Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8828
Gene name	Neuropilin 2
Gene symbol	NRP2
Synonyms (NCBI Gene)	NP2NPN2PRO2714VEGF165R2
Chromosome	2
Chromosome location	2q33.3
Summary	This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, i

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SNP ID	Visualize variation	Clinical significance	Consequence
rs779617179	T>-	Likely-pathogenic	Frameshift variant, coding sequence variant, intron variant, genic downstream transcript variant

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017537	hsa-miR-335-5p	Microarray	18185580
MIRT019236	hsa-miR-331-3p	Sequencing	20371350
MIRT025587	hsa-miR-10b-5p	Reporter assay	21642433
MIRT019236	hsa-miR-331-3p	Luciferase reporter assayWestern blot	24142150
MIRT437981	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT019236	hsa-miR-331-3p	Luciferase reporter assayWestern blot	24142150
MIRT437981	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT019236	hsa-miR-331-3p	qRT-PCR	26259043
MIRT019236	hsa-miR-331-3p	Luciferase reporter assayqRT-PCRWestern blot	27548144
MIRT737160	hsa-miR-146a-3p	Luciferase reporter assayWestern blottingqRT-PCR	33396906
MIRT019236	hsa-miR-331-3p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	31807170
MIRT755581	hsa-miR-200a-3p	Luciferase reporter assayqRT-PCRImmunohistochemistry (IHC)RNA-seqFlow cytometryImmunocytochemistry (ICC)ELISA	38766528
MIRT1194392	hsa-miR-10a	CLIP-seq
MIRT1194393	hsa-miR-10b	CLIP-seq
MIRT1194394	hsa-miR-1179	CLIP-seq
MIRT1194395	hsa-miR-1297	CLIP-seq
MIRT1194396	hsa-miR-1305	CLIP-seq
MIRT1194397	hsa-miR-24	CLIP-seq
MIRT1194398	hsa-miR-26a	CLIP-seq
MIRT1194399	hsa-miR-26b	CLIP-seq
MIRT1194400	hsa-miR-3140-3p	CLIP-seq
MIRT1194401	hsa-miR-3545-3p	CLIP-seq
MIRT1194402	hsa-miR-3607-3p	CLIP-seq
MIRT1194403	hsa-miR-3662	CLIP-seq
MIRT1194404	hsa-miR-3919	CLIP-seq
MIRT1194405	hsa-miR-3925-5p	CLIP-seq
MIRT1194406	hsa-miR-4284	CLIP-seq
MIRT1194407	hsa-miR-4420	CLIP-seq
MIRT1194408	hsa-miR-4436b-5p	CLIP-seq
MIRT1194409	hsa-miR-4465	CLIP-seq
MIRT1194410	hsa-miR-4530	CLIP-seq
MIRT1194411	hsa-miR-498	CLIP-seq
MIRT1194412	hsa-miR-587	CLIP-seq
MIRT1194413	hsa-miR-922	CLIP-seq
MIRT1194414	hsa-miR-106a	CLIP-seq
MIRT1194415	hsa-miR-106b	CLIP-seq
MIRT1194416	hsa-miR-130a	CLIP-seq
MIRT1194417	hsa-miR-130b	CLIP-seq
MIRT1194418	hsa-miR-151-5p	CLIP-seq
MIRT1194419	hsa-miR-151b	CLIP-seq
MIRT1194420	hsa-miR-17	CLIP-seq
MIRT1194421	hsa-miR-19a	CLIP-seq
MIRT1194422	hsa-miR-19b	CLIP-seq
MIRT1194423	hsa-miR-20a	CLIP-seq
MIRT1194424	hsa-miR-20b	CLIP-seq
MIRT1194425	hsa-miR-301a	CLIP-seq
MIRT1194426	hsa-miR-301b	CLIP-seq
MIRT1194427	hsa-miR-3150b-3p	CLIP-seq
MIRT1194428	hsa-miR-3666	CLIP-seq
MIRT1194429	hsa-miR-377	CLIP-seq
MIRT1194430	hsa-miR-4295	CLIP-seq
MIRT1194431	hsa-miR-454	CLIP-seq
MIRT1194432	hsa-miR-4784	CLIP-seq
MIRT1194433	hsa-miR-519a	CLIP-seq
MIRT1194434	hsa-miR-519b-3p	CLIP-seq
MIRT1194435	hsa-miR-519c-3p	CLIP-seq
MIRT1194436	hsa-miR-519d	CLIP-seq
MIRT1194437	hsa-miR-548t	CLIP-seq
MIRT1194438	hsa-miR-93	CLIP-seq
MIRT2056498	hsa-miR-3120-5p	CLIP-seq
MIRT2056499	hsa-miR-3148	CLIP-seq
MIRT1194429	hsa-miR-377	CLIP-seq
MIRT2056500	hsa-miR-425	CLIP-seq
MIRT2056501	hsa-miR-4652-3p	CLIP-seq
MIRT2056502	hsa-miR-4659a-3p	CLIP-seq
MIRT2056503	hsa-miR-4659b-3p	CLIP-seq
MIRT2056504	hsa-miR-4668-5p	CLIP-seq
MIRT2056505	hsa-miR-579	CLIP-seq
MIRT2056506	hsa-miR-875-3p	CLIP-seq
MIRT2442421	hsa-miR-2115	CLIP-seq
MIRT1194429	hsa-miR-377	CLIP-seq
MIRT2442422	hsa-miR-4685-5p	CLIP-seq
MIRT2442423	hsa-miR-516a-3p	CLIP-seq
MIRT2582926	hsa-miR-1273d	CLIP-seq
MIRT2582927	hsa-miR-203	CLIP-seq
MIRT2582928	hsa-miR-224	CLIP-seq
MIRT2582929	hsa-miR-3591-3p	CLIP-seq
MIRT2582930	hsa-miR-3973	CLIP-seq
MIRT2582931	hsa-miR-4428	CLIP-seq
MIRT2582932	hsa-miR-4434	CLIP-seq
MIRT2582933	hsa-miR-4516	CLIP-seq
MIRT2582934	hsa-miR-4522	CLIP-seq
MIRT2582935	hsa-miR-4694-5p	CLIP-seq
MIRT2582936	hsa-miR-520g	CLIP-seq
MIRT2582937	hsa-miR-520h	CLIP-seq
MIRT2582938	hsa-miR-522	CLIP-seq
MIRT2582939	hsa-miR-607	CLIP-seq
MIRT2686582	hsa-miR-1285	CLIP-seq
MIRT2686583	hsa-miR-146a	CLIP-seq
MIRT2686584	hsa-miR-146b-5p	CLIP-seq
MIRT2686585	hsa-miR-15a	CLIP-seq
MIRT2686586	hsa-miR-15b	CLIP-seq
MIRT2686587	hsa-miR-16	CLIP-seq
MIRT2686588	hsa-miR-188-3p	CLIP-seq
MIRT2686589	hsa-miR-190	CLIP-seq
MIRT2686590	hsa-miR-190b	CLIP-seq
MIRT2686591	hsa-miR-195	CLIP-seq
MIRT2582928	hsa-miR-224	CLIP-seq
MIRT2686592	hsa-miR-23a	CLIP-seq
MIRT2686593	hsa-miR-23b	CLIP-seq
MIRT2686594	hsa-miR-23c	CLIP-seq
MIRT2686595	hsa-miR-3117-5p	CLIP-seq
MIRT2686596	hsa-miR-3180-5p	CLIP-seq
MIRT2686597	hsa-miR-3187-5p	CLIP-seq
MIRT2686598	hsa-miR-330-3p	CLIP-seq
MIRT2686599	hsa-miR-338-3p	CLIP-seq
MIRT2582929	hsa-miR-3591-3p	CLIP-seq
MIRT2686600	hsa-miR-3671	CLIP-seq
MIRT2686601	hsa-miR-3917	CLIP-seq
MIRT1194404	hsa-miR-3919	CLIP-seq
MIRT1194405	hsa-miR-3925-5p	CLIP-seq
MIRT2686602	hsa-miR-3929	CLIP-seq
MIRT2686603	hsa-miR-3935	CLIP-seq
MIRT2686604	hsa-miR-3945	CLIP-seq
MIRT2582930	hsa-miR-3973	CLIP-seq
MIRT2686605	hsa-miR-424	CLIP-seq
MIRT2686606	hsa-miR-4253	CLIP-seq
MIRT2686607	hsa-miR-4419b	CLIP-seq
MIRT2686608	hsa-miR-4478	CLIP-seq
MIRT2686609	hsa-miR-4505	CLIP-seq
MIRT1194410	hsa-miR-4530	CLIP-seq
MIRT2686610	hsa-miR-4672	CLIP-seq
MIRT2686611	hsa-miR-4797-5p	CLIP-seq
MIRT2686612	hsa-miR-497	CLIP-seq
MIRT2582936	hsa-miR-520g	CLIP-seq
MIRT2582937	hsa-miR-520h	CLIP-seq
MIRT2686613	hsa-miR-545	CLIP-seq
MIRT2686614	hsa-miR-563	CLIP-seq
MIRT2686615	hsa-miR-591	CLIP-seq
MIRT2582939	hsa-miR-607	CLIP-seq
MIRT2686616	hsa-miR-612	CLIP-seq
MIRT2686617	hsa-miR-888	CLIP-seq
MIRT2686618	hsa-miR-936	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	NAS	11112349
GO:0001764	Process	Neuron migration	IEA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IEA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	TAS	21245381
GO:0002116	Component	Semaphorin receptor complex	NAS	19909241
GO:0003148	Process	Outflow tract septum morphogenesis	IEA
GO:0003148	Process	Outflow tract septum morphogenesis	ISS
GO:0005021	Function	Vascular endothelial growth factor receptor activity	IEA
GO:0005021	Function	Vascular endothelial growth factor receptor activity	NAS	11112349, 19909241
GO:0005021	Function	Vascular endothelial growth factor receptor activity	TAS	9331348
GO:0005515	Function	Protein binding	IPI	25752543
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	NAS	11112349
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	NAS	19909241
GO:0007411	Process	Axon guidance	TAS
GO:0007507	Process	Heart development	IEA
GO:0008201	Function	Heparin binding	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	TAS	21245381
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11112349
GO:0016020	Component	Membrane	TAS
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	NAS	11112349, 19909241
GO:0019838	Function	Growth factor binding	TAS	21245381
GO:0019955	Function	Cytokine binding	NAS	19909241
GO:0021612	Process	Facial nerve structural organization	IEA
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021649	Process	Vestibulocochlear nerve structural organization	IEA
GO:0021675	Process	Nerve development	IEA
GO:0021675	Process	Nerve development	ISS
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0021828	Process	Gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0036484	Process	Trunk neural crest cell migration	IEA
GO:0036486	Process	Ventral trunk neural crest cell migration	IEA
GO:0038023	Function	Signaling receptor activity	TAS
GO:0038084	Process	Vascular endothelial growth factor signaling pathway	IEA
GO:0042802	Function	Identical protein binding	IPI	25752543
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	ISS
GO:0050919	Process	Negative chemotaxis	IEA
GO:0061549	Process	Sympathetic ganglion development	IEA
GO:0061549	Process	Sympathetic ganglion development	ISS
GO:0061551	Process	Trigeminal ganglion development	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0097374	Process	Sensory neuron axon guidance	IEA
GO:0097490	Process	Sympathetic neuron projection extension	IEA
GO:0097490	Process	Sympathetic neuron projection extension	ISS
GO:0097491	Process	Sympathetic neuron projection guidance	IEA
GO:0097491	Process	Sympathetic neuron projection guidance	ISS
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099175	Process	Regulation of postsynapse organization	IEA
GO:1901166	Process	Neural crest cell migration involved in autonomic nervous system development	IEA
GO:1903375	Process	Facioacoustic ganglion development	IEA
GO:1904835	Process	Dorsal root ganglion morphogenesis	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
602070	8005	ENSG00000118257

O60462

Protein name

Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)

Protein function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endoth

PDB

2QQJ , 2QQK , 2QQL , 2QQO , 4QDQ , 4QDR , 4QDS , 5DN2 , 5DQ0 , 6GH8 , 6TDB , 6TJT , 7M22 , 7T4S , 8IVW , 8IVX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00431	CUB	28 → 139	CUB domain	Domain
PF00431	CUB	149 → 264	CUB domain	Domain
PF00754	F5_F8_type_C	292 → 424	F5/8 type C domain	Domain
PF00754	F5_F8_type_C	449 → 589	F5/8 type C domain	Domain
PF00629	MAM	646 → 801	MAM domain, meprin/A5/mu	Domain
PF11980	DUF3481	850 → 931	C-terminal domain of neuropilin glycoprotein	Family

Sequence

MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
SGEIAIDDIRISTDVPLENCMEPISAFAGENFKVDIPEIHEREGYEDEIDDEYEVDWSNS
SSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSR
SCTTLENYNFELYDGLKHKVKMNHQKCCSEA

Sequence length

931

Interactions

View interactions

	KEGG		Reactome
	Virion - Lassa virus and SFTS virus		Neurophilin interactions with VEGF and VEGFR

157

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
NRP2-related disorder	Likely pathogenic	rs779617179	RCV004748864

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs2228642	RCV005903464
Gastric cancer	Benign	rs2228642	RCV005903465
Hirschsprung disease, susceptibility to, 1	Uncertain significance	rs114144673	RCV000508614
Ovarian serous cystadenocarcinoma	Likely benign	rs374822572	RCV005936899
Thyroid cancer, nonmedullary, 1	Benign	rs2228642	RCV005903466

Show/Hide Text Mining Associations (71)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	39232098
Arteriovenous Malformations	Associate	21921738
Asthma	Associate	30206357
Breast Neoplasms	Associate	17912247, 19580679, 23613720, 26673618, 33396906
Breast Neoplasms	Stimulate	22302985
Carcinogenesis	Associate	39232098
Carcinoma Adenoid Cystic	Associate	28961428
Carcinoma Hepatocellular	Associate	26573807, 37928273
Carcinoma Intraductal Noninfiltrating	Associate	28062852
Carcinoma Non Small Cell Lung	Associate	12412174, 12845630
Carcinoma Renal Cell	Associate	26026587, 27766950
Colorectal Neoplasms	Associate	21747928, 35473507
COVID 19	Associate	39218301
Death	Stimulate	36930173
Drug Hypersensitivity	Associate	30206357
Drug Related Side Effects and Adverse Reactions	Associate	23149913
Endometrial Neoplasms	Associate	28656251, 30806307
Esophageal Squamous Cell Carcinoma	Associate	34516335
Glioblastoma	Inhibit	21610314
Glioblastoma	Associate	24142150, 26753562
Glioma	Associate	24142150
Glomerulonephritis Membranous	Stimulate	19736548
Glomerulosclerosis Focal Segmental	Stimulate	19736548
Glycosuria Renal	Associate	19736548
Heart Failure	Associate	33467687
Hemangioma	Associate	19349369
Hypoxia	Associate	18708346
Hypoxia	Inhibit	21610314
Infections	Associate	29120745
Inflammation	Stimulate	34439896
Kidney Diseases	Associate	19736548
Kidney Neoplasms	Stimulate	19736548
Leukemia Lymphocytic Chronic B Cell	Associate	20495622
Lichen Planus	Associate	28065765
Lung Neoplasms	Associate	12845630, 33918816
Lymphatic Metastasis	Associate	19580679
Lymphatic Metastasis	Stimulate	39232098
Lymphedema	Associate	23613720
Lymphoma	Associate	25068647
Lymphoma Follicular	Associate	20220060
Melanoma	Associate	11121133, 21324919, 21840568
Melanoma	Inhibit	21610314
Melanoma	Stimulate	29227334
Melanoma Cutaneous Malignant	Associate	21840568
Mesothelioma	Associate	33937395
Neoplasm Metastasis	Associate	19197975, 21610314, 21840568, 28796261, 33299122
Neoplasm Metastasis	Stimulate	19580679
Neoplasms	Associate	12412174, 18708346, 18781179, 19580679, 20220060, 21610314, 21840568, 23149913, 26673618, 26753562, 28796261, 29229599, 30806307, 33177389, 33299122, 33396906, 35858551 View all (2 more)
Nephrosis Lipoid	Stimulate	19736548
Neuroblastoma	Associate	11815985
Neuroendocrine Tumors	Associate	19197975, 35858551
Nevus	Associate	21840568
Nevus Pigmented	Associate	29227334
Osteoporosis	Associate	40660573
Pain	Inhibit	21796661
Pancreatic Neoplasms	Associate	15476280, 18307536
Personality Disorders	Stimulate	22302985, 35986103
Personality Disorders	Associate	37942701
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	20220060, 25068647
Prostatic Neoplasms	Associate	35858551, 36930173, 37942701
Prostatic Neoplasms	Stimulate	35986103
Prostatitis	Associate	36930173
Pulmonary Heart Disease	Associate	33467687
Retinal Dysplasia	Associate	12845630
Sarcopenia	Associate	40660573
Stomach Neoplasms	Associate	34826008
Triple Negative Breast Neoplasms	Associate	31235595
Ulcer	Associate	35027044
Urinary Bladder Neoplasms	Associate	12875971, 33918816, 33937395
Uterine Cervical Neoplasms	Associate	27548144
Wilms Tumor	Associate	36172369

NRP2 (neuropilin 2)