Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8904
Gene name	Copine 1
Gene symbol	CPNE1
Synonyms (NCBI Gene)	COPN1CPN1
Chromosome	20
Chromosome location	20q11.22
Summary	Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032109	hsa-let-7d-5p	Sequencing	20371350
MIRT043882	hsa-miR-378a-3p	CLASH	23622248
MIRT040983	hsa-miR-532-5p	CLASH	23622248
MIRT037995	hsa-miR-500a-5p	CLASH	23622248
MIRT036389	hsa-miR-1229-3p	CLASH	23622248
MIRT727953	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727952	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727951	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727950	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT906491	hsa-miR-106a	CLIP-seq
MIRT906492	hsa-miR-106b	CLIP-seq
MIRT906493	hsa-miR-1253	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906497	hsa-miR-17	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906499	hsa-miR-20a	CLIP-seq
MIRT906500	hsa-miR-20b	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906503	hsa-miR-302a	CLIP-seq
MIRT906504	hsa-miR-302b	CLIP-seq
MIRT906505	hsa-miR-302c	CLIP-seq
MIRT906506	hsa-miR-302d	CLIP-seq
MIRT906507	hsa-miR-302e	CLIP-seq
MIRT906508	hsa-miR-3150b-3p	CLIP-seq
MIRT906509	hsa-miR-3154	CLIP-seq
MIRT906510	hsa-miR-3163	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906512	hsa-miR-3613-3p	CLIP-seq
MIRT906513	hsa-miR-372	CLIP-seq
MIRT906514	hsa-miR-373	CLIP-seq
MIRT906515	hsa-miR-3940-5p	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906519	hsa-miR-4507	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906522	hsa-miR-4689	CLIP-seq
MIRT906523	hsa-miR-4693-3p	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906527	hsa-miR-4784	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906529	hsa-miR-519d	CLIP-seq
MIRT906530	hsa-miR-520a-3p	CLIP-seq
MIRT906531	hsa-miR-520b	CLIP-seq
MIRT906532	hsa-miR-520c-3p	CLIP-seq
MIRT906533	hsa-miR-520d-3p	CLIP-seq
MIRT906534	hsa-miR-520d-5p	CLIP-seq
MIRT906535	hsa-miR-520e	CLIP-seq
MIRT906536	hsa-miR-520g	CLIP-seq
MIRT906537	hsa-miR-520h	CLIP-seq
MIRT906538	hsa-miR-524-5p	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906540	hsa-miR-548l	CLIP-seq
MIRT906541	hsa-miR-548n	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906543	hsa-miR-548t	CLIP-seq
MIRT906544	hsa-miR-621	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq
MIRT906547	hsa-miR-93	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906549	hsa-miR-3663-5p	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906549	hsa-miR-3663-5p	CLIP-seq
MIRT906550	hsa-miR-412	CLIP-seq
MIRT906551	hsa-miR-4420	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IDA	9430674
GO:0004175	Function	Endopeptidase activity	IDA	18212740
GO:0005509	Function	Calcium ion binding	IMP	25450385
GO:0005515	Function	Protein binding	IPI	12522145, 32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	TAS	9430674
GO:0005634	Component	Nucleus	IDA	18212740, 21087455
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21087455, 25450385
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	12949241, 18212740
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IMP	18212740
GO:0006629	Process	Lipid metabolic process	TAS	9430674
GO:0010629	Process	Negative regulation of gene expression	IMP	18212740
GO:0016020	Component	Membrane	IDA	25450385
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	TAS	9430674
GO:0030154	Process	Cell differentiation	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0042802	Function	Identical protein binding	IPI	18212740
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IBA
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IMP	14674885
GO:0043392	Process	Negative regulation of DNA binding	IDA	18212740
GO:0045666	Process	Positive regulation of neuron differentiation	IDA	23263657
GO:0045666	Process	Positive regulation of neuron differentiation	IMP	25450385
GO:0046872	Function	Metal ion binding	IEA
GO:0051059	Function	NF-kappaB binding	IPI	18212740
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	23263657
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	25450385
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0071277	Process	Cellular response to calcium ion	IBA
GO:0071277	Process	Cellular response to calcium ion	IMP	14674885
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IMP	18212740
GO:1903265	Process	Positive regulation of tumor necrosis factor-mediated signaling pathway	IBA
GO:1903265	Process	Positive regulation of tumor necrosis factor-mediated signaling pathway	IMP	14674885
GO:1990138	Process	Neuron projection extension	IDA	23263657
GO:1990138	Process	Neuron projection extension	IMP	25450385

MIM	HGNC	e!Ensembl
604205	2314	ENSG00000214078

Q99829

Protein name

Copine-1 (Chromobindin 17) (Copine I)

Protein function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calciu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	6 → 116	C2 domain	Domain
PF00168	C2	138 → 255	C2 domain	Domain
PF07002	Copine	304 → 521	Copine	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241). {ECO:0000269|PubMed:12949241}.

Sequence

MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSK
TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGK
PAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEV
IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE
FECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPS
SPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFN
PSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLL
TDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDI
VQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA

Sequence length

537

Interactions

View interactions

	Reactome
			Glycerophospholipid biosynthesis Neutrophil degranulation

CPNE1 (copine 1)