Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8682
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Proliferation and apoptosis adaptor protein 15 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PEA15 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15 |
Chromosome
Chromosome number
|
1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q23.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it |
UniProt ID |
Q15121
|
Protein name |
Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) |
Protein function |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptos |
PDB |
4IZ5
,
4IZA
,
6P6B
,
6P6C
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01335
|
DED |
4 → 85 |
Death effector domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues |
Sequence |
|
Sequence length |
130 |
Interactions |
View interactions
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