KYAT1 (kynurenine aminotransferase 1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
883
Gene name Gene Name - the full gene name approved by the HGNC.
Kynurenine aminotransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KYAT1
Synonyms (NCBI Gene) Gene synonyms aliases
CCBL1, GTK, KAT1, KATI
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of t
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 29892012
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005739 Component Mitochondrion IBA 21873635
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600547 1564 ENSG00000171097
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16773
Protein name Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (K
Protein function Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory a
PDB 1W7L , 1W7M , 1W7N , 3FVS , 3FVU , 3FVX , 4WLH , 4WLJ , 4WP0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00155 Aminotran_1_2 28 → 415 Aminotransferase class I and II Domain
Sequence
Sequence length 422
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cysteine and methionine metabolism
Tryptophan metabolism
Selenocompound metabolism
Metabolic pathways 		  Tryptophan catabolism
Phenylalanine metabolism
Glutamate and glutamine metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 20663906
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Show/Hide Text Mining Associations (17)
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic lateral sclerosis 1 Associate 34194442
Carcinogenesis Associate 15364907
Colorectal Neoplasms Associate 33035787
COVID 19 Associate 35967328
Fatty Liver Associate 38034016
Glioma Associate 25415278
Glycosuria Renal Associate 20663906
Hypertension Associate 15364907
Infections Associate 21473761
Kidney Neoplasms Associate 20663906