Gene Gene information from NCBI Gene database.
Entrez ID 8829
Gene name Neuropilin 1
Gene symbol NRP1
Synonyms (NCBI Gene)
BDCA4CD304NP1NRPVEGF165R
Chromosome 10
Chromosome location 10p11.22
Summary This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, mad
miRNA miRNA information provided by mirtarbase database.
729
miRTarBase ID miRNA Experiments Reference
MIRT001352 hsa-miR-1-3p pSILAC 18668040
MIRT017659 hsa-miR-335-5p Microarray 18185580
MIRT021183 hsa-miR-186-5p Sequencing 20371350
MIRT022578 hsa-miR-124-3p Microarray 18668037
MIRT001352 hsa-miR-1-3p Proteomics;Other 18668040
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
REST Repression 16330548
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
194
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IMP 23639442
GO:0001525 Process Angiogenesis ISS 24401374
GO:0001569 Process Branching involved in blood vessel morphogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602069 8004 ENSG00000099250
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14786
Protein name Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Protein function Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (
PDB 1KEX , 2QQI , 2QQM , 2QQN , 3I97 , 4DEQ , 4RN5 , 5C7G , 5IJR , 5IYY , 5J1X , 5JGI , 5JGQ , 5JHK , 5L73 , 6FMC , 6FMF , 6TKK , 7JJC , 7O1N , 7P5U , 8C5G , 8PFE , 9EOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00431 CUB 27 138 CUB domain Domain
PF00431 CUB 147 262 CUB domain Domain
PF00754 F5_F8_type_C 290 421 F5/8 type C domain Domain
PF00754 F5_F8_type_C 446 580 F5/8 type C domain Domain
PF00629 MAM 650 810 MAM domain, meprin/A5/mu Domain
PF11980 DUF3481 842 923 C-terminal domain of neuropilin glycoprotein Family
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: The expression of isoforms 1 and 2 does not seem to overlap. Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in fibroblasts (at protein level) (PubMed:36213313). Expressed by the blood ves
Sequence
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRY
EIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANY
SVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
V
YGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMEL
LGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCA
KPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
Sequence length 923
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Axon guidance
Human T-cell leukemia virus 1 infection
Coronavirus disease - COVID-19
  Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
117
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hepatocellular carcinoma Likely benign rs145116269 RCV005933509
NRP1-related disorder Uncertain significance; Likely benign; Benign rs371886197, rs374322029, rs749575467, rs201570278, rs367928513, rs751563527, rs779745790, rs778160256, rs141633354, rs769982693, rs936099600, rs1042934113, rs749859903, rs1842743223, rs941004239
View all (96 more)
RCV003410144
RCV004744637
RCV004744640
RCV003963761
RCV003420504
RCV004741540
RCV003946411
RCV004741547
RCV004741569
RCV004741573
RCV004741586
RCV004741587
RCV003399694
RCV003420766
RCV003412089
RCV003405801
RCV003429044
RCV003417160
RCV003418747
RCV003419155
RCV003410683
RCV003402846
RCV003402857
RCV003402866
RCV003405934
RCV003414514
RCV003429071
RCV003410593
RCV003410666
RCV003399470
RCV003399592
RCV003427766
RCV003414267
RCV003418772
RCV003392914
RCV003402723
RCV003402955
RCV003393243
RCV003892243
RCV003899038
RCV003896985
RCV003894759
RCV003907252
RCV003904701
RCV003921598
RCV003921722
RCV003921745
RCV003919723
RCV003929696
RCV003974329
RCV003974623
RCV003896298
RCV003893863
RCV003894023
RCV003902260
RCV003894367
RCV003904422
RCV003904653
RCV003981359
RCV003979796
RCV003984703
RCV003982434
RCV003901662
RCV003901813
RCV003901946
RCV003901975
RCV003911740
RCV003964445
RCV003977090
RCV003967303
RCV003899375
RCV003901425
RCV003911364
RCV003911416
RCV003904756
RCV003943910
RCV003944001
RCV003937322
RCV003952200
RCV003947333
RCV003971941
RCV003954936
RCV003927124
RCV003939574
RCV003934453
RCV003947126
RCV003956914
RCV003959030
RCV003971379
RCV003921970
RCV003932206
RCV003952266
RCV003964303
RCV003979197
RCV003983618
RCV003957241
RCV003962258
RCV003967081
RCV003954805
RCV003976515
RCV003976621
RCV003972184
RCV004741772
RCV004741773
RCV004741774
RCV004741775
RCV003913293
RCV003962874
RCV003970844
RCV003943106
RCV003928498
RCV003910734
RCV003943020
RCV003928606
Thyroid cancer, nonmedullary, 1 Likely benign rs145116269 RCV005933510
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 33937395
Adenocarcinoma of Lung Associate 33461176, 33850110
Adrenocortical Carcinoma Associate 33937395
Agnosia Stimulate 31282408
AMR Syndrome Associate 38453145
Amyotrophic lateral sclerosis 1 Associate 35853630
Arteriovenous Malformations Associate 21921738
Arthritis Associate 22697500
Arthritis Psoriatic Inhibit 29790686
Arthritis Rheumatoid Associate 18292234, 22251373