CCRL2 (C-C motif chemokine receptor like 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9034
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCRL2
Synonyms (NCBI Gene) Gene synonyms aliases
ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune c
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(32)
miRTarBase ID miRNA Experiments Reference
MIRT662225 hsa-miR-6800-3p HITS-CLIP 23824327
MIRT662224 hsa-miR-6854-5p HITS-CLIP 23824327
MIRT662223 hsa-miR-1306-5p HITS-CLIP 23824327
MIRT662222 hsa-miR-6832-3p HITS-CLIP 23824327
MIRT662220 hsa-miR-4469 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004950 Function Chemokine receptor activity IEA
GO:0004950 Function Chemokine receptor activity TAS 9473515
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608379 1612 ENSG00000121797
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O00421
Protein name C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
Protein function Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 55 → 300 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (bot
Sequence
Sequence length 344
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Chemokine receptors bind chemokines
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 1 diabetes N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Show/Hide Text Mining Associations (24)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 22046140
Arthritis Rheumatoid Associate 15188357
Carcinoma Squamous Cell Associate 27907906
Clinical Deterioration Stimulate 25997515
Colorectal Neoplasms Associate 33910576
HIV Infections Associate 31209403
Inflammation Associate 15188357, 22046140
Inflammation Stimulate 25997515
Latent Tuberculosis Associate 33328540
Leukemia Erythroblastic Acute Associate 35179961