Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9052
Gene name Gene Name - the full gene name approved by the HGNC.
G protein-coupled receptor class C group 5 member A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPRC5A
Synonyms (NCBI Gene) Gene synonyms aliases
GPCR5A, PEIG-1, RAI3, RAIG1, TIG1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028489 hsa-miR-30a-5p Proteomics 18668040
MIRT029415 hsa-miR-26b-5p Microarray 19088304
MIRT703132 hsa-miR-34b-3p HITS-CLIP 23313552
MIRT703131 hsa-miR-4499 HITS-CLIP 23313552
MIRT703130 hsa-miR-6808-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005515 Function Protein binding IPI 25311788
GO:0005730 Component Nucleolus IDA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA 18000218
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604138 9836 ENSG00000013588
Protein
UniProt ID Q8NFJ5
Protein name Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)
Protein function Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Fu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00003 7tm_3 39 267 7 transmembrane sweet-taste receptor of 3 GCPR Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:18000218, PubMed:9857033). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small int
Sequence
Sequence length 357
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma Cutaneous Melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
30429480
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 17379860
Unknown
Disease term Disease name Evidence References Source
Malignant melanoma of skin Malignant melanoma of skin of lower limb, Malignant melanoma of skin of upper limb 30429480 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 23154545
Asthma Associate 34088958
Basal Cell Nevus Syndrome Associate 29081410
Breast Neoplasms Associate 19552806, 19789341, 32719397
Carcinogenesis Associate 23154545, 26227221
Carcinoma Hepatocellular Associate 39183055
Carcinoma Non Small Cell Lung Inhibit 23154545, 25311788, 36413416
Carcinoma Non Small Cell Lung Associate 32410473, 36781501
Carcinoma Pancreatic Ductal Associate 27415424, 40362181
Carcinoma Squamous Cell Inhibit 36781501