KYAT1 (kynurenine aminotransferase 1)

Gene

• Entrez ID: 883
• Gene name: Kynurenine aminotransferase 1
• Gene symbol: KYAT1
• Synonyms (NCBI Gene): CCBL1, GTK, KAT1, KATI
• Chromosome: 9
• Chromosome location: 9q34.11
• Summary: This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of t

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 29892012
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	7883047
GO:0008483	Function	Transaminase activity	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0016212	Function	Kynurenine-oxoglutarate transaminase activity	IBA
GO:0016212	Function	Kynurenine-oxoglutarate transaminase activity	IDA	19338303
GO:0016212	Function	Kynurenine-oxoglutarate transaminase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0030170	Function	Pyridoxal phosphate binding	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	15364907
GO:0047316	Function	Glutamine-phenylpyruvate transaminase activity	IEA
GO:0047804	Function	Cysteine-S-conjugate beta-lyase activity	IDA	7883047
GO:0047804	Function	Cysteine-S-conjugate beta-lyase activity	IEA
GO:0070189	Process	Kynurenine metabolic process	IDA	19338303
GO:0097053	Process	L-kynurenine catabolic process	IEA

Other IDs

• MIM: 600547
• HGNC: 1564
• e!Ensembl: ENSG00000171097

Protein

• UniProt ID: Q16773
• Protein name: Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (K
• Protein function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory a
• PDB: 1W7L, 1W7M, 1W7N, 3FVS, 3FVU, 3FVX, 4WLH, 4WLJ, 4WP0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00155	Aminotran_1_2	28 → 415	Aminotransferase class I and II	Domain

• Sequence:

  MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
  NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
  IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
  NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
  TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
  QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
  PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
  EL

• Sequence length: 422

Pathways

KEGG:

Cysteine and methionine metabolism
Tryptophan metabolism
Selenocompound metabolism
Metabolic pathways

Reactome:

Tryptophan catabolism
Phenylalanine metabolism
Glutamate and glutamine metabolism