CCRL2 (C-C motif chemokine receptor like 2)

Gene

• Entrez ID: 9034
• Gene name: C-C motif chemokine receptor like 2
• Gene symbol: CCRL2
• Synonyms (NCBI Gene): ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
• Chromosome: 3
• Chromosome location: 3p21.31
• Summary: This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT662225	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT662224	hsa-miR-6854-5p	HITS-CLIP	23824327
MIRT662223	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT662222	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT662220	hsa-miR-4469	HITS-CLIP	23824327
MIRT662221	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT662219	hsa-miR-4287	HITS-CLIP	23824327
MIRT662218	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT662217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT662216	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT662215	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT662214	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT662213	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT662212	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT662211	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662210	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT662225	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT662224	hsa-miR-6854-5p	HITS-CLIP	23824327
MIRT662223	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT662222	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT662220	hsa-miR-4469	HITS-CLIP	23824327
MIRT662221	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT662219	hsa-miR-4287	HITS-CLIP	23824327
MIRT662218	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT662217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT662216	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT662215	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT662214	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT662213	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT662212	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT662211	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662210	hsa-miR-4659b-3p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	9473515
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IDA	20002784
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9473515
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	9473515
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	ISS
GO:0006955	Process	Immune response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9473515
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019957	Function	C-C chemokine binding	IBA
GO:0042379	Function	Chemokine receptor binding	IPI	14530373
GO:0048020	Function	CCR chemokine receptor binding	IPI	20002784
GO:0060326	Process	Cell chemotaxis	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

Other IDs

• MIM: 608379
• HGNC: 1612
• e!Ensembl: ENSG00000121797

Protein

• UniProt ID: O00421
• Protein name: C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
• Protein function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functio
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	55 → 300	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (bot
• Sequence:

  MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
  LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
  NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
  CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
  FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
  AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

• Sequence length: 344

Pathways

Reactome:

Chemokine receptors bind chemokines