Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9052
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
G protein-coupled receptor class C group 5 member A |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
GPRC5A |
Synonyms (NCBI Gene)
Gene synonyms aliases
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GPCR5A, PEIG-1, RAI3, RAIG1, TIG1 |
Chromosome
Chromosome number
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12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12p13.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic |
UniProt ID |
Q8NFJ5
|
Protein name |
Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) |
Protein function |
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Fu |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00003
|
7tm_3 |
39 → 267 |
7 transmembrane sweet-taste receptor of 3 GCPR |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:18000218, PubMed:9857033). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small int |
Sequence |
|
Sequence length |
357 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Melanoma |
Cutaneous Melanoma |
rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 View all (64 more) |
30429480 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs587776843 |
17379860 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Malignant melanoma of skin |
Malignant melanoma of skin of lower limb, Malignant melanoma of skin of upper limb |
|
30429480 |
ClinVar |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma |
Associate
|
23154545 |
Asthma |
Associate
|
34088958 |
Basal Cell Nevus Syndrome |
Associate
|
29081410 |
Breast Neoplasms |
Associate
|
19552806, 19789341, 32719397 |
Carcinogenesis |
Associate
|
23154545, 26227221 |
Carcinoma Hepatocellular |
Associate
|
39183055 |
Carcinoma Non Small Cell Lung |
Inhibit
|
23154545, 25311788, 36413416 |
Carcinoma Non Small Cell Lung |
Associate
|
32410473, 36781501 |
Carcinoma Pancreatic Ductal |
Associate
|
27415424, 40362181 |
Carcinoma Squamous Cell |
Inhibit
|
36781501 |
Colorectal Neoplasms |
Associate
|
24687888 |
Glioma |
Associate
|
31115523 |
Lung Diseases |
Associate
|
23154545 |
Lung Neoplasms |
Inhibit
|
23154545, 25311788, 32719397 |
Lung Neoplasms |
Associate
|
32410473 |
Lymphatic Metastasis |
Stimulate
|
26227221 |
Melanoma |
Associate
|
36423637 |
Myelodysplastic Syndromes |
Inhibit
|
12411319 |
Myelodysplastic Syndromes |
Associate
|
23320102 |
Neoplasm Metastasis |
Associate
|
36007057, 38335844 |
Neoplasms |
Associate
|
15659406, 19552806, 19789341, 24984703, 27415424, 27715394, 36413416 |
Neoplasms |
Inhibit
|
19279407, 23154545, 23651229, 25311788, 32410473 |
Neoplasms |
Stimulate
|
26227221 |
Ovarian Neoplasms |
Associate
|
34660776 |
Pancreatic Neoplasms |
Associate
|
15659406, 24984703, 27415424, 28114355, 35222383 |
Polycystic Kidney Autosomal Dominant |
Associate
|
36310237 |
Precursor T Cell Lymphoblastic Leukemia Lymphoma |
Associate
|
23320102 |
Pulmonary Disease Chronic Obstructive |
Inhibit
|
23154545 |
Small Cell Lung Carcinoma |
Inhibit
|
36781501 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
23651229 |
Status Asthmaticus |
Associate
|
34088958 |
Stomach Neoplasms |
Associate
|
26227221, 29283424 |
Triple Negative Breast Neoplasms |
Stimulate
|
38335844 |
|