Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	90417
Gene name Gene Name - the full gene name approved by the HGNC.	Kinetochore localized astrin (SPAG5) binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KNSTRN
Synonyms (NCBI Gene) Gene synonyms aliases	C15orf23, HSD11, ROCHIS, SKAP, TRAF4AF1
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q15.1

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SNP ID	Visualize variation	Clinical significance	Consequence
rs868438023	C>T	Likely-pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT046798	hsa-miR-222-3p	CLASH	23622248
MIRT712617	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT712616	hsa-miR-3926	HITS-CLIP	19536157
MIRT712615	hsa-miR-548s	HITS-CLIP	19536157
MIRT712614	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT712613	hsa-miR-588	HITS-CLIP	19536157
MIRT712612	hsa-miR-4435	HITS-CLIP	19536157
MIRT712611	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT667697	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT667696	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT667695	hsa-miR-892a	HITS-CLIP	23824327
MIRT667694	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT667693	hsa-miR-759	HITS-CLIP	23824327
MIRT667692	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667691	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT667690	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT667689	hsa-miR-3135a	HITS-CLIP	23824327
MIRT667688	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT667687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT667686	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667685	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT667684	hsa-miR-3672	HITS-CLIP	23824327
MIRT667683	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT568675	hsa-miR-7845-5p	PAR-CLIP	20371350
MIRT568674	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT568672	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT568673	hsa-miR-4302	PAR-CLIP	20371350
MIRT568671	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT568670	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT568669	hsa-miR-5587-5p	PAR-CLIP	20371350
MIRT568675	hsa-miR-7845-5p	PAR-CLIP	20371350
MIRT568674	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT568672	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT568673	hsa-miR-4302	PAR-CLIP	20371350
MIRT568671	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT568670	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT568669	hsa-miR-5587-5p	PAR-CLIP	20371350
MIRT543091	hsa-miR-1273f	PAR-CLIP	21572407
MIRT543090	hsa-miR-4534	PAR-CLIP	21572407
MIRT543089	hsa-miR-8082	PAR-CLIP	21572407
MIRT543088	hsa-miR-1303	PAR-CLIP	21572407
MIRT192480	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT450981	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT192483	hsa-miR-3153	PAR-CLIP	23592263
MIRT192486	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT192487	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT667689	hsa-miR-3135a	PAR-CLIP	27292025
MIRT667684	hsa-miR-3672	PAR-CLIP	27292025
MIRT667687	hsa-miR-4711-3p	PAR-CLIP	27292025
MIRT667697	hsa-miR-4797-5p	PAR-CLIP	27292025
MIRT667696	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT667694	hsa-miR-5586-3p	PAR-CLIP	27292025
MIRT667686	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT667685	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT667692	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT667683	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT667693	hsa-miR-759	PAR-CLIP	27292025
MIRT667691	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT667690	hsa-miR-873-3p	PAR-CLIP	27292025
MIRT667695	hsa-miR-892a	PAR-CLIP	27292025
MIRT712617	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT712616	hsa-miR-3926	HITS-CLIP	19536157
MIRT712615	hsa-miR-548s	HITS-CLIP	19536157
MIRT712614	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT712613	hsa-miR-588	HITS-CLIP	19536157
MIRT712612	hsa-miR-4435	HITS-CLIP	19536157
MIRT712611	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT667697	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT667696	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT667695	hsa-miR-892a	HITS-CLIP	23824327
MIRT667694	hsa-miR-5586-3p	HITS-CLIP	23824327
MIRT667693	hsa-miR-759	HITS-CLIP	23824327
MIRT667692	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667691	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT667690	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT667689	hsa-miR-3135a	HITS-CLIP	23824327
MIRT667688	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT667687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT667686	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667685	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT667684	hsa-miR-3672	HITS-CLIP	23824327
MIRT667683	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT568675	hsa-miR-7845-5p	PAR-CLIP	20371350
MIRT568674	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT568672	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT568673	hsa-miR-4302	PAR-CLIP	20371350
MIRT568671	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT568670	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT568669	hsa-miR-5587-5p	PAR-CLIP	20371350
MIRT568675	hsa-miR-7845-5p	PAR-CLIP	20371350
MIRT568674	hsa-miR-211-3p	PAR-CLIP	20371350
MIRT568672	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT568673	hsa-miR-4302	PAR-CLIP	20371350
MIRT568671	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT568670	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT568669	hsa-miR-5587-5p	PAR-CLIP	20371350
MIRT543091	hsa-miR-1273f	PAR-CLIP	21572407
MIRT543090	hsa-miR-4534	PAR-CLIP	21572407
MIRT543089	hsa-miR-8082	PAR-CLIP	21572407
MIRT543088	hsa-miR-1303	PAR-CLIP	21572407
MIRT192480	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT450981	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT192483	hsa-miR-3153	PAR-CLIP	23592263
MIRT192486	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT192487	hsa-miR-6739-5p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IBA
GO:0000070	Process	Mitotic sister chromatid segregation	IMP	21402792
GO:0000226	Process	Microtubule cytoskeleton organization	IMP	26242911
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IBA
GO:0000776	Component	Kinetochore	IDA	21402792
GO:0000776	Component	Kinetochore	IEA
GO:0000922	Component	Spindle pole	IEA
GO:0001726	Component	Ruffle	IDA	26242911
GO:0005515	Function	Protein binding	IPI	21402792, 22965910, 26242911, 26496610, 29180244, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005815	Component	Microtubule organizing center	IDA	29180244
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0007051	Process	Spindle organization	IBA
GO:0007051	Process	Spindle organization	IEA
GO:0007051	Process	Spindle organization	IMP	21402792
GO:0007059	Process	Chromosome segregation	IEA
GO:0007059	Process	Chromosome segregation	IMP	21402792
GO:0016477	Process	Cell migration	IMP	26242911
GO:0034451	Component	Centriolar satellite	IBA
GO:0034451	Component	Centriolar satellite	IDA
GO:0035371	Component	Microtubule plus-end	IBA
GO:0035371	Component	Microtubule plus-end	IDA	21402792, 26242911
GO:0042803	Function	Protein homodimerization activity	IPI	26242911
GO:0051010	Function	Microtubule plus-end binding	IDA	26242911
GO:0051301	Process	Cell division	IEA
GO:0051988	Process	Regulation of attachment of spindle microtubules to kinetochore	IBA
GO:0051988	Process	Regulation of attachment of spindle microtubules to kinetochore	IEA
GO:0051988	Process	Regulation of attachment of spindle microtubules to kinetochore	IMP	21402792
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IMP	26242911
GO:0072686	Component	Mitotic spindle	IBA
GO:0072686	Component	Mitotic spindle	IDA	21402792

MIM	HGNC	e!Ensembl
614718	30767	ENSG00000128944

Protein

UniProt ID

Q9Y448

Protein name

Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1)

Protein function

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sis

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, including in skin. {ECO:0000269|PubMed:25194279}.

Sequence

MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK
DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV
DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ
LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE
STTDHMDSMLLLETLQEELKLFNETAKKQMEELQALKVKLEMKEERVRFLEQQTLCNNQV
NDLTTALKEMEQLLEM

Sequence length

316

Interactions

View interactions

KNSTRN (kinetochore localized astrin (SPAG5) binding protein)