Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8743
Gene name Gene Name - the full gene name approved by the HGNC.	TNF superfamily member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TNFSF10
Synonyms (NCBI Gene) Gene synonyms aliases	APO2L, Apo-2L, CD253, TANCR, TL2, TNLG6A, TRAIL
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q26.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed a

Show/Hide all(194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003757	hsa-miR-221-3p	Western blot	18246122
MIRT003756	hsa-miR-222-3p	Western blot	18246122
MIRT027770	hsa-miR-98-5p	Microarray	19088304
MIRT1443311	hsa-miR-3684	CLIP-seq
MIRT1443312	hsa-miR-4305	CLIP-seq
MIRT1443313	hsa-miR-4753-3p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443315	hsa-miR-491-3p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT1443321	hsa-miR-548ac	CLIP-seq
MIRT1443322	hsa-miR-548ae	CLIP-seq
MIRT1443323	hsa-miR-548aj	CLIP-seq
MIRT1443324	hsa-miR-548am	CLIP-seq
MIRT1443325	hsa-miR-548d-3p	CLIP-seq
MIRT1443326	hsa-miR-548x	CLIP-seq
MIRT1443327	hsa-miR-548z	CLIP-seq
MIRT1443328	hsa-miR-586	CLIP-seq
MIRT1443329	hsa-miR-1246	CLIP-seq
MIRT1443330	hsa-miR-1273f	CLIP-seq
MIRT1443331	hsa-miR-1304	CLIP-seq
MIRT1443332	hsa-miR-137	CLIP-seq
MIRT1443333	hsa-miR-154	CLIP-seq
MIRT1443334	hsa-miR-3130-3p	CLIP-seq
MIRT1443335	hsa-miR-3134	CLIP-seq
MIRT1443336	hsa-miR-3613-5p	CLIP-seq
MIRT1443337	hsa-miR-3660	CLIP-seq
MIRT1443338	hsa-miR-3674	CLIP-seq
MIRT1443339	hsa-miR-3934	CLIP-seq
MIRT1443340	hsa-miR-3942-3p	CLIP-seq
MIRT1443341	hsa-miR-409-3p	CLIP-seq
MIRT1443342	hsa-miR-4252	CLIP-seq
MIRT1443343	hsa-miR-4302	CLIP-seq
MIRT1443344	hsa-miR-4445	CLIP-seq
MIRT1443345	hsa-miR-4526	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT1443347	hsa-miR-4645-5p	CLIP-seq
MIRT1443348	hsa-miR-4659a-3p	CLIP-seq
MIRT1443349	hsa-miR-4659b-3p	CLIP-seq
MIRT1443350	hsa-miR-4673	CLIP-seq
MIRT1443351	hsa-miR-4733-3p	CLIP-seq
MIRT1443352	hsa-miR-4742-5p	CLIP-seq
MIRT1443353	hsa-miR-4773	CLIP-seq
MIRT1443354	hsa-miR-552	CLIP-seq
MIRT1443355	hsa-miR-671-5p	CLIP-seq
MIRT1443356	hsa-miR-767-5p	CLIP-seq
MIRT2132661	hsa-miR-122	CLIP-seq
MIRT2132662	hsa-miR-139-5p	CLIP-seq
MIRT2132663	hsa-miR-142-3p	CLIP-seq
MIRT2132664	hsa-miR-3135b	CLIP-seq
MIRT2132665	hsa-miR-3622b-5p	CLIP-seq
MIRT2132666	hsa-miR-3652	CLIP-seq
MIRT2132667	hsa-miR-3677-5p	CLIP-seq
MIRT2132668	hsa-miR-4280	CLIP-seq
MIRT2132669	hsa-miR-4430	CLIP-seq
MIRT2132670	hsa-miR-4695-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2132661	hsa-miR-122	CLIP-seq
MIRT2353690	hsa-miR-129-5p	CLIP-seq
MIRT1443331	hsa-miR-1304	CLIP-seq
MIRT1443332	hsa-miR-137	CLIP-seq
MIRT2132663	hsa-miR-142-3p	CLIP-seq
MIRT1443333	hsa-miR-154	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353694	hsa-miR-26a	CLIP-seq
MIRT2353695	hsa-miR-26b	CLIP-seq
MIRT2353696	hsa-miR-3124-3p	CLIP-seq
MIRT2132664	hsa-miR-3135b	CLIP-seq
MIRT2353697	hsa-miR-3140-3p	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353700	hsa-miR-3174	CLIP-seq
MIRT2353701	hsa-miR-3180-5p	CLIP-seq
MIRT1443336	hsa-miR-3613-5p	CLIP-seq
MIRT2132665	hsa-miR-3622b-5p	CLIP-seq
MIRT2132666	hsa-miR-3652	CLIP-seq
MIRT1443337	hsa-miR-3660	CLIP-seq
MIRT1443338	hsa-miR-3674	CLIP-seq
MIRT2132667	hsa-miR-3677-5p	CLIP-seq
MIRT2353702	hsa-miR-376a	CLIP-seq
MIRT2353703	hsa-miR-376b	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT1443340	hsa-miR-3942-3p	CLIP-seq
MIRT1443341	hsa-miR-409-3p	CLIP-seq
MIRT2132668	hsa-miR-4280	CLIP-seq
MIRT1443343	hsa-miR-4302	CLIP-seq
MIRT2132669	hsa-miR-4430	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2353708	hsa-miR-450b-3p	CLIP-seq
MIRT1443345	hsa-miR-4526	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT2132670	hsa-miR-4695-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443353	hsa-miR-4773	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT2353710	hsa-miR-4793-5p	CLIP-seq
MIRT2353711	hsa-miR-494	CLIP-seq
MIRT2353712	hsa-miR-513c	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353716	hsa-miR-635	CLIP-seq
MIRT2353717	hsa-miR-769-3p	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq
MIRT2462079	hsa-miR-3691-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2462080	hsa-miR-720	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT2647825	hsa-miR-4291	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2647826	hsa-miR-4532	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2647827	hsa-miR-545	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2693705	hsa-miR-1298	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT2647825	hsa-miR-4291	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2647826	hsa-miR-4532	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT1443313	hsa-miR-4753-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2647827	hsa-miR-545	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq

Transcription factors

Show/Hide all(16)

Transcription factor	Regulation	Reference
EGR1	Repression	17932312
FOXO1	Activation	23630076
FOXO3	Activation	23630076
FOXO4	Activation	23630076
HDAC2	Repression	23630076
IRF1	Activation	21858676
NFIL3	Repression	23630076
NFKB1	Activation	11544302;20542572
NFKB1	Repression	11544302
NFKB1	Unknown	21243522
NFKBIA	Repression	11544302
PML	Activation	15459016
RELA	Activation	11544302;20542572
RELA	Repression	11544302
RELA	Unknown	21243522
SP1	Repression	21603612

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	8663110, 8777713
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	21146232
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	10549288, 19427028, 20097879, 20103630, 21459798, 21525171, 21822306, 22266862, 23678861
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	21146232
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8663110
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	8663110
GO:0006955	Process	Immune response	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	TAS	8663110, 8777713
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007267	Process	Cell-cell signaling	TAS	8777713
GO:0008270	Function	Zinc ion binding	IDA	26457518
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	IEA
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	9430228, 21785459
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	9485194
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IMP	10862756, 19090789
GO:0042802	Function	Identical protein binding	IDA	26457518
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21525171
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0045569	Function	TRAIL binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	22266862
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IDA	20097879, 21525171, 22266862
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IEA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
603598	11925	ENSG00000121858

Protein

UniProt ID

P50591

Protein name

Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)

Protein function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy rec

PDB

1D0G , 1D2Q , 1D4V , 1DG6 , 1DU3 , 4N90 , 5CIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00229	TNF	152 → 280	TNF(Tumour Necrosis Factor) family	Domain

Tissue specificity

TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.

Sequence

MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Sequence length

281

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity Pathogenic Escherichia coli infection Salmonella infection Influenza A Lipid and atherosclerosis		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast cancer	Breast cancer, Breast cancer (estrogen-receptor negative)	N/A	N/A	GWAS
Breast Cancer	Breast cancer subtype (triple negative vs luminal A-like)	N/A	N/A	GWAS
Gout	Gout	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (293)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abortion Habitual	Associate	23290504
Abortion Spontaneous	Associate	23290504
Acne Vulgaris	Associate	21564055
Acquired Immunodeficiency Syndrome	Associate	15585654, 21483669
Acro Osteolysis	Associate	12823344
Adenocarcinoma	Associate	16580499, 21513580, 23479507, 24223304, 36550819
Adenocarcinoma of Lung	Inhibit	26972480
Adenocarcinoma of Lung	Associate	28756806
Albuminuria	Associate	36591354
Alzheimer Disease	Associate	18266928, 22420897, 22695614, 26745113, 29384188, 37012089
Ameloblastoma	Associate	19414356
Anemia	Associate	11830480, 15681838
Anemia Aplastic	Associate	22315490
Anemia Refractory with Excess of Blasts	Associate	11698291
Aortic Valve Stenosis	Associate	37175670
Arthritis	Associate	16127151, 21305500
Arthritis Infectious	Associate	24349222
Arthritis Psoriatic	Associate	21305500
Arthritis Rheumatoid	Stimulate	11698291, 19171073, 20799941
Arthritis Rheumatoid	Associate	16284094, 19196465, 21305500, 27403809, 34177888, 36934132
Arthritis Rheumatoid	Inhibit	28850672
Ascites	Inhibit	23158473, 24761768
Asthma	Associate	12421985, 32482836
Astrocytoma	Associate	15112054
Atherosclerosis	Associate	18178561, 33936102
Atherosclerosis	Inhibit	33080110
Autoimmune Diseases	Associate	14872508, 18178561, 21814551, 31114586, 37012089
Autoimmune Lymphoproliferative Syndrome Type IIA	Associate	10412980
Blood Coagulation Disorders	Associate	19265041
Bone Diseases	Associate	12823344
Brain Neoplasms	Associate	11784850, 26163602
Breast Neoplasms	Associate	11677236, 11936954, 12946317, 15241475, 15569667, 15767684, 15831675, 15916713, 16394281, 16489180, 17420249, 17803681, 18266105, 18590557, 19074831 View all (31 more)
Breast Neoplasms	Inhibit	19843632, 24025362, 25854358, 27292433
Burkitt Lymphoma	Associate	12823346, 33971465
Calcinosis Cutis	Associate	11862476, 12946317, 21513580
Calcinosis Cutis	Inhibit	19435900
Carcinogenesis	Inhibit	17592646
Carcinogenesis	Associate	22412903, 23390516, 24098334, 24296757
Carcinoma Adenoid Cystic	Associate	19587531
Carcinoma Hepatocellular	Associate	11749866, 14991932, 15160348, 15699147, 15849810, 15849812, 16024612, 16419152, 16627981, 16750275, 17272514, 18644981, 19261616, 19272388, 19376776 View all (21 more)
Carcinoma Hepatocellular	Inhibit	26261530, 26552967, 29444104, 29476051, 39173282
Carcinoma Non Small Cell Lung	Inhibit	11782771, 18284607, 24289635, 26054751, 29772677, 34400879
Carcinoma Non Small Cell Lung	Associate	16740726, 19661294, 20646307, 21706050, 23470529, 26124099, 26661339, 28202521, 29483839, 30481147, 31894259, 36522309
Carcinoma Ovarian Epithelial	Associate	17569106, 19032793, 20661217, 24690311
Carcinoma Pancreatic Ductal	Inhibit	20398369
Carcinoma Pancreatic Ductal	Associate	25299780, 27053682, 36596765
Carcinoma Papillary Follicular	Associate	30358208
Carcinoma Renal Cell	Associate	10224285, 12771998, 15009365, 20442297, 20663526, 26725939, 27528031, 27768779, 28154184, 28464919, 30360403, 31269715, 33850477, 34684883, 37902279
Carcinoma Renal Cell	Inhibit	16096370, 28529641, 30463333
Carcinoma Squamous Cell	Associate	11442750
Cardiovascular Diseases	Associate	23472162
Carotid Artery Diseases	Associate	35937796, 36959587
Cerebral Infarction	Associate	36582228
Cerebrovascular Disorders	Associate	22048166
Chemical and Drug Induced Liver Injury	Associate	12439929, 15996036, 18802096
Cholangiocarcinoma	Associate	16166346, 16475706, 18723481, 20562908, 20691980, 21483830, 21953056, 24603802, 26514480, 28662515, 36853289
Cholangitis Sclerosing	Stimulate	16166346
Chondrosarcoma	Associate	22914439
Churg Strauss Syndrome	Associate	17265502
Clear cell metastatic renal cell carcinoma	Stimulate	11862476
Colitis Ulcerative	Associate	25720720
Colonic Neoplasms	Associate	11486001, 12218071, 15155747, 15757891, 16998592, 20156289, 37331805
Colorectal Neoplasms	Associate	10933923, 12140294, 12717839, 15155747, 15517918, 15757891, 16036110, 17012835, 17270019, 17579120, 17881904, 19352384, 20673328, 20837473, 21078664 View all (33 more)
Colorectal Neoplasms	Inhibit	22922338
Congenital myasthenic syndrome ib	Stimulate	24589226
Coronary Artery Disease	Stimulate	38357816
COVID 19	Associate	34920753, 36472908, 36555339, 36757525
Crohn Disease	Associate	18942021
Cryptosporidiosis	Associate	35974384
Death	Associate	11279061
Death	Stimulate	32917855
Dementia Vascular	Associate	38452989
Dengue	Associate	17913827
Depressive Disorder	Stimulate	34584171
Depressive Disorder Major	Associate	34584171
Dermatitis	Associate	26982083
Dermatitis Allergic Contact	Stimulate	39408763
Dermatitis Atopic	Associate	16185275
Dermatitis Herpetiformis	Associate	22778762, 22991566
Diabetes Mellitus	Associate	19432816, 28427244, 32732304
Diabetes Mellitus	Inhibit	29999450
Diabetes Mellitus Type 1	Stimulate	18057577
Diabetes Mellitus Type 2	Associate	28427244
Diabetic Nephropathies	Stimulate	18287563
Diabetic Nephropathies	Inhibit	29999450
Digestive System Diseases	Associate	20951133
Drug Hypersensitivity	Stimulate	20663232
Drug Related Side Effects and Adverse Reactions	Stimulate	11830480, 12878867, 15009365, 16026644, 20646307, 21483830, 21513580, 21514380, 22215108, 22411600, 23732517, 24281001, 24603802, 25015549, 25293521 View all (7 more)
Drug Related Side Effects and Adverse Reactions	Associate	12239152, 12767990, 16319225, 16518756, 17551094, 19118042, 19148581, 19372584, 19820719, 22462553, 23051914, 23719242, 23762301, 26044191, 30925759 View all (6 more)
Drug Related Side Effects and Adverse Reactions	Inhibit	31019655
Dyskinesias	Associate	17592646
Embolism Paradoxical	Associate	35937796
Endometrial Neoplasms	Associate	15471875, 15864316, 21435442, 21687633, 23580227, 24649804
Epilepsy Temporal Lobe	Associate	27006531
Epileptic Syndromes	Inhibit	22891927
Erysipelas	Associate	28512644
Esophageal Squamous Cell Carcinoma	Associate	20515944, 27731378
Fatty Liver	Associate	19247452
Fibrosarcoma	Associate	19077262
Fuchs' Endothelial Dystrophy	Associate	18339897
Gallbladder Neoplasms	Inhibit	19282655
Glioblastoma	Associate	15504253, 16199861, 17928957, 20484045, 20623264, 21697087, 22585859, 24213561, 24272336, 27029345, 28661478, 29384188, 30385739, 30464207, 30670698 View all (4 more)
Glioblastoma	Inhibit	17699104, 19432816, 26469969
Glioma	Associate	11770895, 12610517, 14655759, 15504253, 15711939, 16080161, 16103081, 17804742, 18239851, 18341587, 19001440, 20638385, 21220502, 21292685, 23740602 View all (5 more)
Glioma	Inhibit	19158480, 21945617, 22942757
Glomerulonephritis Membranous	Stimulate	16998592
Glucosephosphate Dehydrogenase Deficiency	Associate	36901724
Graft vs Host Disease	Associate	18814951
Granuloma	Associate	32411623
Granulosa Cell Tumor	Associate	27067438
Head and Neck Neoplasms	Associate	25314064, 30131570
Hematologic Neoplasms	Associate	12644023, 15723658
Hepatitis B	Associate	12439929
Hepatitis B Chronic	Associate	15996036
Hepatitis C	Associate	18802096, 22449797
Hepatitis C Chronic	Associate	19747917
Hepatitis D	Associate	38143742
Hepatoblastoma	Associate	22202031
Hereditary Breast and Ovarian Cancer Syndrome	Stimulate	35395021
Hip Injuries	Associate	21760914
Hippocampal Sclerosis	Associate	27006531
HIV Infections	Associate	12390316, 16046522, 18769477, 21483669, 21859711, 21926463, 29263214, 29597250, 31149947, 31189571, 9485194
HIV Infections	Stimulate	15585654, 16174727, 19404407
Hyperparathyroidism Primary	Associate	27763797
Hyperplasia	Stimulate	27763797
Hyperthyroidism	Stimulate	28551332
Hypothyroidism	Inhibit	28551332
Hypoxia	Associate	16294025, 17895594, 34356656
Hypoxia	Stimulate	17803681, 23492767
Hypoxia Brain	Associate	16294025, 17895594
Idiopathic Pulmonary Fibrosis	Associate	20451601, 24551275
Infections	Inhibit	11035092
Infections	Associate	18178561, 34920753, 36901724
Infections	Stimulate	36611893
Inflammation	Stimulate	12839575, 38357816
Inflammation	Associate	15644410, 16185275, 17353365, 18842989, 19265041, 19349211, 22048166, 23480056, 23699397, 24349222, 24445954, 28720906, 30258037, 30625987, 31507593, 34584171, 35792171, 36582228 View all (3 more)
Inflammation	Inhibit	32482836
Influenza Human	Stimulate	18723061
Influenza Human	Associate	36901724
Insulin Resistance	Associate	23472162
Intervertebral Disc Degeneration	Associate	26245704, 26261645, 35126933
Intervertebral disc disease	Associate	26261645
Joint Diseases	Associate	21305500
Kidney Diseases	Associate	34356656
Kidney Neoplasms	Associate	15614529, 18544564, 33000263, 34684883, 36674555
Leiomyoma	Associate	15374708, 22320196
Leukemia	Associate	12506034, 14726404, 17157162, 17551094, 17697742, 19820719, 20696207, 23046813, 26782504, 30626136, 34198757, 35011619, 35204655, 9485194
Leukemia Large Granular Lymphocytic	Associate	29699990
Leukemia Lymphocytic Chronic B Cell	Associate	16314473, 17697742, 19965642, 26745113, 29131242
Leukemia Lymphoma Adult T Cell	Associate	15638862, 15650163, 20706274, 22086925
Leukemia Lymphoma Adult T Cell	Inhibit	16195335
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	12506034, 17927986, 18922853, 21741707
Leukemia Myeloid	Associate	18838202, 22898820, 25321472
Leukemia Myeloid Acute	Associate	11090076, 12239152, 15619633, 18988868, 19010914, 21070598, 24895135, 26782504, 27013583, 28362429
Leukemia Myeloid Acute	Inhibit	18187663, 18476767
Leukemia Prolymphocytic T Cell	Associate	19573080, 21750559, 37528310
Leukemia T Cell	Associate	23096115
Liposarcoma	Associate	31126284
Liver Cirrhosis	Inhibit	28717244
Liver Failure	Associate	12439929, 15502938, 15996036, 19247452, 19747917
Liver Neoplasms	Inhibit	18778280
Liver Neoplasms	Associate	21368859, 27580702, 28270653, 38279326
Lung Neoplasms	Associate	11782771, 16740726, 17172826, 17895594, 18253090, 18523266, 19435900, 20450916, 20848283, 21525012, 22215108, 24019170, 26757822, 28460464, 30332761 View all (5 more)
Lung Neoplasms	Stimulate	18483303
Lung Neoplasms	Inhibit	20977779, 23174563, 26080425, 27484721, 32626921
Lupus Erythematosus Systemic	Associate	12421989, 14872508, 15001474, 18348311, 19349211, 31790472
Lupus Erythematosus Systemic	Stimulate	19644848
Lupus Nephritis	Stimulate	19349211
Lymphatic Metastasis	Associate	30358208
Lymphoma	Associate	10438545, 21933852, 25446254
Lymphoma	Inhibit	16848771
Lymphoma B Cell	Associate	16611333, 23555990, 25738497
Lymphoma Follicular	Associate	18606651, 9858217
Lymphoma Large B Cell Diffuse	Associate	16848771, 21931821
Lymphoma Mantle Cell	Associate	17237443
Lymphoma Non Hodgkin	Associate	21822052, 21933852
Lymphoma Primary Cutaneous Anaplastic Large Cell	Associate	19890350
Lymphoma Primary Effusion	Associate	12406882, 27893813, 36801923
Lymphoma T Cell Cutaneous	Associate	22011910, 22551975
Malformations of Cortical Development Group I	Stimulate	22411600
Mast Cell Activation Disorders	Inhibit	16455983
Medulloblastoma	Associate	18992144, 19148581
Medulloblastoma	Inhibit	22313685
Melanoma	Associate	11067917, 15373780, 15580309, 15792800, 16297203, 17070520, 17545621, 19383853, 20003459, 20417200, 20461078, 21268068, 21508672, 21910007, 22553342 View all (13 more)
Melanoma	Inhibit	18222423, 29845256
Meningeal Carcinomatosis	Associate	34108203
Mesothelioma	Associate	12707267, 16123394, 18339627
Mesothelioma Malignant	Associate	16529749, 17953743, 34597666
Metabolic Diseases	Associate	36078120
Minicore Myopathy with External Ophthalmoplegia	Associate	28362510
Mitochondrial Diseases	Stimulate	11461904, 12919886, 17420249, 23740602
Mitochondrial Diseases	Associate	11568006, 20168333, 21483830, 23703388, 30896851
Mouth Diseases	Inhibit	15509531
Mouth Neoplasms	Associate	16362335, 17592646, 18519235
Mucocutaneous Lymph Node Syndrome	Associate	38357816
Multiple Myeloma	Associate	11495702, 11568006, 11830480, 11877293, 12531793, 12823344, 15308561, 16026644, 17201122, 17823654, 18209050, 19749795, 20953137, 21179037, 22308310 View all (5 more)
Multiple Sclerosis	Associate	18348311, 21814551, 23658636, 24932510, 25736057
Multiple Sclerosis Relapsing Remitting	Associate	22106296
Myelodysplastic Syndromes	Associate	11698291, 15681838
Myelodysplastic Syndromes	Inhibit	18838202
Myocardial Infarction	Associate	14711179
Necrosis	Associate	10468881, 25611393
Neoplasm Metastasis	Inhibit	12946317, 24025362
Neoplasm Metastasis	Associate	16489180, 18483303, 19573813, 25778692
Neoplasm Metastasis	Stimulate	23470529
Neoplasms	Associate	10209050, 10468881, 10485660, 10891490, 10946322, 11035092, 11350953, 11486001, 11557065, 11755527, 11782443, 11782771, 11862476, 11940602, 12174820 View all (278 more)
Neoplasms	Inhibit	11677236, 11749866, 15087450, 15511228, 15569667, 15638862, 15644326, 15653686, 16024612, 16166346, 16930472, 18424742, 18988868, 19435900, 19625063 View all (39 more)
Neoplasms	Stimulate	22389673
Neoplasms Adipose Tissue	Associate	23472162, 24966465, 27735943, 32732304
Neoplasms Squamous Cell	Associate	16023108
Nerve Degeneration	Stimulate	18266928
Nerve Degeneration	Associate	19305384, 30552797
Neuroblastoma	Associate	14670183, 15632181, 16930472, 17962944, 19223550, 23719242, 24263099, 27821809, 30724400, 30870485
Neuroblastoma	Inhibit	21910007
Neurofibrosarcoma	Associate	23437333
Neurotoxicity Syndromes	Associate	18266928, 30552797
Neutropenia	Associate	15001474
Non alcoholic Fatty Liver Disease	Stimulate	39583964
Non Muscle Invasive Bladder Neoplasms	Associate	37380559
Obesity	Associate	28720906, 32732304
Obesity	Stimulate	28720906
Obesity	Inhibit	33101297
Odontogenic Cysts	Associate	28025428
Odontogenic Tumors	Associate	28025428
Osteoporotic Fractures	Associate	21760914
Osteosarcoma	Associate	12838325, 28002586, 29845256
Osteosarcoma	Inhibit	21297379, 22313685
Ovarian Neoplasms	Associate	15634191, 15972852, 16093247, 16731632, 17136319, 19959214, 21855847, 22558117, 24272484, 24761768, 25446129, 29070784, 29267342, 32187278, 32332713, 37809073 View all (1 more)
Ovarian Neoplasms	Inhibit	15831675, 23158473, 23696862
Pancreatic Neoplasms	Associate	17050666, 19118042, 20197401, 20398369, 20442774, 20848283, 22320973, 22666346, 23918603, 25955843, 29233971, 35819261, 36596765, 37012089
Pancreatic Neoplasms	Inhibit	22829912, 25299780, 28476883, 29867042
Pancreatitis Chronic	Associate	12808117, 16127431
Papillomavirus Infections	Inhibit	25341043
Paralysis	Associate	24349222
Parathyroid Diseases	Associate	27763797
Pathological Conditions Anatomical	Associate	26245704
Penile Neoplasms	Associate	28751665
Periodontal Diseases	Associate	19309556
Periodontitis	Associate	19309556
Philadelphia Chromosome	Associate	12506034
Pleural Effusion	Associate	22159518
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	18599181, 34198757
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	21575156, 27176505
Prostatic Neoplasms	Inhibit	11461904, 18460741, 18599488
Prostatic Neoplasms	Associate	12351634, 12496481, 12782325, 15456405, 17178731, 17893044, 18483298, 18617897, 19074830, 19123467, 19895686, 20096292, 20168333, 20177075, 20224297 View all (22 more)
Prostatitis	Inhibit	12351634
Prostatitis	Associate	15771957, 17911631, 19584265
Pulmonary Disease Chronic Obstructive	Stimulate	36901724
Pulmonary Fibrosis	Associate	36555339
Purpura Thrombocytopenic Idiopathic	Associate	20671119
Purpura Thrombotic Thrombocytopenic	Associate	18339897
Pyelonephritis	Associate	23480056
Reperfusion Injury	Stimulate	20440768
Respiratory Distress Syndrome	Associate	36555339
Rhabdomyosarcoma	Associate	31988307
Rheumatic Fever	Associate	40226625
Sarcoma	Associate	12919886, 16619517, 24618889, 29955091
Sarcoma Ewing	Associate	22258765, 30131449
Sarcoma Ewing	Inhibit	22313685
Schizophrenia	Associate	34584171
Scleroderma Systemic	Inhibit	21769840
Sepsis	Associate	24349222
Sezary Syndrome	Associate	18314443
Simpson Golabi Behmel syndrome	Associate	27735943, 28720906
Sjogren's Syndrome	Associate	29655283, 39819714
Sjogren's Syndrome	Stimulate	35309355
Skin Neoplasms	Associate	30172026
Sleep Deprivation	Stimulate	16998592, 30896851
Small Cell Lung Carcinoma	Inhibit	21965726
Solitary Pulmonary Nodule	Associate	12946317
Squamous Cell Carcinoma of Head and Neck	Associate	16362335, 17592646, 21914854, 23010686, 25314064, 25605161, 33737574, 36969496
Squamous Cell Carcinoma of Head and Neck	Inhibit	31309556
Status Asthmaticus	Stimulate	12421985
Stomach Neoplasms	Associate	11862476, 14662022, 14695762, 20032392, 21725207, 22589394, 23536831, 23937794, 24324958, 26615420, 26831669, 28972304, 29374180, 31673231, 32260540, 34845969 View all (1 more)
Stomach Neoplasms	Inhibit	39173282
Temporomandibular Joint Dysfunction Syndrome	Associate	20839416
Testicular Neoplasms	Associate	26024393
Thyroid Cancer Papillary	Associate	10438545, 30358208
Thyroid Carcinoma Anaplastic	Associate	27353001
Thyroid Neoplasms	Associate	12163389, 16024612, 19190106, 22998497
Thyroiditis	Associate	10438545, 27353001
Triple Negative Breast Neoplasms	Associate	18266105, 22112940, 24505496, 24745479, 27618431, 29434187, 29663486
Triple Negative Breast Neoplasms	Inhibit	24025362
Tuberculosis Multidrug Resistant	Stimulate	20663232
Tuberculosis Multidrug Resistant	Associate	21514380
Tuberculosis Osteoarticular	Associate	26245704
Urinary Bladder Neoplasms	Associate	16984382, 17617740, 19625063, 20430723, 20814238, 24566141, 35985770, 37380559
Uterine Cervical Neoplasms	Associate	29291370, 31019655
Vascular Calcification	Stimulate	33080110
Virus Diseases	Associate	11306566, 36901724
Vitiligo	Associate	15816839
Waldenstrom Macroglobulinemia	Associate	19573080
Wounds and Injuries	Associate	22926077

TNFSF10 (TNF superfamily member 10)