Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9037
Gene name Gene Name - the full gene name approved by the HGNC.
Semaphorin 5A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SEMA5A
Synonyms (NCBI Gene) Gene synonyms aliases
SEMAF, semF
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p15.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030970 hsa-miR-21-5p Microarray 18591254
MIRT662456 hsa-miR-4714-3p HITS-CLIP 23824327
MIRT662455 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT662454 hsa-miR-6736-3p HITS-CLIP 23824327
MIRT662453 hsa-miR-660-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001755 Process Neural crest cell migration IBA 21873635
GO:0001938 Process Positive regulation of endothelial cell proliferation ISS
GO:0002043 Process Blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
GO:0005886 Component Plasma membrane TAS
GO:0007155 Process Cell adhesion TAS 9049630
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609297 10736 ENSG00000112902
Protein
UniProt ID Q13591
Protein name Semaphorin-5A (Semaphorin-F) (Sema F)
Protein function Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglyc
PDB 8CKG , 8CKK , 8CKL , 8CKM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01403 Sema 60 466 Sema domain Family
PF00090 TSP_1 599 650 Thrombospondin type 1 domain Domain
PF00090 TSP_1 657 701 Thrombospondin type 1 domain Domain
PF00090 TSP_1 788 838 Thrombospondin type 1 domain Domain
PF00090 TSP_1 845 895 Thrombospondin type 1 domain Domain
PF00090 TSP_1 900 944 Thrombospondin type 1 domain Domain
Sequence
MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQ
LTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRV
LLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELY
AATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH
DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL
DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTV
DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHII
YLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILH
SQSVLFVGLREHVV
KIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVD
GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTP
WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLC
PPHMFWTGWG
PWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPC
PELKKTTPWTPWTPVNISD
NGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSA
HTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPV
DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWS
EWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDS
NFIPEVSVARSSSVEE
KRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITN
HINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
Sequence length 1074
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Axon guidance   Other semaphorin interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
17028446
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Mental retardation Severe intellectual disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Asthma Childhood asthma 23829686 ClinVar
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Dementia Dementia GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 27600491
Alzheimer Disease Associate 28626864
Arthritis Rheumatoid Stimulate 35835748
Autism Spectrum Disorder Associate 23575222, 26395558
Autistic Disorder Inhibit 17028446, 19812673
Autistic Disorder Associate 23575222
Autoimmune Diseases Associate 28063160
Azoospermia Associate 32860660
Carcinoma Non Small Cell Lung Associate 22631660, 36451418
Charcot Marie Tooth Disease Associate 25648254