Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	90427
Gene name	Bcl2 modifying factor
Gene symbol	BMF
Synonyms (NCBI Gene)	-
Chromosome	15
Chromosome location	15q15.1
Summary	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003394	hsa-miR-125b-5p	immunoblotLuciferase reporter assayqRT-PCR	19471102
MIRT003394	hsa-miR-125b-5p	Review	20029422
MIRT000141	hsa-miR-221-3p	Luciferase reporter assayqRT-PCRWestern blot	19671867
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT438409	hsa-miR-197-3p	FlowLuciferase reporter assayqRT-PCR	24488097
MIRT822230	hsa-miR-1343	CLIP-seq
MIRT822231	hsa-miR-153	CLIP-seq
MIRT822232	hsa-miR-3119	CLIP-seq
MIRT822233	hsa-miR-4426	CLIP-seq
MIRT822234	hsa-miR-448	CLIP-seq
MIRT822235	hsa-miR-4534	CLIP-seq
MIRT822236	hsa-miR-4647	CLIP-seq
MIRT822237	hsa-miR-4662b	CLIP-seq
MIRT822238	hsa-miR-2467-3p	CLIP-seq
MIRT822239	hsa-miR-298	CLIP-seq
MIRT822240	hsa-miR-3064-3p	CLIP-seq
MIRT822241	hsa-miR-3158-5p	CLIP-seq
MIRT822242	hsa-miR-3678-3p	CLIP-seq
MIRT822243	hsa-miR-4493	CLIP-seq
MIRT822244	hsa-miR-4760-5p	CLIP-seq
MIRT1922597	hsa-miR-1200	CLIP-seq
MIRT1922598	hsa-miR-1976	CLIP-seq
MIRT1922599	hsa-miR-2467-5p	CLIP-seq
MIRT1922600	hsa-miR-3184	CLIP-seq
MIRT1922601	hsa-miR-3188	CLIP-seq
MIRT1922602	hsa-miR-3975	CLIP-seq
MIRT1922603	hsa-miR-423-5p	CLIP-seq
MIRT1922604	hsa-miR-4324	CLIP-seq
MIRT1922605	hsa-miR-4649-3p	CLIP-seq
MIRT1922606	hsa-miR-4688	CLIP-seq
MIRT1922607	hsa-miR-4723-5p	CLIP-seq
MIRT1922608	hsa-miR-4728-5p	CLIP-seq
MIRT1922609	hsa-miR-4736	CLIP-seq
MIRT1922610	hsa-miR-485-5p	CLIP-seq
MIRT1922611	hsa-miR-486-3p	CLIP-seq
MIRT1922612	hsa-miR-544b	CLIP-seq
MIRT1942999	hsa-miR-1207-3p	CLIP-seq
MIRT2181765	hsa-miR-1208	CLIP-seq
MIRT2181766	hsa-miR-1285	CLIP-seq
MIRT822230	hsa-miR-1343	CLIP-seq
MIRT2181767	hsa-miR-1915	CLIP-seq
MIRT2181768	hsa-miR-24	CLIP-seq
MIRT2181769	hsa-miR-29a	CLIP-seq
MIRT2181770	hsa-miR-29b	CLIP-seq
MIRT2181771	hsa-miR-29c	CLIP-seq
MIRT2181772	hsa-miR-3187-5p	CLIP-seq
MIRT2181773	hsa-miR-3189-5p	CLIP-seq
MIRT2181774	hsa-miR-3607-5p	CLIP-seq
MIRT2181775	hsa-miR-3611	CLIP-seq
MIRT2181776	hsa-miR-3616-3p	CLIP-seq
MIRT2181777	hsa-miR-3649	CLIP-seq
MIRT2181778	hsa-miR-3664-3p	CLIP-seq
MIRT2181779	hsa-miR-3667-3p	CLIP-seq
MIRT2181780	hsa-miR-3682-5p	CLIP-seq
MIRT2181781	hsa-miR-3691-3p	CLIP-seq
MIRT2181782	hsa-miR-409-3p	CLIP-seq
MIRT2181783	hsa-miR-4277	CLIP-seq
MIRT2181784	hsa-miR-4420	CLIP-seq
MIRT2181785	hsa-miR-4436b-3p	CLIP-seq
MIRT2181786	hsa-miR-4468	CLIP-seq
MIRT2181787	hsa-miR-4648	CLIP-seq
MIRT2181788	hsa-miR-4674	CLIP-seq
MIRT2181789	hsa-miR-4690-3p	CLIP-seq
MIRT2181790	hsa-miR-4709-3p	CLIP-seq
MIRT2181791	hsa-miR-4726-3p	CLIP-seq
MIRT2181792	hsa-miR-4758-3p	CLIP-seq
MIRT2181793	hsa-miR-4778-3p	CLIP-seq
MIRT2181794	hsa-miR-511	CLIP-seq
MIRT2181795	hsa-miR-520a-5p	CLIP-seq
MIRT2181796	hsa-miR-525-5p	CLIP-seq
MIRT2181797	hsa-miR-612	CLIP-seq
MIRT2181798	hsa-miR-760	CLIP-seq
MIRT822230	hsa-miR-1343	CLIP-seq
MIRT2181778	hsa-miR-3664-3p	CLIP-seq
MIRT2384791	hsa-miR-4685-5p	CLIP-seq
MIRT2435797	hsa-miR-1229	CLIP-seq
MIRT2441994	hsa-miR-1202	CLIP-seq
MIRT1942999	hsa-miR-1207-3p	CLIP-seq
MIRT2441995	hsa-miR-124	CLIP-seq
MIRT2441996	hsa-miR-15a	CLIP-seq
MIRT2441997	hsa-miR-15b	CLIP-seq
MIRT2441998	hsa-miR-16	CLIP-seq
MIRT2181767	hsa-miR-1915	CLIP-seq
MIRT2441999	hsa-miR-195	CLIP-seq
MIRT2442000	hsa-miR-205	CLIP-seq
MIRT2442001	hsa-miR-3194-5p	CLIP-seq
MIRT2442002	hsa-miR-3972	CLIP-seq
MIRT2442003	hsa-miR-421	CLIP-seq
MIRT2442004	hsa-miR-424	CLIP-seq
MIRT2442005	hsa-miR-4281	CLIP-seq
MIRT2442006	hsa-miR-4438	CLIP-seq
MIRT2442007	hsa-miR-4530	CLIP-seq
MIRT2442008	hsa-miR-4709-5p	CLIP-seq
MIRT2181791	hsa-miR-4726-3p	CLIP-seq
MIRT2442009	hsa-miR-497	CLIP-seq
MIRT2442010	hsa-miR-506	CLIP-seq
MIRT2442011	hsa-miR-548an	CLIP-seq
MIRT2442012	hsa-miR-642b	CLIP-seq
MIRT2181795	hsa-miR-520a-5p	CLIP-seq
MIRT2181796	hsa-miR-525-5p	CLIP-seq
MIRT2675997	hsa-miR-3657	CLIP-seq
MIRT2675998	hsa-miR-4302	CLIP-seq
MIRT2675999	hsa-miR-4669	CLIP-seq
MIRT2676000	hsa-miR-4676-5p	CLIP-seq
MIRT2676001	hsa-miR-4697-3p	CLIP-seq
MIRT2676002	hsa-miR-575	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11546872, 25416956, 26871637, 31515488, 32296183, 32814053
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0010507	Process	Negative regulation of autophagy	IBA
GO:0010507	Process	Negative regulation of autophagy	IDA	23629966
GO:0016459	Component	Myosin complex	IBA
GO:0016459	Component	Myosin complex	ISS	11546872
GO:0031334	Process	Positive regulation of protein-containing complex assembly	ISS
GO:0034644	Process	Cellular response to UV	IDA	23629966
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	19671867
GO:0043276	Process	Anoikis	IDA	11546872
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	ISS

MIM	HGNC	e!Ensembl
606266	24132	ENSG00000104081

Q96LC9

Protein name

Bcl-2-modifying factor

Protein function

May play a role in apoptosis. Isoform 1 seems to be the main initiator.

PDB

7CNU , 8IQK , 8IQL , 8IQM , 8R58

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15185	BMF	1 → 184	Bcl-2-modifying factor, apoptosis	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. {ECO:0000269|PubMed:14574334}.

Sequence

MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGL
RPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAVLPIGEQP
PEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVWWQILLFLHNLALNGEENRNG
AGPR

Sequence length

184

Interactions

View interactions

	KEGG		Reactome
	MicroRNAs in cancer		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria

BMF (Bcl2 modifying factor)