Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8880
Gene name Gene Name - the full gene name approved by the HGNC.
Far upstream element binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FUBP1
Synonyms (NCBI Gene) Gene synonyms aliases
FBP, FUBP, hDH V
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the re
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020591 hsa-miR-155-5p Proteomics 18668040
MIRT023618 hsa-miR-1-3p Proteomics 18668040
MIRT024616 hsa-miR-215-5p Microarray 19074876
MIRT026246 hsa-miR-192-5p Microarray 19074876
MIRT030728 hsa-miR-21-5p Microarray 18591254
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003697 Function Single-stranded DNA binding TAS 8125259
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 21285945, 21779003, 21988832
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603444 4004 ENSG00000162613
Protein
UniProt ID Q96AE4
Protein name Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V)
Protein function Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
PDB 1J4W , 2KXH , 4LIJ , 6Y24 , 6Y2C , 6Y2D , 8P25
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00013 KH_1 102 166 KH domain Domain
PF00013 KH_1 187 253 KH domain Domain
PF00013 KH_1 277 341 KH domain Domain
PF00013 KH_1 378 445 KH domain Domain
PF09005 DUF1897 572 599 Domain of unknown function (DUF1897) Domain
PF09005 DUF1897 602 626 Domain of unknown function (DUF1897) Domain
Sequence
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGY
GGQKRPLEDGDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGG
EQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQ
IVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGD
PYKVQQAKEMVLE
LIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKK
IQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITD
LLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNA
DPNMKLFTIRGTPQQIDYARQLIEE
KIGGPVNPLGPPVPHGPHGVPGPHGPPGPPGPGTP
MGPYNPAPYNPGPPGPAPHGPPAPYAPQGWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAY
YAHYYQQQAQPPPAAPAGAPTTTQTNGQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAP
TGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGQ
Sequence length 644
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioma Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
Associations from Text Mining
Disease Name Relationship Type References
Brain Neoplasms Associate 22869205
Breast Neoplasms Associate 32626933
Carcinogenesis Stimulate 25995247
Carcinogenesis Associate 28076379
Carcinoma Hepatocellular Associate 25487856, 25995247, 26901106, 33954195
Carcinoma Pancreatic Ductal Stimulate 37910256
Carcinoma Renal Cell Stimulate 28076379
Colorectal Neoplasms Stimulate 34288405
Colorectal Neoplasms Associate 35546072
COVID 19 Associate 37932299