Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8825
Gene name	Lin-7 cell polarity scaffold A
Gene symbol	LIN7A
Synonyms (NCBI Gene)	LIN-7ALIN7MALS-1MALS1TIP-33VELI1
Chromosome	12
Chromosome location	12q21.31
Summary	The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017177	hsa-miR-335-5p	Microarray	18185580
MIRT022330	hsa-miR-124-3p	Microarray	18668037
MIRT437380	hsa-miR-199a-5p	Luciferase reporter assay	23201090
MIRT437380	hsa-miR-199a-5p	Luciferase reporter assay	23201090
MIRT437380	hsa-miR-199a-5p	Luciferase reporter assay	23201090
MIRT437380	hsa-miR-199a-5p	Luciferase reporter assay	23201090
MIRT756364	hsa-miR-29b-3p	Luciferase reporter assayqRT-PCR	38957040
MIRT1110378	hsa-miR-134	CLIP-seq
MIRT739696	hsa-miR-219-1-3p	CLIP-seq
MIRT1110379	hsa-miR-3118	CLIP-seq
MIRT1110380	hsa-miR-3164	CLIP-seq
MIRT1110381	hsa-miR-3166	CLIP-seq
MIRT1110382	hsa-miR-3671	CLIP-seq
MIRT1110383	hsa-miR-3678-3p	CLIP-seq
MIRT739694	hsa-miR-3919	CLIP-seq
MIRT1110384	hsa-miR-4320	CLIP-seq
MIRT1110385	hsa-miR-4328	CLIP-seq
MIRT739693	hsa-miR-4423-5p	CLIP-seq
MIRT1110386	hsa-miR-455-5p	CLIP-seq
MIRT1110387	hsa-miR-4731-5p	CLIP-seq
MIRT1110388	hsa-miR-4771	CLIP-seq
MIRT1110389	hsa-miR-511	CLIP-seq
MIRT739695	hsa-miR-571	CLIP-seq
MIRT1110390	hsa-miR-607	CLIP-seq
MIRT1110391	hsa-miR-758	CLIP-seq
MIRT2030797	hsa-miR-1260	CLIP-seq
MIRT2030798	hsa-miR-1260b	CLIP-seq
MIRT2030799	hsa-miR-188-3p	CLIP-seq
MIRT2030800	hsa-miR-27a	CLIP-seq
MIRT2030801	hsa-miR-27b	CLIP-seq
MIRT2030802	hsa-miR-3156-3p	CLIP-seq
MIRT2030803	hsa-miR-4251	CLIP-seq
MIRT2030804	hsa-miR-4301	CLIP-seq
MIRT2030805	hsa-miR-4418	CLIP-seq
MIRT2030806	hsa-miR-509-3-5p	CLIP-seq
MIRT2030807	hsa-miR-509-5p	CLIP-seq
MIRT2030808	hsa-miR-513a-5p	CLIP-seq
MIRT2030809	hsa-miR-526b	CLIP-seq
MIRT2030810	hsa-miR-580	CLIP-seq
MIRT2030800	hsa-miR-27a	CLIP-seq
MIRT2030801	hsa-miR-27b	CLIP-seq
MIRT2261458	hsa-miR-361-5p	CLIP-seq
MIRT739694	hsa-miR-3919	CLIP-seq
MIRT2261459	hsa-miR-4302	CLIP-seq
MIRT2261460	hsa-miR-4468	CLIP-seq
MIRT2261461	hsa-miR-4519	CLIP-seq
MIRT1110386	hsa-miR-455-5p	CLIP-seq
MIRT2261462	hsa-miR-498	CLIP-seq
MIRT1110389	hsa-miR-511	CLIP-seq
MIRT2030808	hsa-miR-513a-5p	CLIP-seq
MIRT2030809	hsa-miR-526b	CLIP-seq
MIRT2261463	hsa-miR-662	CLIP-seq
MIRT2261464	hsa-miR-944	CLIP-seq
MIRT2030797	hsa-miR-1260	CLIP-seq
MIRT2030798	hsa-miR-1260b	CLIP-seq
MIRT2030799	hsa-miR-188-3p	CLIP-seq
MIRT2030802	hsa-miR-3156-3p	CLIP-seq
MIRT2030803	hsa-miR-4251	CLIP-seq
MIRT2030804	hsa-miR-4301	CLIP-seq
MIRT2030805	hsa-miR-4418	CLIP-seq
MIRT2030806	hsa-miR-509-3-5p	CLIP-seq
MIRT2030807	hsa-miR-509-5p	CLIP-seq
MIRT2030810	hsa-miR-580	CLIP-seq
MIRT2561433	hsa-miR-1208	CLIP-seq
MIRT2561434	hsa-miR-1257	CLIP-seq
MIRT2030797	hsa-miR-1260	CLIP-seq
MIRT2030798	hsa-miR-1260b	CLIP-seq
MIRT2561435	hsa-miR-1297	CLIP-seq
MIRT1110378	hsa-miR-134	CLIP-seq
MIRT2030799	hsa-miR-188-3p	CLIP-seq
MIRT2561436	hsa-miR-26a	CLIP-seq
MIRT2561437	hsa-miR-26b	CLIP-seq
MIRT2561438	hsa-miR-297	CLIP-seq
MIRT1110379	hsa-miR-3118	CLIP-seq
MIRT2561439	hsa-miR-3130-3p	CLIP-seq
MIRT2030802	hsa-miR-3156-3p	CLIP-seq
MIRT1110380	hsa-miR-3164	CLIP-seq
MIRT1110381	hsa-miR-3166	CLIP-seq
MIRT2561440	hsa-miR-3202	CLIP-seq
MIRT2261458	hsa-miR-361-5p	CLIP-seq
MIRT1110382	hsa-miR-3671	CLIP-seq
MIRT1110383	hsa-miR-3678-3p	CLIP-seq
MIRT2561441	hsa-miR-380	CLIP-seq
MIRT2561442	hsa-miR-3974	CLIP-seq
MIRT2030803	hsa-miR-4251	CLIP-seq
MIRT2561443	hsa-miR-4287	CLIP-seq
MIRT2030804	hsa-miR-4301	CLIP-seq
MIRT2261459	hsa-miR-4302	CLIP-seq
MIRT1110384	hsa-miR-4320	CLIP-seq
MIRT1110385	hsa-miR-4328	CLIP-seq
MIRT2030805	hsa-miR-4418	CLIP-seq
MIRT2561444	hsa-miR-4446-5p	CLIP-seq
MIRT2561445	hsa-miR-4465	CLIP-seq
MIRT2261460	hsa-miR-4468	CLIP-seq
MIRT2561446	hsa-miR-4469	CLIP-seq
MIRT2561447	hsa-miR-4495	CLIP-seq
MIRT2261461	hsa-miR-4519	CLIP-seq
MIRT2561448	hsa-miR-452	CLIP-seq
MIRT2561449	hsa-miR-4533	CLIP-seq
MIRT1110386	hsa-miR-455-5p	CLIP-seq
MIRT2561450	hsa-miR-4676-3p	CLIP-seq
MIRT2561451	hsa-miR-4685-3p	CLIP-seq
MIRT1110387	hsa-miR-4731-5p	CLIP-seq
MIRT2561452	hsa-miR-4755-5p	CLIP-seq
MIRT1110388	hsa-miR-4771	CLIP-seq
MIRT2561453	hsa-miR-4790-3p	CLIP-seq
MIRT2561454	hsa-miR-4793-3p	CLIP-seq
MIRT2561455	hsa-miR-493	CLIP-seq
MIRT2261462	hsa-miR-498	CLIP-seq
MIRT2030806	hsa-miR-509-3-5p	CLIP-seq
MIRT2030807	hsa-miR-509-5p	CLIP-seq
MIRT1110389	hsa-miR-511	CLIP-seq
MIRT2561456	hsa-miR-562	CLIP-seq
MIRT2561457	hsa-miR-567	CLIP-seq
MIRT2030810	hsa-miR-580	CLIP-seq
MIRT1110390	hsa-miR-607	CLIP-seq
MIRT2561458	hsa-miR-642a	CLIP-seq
MIRT2261463	hsa-miR-662	CLIP-seq
MIRT1110391	hsa-miR-758	CLIP-seq
MIRT2261464	hsa-miR-944	CLIP-seq
MIRT2561435	hsa-miR-1297	CLIP-seq
MIRT1110378	hsa-miR-134	CLIP-seq
MIRT2561436	hsa-miR-26a	CLIP-seq
MIRT2561437	hsa-miR-26b	CLIP-seq
MIRT1110379	hsa-miR-3118	CLIP-seq
MIRT1110380	hsa-miR-3164	CLIP-seq
MIRT2261458	hsa-miR-361-5p	CLIP-seq
MIRT1110382	hsa-miR-3671	CLIP-seq
MIRT2261459	hsa-miR-4302	CLIP-seq
MIRT1110384	hsa-miR-4320	CLIP-seq
MIRT2561444	hsa-miR-4446-5p	CLIP-seq
MIRT2561445	hsa-miR-4465	CLIP-seq
MIRT1110386	hsa-miR-455-5p	CLIP-seq
MIRT1110387	hsa-miR-4731-5p	CLIP-seq
MIRT2561452	hsa-miR-4755-5p	CLIP-seq
MIRT1110389	hsa-miR-511	CLIP-seq
MIRT2561456	hsa-miR-562	CLIP-seq
MIRT1110390	hsa-miR-607	CLIP-seq
MIRT2561458	hsa-miR-642a	CLIP-seq
MIRT1110391	hsa-miR-758	CLIP-seq
MIRT2261464	hsa-miR-944	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11311936, 16688213, 16855024, 24366813, 25416956, 31515488, 32296183, 32707033, 33961781
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IBA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0006887	Process	Exocytosis	TAS	9753324
GO:0007269	Process	Neurotransmitter secretion	IBA
GO:0007269	Process	Neurotransmitter secretion	IEA
GO:0008582	Process	Regulation of synaptic assembly at neuromuscular junction	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0048489	Process	Synaptic vesicle transport	IBA
GO:0048489	Process	Synaptic vesicle transport	IEA
GO:0048839	Process	Inner ear development	IEA
GO:0065003	Process	Protein-containing complex assembly	TAS	9482110
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070161	Component	Anchoring junction	IEA
GO:0097016	Function	L27 domain binding	IEA
GO:0097016	Function	L27 domain binding	IPI	17237226
GO:0097025	Component	MPP7-DLG1-LIN7 complex	IBA
GO:0098793	Component	Presynapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA

MIM	HGNC	e!Ensembl
603380	17787	ENSG00000111052

O14910

Protein name

Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)

Protein function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02828	L27	29 → 82	L27 domain	Domain
PF00595	PDZ	108 → 187	PDZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, testis, kidney, placenta and liver. {ECO:0000269|PubMed:11311936}.

Sequence

MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE
FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF
NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD
SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS

Sequence length

233

Interactions

View interactions

	Reactome
			Dopamine Neurotransmitter Release Cycle

LIN7A (lin-7 cell polarity scaffold A)