor of 3 GCPR Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:18000218, PubMed:9857033). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small int
Sequence
Sequence length 357
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign rs151264483 RCV005911742
Clear cell carcinoma of kidney Benign rs151264483 RCV005911743
Uterine corpus endometrial carcinoma Benign rs151264483 RCV005911744
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 23154545
Asthma Associate 34088958
Basal Cell Nevus Syndrome Associate 29081410
Breast Neoplasms Associate 19552806, 19789341, 32719397
Carcinogenesis Associate 23154545, 26227221
Carcinoma Hepatocellular Associate 39183055
Carcinoma Non Small Cell Lung Inhibit 23154545, 25311788, 36413416
Carcinoma Non Small Cell Lung Associate 32410473, 36781501
Carcinoma Pancreatic Ductal Associate 27415424, 40362181
Carcinoma Squamous Cell Inhibit 36781501