Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	873
Gene name	Carbonyl reductase 1
Gene symbol	CBR1
Synonyms (NCBI Gene)	CBRPG-9-KRSDR21C1hCBR1
Chromosome	21
Chromosome location	21q22.12
Summary	The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049536	hsa-miR-92a-3p	CLASH	23622248
MIRT045152	hsa-miR-186-5p	CLASH	23622248
MIRT042005	hsa-miR-484	CLASH	23622248
MIRT038897	hsa-miR-93-3p	CLASH	23622248
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT1956746	hsa-miR-3660	CLIP-seq
MIRT1956747	hsa-miR-4257	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT1956748	hsa-miR-4526	CLIP-seq
MIRT1956749	hsa-miR-4711-5p	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT2677471	hsa-miR-1225-3p	CLIP-seq
MIRT2677472	hsa-miR-1233	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IBA
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	1921984, 18449627
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IEA
GO:0004090	Function	Carbonyl reductase (NADPH) activity	TAS	9740676
GO:0005515	Function	Protein binding	IPI	26496610, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	18449627
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	IEA
GO:0008211	Process	Glucocorticoid metabolic process	IDA	28878267
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	28878267
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0042373	Process	Vitamin K metabolic process	IDA	18449627
GO:0046457	Process	Prostanoid biosynthetic process	TAS
GO:0047020	Function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA
GO:0047021	Function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity	IEA
GO:0047021	Function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity	ISS
GO:0050221	Function	Prostaglandin E2 9-reductase activity	EXP	7005231
GO:0050221	Function	Prostaglandin E2 9-reductase activity	IEA
GO:0050221	Function	Prostaglandin E2 9-reductase activity	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0160163	Function	S-nitrosoglutathione reductase (NADPH) activity	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	IDA	19442656

MIM	HGNC	e!Ensembl
114830	1548	ENSG00000159228

P16152

Protein name

Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (

Protein function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthrac

PDB

1WMA , 2PFG , 3BHI , 3BHJ , 3BHM , 4Z3D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	6 → 152	short chain dehydrogenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney (at protein level). {ECO:0000269|PubMed:1597188}.

Sequence

MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW

Sequence length

277

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Folate biosynthesis Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - reactive oxygen species		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

CBR1 (carbonyl reductase 1)