NAT1 (N-acetyltransferase 1)

Gene

• Entrez ID: 9
• Gene name: N-acetyltransferase 1
• Gene symbol: NAT1
• Synonyms (NCBI Gene): AAC1, MNAT, NAT-1, NATI
• Chromosome: 8
• Chromosome location: 8p22
• Summary: This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030309	hsa-miR-26b-5p	Microarray	19088304
MIRT050208	hsa-miR-25-3p	CLASH	23622248
MIRT1174316	hsa-miR-1264	CLIP-seq
MIRT1174317	hsa-miR-3613-3p	CLIP-seq
MIRT1174318	hsa-miR-548aa	CLIP-seq
MIRT1174319	hsa-miR-548ac	CLIP-seq
MIRT1174320	hsa-miR-548d-3p	CLIP-seq
MIRT1174321	hsa-miR-548z	CLIP-seq
MIRT1174322	hsa-miR-1305	CLIP-seq
MIRT1174317	hsa-miR-3613-3p	CLIP-seq
MIRT1174323	hsa-miR-3671	CLIP-seq
MIRT1174318	hsa-miR-548aa	CLIP-seq
MIRT1174319	hsa-miR-548ac	CLIP-seq
MIRT1174320	hsa-miR-548d-3p	CLIP-seq
MIRT1174321	hsa-miR-548z	CLIP-seq
MIRT1174324	hsa-miR-607	CLIP-seq
MIRT2050434	hsa-miR-582-3p	CLIP-seq
MIRT2279521	hsa-miR-1290	CLIP-seq
MIRT2279522	hsa-miR-2964a-5p	CLIP-seq
MIRT2279523	hsa-miR-3159	CLIP-seq
MIRT2279524	hsa-miR-4659a-3p	CLIP-seq
MIRT2279525	hsa-miR-4659b-3p	CLIP-seq
MIRT2279526	hsa-miR-4698	CLIP-seq
MIRT2391356	hsa-miR-151-5p	CLIP-seq
MIRT2391357	hsa-miR-151b	CLIP-seq
MIRT2391358	hsa-miR-3131	CLIP-seq
MIRT2391359	hsa-miR-611	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Activation	17210686
HSF1	Activation	20176657

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004060	Function	Arylamine N-acetyltransferase activity	IBA	21873635
GO:0004060	Function	Arylamine N-acetyltransferase activity	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006805	Process	Xenobiotic metabolic process	TAS

Other IDs

• MIM: 108345
• HGNC: 7645
• e!Ensembl: ENSG00000171428

Protein

• UniProt ID: P18440
• Protein name: Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)
• Protein function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
• PDB: 2IJA, 2PQT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00797	Acetyltransf_2	20 → 280	N-acetyltransferase	Family

• Sequence:

  MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVV
  RRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYI
  VDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDL
  LEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLT
  HRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI

• Sequence length: 290

Pathways

KEGG:

Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Chemical carcinogenesis - DNA adducts

Reactome:

Acetylation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Dermatitis	Dermatitis, Occupational	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	19834256
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	12618593

Unknown
Disease term	Disease name	Evidence	References	Source
Metabolic Syndrome	Metabolic Syndrome			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenoma	Associate	22552404
Adenomatous Polyposis Coli	Associate	14724163
Alzheimer Disease	Associate	15142281
Asthma	Associate	26641831, 31809667
Breast Neoplasms	Associate	15084249, 26965286, 29315819, 29339455, 29901116, 29969986, 31910058, 32555504, 33176066, 35906899, 37107601
Breast Neoplasms	Stimulate	29964355
Breast Neoplasms Male	Associate	22333393, 27648926
Carcinogenesis	Associate	17537267, 18069763, 26547586
Carcinoma Hepatocellular	Associate	15770721, 8396914
Cholangiocarcinoma	Associate	18069763
Colitis Ulcerative	Associate	18322880
Colonic Neoplasms	Associate	37626132
Colonic Polyps	Associate	18268115
Colorectal Neoplasms	Associate	18022202, 19549810, 35485310, 9528834
Colorectal Neoplasms	Inhibit	35485310
Conotruncal cardiac defects	Associate	21254360
Diabetes Mellitus Type 2	Associate	26409796
Drug Related Side Effects and Adverse Reactions	Associate	18069763, 25413361
Glioma	Associate	35285582
Head and Neck Neoplasms	Associate	38099560
Hereditary Breast and Ovarian Cancer Syndrome	Associate	15084249, 29339455
Inflammation	Inhibit	18069763
Leukemia Lymphocytic Chronic B Cell	Associate	20029944
Leukemia Promyelocytic Acute	Associate	15142884
Lymphoma Non Hodgkin	Associate	16847422, 17522066, 19809881, 20029944
Lymphoma T Cell	Associate	19809881
Mouth Neoplasms	Associate	23168701
Neoplasm Metastasis	Associate	29609951
Neoplasms	Associate	12832400, 15084249, 16416399, 16788383, 17210686, 17537267, 29315819, 29339455, 29969986, 31910058, 33176066, 35906899, 40054776
Neoplasms	Stimulate	29964355
Pancreatic Neoplasms	Associate	15987714, 18006927, 18499698
Precancerous Conditions	Associate	17537267, 20570911, 9577349
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	37103073
Smoke Inhalation Injury	Associate	18499698, 19809881
Stomach Neoplasms	Associate	17646057
Triple Negative Breast Neoplasms	Stimulate	29964355, 32555504
Urinary Bladder Neoplasms	Associate	10507782, 17026750, 23803105, 8110178, 8396914