Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9002
Gene name Gene Name - the full gene name approved by the HGNC.
F2R like thrombin or trypsin receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
F2RL3
Synonyms (NCBI Gene) Gene synonyms aliases
PAR4
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT519209 hsa-miR-759 HITS-CLIP 23824327
MIRT664999 hsa-miR-221-5p HITS-CLIP 23824327
MIRT664998 hsa-miR-8073 HITS-CLIP 23824327
MIRT519202 hsa-miR-6778-3p HITS-CLIP 23824327
MIRT664997 hsa-miR-6815-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602779 3540 ENSG00000127533
Protein
UniProt ID Q96RI0
Protein name Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
Protein function Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109).
PDB 2ZPK , 3QDZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 94 340 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
Sequence
Sequence length 385
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Platelet activation
Pathways in cancer
  Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cholestasis Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 20974703
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 32062795
Adenocarcinoma of Lung Inhibit 23886184
Atherosclerosis Associate 35012325
Blood Platelet Disorders Associate 25278289, 29269513, 30055940, 30851630
Carcinoma Ovarian Epithelial Associate 28148395
Carcinoma Renal Cell Associate 37781030
Cardiomyopathies Associate 22228373
Cardiovascular Diseases Associate 24510982, 31369996, 35012325, 35708029
Colorectal Neoplasms Associate 20056842, 21907696, 25876034
Colorectal Neoplasms Stimulate 30462538