Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8794
Gene name Gene Name - the full gene name approved by the HGNC.	TNF receptor superfamily member 10c
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TNFRSF10C
Synonyms (NCBI Gene) Gene synonyms aliases	CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and

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miRTarBase ID	miRNA	Experiments
MIRT1442773	hsa-miR-1207-5p	CLIP-seq
MIRT1442774	hsa-miR-1292	CLIP-seq
MIRT1442775	hsa-miR-1321	CLIP-seq
MIRT1442776	hsa-miR-1827	CLIP-seq
MIRT1442777	hsa-miR-1909	CLIP-seq
MIRT1442778	hsa-miR-2467-3p	CLIP-seq
MIRT1442779	hsa-miR-3126-5p	CLIP-seq
MIRT1442780	hsa-miR-3199	CLIP-seq
MIRT1442781	hsa-miR-3612	CLIP-seq
MIRT1442782	hsa-miR-361-3p	CLIP-seq
MIRT1442783	hsa-miR-4260	CLIP-seq
MIRT1442784	hsa-miR-4267	CLIP-seq
MIRT1442785	hsa-miR-4419a	CLIP-seq
MIRT1442786	hsa-miR-4436b-3p	CLIP-seq
MIRT1442787	hsa-miR-4471	CLIP-seq
MIRT1442788	hsa-miR-4510	CLIP-seq
MIRT1442789	hsa-miR-4648	CLIP-seq
MIRT1442790	hsa-miR-4654	CLIP-seq
MIRT1442791	hsa-miR-4688	CLIP-seq
MIRT1442792	hsa-miR-4733-3p	CLIP-seq
MIRT1442793	hsa-miR-4739	CLIP-seq
MIRT1442794	hsa-miR-4740-5p	CLIP-seq
MIRT1442795	hsa-miR-4756-5p	CLIP-seq
MIRT1442796	hsa-miR-4763-3p	CLIP-seq
MIRT1442797	hsa-miR-4768-3p	CLIP-seq
MIRT1442798	hsa-miR-4769-5p	CLIP-seq
MIRT1442799	hsa-miR-486-3p	CLIP-seq
MIRT1442800	hsa-miR-650	CLIP-seq
MIRT1442801	hsa-miR-665	CLIP-seq
MIRT1442802	hsa-miR-922	CLIP-seq
MIRT1442803	hsa-miR-940	CLIP-seq
MIRT1442773	hsa-miR-1207-5p	CLIP-seq
MIRT1442774	hsa-miR-1292	CLIP-seq
MIRT2132513	hsa-miR-3120-5p	CLIP-seq
MIRT1442787	hsa-miR-4471	CLIP-seq
MIRT1442789	hsa-miR-4648	CLIP-seq
MIRT1442790	hsa-miR-4654	CLIP-seq
MIRT1442796	hsa-miR-4763-3p	CLIP-seq
MIRT1442798	hsa-miR-4769-5p	CLIP-seq
MIRT1442773	hsa-miR-1207-5p	CLIP-seq
MIRT2693662	hsa-miR-1254	CLIP-seq
MIRT2693663	hsa-miR-1291	CLIP-seq
MIRT1442775	hsa-miR-1321	CLIP-seq
MIRT1442776	hsa-miR-1827	CLIP-seq
MIRT2693664	hsa-miR-193a-3p	CLIP-seq
MIRT2693665	hsa-miR-193b	CLIP-seq
MIRT1442778	hsa-miR-2467-3p	CLIP-seq
MIRT2693666	hsa-miR-2861	CLIP-seq
MIRT2693667	hsa-miR-3064-5p	CLIP-seq
MIRT2693668	hsa-miR-3116	CLIP-seq
MIRT2693669	hsa-miR-3173-5p	CLIP-seq
MIRT2693670	hsa-miR-328	CLIP-seq
MIRT1442781	hsa-miR-3612	CLIP-seq
MIRT2693671	hsa-miR-3652	CLIP-seq
MIRT2693672	hsa-miR-3689a-3p	CLIP-seq
MIRT2693673	hsa-miR-3689c	CLIP-seq
MIRT2693674	hsa-miR-3928	CLIP-seq
MIRT2693675	hsa-miR-4290	CLIP-seq
MIRT2693676	hsa-miR-4313	CLIP-seq
MIRT2693677	hsa-miR-432	CLIP-seq
MIRT1442785	hsa-miR-4419a	CLIP-seq
MIRT2693678	hsa-miR-4426	CLIP-seq
MIRT2693679	hsa-miR-4430	CLIP-seq
MIRT1442786	hsa-miR-4436b-3p	CLIP-seq
MIRT2693680	hsa-miR-4505	CLIP-seq
MIRT1442788	hsa-miR-4510	CLIP-seq
MIRT2693681	hsa-miR-4647	CLIP-seq
MIRT2693682	hsa-miR-4662b	CLIP-seq
MIRT2693683	hsa-miR-4699-5p	CLIP-seq
MIRT2693684	hsa-miR-4728-5p	CLIP-seq
MIRT1442793	hsa-miR-4739	CLIP-seq
MIRT1442795	hsa-miR-4756-5p	CLIP-seq
MIRT1442796	hsa-miR-4763-3p	CLIP-seq
MIRT1442800	hsa-miR-650	CLIP-seq
MIRT2693685	hsa-miR-661	CLIP-seq
MIRT1442802	hsa-miR-922	CLIP-seq
MIRT1442803	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9314565
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9314565
GO:0006915	Process	Apoptotic process	IEA
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	IEA
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0045569	Function	TRAIL binding	IEA
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
603613	11906	ENSG00000173535

Protein

UniProt ID

O14798

Protein name

Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TR

Protein function

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00020	TNFR_c6	69 → 109	TNFR/NGFR cysteine-rich region	Domain
PF00020	TNFR_c6	111 → 149	TNFR/NGFR cysteine-rich region	Domain

Tissue specificity

TISSUE SPECIFICITY: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Sequence

MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRS
EHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNEN
SPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAE
ETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHY
LSCTIVGIIVLIVLLIVFV

Sequence length

259

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor		TP53 Regulates Transcription of Death Receptors and Ligands

TNFRSF10C (TNF receptor superfamily member 10c)