Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9025
Gene name Gene Name - the full gene name approved by the HGNC.	Ring finger protein 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RNF8
Synonyms (NCBI Gene) Gene synonyms aliases	hRNF8
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin liga

Show/Hide all(356)

miRTarBase ID	miRNA	Experiments	Reference
MIRT717307	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT717306	hsa-miR-4744	HITS-CLIP	19536157
MIRT717305	hsa-miR-4509	HITS-CLIP	19536157
MIRT717304	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT717303	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT717301	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT717302	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT717300	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT717299	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT717298	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT317777	hsa-miR-4310	HITS-CLIP	23824327
MIRT317781	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT632490	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT632489	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT632488	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632487	hsa-miR-7977	HITS-CLIP	23824327
MIRT632486	hsa-miR-1303	HITS-CLIP	23824327
MIRT737211	hsa-miR-622	Western blotting, qRT-PCR	31709182
MIRT717307	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT717306	hsa-miR-4744	HITS-CLIP	19536157
MIRT717305	hsa-miR-4509	HITS-CLIP	19536157
MIRT717304	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT717303	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT717301	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT717302	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT717300	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT717299	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT717298	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT317777	hsa-miR-4310	HITS-CLIP	23824327
MIRT317781	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT632490	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT632489	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT632488	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632487	hsa-miR-7977	HITS-CLIP	23824327
MIRT632486	hsa-miR-1303	HITS-CLIP	23824327
MIRT755736	hsa-miR-654-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35742854
MIRT1313727	hsa-miR-1184	CLIP-seq
MIRT1313728	hsa-miR-1205	CLIP-seq
MIRT1313729	hsa-miR-1224-3p	CLIP-seq
MIRT1313730	hsa-miR-1245b-3p	CLIP-seq
MIRT1313731	hsa-miR-1267	CLIP-seq
MIRT1313732	hsa-miR-1270	CLIP-seq
MIRT1313733	hsa-miR-1299	CLIP-seq
MIRT1313734	hsa-miR-1301	CLIP-seq
MIRT1313735	hsa-miR-1323	CLIP-seq
MIRT1313736	hsa-miR-135a	CLIP-seq
MIRT1313737	hsa-miR-135b	CLIP-seq
MIRT1313738	hsa-miR-146a	CLIP-seq
MIRT1313739	hsa-miR-146b-5p	CLIP-seq
MIRT1313740	hsa-miR-2392	CLIP-seq
MIRT1313741	hsa-miR-2682	CLIP-seq
MIRT1313742	hsa-miR-3064-3p	CLIP-seq
MIRT1313743	hsa-miR-3065-5p	CLIP-seq
MIRT1313744	hsa-miR-30a	CLIP-seq
MIRT1313745	hsa-miR-30b	CLIP-seq
MIRT1313746	hsa-miR-30c	CLIP-seq
MIRT1313747	hsa-miR-30d	CLIP-seq
MIRT1313748	hsa-miR-30e	CLIP-seq
MIRT1313749	hsa-miR-3135	CLIP-seq
MIRT1313750	hsa-miR-3158-5p	CLIP-seq
MIRT1313751	hsa-miR-3159	CLIP-seq
MIRT1313752	hsa-miR-3163	CLIP-seq
MIRT1313753	hsa-miR-3165	CLIP-seq
MIRT1313754	hsa-miR-3173-3p	CLIP-seq
MIRT1313755	hsa-miR-3174	CLIP-seq
MIRT1313756	hsa-miR-3180-5p	CLIP-seq
MIRT1313757	hsa-miR-3184	CLIP-seq
MIRT1313758	hsa-miR-3192	CLIP-seq
MIRT1313759	hsa-miR-342-3p	CLIP-seq
MIRT1313760	hsa-miR-34b	CLIP-seq
MIRT1313761	hsa-miR-3605-5p	CLIP-seq
MIRT1313762	hsa-miR-3646	CLIP-seq
MIRT1313763	hsa-miR-3665	CLIP-seq
MIRT1313764	hsa-miR-3677-5p	CLIP-seq
MIRT1313765	hsa-miR-3688-3p	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT1313768	hsa-miR-3689d	CLIP-seq
MIRT1313769	hsa-miR-377	CLIP-seq
MIRT1313770	hsa-miR-3919	CLIP-seq
MIRT1313771	hsa-miR-3925-5p	CLIP-seq
MIRT1313772	hsa-miR-423-5p	CLIP-seq
MIRT1313773	hsa-miR-4267	CLIP-seq
MIRT1313774	hsa-miR-4284	CLIP-seq
MIRT1313775	hsa-miR-4314	CLIP-seq
MIRT1313776	hsa-miR-4423-5p	CLIP-seq
MIRT1313777	hsa-miR-4433	CLIP-seq
MIRT1313778	hsa-miR-4434	CLIP-seq
MIRT1313779	hsa-miR-4459	CLIP-seq
MIRT1313780	hsa-miR-449c	CLIP-seq
MIRT1313781	hsa-miR-4516	CLIP-seq
MIRT1313782	hsa-miR-4521	CLIP-seq
MIRT1313783	hsa-miR-4531	CLIP-seq
MIRT1313784	hsa-miR-4536	CLIP-seq
MIRT1313785	hsa-miR-4637	CLIP-seq
MIRT1313786	hsa-miR-4639-3p	CLIP-seq
MIRT1313787	hsa-miR-4646-5p	CLIP-seq
MIRT1313788	hsa-miR-4660	CLIP-seq
MIRT1313789	hsa-miR-4715-3p	CLIP-seq
MIRT1313790	hsa-miR-4716-3p	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT1313792	hsa-miR-4736	CLIP-seq
MIRT1313793	hsa-miR-4761-5p	CLIP-seq
MIRT1313794	hsa-miR-4766-5p	CLIP-seq
MIRT1313795	hsa-miR-4768-3p	CLIP-seq
MIRT1313796	hsa-miR-4779	CLIP-seq
MIRT1313797	hsa-miR-4797-5p	CLIP-seq
MIRT1313798	hsa-miR-4802-3p	CLIP-seq
MIRT1313799	hsa-miR-483-3p	CLIP-seq
MIRT1313800	hsa-miR-488	CLIP-seq
MIRT1313801	hsa-miR-5047	CLIP-seq
MIRT1313802	hsa-miR-520a-5p	CLIP-seq
MIRT1313803	hsa-miR-525-5p	CLIP-seq
MIRT1313804	hsa-miR-548ag	CLIP-seq
MIRT1313805	hsa-miR-548ai	CLIP-seq
MIRT1313806	hsa-miR-548o	CLIP-seq
MIRT1313807	hsa-miR-620	CLIP-seq
MIRT1313808	hsa-miR-624	CLIP-seq
MIRT1313809	hsa-miR-625	CLIP-seq
MIRT1313810	hsa-miR-627	CLIP-seq
MIRT1313811	hsa-miR-635	CLIP-seq
MIRT1313812	hsa-miR-760	CLIP-seq
MIRT1313813	hsa-miR-802	CLIP-seq
MIRT1313814	hsa-miR-875-3p	CLIP-seq
MIRT1313815	hsa-miR-877	CLIP-seq
MIRT1313816	hsa-miR-921	CLIP-seq
MIRT1313817	hsa-miR-924	CLIP-seq
MIRT1313818	hsa-miR-935	CLIP-seq
MIRT1313819	hsa-miR-940	CLIP-seq
MIRT1313820	hsa-miR-1268	CLIP-seq
MIRT1313821	hsa-miR-1268b	CLIP-seq
MIRT1313822	hsa-miR-128	CLIP-seq
MIRT1313823	hsa-miR-144	CLIP-seq
MIRT1313824	hsa-miR-15a	CLIP-seq
MIRT1313825	hsa-miR-15b	CLIP-seq
MIRT1313826	hsa-miR-16	CLIP-seq
MIRT1313827	hsa-miR-195	CLIP-seq
MIRT1313828	hsa-miR-2117	CLIP-seq
MIRT1313829	hsa-miR-24	CLIP-seq
MIRT1313830	hsa-miR-25	CLIP-seq
MIRT1313831	hsa-miR-27a	CLIP-seq
MIRT1313832	hsa-miR-27b	CLIP-seq
MIRT1313833	hsa-miR-3064-5p	CLIP-seq
MIRT1313834	hsa-miR-3148	CLIP-seq
MIRT1313835	hsa-miR-3160-3p	CLIP-seq
MIRT1313756	hsa-miR-3180-5p	CLIP-seq
MIRT1313836	hsa-miR-3189-5p	CLIP-seq
MIRT1313837	hsa-miR-32	CLIP-seq
MIRT1313838	hsa-miR-363	CLIP-seq
MIRT1313839	hsa-miR-367	CLIP-seq
MIRT1313840	hsa-miR-3672	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT1313768	hsa-miR-3689d	CLIP-seq
MIRT1313841	hsa-miR-374c	CLIP-seq
MIRT1313842	hsa-miR-375	CLIP-seq
MIRT1313843	hsa-miR-3922-5p	CLIP-seq
MIRT1313844	hsa-miR-3926	CLIP-seq
MIRT1313845	hsa-miR-3929	CLIP-seq
MIRT1313846	hsa-miR-3974	CLIP-seq
MIRT1313847	hsa-miR-3977	CLIP-seq
MIRT1313848	hsa-miR-421	CLIP-seq
MIRT1313849	hsa-miR-424	CLIP-seq
MIRT1313850	hsa-miR-4272	CLIP-seq
MIRT1313851	hsa-miR-4273	CLIP-seq
MIRT1313852	hsa-miR-4279	CLIP-seq
MIRT1313774	hsa-miR-4284	CLIP-seq
MIRT1313853	hsa-miR-4325	CLIP-seq
MIRT1313854	hsa-miR-4419b	CLIP-seq
MIRT1313855	hsa-miR-4422	CLIP-seq
MIRT1313777	hsa-miR-4433	CLIP-seq
MIRT1313779	hsa-miR-4459	CLIP-seq
MIRT1313856	hsa-miR-4478	CLIP-seq
MIRT1313857	hsa-miR-4486	CLIP-seq
MIRT1313858	hsa-miR-4487	CLIP-seq
MIRT1313859	hsa-miR-4505	CLIP-seq
MIRT1313860	hsa-miR-4528	CLIP-seq
MIRT1313861	hsa-miR-4677-5p	CLIP-seq
MIRT1313862	hsa-miR-4684-5p	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT1313863	hsa-miR-4733-5p	CLIP-seq
MIRT1313795	hsa-miR-4768-3p	CLIP-seq
MIRT1313864	hsa-miR-4786-5p	CLIP-seq
MIRT1313799	hsa-miR-483-3p	CLIP-seq
MIRT1313865	hsa-miR-497	CLIP-seq
MIRT1313866	hsa-miR-513a-5p	CLIP-seq
MIRT1313802	hsa-miR-520a-5p	CLIP-seq
MIRT1313803	hsa-miR-525-5p	CLIP-seq
MIRT1313867	hsa-miR-548n	CLIP-seq
MIRT1313868	hsa-miR-548s	CLIP-seq
MIRT1313869	hsa-miR-558	CLIP-seq
MIRT1313870	hsa-miR-585	CLIP-seq
MIRT1313871	hsa-miR-604	CLIP-seq
MIRT1313872	hsa-miR-647	CLIP-seq
MIRT1313873	hsa-miR-655	CLIP-seq
MIRT1313874	hsa-miR-668	CLIP-seq
MIRT1313875	hsa-miR-769-5p	CLIP-seq
MIRT1313876	hsa-miR-873	CLIP-seq
MIRT1313877	hsa-miR-92a	CLIP-seq
MIRT1313878	hsa-miR-92b	CLIP-seq
MIRT1313836	hsa-miR-3189-5p	CLIP-seq
MIRT1313843	hsa-miR-3922-5p	CLIP-seq
MIRT1313808	hsa-miR-624	CLIP-seq
MIRT1313831	hsa-miR-27a	CLIP-seq
MIRT1313832	hsa-miR-27b	CLIP-seq
MIRT2093388	hsa-miR-3613-3p	CLIP-seq
MIRT1313799	hsa-miR-483-3p	CLIP-seq
MIRT1313866	hsa-miR-513a-5p	CLIP-seq
MIRT2093389	hsa-miR-593	CLIP-seq
MIRT2093390	hsa-miR-657	CLIP-seq
MIRT2093391	hsa-miR-1252	CLIP-seq
MIRT2093392	hsa-miR-4747-5p	CLIP-seq
MIRT2093391	hsa-miR-1252	CLIP-seq
MIRT2317920	hsa-miR-2114	CLIP-seq
MIRT2317921	hsa-miR-216a	CLIP-seq
MIRT2317922	hsa-miR-216b	CLIP-seq
MIRT1313829	hsa-miR-24	CLIP-seq
MIRT1313831	hsa-miR-27a	CLIP-seq
MIRT1313832	hsa-miR-27b	CLIP-seq
MIRT2317923	hsa-miR-3065-3p	CLIP-seq
MIRT2317924	hsa-miR-3122	CLIP-seq
MIRT1313836	hsa-miR-3189-5p	CLIP-seq
MIRT1313758	hsa-miR-3192	CLIP-seq
MIRT2317925	hsa-miR-3660	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT1313768	hsa-miR-3689d	CLIP-seq
MIRT2317926	hsa-miR-3913-5p	CLIP-seq
MIRT1313843	hsa-miR-3922-5p	CLIP-seq
MIRT1313773	hsa-miR-4267	CLIP-seq
MIRT1313774	hsa-miR-4284	CLIP-seq
MIRT2317927	hsa-miR-4293	CLIP-seq
MIRT1313775	hsa-miR-4314	CLIP-seq
MIRT2317928	hsa-miR-4514	CLIP-seq
MIRT2317929	hsa-miR-4526	CLIP-seq
MIRT2317930	hsa-miR-4633-5p	CLIP-seq
MIRT1313787	hsa-miR-4646-5p	CLIP-seq
MIRT2317931	hsa-miR-4663	CLIP-seq
MIRT2317932	hsa-miR-4692	CLIP-seq
MIRT2317933	hsa-miR-4701-5p	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT1313793	hsa-miR-4761-5p	CLIP-seq
MIRT2317934	hsa-miR-4796-3p	CLIP-seq
MIRT1313797	hsa-miR-4797-5p	CLIP-seq
MIRT1313866	hsa-miR-513a-5p	CLIP-seq
MIRT2317935	hsa-miR-532-5p	CLIP-seq
MIRT2317936	hsa-miR-588	CLIP-seq
MIRT1313810	hsa-miR-627	CLIP-seq
MIRT2317937	hsa-miR-890	CLIP-seq
MIRT1313817	hsa-miR-924	CLIP-seq
MIRT2317920	hsa-miR-2114	CLIP-seq
MIRT1313829	hsa-miR-24	CLIP-seq
MIRT1313836	hsa-miR-3189-5p	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT1313843	hsa-miR-3922-5p	CLIP-seq
MIRT1313774	hsa-miR-4284	CLIP-seq
MIRT2317930	hsa-miR-4633-5p	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT2317935	hsa-miR-532-5p	CLIP-seq
MIRT2317937	hsa-miR-890	CLIP-seq
MIRT2439964	hsa-miR-3127-5p	CLIP-seq
MIRT2439965	hsa-miR-383	CLIP-seq
MIRT2439966	hsa-miR-3918	CLIP-seq
MIRT2439967	hsa-miR-4772-5p	CLIP-seq
MIRT2458477	hsa-miR-1183	CLIP-seq
MIRT2458478	hsa-miR-3145-5p	CLIP-seq
MIRT2458479	hsa-miR-320a	CLIP-seq
MIRT2458480	hsa-miR-320b	CLIP-seq
MIRT2458481	hsa-miR-320c	CLIP-seq
MIRT2458482	hsa-miR-320d	CLIP-seq
MIRT1313773	hsa-miR-4267	CLIP-seq
MIRT2458483	hsa-miR-4330	CLIP-seq
MIRT2458484	hsa-miR-4429	CLIP-seq
MIRT1313778	hsa-miR-4434	CLIP-seq
MIRT2458485	hsa-miR-4453	CLIP-seq
MIRT1313781	hsa-miR-4516	CLIP-seq
MIRT2458486	hsa-miR-451b	CLIP-seq
MIRT2458487	hsa-miR-4538	CLIP-seq
MIRT2458488	hsa-miR-4742-3p	CLIP-seq
MIRT2458489	hsa-miR-508-5p	CLIP-seq
MIRT1313811	hsa-miR-635	CLIP-seq
MIRT2458490	hsa-miR-766	CLIP-seq
MIRT2613599	hsa-miR-10a	CLIP-seq
MIRT2613600	hsa-miR-10b	CLIP-seq
MIRT2458477	hsa-miR-1183	CLIP-seq
MIRT2613601	hsa-miR-1298	CLIP-seq
MIRT1313735	hsa-miR-1323	CLIP-seq
MIRT2613602	hsa-miR-139-5p	CLIP-seq
MIRT2613603	hsa-miR-142-3p	CLIP-seq
MIRT1313738	hsa-miR-146a	CLIP-seq
MIRT1313739	hsa-miR-146b-5p	CLIP-seq
MIRT2613604	hsa-miR-202	CLIP-seq
MIRT2317921	hsa-miR-216a	CLIP-seq
MIRT2317922	hsa-miR-216b	CLIP-seq
MIRT2613605	hsa-miR-297	CLIP-seq
MIRT2317923	hsa-miR-3065-3p	CLIP-seq
MIRT1313743	hsa-miR-3065-5p	CLIP-seq
MIRT2317924	hsa-miR-3122	CLIP-seq
MIRT2458478	hsa-miR-3145-5p	CLIP-seq
MIRT2613606	hsa-miR-3158-3p	CLIP-seq
MIRT1313755	hsa-miR-3174	CLIP-seq
MIRT2613607	hsa-miR-339-5p	CLIP-seq
MIRT2613608	hsa-miR-3616-3p	CLIP-seq
MIRT2613609	hsa-miR-3662	CLIP-seq
MIRT2613610	hsa-miR-3671	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT1313768	hsa-miR-3689d	CLIP-seq
MIRT2317926	hsa-miR-3913-5p	CLIP-seq
MIRT1313771	hsa-miR-3925-5p	CLIP-seq
MIRT1313773	hsa-miR-4267	CLIP-seq
MIRT2613611	hsa-miR-4421	CLIP-seq
MIRT2458485	hsa-miR-4453	CLIP-seq
MIRT1313784	hsa-miR-4536	CLIP-seq
MIRT2458487	hsa-miR-4538	CLIP-seq
MIRT1313862	hsa-miR-4684-5p	CLIP-seq
MIRT2613612	hsa-miR-4721	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT1313793	hsa-miR-4761-5p	CLIP-seq
MIRT2613613	hsa-miR-505	CLIP-seq
MIRT2458489	hsa-miR-508-5p	CLIP-seq
MIRT2613614	hsa-miR-516a-3p	CLIP-seq
MIRT2613615	hsa-miR-548c-3p	CLIP-seq
MIRT1313806	hsa-miR-548o	CLIP-seq
MIRT2613616	hsa-miR-567	CLIP-seq
MIRT2093389	hsa-miR-593	CLIP-seq
MIRT2613617	hsa-miR-618	CLIP-seq
MIRT1313811	hsa-miR-635	CLIP-seq
MIRT2613618	hsa-miR-654-3p	CLIP-seq
MIRT2458490	hsa-miR-766	CLIP-seq
MIRT1313813	hsa-miR-802	CLIP-seq
MIRT2613619	hsa-miR-888	CLIP-seq
MIRT1313816	hsa-miR-921	CLIP-seq
MIRT2613620	hsa-miR-95	CLIP-seq
MIRT2613599	hsa-miR-10a	CLIP-seq
MIRT2613600	hsa-miR-10b	CLIP-seq
MIRT2613602	hsa-miR-139-5p	CLIP-seq
MIRT2317921	hsa-miR-216a	CLIP-seq
MIRT2317922	hsa-miR-216b	CLIP-seq
MIRT2317923	hsa-miR-3065-3p	CLIP-seq
MIRT2317924	hsa-miR-3122	CLIP-seq
MIRT2613606	hsa-miR-3158-3p	CLIP-seq
MIRT2613607	hsa-miR-339-5p	CLIP-seq
MIRT2613608	hsa-miR-3616-3p	CLIP-seq
MIRT1313766	hsa-miR-3689a-3p	CLIP-seq
MIRT1313767	hsa-miR-3689c	CLIP-seq
MIRT2317926	hsa-miR-3913-5p	CLIP-seq
MIRT2613611	hsa-miR-4421	CLIP-seq
MIRT1313784	hsa-miR-4536	CLIP-seq
MIRT1313862	hsa-miR-4684-5p	CLIP-seq
MIRT2613612	hsa-miR-4721	CLIP-seq
MIRT1313791	hsa-miR-4728-5p	CLIP-seq
MIRT1313793	hsa-miR-4761-5p	CLIP-seq
MIRT2613614	hsa-miR-516a-3p	CLIP-seq
MIRT2093389	hsa-miR-593	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
CHD4	Unknown	22531782

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IBA	21873635
GO:0000151	Component	Ubiquitin ligase complex	IDA	18001824, 18001825
GO:0000781	Component	Chromosome, telomeric region	ISS
GO:0003682	Function	Chromatin binding	IDA	18001824, 18001825
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	18001824, 18001825, 18948756, 21911360, 22266820, 22373579, 22980979
GO:0005515	Function	Protein binding	IPI	16189514, 18001824, 18001825, 19690564, 20023648, 21516116, 22266820, 22373579, 22508508, 25416956, 25512560, 26869104, 27715493, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	18001824, 18001825
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006302	Process	Double-strand break repair	IBA	21873635
GO:0006302	Process	Double-strand break repair	IDA	18001824, 18001825, 22980979
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	ISS
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	22266820, 22373579
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	20550933, 21911360, 22266820, 22373579, 22980979
GO:0007049	Process	Cell cycle	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0008270	Function	Zinc ion binding	IDA	22980979
GO:0010212	Process	Response to ionizing radiation	IDA	18001824, 18001825
GO:0016032	Process	Viral process	IEA
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0030496	Component	Midbody	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	22266820
GO:0033522	Process	Histone H2A ubiquitination	IDA	18001824, 18001825
GO:0033523	Process	Histone H2B ubiquitination	ISS
GO:0034244	Process	Negative regulation of transcription elongation from RNA polymerase II promoter	IMP	20550933
GO:0035093	Process	Spermatogenesis, exchange of chromosomal proteins	ISS
GO:0035861	Component	Site of double-strand break	IBA	21873635
GO:0035861	Component	Site of double-strand break	IDA	22266820
GO:0036297	Process	Interstrand cross-link repair	TAS	22705371
GO:0042393	Function	Histone binding	IBA	21873635
GO:0042393	Function	Histone binding	IDA	18001824, 18001825
GO:0042802	Function	Identical protein binding	IPI	22980979, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	22980979
GO:0043130	Function	Ubiquitin binding	IEA
GO:0043486	Process	Histone exchange	ISS
GO:0045190	Process	Isotype switching	ISS
GO:0045739	Process	Positive regulation of DNA repair	IDA	18001824, 18001825
GO:0051301	Process	Cell division	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	22266820
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	21911360
GO:0070535	Process	Histone H2A K63-linked ubiquitination	IBA	21873635
GO:0070535	Process	Histone H2A K63-linked ubiquitination	IDA	22980979
GO:0070535	Process	Histone H2A K63-linked ubiquitination	IMP	20550933
GO:0070936	Process	Protein K48-linked ubiquitination	IBA	21873635
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	21911360, 22266820, 22373579

MIM	HGNC	e!Ensembl
611685	10071	ENSG00000112130

Protein

UniProt ID

O76064

Protein name

E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)

Protein function

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks

PDB

2CSW , 2PIE , 4AYC , 4ORH , 4WHV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00498	FHA	38 → 109	FHA domain	Family
PF13920	zf-C3HC4_3	399 → 447		Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. In fetal tissues, highest expression in brain, thymus and liver. In adult tissues, highest levels in brain and testis, lowest levels in peripheral blood cells. {ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:9852682}.

Sequence

MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAH
SFCSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIRERK
AKRLF

Sequence length

485

Interactions

View interactions

	Reactome
			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	18621663

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text Mining
Alternating hemiplegia of childhood	Associate	28398700
Breast Neoplasms	Associate	24581343, 27909234, 28216286, 31294443, 32753472, 37154586
Carcinogenesis	Associate	28507061
Carcinoma Hepatocellular	Associate	37154586
Chromosomal Instability	Inhibit	25483088
Colorectal Neoplasms	Associate	23935401
Colorectal Neoplasms	Stimulate	38204601
Congenital thrombotic disease due to Protein C deficiency	Associate	35428760
DNA Virus Infections	Associate	32453758
Drug Hypersensitivity	Associate	19797077
Endocrine System Diseases	Associate	35428760
Glioma	Associate	37468549
Infections	Associate	32453758
Leukemia Lymphoma Adult T Cell	Associate	26285145, 32453758
Lung Neoplasms	Stimulate	32753472
Neoplasm Metastasis	Associate	32753472, 33205415
Neoplasms	Associate	28507061, 32502756, 35831895, 37154586
Neurodegenerative Diseases	Associate	35831895
Ovarian Neoplasms	Associate	25483088, 27391345
Prostatic Neoplasms	Associate	35428760
Prostatic Neoplasms Castration Resistant	Associate	35428760
Triple Negative Breast Neoplasms	Associate	24581343, 33205415

RNF8 (ring finger protein 8)