Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8989
Gene name Gene Name - the full gene name approved by the HGNC.
Transient receptor potential cation channel subfamily A member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRPA1
Synonyms (NCBI Gene) Gene synonyms aliases
ANKTM1, FEPS, FEPS1, p120
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FEPS1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.11
Summary Summary of gene provided in NCBI Entrez Gene.
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in si
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023904 hsa-miR-1-3p Microarray 18668037
MIRT025846 hsa-miR-7-5p Microarray 17612493
MIRT1457191 hsa-miR-1257 CLIP-seq
MIRT1457192 hsa-miR-1293 CLIP-seq
MIRT1457193 hsa-miR-1324 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IMP 20547126, 25855297
GO:0006811 Process Ion transport TAS 10066796
GO:0007166 Process Cell surface receptor signaling pathway IEA
GO:0009409 Process Response to cold IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604775 497 ENSG00000104321
Protein
UniProt ID O75762
Protein name Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
Protein function Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:218739
PDB 3J9P , 6HC8 , 6PQO , 6PQP , 6PQQ , 6V9V , 6V9W , 6V9X , 6V9Y , 6WJ5 , 6X2J , 7JUP , 7OR0 , 7OR1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00023 Ank 97 129 Ankyrin repeat Repeat
PF00023 Ank 240 269 Ankyrin repeat Repeat
PF00023 Ank 341 373 Ankyrin repeat Repeat
PF00023 Ank 412 442 Ankyrin repeat Repeat
PF00023 Ank 481 511 Ankyrin repeat Repeat
PF00023 Ank 547 579 Ankyrin repeat Repeat
PF00520 Ion_trans 721 972 Ion transport protein Family
Sequence
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNF
NMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVE
KGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDN
FGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSK
SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHAS
LKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
Sequence length 1119
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inflammatory mediator regulation of TRP channels   TRP channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Episodic pain syndrome EPISODIC PAIN SYNDROME, FAMILIAL, 1, Familial episodic pain syndrome with predominantly upper body involvement rs398123010, rs138607170, rs483352921, rs1230622899 20547126, 28436534, 21468319
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 19458046 ClinVar
Peripheral Neuropathy hereditary peripheral neuropathy GenCC
Episodic Pain Syndrome familial episodic pain syndrome with predominantly upper body involvement GenCC
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Pain Associate 33530940
Acute Pain Associate 29620434
Adenocarcinoma of Lung Associate 35733175
Anemia Sickle Cell Associate 29620434
Arthritis Associate 37373205
Asthma Associate 26039217, 27758864, 27779810, 28076424, 36847817, 37386145
Atrial Fibrillation Stimulate 28839241
Breast Neoplasms Associate 38564162
Carcinoma Pancreatic Ductal Associate 33479347
Cartilage Diseases Associate 37373205