Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8798
Gene name Gene Name - the full gene name approved by the HGNC.	Dual specificity tyrosine phosphorylation regulated kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DYRK4
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in develo

Show/Hide all(98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720553	hsa-miR-4282	HITS-CLIP	19536157
MIRT720552	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT720551	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT720550	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT720549	hsa-miR-6740-5p	HITS-CLIP	19536157
MIRT661374	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT661373	hsa-miR-3123	HITS-CLIP	23824327
MIRT661372	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT661371	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT661370	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT661369	hsa-miR-4780	HITS-CLIP	23824327
MIRT661368	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT661367	hsa-miR-520g-5p	HITS-CLIP	23824327
MIRT661366	hsa-miR-554	HITS-CLIP	23824327
MIRT661365	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT661364	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT661363	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT661362	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT661361	hsa-miR-3153	HITS-CLIP	23824327
MIRT661360	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT661359	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT661358	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT661357	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT661356	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT661355	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT661354	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT661353	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT661352	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT661351	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT661350	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT661349	hsa-miR-526a	HITS-CLIP	23824327
MIRT661348	hsa-miR-5691	HITS-CLIP	23824327
MIRT661347	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT661346	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT661345	hsa-miR-3122	HITS-CLIP	23824327
MIRT661344	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT661343	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT661342	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT720553	hsa-miR-4282	HITS-CLIP	19536157
MIRT720552	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT720551	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT720550	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT720549	hsa-miR-6740-5p	HITS-CLIP	19536157
MIRT661374	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT661373	hsa-miR-3123	HITS-CLIP	23824327
MIRT661372	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT661371	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT661370	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT661369	hsa-miR-4780	HITS-CLIP	23824327
MIRT661368	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT661367	hsa-miR-520g-5p	HITS-CLIP	23824327
MIRT661366	hsa-miR-554	HITS-CLIP	23824327
MIRT661365	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT661364	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT661363	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT661362	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT661361	hsa-miR-3153	HITS-CLIP	23824327
MIRT661360	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT661359	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT661358	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT661357	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT661356	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT661355	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT661354	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT661353	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT661352	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT661351	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT661350	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT661349	hsa-miR-526a	HITS-CLIP	23824327
MIRT661348	hsa-miR-5691	HITS-CLIP	23824327
MIRT661347	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT661346	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT661345	hsa-miR-3122	HITS-CLIP	23824327
MIRT661344	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT661343	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT661342	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT949860	hsa-miR-302a	CLIP-seq
MIRT949861	hsa-miR-302b	CLIP-seq
MIRT949862	hsa-miR-302c	CLIP-seq
MIRT949863	hsa-miR-302d	CLIP-seq
MIRT949864	hsa-miR-302e	CLIP-seq
MIRT949865	hsa-miR-3165	CLIP-seq
MIRT949866	hsa-miR-338-5p	CLIP-seq
MIRT949867	hsa-miR-34b	CLIP-seq
MIRT949868	hsa-miR-372	CLIP-seq
MIRT949869	hsa-miR-373	CLIP-seq
MIRT949870	hsa-miR-374c	CLIP-seq
MIRT949871	hsa-miR-3978	CLIP-seq
MIRT949872	hsa-miR-4456	CLIP-seq
MIRT949873	hsa-miR-519a	CLIP-seq
MIRT949874	hsa-miR-519b-3p	CLIP-seq
MIRT949875	hsa-miR-519c-3p	CLIP-seq
MIRT949876	hsa-miR-520a-3p	CLIP-seq
MIRT949877	hsa-miR-520b	CLIP-seq
MIRT949878	hsa-miR-520c-3p	CLIP-seq
MIRT949879	hsa-miR-520d-3p	CLIP-seq
MIRT949880	hsa-miR-520e	CLIP-seq
MIRT949881	hsa-miR-655	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 23602568, 25036637, 25416956, 32707033, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
609181	3095	ENSG00000010219

Protein

UniProt ID

Q9NR20

Protein name

Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)

Protein function

Possible non-essential role in spermiogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	104 → 400	Protein kinase domain	Domain

Sequence

MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV

Sequence length

520

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	33172895
Neoplasms	Associate	33172895

DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4)