Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8895
Gene name Gene Name - the full gene name approved by the HGNC.
Copine 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPNE3
Synonyms (NCBI Gene) Gene synonyms aliases
CPN3, PRO1071
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the car
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002575 hsa-miR-124-3p Microarray 15685193
MIRT007128 hsa-miR-133b Luciferase reporter assay 23451058
MIRT002575 hsa-miR-124-3p Microarray;Other 15685193
MIRT052920 hsa-miR-451a Luciferase reporter assay, qRT-PCR, Western blot 24574214
MIRT052920 hsa-miR-451a Luciferase reporter assay, qRT-PCR, Western blot 24574214
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0004674 Function Protein serine/threonine kinase activity IDA 11041869
GO:0005515 Function Protein binding IPI 20010870, 21044950
GO:0005544 Function Calcium-dependent phospholipid binding IBA 21873635
GO:0005544 Function Calcium-dependent phospholipid binding IDA 9430674, 20010870
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604207 2316 ENSG00000085719
Protein
UniProt ID O75131
Protein name Copine-3 (Copine III)
Protein function Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00168 C2 8 116 C2 domain Domain
PF00168 C2 138 249 C2 domain Domain
PF07002 Copine 310 527 Copine Family
Tissue specificity TISSUE SPECIFICITY: Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precur
Sequence
Sequence length 537
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Glycerophospholipid biosynthesis
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 18264096
Associations from Text Mining
Disease Name Relationship Type References
Anxiety Associate 33767297
Breast Neoplasms Associate 39524444
Carcinogenesis Associate 28670859
Coronary Artery Disease Associate 29297177
Diabetes Mellitus Type 2 Associate 34667273
Hyperglycemic Hyperosmolar Nonketotic Coma Inhibit 34667273
Leukemia Lymphoma Adult T Cell Associate 33630973
Leukemia Myeloid Acute Associate 28670859
Multiple Myeloma Associate 33780365
Myocardial Infarction Inhibit 29297177