CCN4 (cellular communication network factor 4)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8840
Gene name Gene Name - the full gene name approved by the HGNC.
Cellular communication network factor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCN4
Synonyms (NCBI Gene) Gene synonyms aliases
WISP1, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate di
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation IEA
GO:0001817 Process Regulation of cytokine production IDA 25281430
GO:0005178 Function Integrin binding IBA 21873635
GO:0005515 Function Protein binding IPI 11598131, 20684029, 32296183
GO:0005520 Function Insulin-like growth factor binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603398 12769 ENSG00000104415
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95388
Protein name CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein)
Protein function Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP 49 → 101 Insulin-like growth factor binding protein Domain
PF00093 VWC 123 → 185 von Willebrand factor type C domain Family
PF19035 TSP1_CCN 216 → 259 CCN3 Nov like TSP1 domain Domain
PF00007 Cys_knot 270 → 363 Cystine-knot domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers inc
Sequence
Sequence length 367
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Wnt signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 30595370
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)		 30595370
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis GWAS
Diabetes Diabetes GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Show/Hide Text Mining Associations (50)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36640859
Alzheimer Disease Associate 22873724
Arthritis Rheumatoid Associate 31689765, 32361708
Bone Diseases Associate 20362080
Breast Neoplasms Stimulate 24426833, 25732125
Breast Neoplasms Associate 31689877, 35481425
Carcinogenesis Associate 17579708, 17657846, 25732125, 28426731, 29889892, 33239483
Carcinoma Hepatocellular Associate 29889892, 33155200, 33239483
Carcinoma Renal Cell Associate 29282485, 39754169
Cluster Headache Associate 40114078