Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8743
Gene name Gene Name - the full gene name approved by the HGNC.
TNF superfamily member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNFSF10
Synonyms (NCBI Gene) Gene synonyms aliases
APO2L, Apo-2L, CD253, TANCR, TL2, TNLG6A, TRAIL
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003757 hsa-miR-221-3p Western blot 18246122
MIRT003756 hsa-miR-222-3p Western blot 18246122
MIRT027770 hsa-miR-98-5p Microarray 19088304
MIRT1443311 hsa-miR-3684 CLIP-seq
MIRT1443312 hsa-miR-4305 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
EGR1 Repression 17932312
FOXO1 Activation 23630076
FOXO3 Activation 23630076
FOXO4 Activation 23630076
HDAC2 Repression 23630076
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding TAS 8663110, 8777713
GO:0005125 Function Cytokine activity IEA
GO:0005164 Function Tumor necrosis factor receptor binding IEA
GO:0005515 Function Protein binding IPI 10549288, 19427028, 20097879, 20103630, 21459798, 21525171, 21822306, 22266862, 23678861
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603598 11925 ENSG00000121858
Protein
UniProt ID P50591
Protein name Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Protein function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy rec
PDB 1D0G , 1D2Q , 1D4V , 1DG6 , 1DU3 , 4N90 , 5CIR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00229 TNF 152 280 TNF(Tumour Necrosis Factor) family Domain
Tissue specificity TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLV
G
Sequence length 281
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
FoxO signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity
Pathogenic Escherichia coli infection
Salmonella infection
Influenza A
Lipid and atherosclerosis
  Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
18483385
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
18483385
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 15993848
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
17273769
Unknown
Disease term Disease name Evidence References Source
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 20403343 ClinVar
Gout Gout GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 23290504
Abortion Spontaneous Associate 23290504
Acne Vulgaris Associate 21564055
Acquired Immunodeficiency Syndrome Associate 15585654, 21483669
Acro Osteolysis Associate 12823344
Adenocarcinoma Associate 16580499, 21513580, 23479507, 24223304, 36550819
Adenocarcinoma of Lung Inhibit 26972480
Adenocarcinoma of Lung Associate 28756806
Albuminuria Associate 36591354
Alzheimer Disease Associate 18266928, 22420897, 22695614, 26745113, 29384188, 37012089