Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	873
Gene name Gene Name - the full gene name approved by the HGNC.	Carbonyl reductase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CBR1
Synonyms (NCBI Gene) Gene synonyms aliases	CBR, PG-9-KR, SDR21C1, hCBR1
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics

Show/Hide all(104)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049536	hsa-miR-92a-3p	CLASH	23622248
MIRT045152	hsa-miR-186-5p	CLASH	23622248
MIRT042005	hsa-miR-484	CLASH	23622248
MIRT038897	hsa-miR-93-3p	CLASH	23622248
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT1956746	hsa-miR-3660	CLIP-seq
MIRT1956747	hsa-miR-4257	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT1956748	hsa-miR-4526	CLIP-seq
MIRT1956749	hsa-miR-4711-5p	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT2677471	hsa-miR-1225-3p	CLIP-seq
MIRT2677472	hsa-miR-1233	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IBA
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	1921984, 18449627
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IEA
GO:0004090	Function	Carbonyl reductase (NADPH) activity	TAS	9740676
GO:0005515	Function	Protein binding	IPI	26496610, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	18449627
GO:0008106	Function	Alcohol dehydrogenase (NADP+) activity	IEA
GO:0008211	Process	Glucocorticoid metabolic process	IDA	28878267
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	28878267
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0042373	Process	Vitamin K metabolic process	IDA	18449627
GO:0046457	Process	Prostanoid biosynthetic process	TAS
GO:0047020	Function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA
GO:0047021	Function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity	IEA
GO:0047021	Function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity	ISS
GO:0050221	Function	Prostaglandin E2 9-reductase activity	EXP	7005231
GO:0050221	Function	Prostaglandin E2 9-reductase activity	IEA
GO:0050221	Function	Prostaglandin E2 9-reductase activity	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0160163	Function	S-nitrosoglutathione reductase (NADPH) activity	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	IDA	19442656

MIM	HGNC	e!Ensembl
114830	1548	ENSG00000159228

Protein

UniProt ID

P16152

Protein name

Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (

Protein function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthrac

PDB

1WMA , 2PFG , 3BHI , 3BHJ , 3BHM , 4Z3D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	6 → 152	short chain dehydrogenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney (at protein level). {ECO:0000269|PubMed:1597188}.

Sequence

MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW

Sequence length

277

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Folate biosynthesis Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - reactive oxygen species		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

CBR1 (carbonyl reductase 1)