CDKL2 (cyclin dependent kinase like 2)

Gene

• Entrez ID: 8999
• Gene name: Cyclin dependent kinase like 2
• Gene symbol: CDKL2
• Synonyms (NCBI Gene): KKIAMRE, P56
• Chromosome: 4
• Chromosome location: 4q21.1
• Summary: This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028804	hsa-miR-26b-5p	Microarray	19088304
MIRT625368	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625367	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625366	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625365	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625364	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625363	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625362	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625361	hsa-miR-6750-3p	HITS-CLIP	23824327
MIRT625360	hsa-miR-4719	HITS-CLIP	23824327
MIRT444678	hsa-miR-1243	PAR-CLIP	22100165
MIRT444677	hsa-miR-654-3p	PAR-CLIP	22100165
MIRT444676	hsa-miR-181a-2-3p	PAR-CLIP	22100165
MIRT444675	hsa-miR-1273g-3p	PAR-CLIP	22100165
MIRT444674	hsa-miR-4635	PAR-CLIP	22100165
MIRT444673	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT444672	hsa-miR-190b	PAR-CLIP	22100165
MIRT444671	hsa-miR-3201	PAR-CLIP	22100165
MIRT444669	hsa-miR-4791	PAR-CLIP	22100165
MIRT444670	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444668	hsa-miR-6509-3p	PAR-CLIP	22100165
MIRT444667	hsa-miR-4436b-5p	PAR-CLIP	22100165
MIRT444666	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT625368	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625367	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625366	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625365	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625364	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625363	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625362	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625361	hsa-miR-6750-3p	HITS-CLIP	23824327
MIRT625360	hsa-miR-4719	HITS-CLIP	23824327
MIRT444678	hsa-miR-1243	PAR-CLIP	22100165
MIRT444677	hsa-miR-654-3p	PAR-CLIP	22100165
MIRT444676	hsa-miR-181a-2-3p	PAR-CLIP	22100165
MIRT444675	hsa-miR-1273g-3p	PAR-CLIP	22100165
MIRT444674	hsa-miR-4635	PAR-CLIP	22100165
MIRT444673	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT444672	hsa-miR-190b	PAR-CLIP	22100165
MIRT444671	hsa-miR-3201	PAR-CLIP	22100165
MIRT444669	hsa-miR-4791	PAR-CLIP	22100165
MIRT444670	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444668	hsa-miR-6509-3p	PAR-CLIP	22100165
MIRT444667	hsa-miR-4436b-5p	PAR-CLIP	22100165
MIRT444666	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT881597	hsa-miR-1226	CLIP-seq
MIRT881598	hsa-miR-1284	CLIP-seq
MIRT881599	hsa-miR-134	CLIP-seq
MIRT881600	hsa-miR-300	CLIP-seq
MIRT881601	hsa-miR-3118	CLIP-seq
MIRT881602	hsa-miR-3145-3p	CLIP-seq
MIRT881603	hsa-miR-3160-3p	CLIP-seq
MIRT881604	hsa-miR-3164	CLIP-seq
MIRT881605	hsa-miR-3591-5p	CLIP-seq
MIRT881606	hsa-miR-3647-3p	CLIP-seq
MIRT881607	hsa-miR-381	CLIP-seq
MIRT881608	hsa-miR-3938	CLIP-seq
MIRT881609	hsa-miR-4487	CLIP-seq
MIRT881610	hsa-miR-4666-3p	CLIP-seq
MIRT881611	hsa-miR-4733-3p	CLIP-seq
MIRT881612	hsa-miR-558	CLIP-seq
MIRT881613	hsa-miR-584	CLIP-seq
MIRT881614	hsa-miR-648	CLIP-seq
MIRT881599	hsa-miR-134	CLIP-seq
MIRT1961164	hsa-miR-203	CLIP-seq
MIRT881601	hsa-miR-3118	CLIP-seq
MIRT881604	hsa-miR-3164	CLIP-seq
MIRT881605	hsa-miR-3591-5p	CLIP-seq
MIRT881608	hsa-miR-3938	CLIP-seq
MIRT1961165	hsa-miR-4768-5p	CLIP-seq
MIRT881614	hsa-miR-648	CLIP-seq
MIRT2197947	hsa-miR-4279	CLIP-seq
MIRT2197948	hsa-miR-4659a-3p	CLIP-seq
MIRT2197949	hsa-miR-4659b-3p	CLIP-seq
MIRT2197950	hsa-miR-635	CLIP-seq
MIRT2465079	hsa-miR-3914	CLIP-seq
MIRT2465080	hsa-miR-4693-3p	CLIP-seq
MIRT2465081	hsa-miR-4712-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9000130
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0007165	Process	Signal transduction	TAS	9000130
GO:0007548	Process	Sex differentiation	TAS	9000130
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 603442
• HGNC: 1782
• e!Ensembl: ENSG00000138769

Protein

• UniProt ID: Q92772
• Protein name: Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE)
• PDB: 4AAA, 4BBM, 8S6I
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	4 → 287	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis and kidney, and at lower level in brain and lung. {ECO:0000269|PubMed:9000130}.
• Sequence:

  MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH
  ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH
  NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG
  KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL
  PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL
  QLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSK
  IDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLS
  AVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSD
  DSGADLPQMEHQH

• Sequence length: 493