Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	8743
Gene name	TNF superfamily member 10
Gene symbol	TNFSF10
Synonyms (NCBI Gene)	APO2LApo-2LCD253TANCRTL2TNLG6ATRAIL
Chromosome	3
Chromosome location	3q26.31
Summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003757	hsa-miR-221-3p	Western blot	18246122
MIRT003756	hsa-miR-222-3p	Western blot	18246122
MIRT027770	hsa-miR-98-5p	Microarray	19088304
MIRT1443311	hsa-miR-3684	CLIP-seq
MIRT1443312	hsa-miR-4305	CLIP-seq
MIRT1443313	hsa-miR-4753-3p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443315	hsa-miR-491-3p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT1443321	hsa-miR-548ac	CLIP-seq
MIRT1443322	hsa-miR-548ae	CLIP-seq
MIRT1443323	hsa-miR-548aj	CLIP-seq
MIRT1443324	hsa-miR-548am	CLIP-seq
MIRT1443325	hsa-miR-548d-3p	CLIP-seq
MIRT1443326	hsa-miR-548x	CLIP-seq
MIRT1443327	hsa-miR-548z	CLIP-seq
MIRT1443328	hsa-miR-586	CLIP-seq
MIRT1443329	hsa-miR-1246	CLIP-seq
MIRT1443330	hsa-miR-1273f	CLIP-seq
MIRT1443331	hsa-miR-1304	CLIP-seq
MIRT1443332	hsa-miR-137	CLIP-seq
MIRT1443333	hsa-miR-154	CLIP-seq
MIRT1443334	hsa-miR-3130-3p	CLIP-seq
MIRT1443335	hsa-miR-3134	CLIP-seq
MIRT1443336	hsa-miR-3613-5p	CLIP-seq
MIRT1443337	hsa-miR-3660	CLIP-seq
MIRT1443338	hsa-miR-3674	CLIP-seq
MIRT1443339	hsa-miR-3934	CLIP-seq
MIRT1443340	hsa-miR-3942-3p	CLIP-seq
MIRT1443341	hsa-miR-409-3p	CLIP-seq
MIRT1443342	hsa-miR-4252	CLIP-seq
MIRT1443343	hsa-miR-4302	CLIP-seq
MIRT1443344	hsa-miR-4445	CLIP-seq
MIRT1443345	hsa-miR-4526	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT1443347	hsa-miR-4645-5p	CLIP-seq
MIRT1443348	hsa-miR-4659a-3p	CLIP-seq
MIRT1443349	hsa-miR-4659b-3p	CLIP-seq
MIRT1443350	hsa-miR-4673	CLIP-seq
MIRT1443351	hsa-miR-4733-3p	CLIP-seq
MIRT1443352	hsa-miR-4742-5p	CLIP-seq
MIRT1443353	hsa-miR-4773	CLIP-seq
MIRT1443354	hsa-miR-552	CLIP-seq
MIRT1443355	hsa-miR-671-5p	CLIP-seq
MIRT1443356	hsa-miR-767-5p	CLIP-seq
MIRT2132661	hsa-miR-122	CLIP-seq
MIRT2132662	hsa-miR-139-5p	CLIP-seq
MIRT2132663	hsa-miR-142-3p	CLIP-seq
MIRT2132664	hsa-miR-3135b	CLIP-seq
MIRT2132665	hsa-miR-3622b-5p	CLIP-seq
MIRT2132666	hsa-miR-3652	CLIP-seq
MIRT2132667	hsa-miR-3677-5p	CLIP-seq
MIRT2132668	hsa-miR-4280	CLIP-seq
MIRT2132669	hsa-miR-4430	CLIP-seq
MIRT2132670	hsa-miR-4695-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2132661	hsa-miR-122	CLIP-seq
MIRT2353690	hsa-miR-129-5p	CLIP-seq
MIRT1443331	hsa-miR-1304	CLIP-seq
MIRT1443332	hsa-miR-137	CLIP-seq
MIRT2132663	hsa-miR-142-3p	CLIP-seq
MIRT1443333	hsa-miR-154	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353694	hsa-miR-26a	CLIP-seq
MIRT2353695	hsa-miR-26b	CLIP-seq
MIRT2353696	hsa-miR-3124-3p	CLIP-seq
MIRT2132664	hsa-miR-3135b	CLIP-seq
MIRT2353697	hsa-miR-3140-3p	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353700	hsa-miR-3174	CLIP-seq
MIRT2353701	hsa-miR-3180-5p	CLIP-seq
MIRT1443336	hsa-miR-3613-5p	CLIP-seq
MIRT2132665	hsa-miR-3622b-5p	CLIP-seq
MIRT2132666	hsa-miR-3652	CLIP-seq
MIRT1443337	hsa-miR-3660	CLIP-seq
MIRT1443338	hsa-miR-3674	CLIP-seq
MIRT2132667	hsa-miR-3677-5p	CLIP-seq
MIRT2353702	hsa-miR-376a	CLIP-seq
MIRT2353703	hsa-miR-376b	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT1443340	hsa-miR-3942-3p	CLIP-seq
MIRT1443341	hsa-miR-409-3p	CLIP-seq
MIRT2132668	hsa-miR-4280	CLIP-seq
MIRT1443343	hsa-miR-4302	CLIP-seq
MIRT2132669	hsa-miR-4430	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2353708	hsa-miR-450b-3p	CLIP-seq
MIRT1443345	hsa-miR-4526	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT2132670	hsa-miR-4695-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443353	hsa-miR-4773	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT2353710	hsa-miR-4793-5p	CLIP-seq
MIRT2353711	hsa-miR-494	CLIP-seq
MIRT2353712	hsa-miR-513c	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353716	hsa-miR-635	CLIP-seq
MIRT2353717	hsa-miR-769-3p	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq
MIRT2462079	hsa-miR-3691-3p	CLIP-seq
MIRT2132671	hsa-miR-4755-3p	CLIP-seq
MIRT2462080	hsa-miR-720	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT2647825	hsa-miR-4291	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2647826	hsa-miR-4532	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2647827	hsa-miR-545	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq
MIRT2353682	hsa-let-7a	CLIP-seq
MIRT2353683	hsa-let-7b	CLIP-seq
MIRT2353684	hsa-let-7c	CLIP-seq
MIRT2353685	hsa-let-7d	CLIP-seq
MIRT2353686	hsa-let-7e	CLIP-seq
MIRT2353687	hsa-let-7f	CLIP-seq
MIRT2353688	hsa-let-7g	CLIP-seq
MIRT2353689	hsa-let-7i	CLIP-seq
MIRT2693705	hsa-miR-1298	CLIP-seq
MIRT2353691	hsa-miR-190	CLIP-seq
MIRT2353692	hsa-miR-190b	CLIP-seq
MIRT2353693	hsa-miR-202	CLIP-seq
MIRT2353698	hsa-miR-3140-5p	CLIP-seq
MIRT2353699	hsa-miR-3156-5p	CLIP-seq
MIRT2353704	hsa-miR-3927	CLIP-seq
MIRT2647825	hsa-miR-4291	CLIP-seq
MIRT2353705	hsa-miR-4451	CLIP-seq
MIRT2353706	hsa-miR-4458	CLIP-seq
MIRT2353707	hsa-miR-4500	CLIP-seq
MIRT2647826	hsa-miR-4532	CLIP-seq
MIRT1443346	hsa-miR-4645-3p	CLIP-seq
MIRT1443313	hsa-miR-4753-3p	CLIP-seq
MIRT2353709	hsa-miR-4766-5p	CLIP-seq
MIRT1443314	hsa-miR-4777-5p	CLIP-seq
MIRT1443316	hsa-miR-518d-5p	CLIP-seq
MIRT1443317	hsa-miR-519b-5p	CLIP-seq
MIRT1443318	hsa-miR-519c-5p	CLIP-seq
MIRT1443319	hsa-miR-520c-5p	CLIP-seq
MIRT1443320	hsa-miR-526a	CLIP-seq
MIRT2353713	hsa-miR-544	CLIP-seq
MIRT2647827	hsa-miR-545	CLIP-seq
MIRT2353714	hsa-miR-548p	CLIP-seq
MIRT2353715	hsa-miR-621	CLIP-seq
MIRT2353718	hsa-miR-98	CLIP-seq

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Transcription factor	Regulation	Reference
EGR1	Repression	17932312
FOXO1	Activation	23630076
FOXO3	Activation	23630076
FOXO4	Activation	23630076
HDAC2	Repression	23630076
IRF1	Activation	21858676
NFIL3	Repression	23630076
NFKB1	Activation	11544302;20542572
NFKB1	Repression	11544302
NFKB1	Unknown	21243522
NFKBIA	Repression	11544302
PML	Activation	15459016
RELA	Activation	11544302;20542572
RELA	Repression	11544302
RELA	Unknown	21243522
SP1	Repression	21603612

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	8663110, 8777713
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	21146232
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	10549288, 19427028, 20097879, 20103630, 21459798, 21525171, 21822306, 22266862, 23678861
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	21146232
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8663110
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	8663110
GO:0006955	Process	Immune response	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	TAS	8663110, 8777713
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007267	Process	Cell-cell signaling	TAS	8777713
GO:0008270	Function	Zinc ion binding	IDA	26457518
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	IEA
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	9430228, 21785459
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	9485194
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IMP	10862756, 19090789
GO:0042802	Function	Identical protein binding	IDA	26457518
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21525171
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0045569	Function	TRAIL binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	22266862
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IDA	20097879, 21525171, 22266862
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IEA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
603598	11925	ENSG00000121858

P50591

Protein name

Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)

Protein function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy rec

PDB

1D0G , 1D2Q , 1D4V , 1DG6 , 1DU3 , 4N90 , 5CIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00229	TNF	152 → 280	TNF(Tumour Necrosis Factor) family	Domain

Tissue specificity

TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.

Sequence

MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Sequence length

281

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity Pathogenic Escherichia coli infection Salmonella infection Influenza A Lipid and atherosclerosis		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling

TNFSF10 (TNF superfamily member 10)