Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8914
Gene name	Timeless circadian regulator
Gene symbol	TIMELESS
Synonyms (NCBI Gene)	FASPS4TIMTIM1hTIM
Chromosome	12
Chromosome location	12q13.3
Summary	The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a

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Show/Hide all (203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047095	hsa-miR-183-5p	CLASH	23622248
MIRT043049	hsa-miR-324-5p	CLASH	23622248
MIRT041838	hsa-miR-484	CLASH	23622248
MIRT041838	hsa-miR-484	CLASH	23622248
MIRT039980	hsa-miR-615-3p	CLASH	23622248
MIRT036827	hsa-miR-877-3p	CLASH	23622248
MIRT036827	hsa-miR-877-3p	CLASH	23622248
MIRT036201	hsa-miR-320b	CLASH	23622248
MIRT665834	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT665833	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT665832	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT519321	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT665831	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT665830	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT665829	hsa-miR-4252	HITS-CLIP	23824327
MIRT665828	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT665827	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT665826	hsa-miR-7703	HITS-CLIP	23824327
MIRT652675	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT652674	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT652673	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT652672	hsa-miR-635	HITS-CLIP	23824327
MIRT652671	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT652670	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT652669	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT652668	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT652667	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT652666	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT652665	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT652664	hsa-miR-4507	HITS-CLIP	23824327
MIRT652663	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT519335	hsa-miR-3681-5p	PAR-CLIP	23446348
MIRT519334	hsa-miR-6849-5p	PAR-CLIP	23446348
MIRT519333	hsa-miR-1273f	PAR-CLIP	23446348
MIRT519332	hsa-miR-4683	PAR-CLIP	23446348
MIRT519330	hsa-miR-3167	PAR-CLIP	23446348
MIRT519331	hsa-miR-876-5p	PAR-CLIP	23446348
MIRT519329	hsa-miR-4727-3p	PAR-CLIP	23446348
MIRT519328	hsa-miR-4460	PAR-CLIP	23446348
MIRT519327	hsa-miR-1270	PAR-CLIP	23446348
MIRT519326	hsa-miR-620	PAR-CLIP	23446348
MIRT519325	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT519324	hsa-miR-3591-5p	PAR-CLIP	23446348
MIRT519323	hsa-miR-3149	PAR-CLIP	23446348
MIRT519321	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT519322	hsa-miR-6748-3p	PAR-CLIP	23446348
MIRT519320	hsa-miR-4421	PAR-CLIP	23446348
MIRT519319	hsa-miR-5699-3p	PAR-CLIP	23446348
MIRT519318	hsa-miR-3190-5p	PAR-CLIP	23446348
MIRT519317	hsa-miR-3926	PAR-CLIP	23446348
MIRT519316	hsa-miR-548s	PAR-CLIP	23446348
MIRT519318	hsa-miR-3190-5p	PAR-CLIP	27292025
MIRT519317	hsa-miR-3926	PAR-CLIP	27292025
MIRT519320	hsa-miR-4421	PAR-CLIP	27292025
MIRT519316	hsa-miR-548s	PAR-CLIP	27292025
MIRT519319	hsa-miR-5699-3p	PAR-CLIP	27292025
MIRT519322	hsa-miR-6748-3p	PAR-CLIP	27292025
MIRT665834	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT665833	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT665832	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT519321	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT665831	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT665830	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT665829	hsa-miR-4252	HITS-CLIP	23824327
MIRT665828	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT665827	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT665826	hsa-miR-7703	HITS-CLIP	23824327
MIRT652675	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT652674	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT652673	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT652672	hsa-miR-635	HITS-CLIP	23824327
MIRT652671	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT652670	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT652669	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT652668	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT652667	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT652666	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT652665	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT652664	hsa-miR-4507	HITS-CLIP	23824327
MIRT652663	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT519335	hsa-miR-3681-5p	PAR-CLIP	23446348
MIRT519334	hsa-miR-6849-5p	PAR-CLIP	23446348
MIRT519333	hsa-miR-1273f	PAR-CLIP	23446348
MIRT519332	hsa-miR-4683	PAR-CLIP	23446348
MIRT519330	hsa-miR-3167	PAR-CLIP	23446348
MIRT519331	hsa-miR-876-5p	PAR-CLIP	23446348
MIRT519329	hsa-miR-4727-3p	PAR-CLIP	23446348
MIRT519328	hsa-miR-4460	PAR-CLIP	23446348
MIRT519327	hsa-miR-1270	PAR-CLIP	23446348
MIRT519326	hsa-miR-620	PAR-CLIP	23446348
MIRT519325	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT519324	hsa-miR-3591-5p	PAR-CLIP	23446348
MIRT519323	hsa-miR-3149	PAR-CLIP	23446348
MIRT519321	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT519322	hsa-miR-6748-3p	PAR-CLIP	23446348
MIRT519320	hsa-miR-4421	PAR-CLIP	23446348
MIRT519319	hsa-miR-5699-3p	PAR-CLIP	23446348
MIRT519318	hsa-miR-3190-5p	PAR-CLIP	23446348
MIRT519317	hsa-miR-3926	PAR-CLIP	23446348
MIRT519316	hsa-miR-548s	PAR-CLIP	23446348
MIRT755388	hsa-miR-129-2-3p	Luciferase reporter assayWestern blottingqRT-PCR	37550944
MIRT1424812	hsa-miR-106a	CLIP-seq
MIRT1424813	hsa-miR-106b	CLIP-seq
MIRT1424814	hsa-miR-1197	CLIP-seq
MIRT1424815	hsa-miR-125a-3p	CLIP-seq
MIRT1424816	hsa-miR-1343	CLIP-seq
MIRT1424817	hsa-miR-150	CLIP-seq
MIRT1424818	hsa-miR-17	CLIP-seq
MIRT1424819	hsa-miR-1976	CLIP-seq
MIRT1424820	hsa-miR-20a	CLIP-seq
MIRT1424821	hsa-miR-20b	CLIP-seq
MIRT1424822	hsa-miR-302a	CLIP-seq
MIRT1424823	hsa-miR-302b	CLIP-seq
MIRT1424824	hsa-miR-302c	CLIP-seq
MIRT1424825	hsa-miR-302d	CLIP-seq
MIRT1424826	hsa-miR-302e	CLIP-seq
MIRT1424827	hsa-miR-3157-5p	CLIP-seq
MIRT1424828	hsa-miR-3192	CLIP-seq
MIRT1424829	hsa-miR-3652	CLIP-seq
MIRT1424830	hsa-miR-3681	CLIP-seq
MIRT1424831	hsa-miR-372	CLIP-seq
MIRT1424832	hsa-miR-373	CLIP-seq
MIRT1424833	hsa-miR-3934	CLIP-seq
MIRT1424834	hsa-miR-4269	CLIP-seq
MIRT1424835	hsa-miR-4279	CLIP-seq
MIRT1424836	hsa-miR-4430	CLIP-seq
MIRT1424837	hsa-miR-4438	CLIP-seq
MIRT1424838	hsa-miR-4454	CLIP-seq
MIRT1424839	hsa-miR-4499	CLIP-seq
MIRT1424840	hsa-miR-4505	CLIP-seq
MIRT1424841	hsa-miR-4506	CLIP-seq
MIRT1424842	hsa-miR-4513	CLIP-seq
MIRT1424843	hsa-miR-4514	CLIP-seq
MIRT1424844	hsa-miR-4691-3p	CLIP-seq
MIRT1424845	hsa-miR-4692	CLIP-seq
MIRT1424846	hsa-miR-4707-3p	CLIP-seq
MIRT1424847	hsa-miR-4722-3p	CLIP-seq
MIRT1424848	hsa-miR-4742-5p	CLIP-seq
MIRT1424849	hsa-miR-5095	CLIP-seq
MIRT1424850	hsa-miR-519d	CLIP-seq
MIRT1424851	hsa-miR-520a-3p	CLIP-seq
MIRT1424852	hsa-miR-520b	CLIP-seq
MIRT1424853	hsa-miR-520c-3p	CLIP-seq
MIRT1424854	hsa-miR-520d-3p	CLIP-seq
MIRT1424855	hsa-miR-520e	CLIP-seq
MIRT1424856	hsa-miR-520g	CLIP-seq
MIRT1424857	hsa-miR-520h	CLIP-seq
MIRT1424858	hsa-miR-548a-3p	CLIP-seq
MIRT1424859	hsa-miR-548ac	CLIP-seq
MIRT1424860	hsa-miR-548ae	CLIP-seq
MIRT1424861	hsa-miR-548aj	CLIP-seq
MIRT1424862	hsa-miR-548am	CLIP-seq
MIRT1424863	hsa-miR-548d-3p	CLIP-seq
MIRT1424864	hsa-miR-548e	CLIP-seq
MIRT1424865	hsa-miR-548f	CLIP-seq
MIRT1424866	hsa-miR-548u	CLIP-seq
MIRT1424867	hsa-miR-548x	CLIP-seq
MIRT1424868	hsa-miR-548z	CLIP-seq
MIRT1424869	hsa-miR-555	CLIP-seq
MIRT1424870	hsa-miR-764	CLIP-seq
MIRT1424871	hsa-miR-93	CLIP-seq
MIRT2127266	hsa-miR-1279	CLIP-seq
MIRT1424816	hsa-miR-1343	CLIP-seq
MIRT2127267	hsa-miR-198	CLIP-seq
MIRT2127268	hsa-miR-28-5p	CLIP-seq
MIRT2127269	hsa-miR-3139	CLIP-seq
MIRT2127270	hsa-miR-371-5p	CLIP-seq
MIRT2127271	hsa-miR-371b-5p	CLIP-seq
MIRT1424834	hsa-miR-4269	CLIP-seq
MIRT2127272	hsa-miR-4314	CLIP-seq
MIRT1424843	hsa-miR-4514	CLIP-seq
MIRT1424845	hsa-miR-4692	CLIP-seq
MIRT1424847	hsa-miR-4722-3p	CLIP-seq
MIRT1424848	hsa-miR-4742-5p	CLIP-seq
MIRT2127273	hsa-miR-4778-3p	CLIP-seq
MIRT2127274	hsa-miR-4796-3p	CLIP-seq
MIRT2127275	hsa-miR-486-5p	CLIP-seq
MIRT2127276	hsa-miR-548n	CLIP-seq
MIRT2127277	hsa-miR-548t	CLIP-seq
MIRT2127278	hsa-miR-708	CLIP-seq
MIRT1424816	hsa-miR-1343	CLIP-seq
MIRT1424819	hsa-miR-1976	CLIP-seq
MIRT1424829	hsa-miR-3652	CLIP-seq
MIRT1424835	hsa-miR-4279	CLIP-seq
MIRT1424836	hsa-miR-4430	CLIP-seq
MIRT1424837	hsa-miR-4438	CLIP-seq
MIRT1424840	hsa-miR-4505	CLIP-seq
MIRT1424849	hsa-miR-5095	CLIP-seq
MIRT2349108	hsa-miR-558	CLIP-seq
MIRT2127268	hsa-miR-28-5p	CLIP-seq
MIRT2127269	hsa-miR-3139	CLIP-seq
MIRT2127272	hsa-miR-4314	CLIP-seq
MIRT2127278	hsa-miR-708	CLIP-seq
MIRT1424816	hsa-miR-1343	CLIP-seq
MIRT1424834	hsa-miR-4269	CLIP-seq
MIRT1424843	hsa-miR-4514	CLIP-seq
MIRT1424845	hsa-miR-4692	CLIP-seq
MIRT1424848	hsa-miR-4742-5p	CLIP-seq
MIRT1424816	hsa-miR-1343	CLIP-seq
MIRT1424834	hsa-miR-4269	CLIP-seq
MIRT1424843	hsa-miR-4514	CLIP-seq
MIRT1424845	hsa-miR-4692	CLIP-seq
MIRT1424848	hsa-miR-4742-5p	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000076	Process	DNA replication checkpoint signaling	IBA
GO:0000785	Component	Chromatin	IDA	17102137
GO:0002009	Process	Morphogenesis of an epithelium	IEA
GO:0002009	Process	Morphogenesis of an epithelium	ISS
GO:0003677	Function	DNA binding	IBA
GO:0005515	Function	Protein binding	IPI	15798197, 17102137, 17116885, 20124417, 26344098, 30356214, 32705708, 33961781
GO:0005634	Component	Nucleus	IC	9856465
GO:0005634	Component	Nucleus	IDA	17102137
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IBA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	23797032
GO:0006974	Process	DNA damage response	ISS
GO:0007623	Process	Circadian rhythm	IEA
GO:0007623	Process	Circadian rhythm	ISS
GO:0007623	Process	Circadian rhythm	TAS	9856465
GO:0008047	Function	Enzyme activator activity	IDA	26503245
GO:0009582	Process	Detection of abiotic stimulus	TAS	9856466
GO:0030324	Process	Lung development	IEA
GO:0031297	Process	Replication fork processing	IMP	26503245
GO:0031298	Component	Replication fork protection complex	IBA
GO:0035861	Component	Site of double-strand break	IDA	26344098, 30356214
GO:0042127	Process	Regulation of cell population proliferation	IMP	17102137
GO:0042752	Process	Regulation of circadian rhythm	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	23418588
GO:0042802	Function	Identical protein binding	IEA
GO:0043111	Process	Replication fork arrest	IBA
GO:0044770	Process	Cell cycle phase transition	IMP	17102137
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	9856465
GO:0048511	Process	Rhythmic process	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	IEA
GO:0051301	Process	Cell division	IEA
GO:0072711	Process	Cellular response to hydroxyurea	IMP	23797032
GO:0072719	Process	Cellular response to cisplatin	IMP	23797032
GO:1904976	Process	Cellular response to bleomycin	IMP	23797032
GO:1905168	Process	Positive regulation of double-strand break repair via homologous recombination	IDA	26344098, 30356214
GO:2000781	Process	Positive regulation of double-strand break repair	IMP	23797032

MIM	HGNC	e!Ensembl
603887	11813	ENSG00000111602

Q9UNS1

Protein name

Protein timeless homolog (hTIM)

Protein function

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, Pu

PDB

4XHT , 4XHU , 4XHW , 5MQI , 6T9Q , 6TAZ , 7PFO , 7PLO , 8B9D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04821	TIMELESS	24 → 284	Timeless protein	Family
PF05029	TIMELESS_C	1006 → 1092	Timeless PAB domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. {ECO:0000269|PubMed:9

Sequence

MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQI
LQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPKEPSFRHHFLQVLTYLQAY
KEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKID
DDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQG
RLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKG
LHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGS
VKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYE
MMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRE
LFLALFRKFDERCQPRSFLRDLVETTHLFLKMLERFCRSRGNLVVQNKQKKRRKKKKKVL
DQAIVSGNVPSSPEEVEAVWPALAEQLQCCAQNSELSMDSVVPFDAASEVPVEEQRAEAM
VRIQDCLLAGQAPQALTLLRSAREVWPEGDVFGSQDISPEEEIQLLKQILSAPLPRQQGP
EERGAEEEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAH
TNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFAL
AAVNQKAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLANKDV
EGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRL
FEEFRDSDDVLGHIMKNITAKRSRARIVDKLLALGLVAERRELYKKRQKKLASSILPNGA
ESLKDFCQEDLEEEENLPEEDSEEEEEGGSEAEQVQGSLVLSNENLGQSLHQEGFSIPLL
WLQNCLIRAADDREEDGCSQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPASGQETFW
RIPAKLSPTQLRRAAASLSQPEEEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLA
HKKKAGLASPEEEDAVGKEPLKAAPKKRQLLDSDEEQEEDEGRNRAPELGAPGIQKKKRY
QIEDDEDD

Sequence length

1208

Interactions

View interactions

	Reactome
			Processing of DNA double-strand break ends

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Advance sleep phase syndrome, familial, 4	Pathogenic	rs1465092391	RCV006252577

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Likely benign	rs764005683	RCV005929257
Malignant tumor of esophagus	Likely benign	rs764005683	RCV005929256

Show/Hide Text Mining Associations (25)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	38261568
Antiphospholipid Syndrome	Associate	36241659
Bipolar Disorder	Associate	18228528
Breast Neoplasms	Stimulate	24161199, 28464854
Breast Neoplasms	Associate	29958276, 37340461, 38053143
Carcinogenesis	Associate	24161199, 30249891, 35034102, 38053143
Carcinoma Hepatocellular	Associate	34745328
Carcinoma Non Small Cell Lung	Stimulate	23173913
Carcinoma Non Small Cell Lung	Associate	35078435, 35575281
Colorectal Neoplasms	Associate	30629587, 34689170, 35034102
COVID 19	Associate	36241659
Depressive Disorder	Associate	20174623
Endometrial Neoplasms	Associate	38211843
Esophageal Squamous Cell Carcinoma	Associate	34365093
Fatigue	Associate	20174623
Glioma	Associate	30249891
Lung Neoplasms	Associate	23173913
Lung Neoplasms	Stimulate	35078435
Mandibulofacial Dysostosis	Associate	37129330
Neoplasms	Associate	23173913, 24161199, 26468983, 29958276, 30249891, 30796221, 35034102, 35078435, 37340461, 38053143, 38211843, 38261568
Neoplasms	Stimulate	30629587, 33442944
Ovarian Neoplasms	Associate	35715407
Sleep Wake Disorders	Associate	20174623, 36137075
Small Cell Lung Carcinoma	Associate	23173913
Thrombosis	Associate	36241659

TIMELESS (timeless circadian regulator)