Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8682
Gene name Gene Name - the full gene name approved by the HGNC.
Proliferation and apoptosis adaptor protein 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PEA15
Synonyms (NCBI Gene) Gene synonyms aliases
HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004501 hsa-miR-212-3p qRT-PCR, Luciferase reporter assay, Western blot 20388802
MIRT004502 hsa-miR-34a-5p Western blot 20388802
MIRT004503 hsa-miR-124-3p Western blot 20388802
MIRT023321 hsa-miR-122-5p Microarray 17612493
MIRT004502 hsa-miR-34a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
RUNX3 Repression 17956589
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0005515 Function Protein binding IPI 10442631, 17255949, 21044950, 21900206, 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603434 8822 ENSG00000162734
Protein
UniProt ID Q15121
Protein name Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)
Protein function Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptos
PDB 4IZ5 , 4IZA , 6P6B , 6P6C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01335 DED 4 85 Death effector domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues
Sequence
Sequence length 130
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 25075716 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Associate 23604467
Breast Neoplasms Associate 23543364, 24584939, 34907034
Breast Neoplasms Inhibit 25796184
Carcinogenesis Inhibit 25796184
Carcinoma Hepatocellular Associate 29072691, 30981109
Colorectal Neoplasms Associate 28936799, 33787596
Colorectal Neoplasms Hereditary Nonpolyposis Associate 23604467
Diabetes Mellitus Associate 20452983
Diabetes Mellitus Type 2 Associate 32993798, 35271662
Diabetes Mellitus Type 2 Stimulate 9670003