TNK1 (tyrosine kinase non receptor 1)

Gene

• Entrez ID: 8711
• Gene name: Tyrosine kinase non receptor 1
• Gene symbol: TNK1
• Synonyms (NCBI Gene): KOS1
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is high

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051086	hsa-miR-16-5p	CLASH	23622248
MIRT1443684	hsa-miR-1272	CLIP-seq
MIRT1443685	hsa-miR-1322	CLIP-seq
MIRT1443686	hsa-miR-15a	CLIP-seq
MIRT1443687	hsa-miR-15b	CLIP-seq
MIRT1443688	hsa-miR-16	CLIP-seq
MIRT1443689	hsa-miR-195	CLIP-seq
MIRT1443690	hsa-miR-3171	CLIP-seq
MIRT1443691	hsa-miR-424	CLIP-seq
MIRT1443692	hsa-miR-4524	CLIP-seq
MIRT1443693	hsa-miR-4659a-3p	CLIP-seq
MIRT1443694	hsa-miR-4659b-3p	CLIP-seq
MIRT1443695	hsa-miR-4660	CLIP-seq
MIRT1443696	hsa-miR-497	CLIP-seq
MIRT1443697	hsa-miR-503	CLIP-seq
MIRT1443698	hsa-miR-646	CLIP-seq
MIRT2132766	hsa-miR-105	CLIP-seq
MIRT2132767	hsa-miR-1825	CLIP-seq
MIRT2132768	hsa-miR-199a-5p	CLIP-seq
MIRT2132769	hsa-miR-199b-5p	CLIP-seq
MIRT2132770	hsa-miR-2392	CLIP-seq
MIRT2132771	hsa-miR-338-3p	CLIP-seq
MIRT2132772	hsa-miR-4489	CLIP-seq
MIRT2132773	hsa-miR-4687-3p	CLIP-seq
MIRT2132774	hsa-miR-634	CLIP-seq
MIRT2132767	hsa-miR-1825	CLIP-seq
MIRT2132768	hsa-miR-199a-5p	CLIP-seq
MIRT2132769	hsa-miR-199b-5p	CLIP-seq
MIRT2132770	hsa-miR-2392	CLIP-seq
MIRT2353844	hsa-miR-23a	CLIP-seq
MIRT2353845	hsa-miR-23b	CLIP-seq
MIRT2353846	hsa-miR-23c	CLIP-seq
MIRT2353847	hsa-miR-4302	CLIP-seq
MIRT2132773	hsa-miR-4687-3p	CLIP-seq
MIRT2353848	hsa-miR-4717-3p	CLIP-seq
MIRT2353849	hsa-miR-644	CLIP-seq
MIRT2353850	hsa-miR-663b	CLIP-seq
MIRT2693759	hsa-miR-1285	CLIP-seq
MIRT2693760	hsa-miR-3187-5p	CLIP-seq
MIRT2693761	hsa-miR-326	CLIP-seq
MIRT2693762	hsa-miR-330-5p	CLIP-seq
MIRT2693763	hsa-miR-378g	CLIP-seq
MIRT2693764	hsa-miR-4268	CLIP-seq
MIRT2693765	hsa-miR-4437	CLIP-seq
MIRT2693766	hsa-miR-4486	CLIP-seq
MIRT2693767	hsa-miR-455-5p	CLIP-seq
MIRT2693768	hsa-miR-4674	CLIP-seq
MIRT2693769	hsa-miR-4691-5p	CLIP-seq
MIRT2693770	hsa-miR-4716-5p	CLIP-seq
MIRT2693771	hsa-miR-612	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004713	Function	Protein tyrosine kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	IDA	10873601
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA	21873635
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	NAS	10873601
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10873601, 15778465, 25852190
GO:0005524	Function	ATP binding	IDA	10873601
GO:0005737	Component	Cytoplasm	IDA	10873601
GO:0006468	Process	Protein phosphorylation	TAS	8632913
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0016020	Component	Membrane	IDA	10873601
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046777	Process	Protein autophosphorylation	IDA	10873601

Other IDs

• MIM: 608076
• HGNC: 11940
• e!Ensembl: ENSG00000174292

Protein

• UniProt ID: Q13470
• Protein name: Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
• Protein function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult
• PDB: 7T8J, 7TCY, 7TDY, 7U4W, 7U4Z, 9CPL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	116 → 377	Protein tyrosine and serine/threonine kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, tes
• Sequence:

  MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
  EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
  LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
  LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
  LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
  SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
  APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDST
  IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD
  APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP
  PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL
  SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR
  YVLARP

• Sequence length: 666

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382

Unknown
Disease term	Disease name	Evidence	References	Source
Uterine Fibroids	Uterine Fibroids			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	18830724
Dementia	Associate	31836585
Hodgkin Disease	Associate	36334623
Lymphoma	Associate	37847650
Lymphoma Primary Cutaneous Anaplastic Large Cell	Associate	34382383
Neoplasms	Associate	34382383, 37776857
Pancreatic Neoplasms	Associate	21536687