Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8876
Gene name	Vanin 1
Gene symbol	VNN1
Synonyms (NCBI Gene)	HDLCQ8Tiff66
Chromosome	6
Chromosome location	6q23.2
Summary	This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participa

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Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT1485676	hsa-miR-10a	CLIP-seq
MIRT1485677	hsa-miR-10b	CLIP-seq
MIRT1485678	hsa-miR-1207-5p	CLIP-seq
MIRT1485679	hsa-miR-1255a	CLIP-seq
MIRT1485680	hsa-miR-1255b	CLIP-seq
MIRT1485681	hsa-miR-1290	CLIP-seq
MIRT1485682	hsa-miR-1305	CLIP-seq
MIRT1485683	hsa-miR-296-3p	CLIP-seq
MIRT1485684	hsa-miR-3133	CLIP-seq
MIRT1485685	hsa-miR-3182	CLIP-seq
MIRT1485686	hsa-miR-339-5p	CLIP-seq
MIRT1485687	hsa-miR-3667-5p	CLIP-seq
MIRT1485688	hsa-miR-3671	CLIP-seq
MIRT1485689	hsa-miR-4307	CLIP-seq
MIRT1485690	hsa-miR-4318	CLIP-seq
MIRT1485691	hsa-miR-432	CLIP-seq
MIRT1485692	hsa-miR-4421	CLIP-seq
MIRT1485693	hsa-miR-4474-3p	CLIP-seq
MIRT1485694	hsa-miR-4652-3p	CLIP-seq
MIRT1485695	hsa-miR-4659a-3p	CLIP-seq
MIRT1485696	hsa-miR-4659b-3p	CLIP-seq
MIRT1485697	hsa-miR-4725-5p	CLIP-seq
MIRT1485698	hsa-miR-4736	CLIP-seq
MIRT1485699	hsa-miR-4761-5p	CLIP-seq
MIRT1485700	hsa-miR-4763-3p	CLIP-seq
MIRT1485701	hsa-miR-504	CLIP-seq
MIRT1485702	hsa-miR-515-5p	CLIP-seq
MIRT1485703	hsa-miR-548u	CLIP-seq
MIRT1485704	hsa-miR-578	CLIP-seq
MIRT1485705	hsa-miR-607	CLIP-seq
MIRT1485706	hsa-miR-888	CLIP-seq
MIRT2146015	hsa-miR-3652	CLIP-seq
MIRT2146016	hsa-miR-4430	CLIP-seq
MIRT1485699	hsa-miR-4761-5p	CLIP-seq
MIRT2146017	hsa-miR-485-5p	CLIP-seq
MIRT2366485	hsa-miR-219-1-3p	CLIP-seq
MIRT2366486	hsa-miR-23a	CLIP-seq
MIRT2366487	hsa-miR-23b	CLIP-seq
MIRT2366488	hsa-miR-23c	CLIP-seq
MIRT2366489	hsa-miR-335	CLIP-seq
MIRT2366490	hsa-miR-3977	CLIP-seq
MIRT2366491	hsa-miR-4303	CLIP-seq
MIRT2366492	hsa-miR-4473	CLIP-seq
MIRT2366493	hsa-miR-4495	CLIP-seq
MIRT2366494	hsa-miR-4649-3p	CLIP-seq
MIRT2366495	hsa-miR-4682	CLIP-seq
MIRT2366496	hsa-miR-4704-3p	CLIP-seq
MIRT2366497	hsa-miR-512-3p	CLIP-seq
MIRT2366498	hsa-miR-520f	CLIP-seq
MIRT2366499	hsa-miR-571	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002526	Process	Acute inflammatory response	IEA
GO:0002526	Process	Acute inflammatory response	ISS	14966568
GO:0002544	Process	Chronic inflammatory response	IEA
GO:0002544	Process	Chronic inflammatory response	ISS	14966568
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	ISS	15282320
GO:0006979	Process	Response to oxidative stress	TAS	17145956
GO:0015938	Process	Coenzyme A catabolic process	IEA
GO:0015939	Process	Pantothenate metabolic process	IBA
GO:0015939	Process	Pantothenate metabolic process	IDA	11491533, 25478849
GO:0015939	Process	Pantothenate metabolic process	TAS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	17145956
GO:0016787	Function	Hydrolase activity	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
GO:0017159	Function	Pantetheine hydrolase activity	IBA
GO:0017159	Function	Pantetheine hydrolase activity	IDA	11491533, 25478849
GO:0017159	Function	Pantetheine hydrolase activity	IEA
GO:0017159	Function	Pantetheine hydrolase activity	TAS
GO:0033089	Process	Positive regulation of T cell differentiation in thymus	IEA
GO:0033089	Process	Positive regulation of T cell differentiation in thymus	ISS	11491533
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	ISS	14966568
GO:0098552	Component	Side of membrane	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098609	Process	Cell-cell adhesion	ISS	11491533
GO:1902177	Process	Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA
GO:1902177	Process	Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS	15282320

MIM	HGNC	e!Ensembl
603570	12705	ENSG00000112299

O95497

Protein name

Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)

Protein function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533, ECO:0000269|PubMed:2547

PDB

4CYF , 4CYG , 4CYY , 7SLV , 7SLX , 7SLY , 9IZL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00795	CN_hydrolase	50 → 299	Carbon-nitrogen hydrolase	Family
PF19018	Vanin_C	331 → 483	Vanin C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. {ECO:0000269|PubMed:19322213}.

Sequence

MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW

Sequence length

513

Interactions

View interactions

	KEGG		Reactome
	Pantothenate and CoA biosynthesis Metabolic pathways		Post-translational modification: synthesis of GPI-anchored proteins Vitamin B5 (pantothenate) metabolism Neutrophil degranulation

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs45458697	RCV005903526
Cholangiocarcinoma	Benign	rs45458697	RCV005903528
Clear cell carcinoma of kidney	Benign	rs45458697	RCV005903527
RECLASSIFIED - VNN1 POLYMORPHISM	Benign	rs4897612	RCV000006608

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	38022651
Carcinoma Pancreatic Ductal	Associate	36395397
Colitis	Associate	19322213
Colorectal Neoplasms	Associate	20846378
COVID 19	Associate	36740582
Dyslipidemias	Associate	32424199
Fibrosis	Associate	40147728
Hypertension	Associate	18043751
Inflammation	Associate	19322213, 40147728
Periodontitis	Stimulate	36527111
Psoriasis	Associate	19322213
Pulmonary edema of mountaineers	Associate	40640242
Purpura Thrombocytopenic Idiopathic	Associate	21325602
Purpura Thrombocytopenic Idiopathic	Stimulate	23534352
Stress Disorders Post Traumatic	Associate	38212778
Tissue Adhesions	Associate	40147728

VNN1 (vanin 1)