Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	8798
Gene name	Dual specificity tyrosine phosphorylation regulated kinase 4
Gene symbol	DYRK4
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12p13.32
Summary	This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in develo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT720553	hsa-miR-4282	HITS-CLIP	19536157
MIRT720552	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT720551	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT720550	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT720549	hsa-miR-6740-5p	HITS-CLIP	19536157
MIRT661374	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT661373	hsa-miR-3123	HITS-CLIP	23824327
MIRT661372	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT661371	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT661370	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT661369	hsa-miR-4780	HITS-CLIP	23824327
MIRT661368	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT661367	hsa-miR-520g-5p	HITS-CLIP	23824327
MIRT661366	hsa-miR-554	HITS-CLIP	23824327
MIRT661365	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT661364	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT661363	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT661362	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT661361	hsa-miR-3153	HITS-CLIP	23824327
MIRT661360	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT661359	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT661358	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT661357	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT661356	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT661355	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT661354	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT661353	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT661352	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT661351	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT661350	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT661349	hsa-miR-526a	HITS-CLIP	23824327
MIRT661348	hsa-miR-5691	HITS-CLIP	23824327
MIRT661347	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT661346	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT661345	hsa-miR-3122	HITS-CLIP	23824327
MIRT661344	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT661343	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT661342	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT720553	hsa-miR-4282	HITS-CLIP	19536157
MIRT720552	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT720551	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT720550	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT720549	hsa-miR-6740-5p	HITS-CLIP	19536157
MIRT661374	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT661373	hsa-miR-3123	HITS-CLIP	23824327
MIRT661372	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT661371	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT661370	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT661369	hsa-miR-4780	HITS-CLIP	23824327
MIRT661368	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT661367	hsa-miR-520g-5p	HITS-CLIP	23824327
MIRT661366	hsa-miR-554	HITS-CLIP	23824327
MIRT661365	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT661364	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT661363	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT661362	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT661361	hsa-miR-3153	HITS-CLIP	23824327
MIRT661360	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT661359	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT661358	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT661357	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT661356	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT661355	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT661354	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT661353	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT661352	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT661351	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT661350	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT661349	hsa-miR-526a	HITS-CLIP	23824327
MIRT661348	hsa-miR-5691	HITS-CLIP	23824327
MIRT661347	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT661346	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT661345	hsa-miR-3122	HITS-CLIP	23824327
MIRT661344	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT661343	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT661342	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT949860	hsa-miR-302a	CLIP-seq
MIRT949861	hsa-miR-302b	CLIP-seq
MIRT949862	hsa-miR-302c	CLIP-seq
MIRT949863	hsa-miR-302d	CLIP-seq
MIRT949864	hsa-miR-302e	CLIP-seq
MIRT949865	hsa-miR-3165	CLIP-seq
MIRT949866	hsa-miR-338-5p	CLIP-seq
MIRT949867	hsa-miR-34b	CLIP-seq
MIRT949868	hsa-miR-372	CLIP-seq
MIRT949869	hsa-miR-373	CLIP-seq
MIRT949870	hsa-miR-374c	CLIP-seq
MIRT949871	hsa-miR-3978	CLIP-seq
MIRT949872	hsa-miR-4456	CLIP-seq
MIRT949873	hsa-miR-519a	CLIP-seq
MIRT949874	hsa-miR-519b-3p	CLIP-seq
MIRT949875	hsa-miR-519c-3p	CLIP-seq
MIRT949876	hsa-miR-520a-3p	CLIP-seq
MIRT949877	hsa-miR-520b	CLIP-seq
MIRT949878	hsa-miR-520c-3p	CLIP-seq
MIRT949879	hsa-miR-520d-3p	CLIP-seq
MIRT949880	hsa-miR-520e	CLIP-seq
MIRT949881	hsa-miR-655	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 23602568, 25036637, 25416956, 32707033, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
609181	3095	ENSG00000010219

Q9NR20

Protein name

Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)

Protein function

Possible non-essential role in spermiogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	104 → 400	Protein kinase domain	Domain

Sequence

MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV

Sequence length

520

Interactions

View interactions

DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4)