Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8672
Gene name	Eukaryotic translation initiation factor 4 gamma 3
Gene symbol	EIF4G3
Synonyms (NCBI Gene)	eIF-4G 3eIF4G 3eIF4GII
Chromosome	1
Chromosome location	1p36.12
Summary	The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthes

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019790	hsa-miR-375	Microarray	20215506
MIRT030431	hsa-miR-24-3p	Microarray	19748357
MIRT031458	hsa-miR-16-5p	Proteomics	18668040
MIRT050935	hsa-miR-17-5p	CLASH	23622248
MIRT046895	hsa-miR-221-3p	CLASH	23622248
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT664712	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT664711	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT664710	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440730	hsa-miR-543	HITS-CLIP	24374217
MIRT440733	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440730	hsa-miR-543	HITS-CLIP	24374217
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440730	hsa-miR-543	HITS-CLIP	24374217
MIRT440733	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440732	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440731	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440730	hsa-miR-543	HITS-CLIP	24374217
MIRT019790	hsa-miR-375	Luciferase reporter assayWestern blottingMicroarrayqRT-PCRFlow cytometryImmunocytochemistry (ICC)	34194495
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT664712	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT664711	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT664710	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614544	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT231644	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT958904	hsa-miR-1305	CLIP-seq
MIRT958905	hsa-miR-3179	CLIP-seq
MIRT958906	hsa-miR-3609	CLIP-seq
MIRT958907	hsa-miR-369-3p	CLIP-seq
MIRT958908	hsa-miR-3924	CLIP-seq
MIRT958909	hsa-miR-3973	CLIP-seq
MIRT958910	hsa-miR-4273	CLIP-seq
MIRT958911	hsa-miR-4635	CLIP-seq
MIRT958912	hsa-miR-4677-5p	CLIP-seq
MIRT958913	hsa-miR-4699-3p	CLIP-seq
MIRT958914	hsa-miR-4728-5p	CLIP-seq
MIRT958915	hsa-miR-520g	CLIP-seq
MIRT958916	hsa-miR-520h	CLIP-seq
MIRT958917	hsa-miR-548ah	CLIP-seq
MIRT958918	hsa-miR-561	CLIP-seq
MIRT958919	hsa-miR-607	CLIP-seq
MIRT1984032	hsa-miR-1237	CLIP-seq
MIRT1984033	hsa-miR-1248	CLIP-seq
MIRT1984034	hsa-miR-3182	CLIP-seq
MIRT958908	hsa-miR-3924	CLIP-seq
MIRT958910	hsa-miR-4273	CLIP-seq
MIRT1984035	hsa-miR-4310	CLIP-seq
MIRT1984036	hsa-miR-4652-3p	CLIP-seq
MIRT2219240	hsa-miR-4447	CLIP-seq
MIRT2219241	hsa-miR-4472	CLIP-seq
MIRT2522481	hsa-miR-1256	CLIP-seq
MIRT2522482	hsa-miR-1910	CLIP-seq
MIRT2522483	hsa-miR-3124-3p	CLIP-seq
MIRT2522484	hsa-miR-335	CLIP-seq
MIRT2522485	hsa-miR-3679-3p	CLIP-seq
MIRT958908	hsa-miR-3924	CLIP-seq
MIRT958910	hsa-miR-4273	CLIP-seq
MIRT2522486	hsa-miR-4477a	CLIP-seq
MIRT2522487	hsa-miR-4509	CLIP-seq
MIRT958912	hsa-miR-4677-5p	CLIP-seq
MIRT958913	hsa-miR-4699-3p	CLIP-seq
MIRT2522488	hsa-miR-4738-3p	CLIP-seq
MIRT2522489	hsa-miR-4744	CLIP-seq
MIRT2522490	hsa-miR-4753-3p	CLIP-seq
MIRT2522491	hsa-miR-4768-5p	CLIP-seq
MIRT2522492	hsa-miR-496	CLIP-seq
MIRT2522493	hsa-miR-498	CLIP-seq
MIRT2522494	hsa-miR-548n	CLIP-seq
MIRT2522495	hsa-miR-548t	CLIP-seq
MIRT958918	hsa-miR-561	CLIP-seq
MIRT2522488	hsa-miR-4738-3p	CLIP-seq
MIRT2679884	hsa-miR-579	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000339	Function	RNA cap binding	TAS	9418880
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0003743	Function	Translation initiation factor activity	ISS	35951695
GO:0005515	Function	Protein binding	IPI	20212144, 21191102
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IBA
GO:0006413	Process	Translational initiation	IEA
GO:0006413	Process	Translational initiation	NAS	19239892
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IEA
GO:0006446	Process	Regulation of translational initiation	TAS	9418880
GO:0007286	Process	Spermatid development	ISS	35951695
GO:0008135	Function	Translation factor activity, RNA binding	IEA
GO:0008135	Function	Translation factor activity, RNA binding	TAS	9418880
GO:0010507	Process	Negative regulation of autophagy	IMP	18426977
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	IBA
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	NAS	19239892
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	TAS	9418880
GO:0045727	Process	Positive regulation of translation	ISS	35951695

MIM	HGNC	e!Ensembl
603929	3298	ENSG00000075151

O43432

Protein name

Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)

Protein function

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubM

PDB

1HU3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02854	MIF4G	755 → 983	MIF4G domain	Family
PF02847	MA3	1222 → 1334	MA3 domain	Family
PF02020	W2	1506 → 1585	eIF4-gamma/eIF5/eIF2-epsilon	Family

Sequence

MNSQPQTRSPFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPV
PQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQ
SAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTP
PQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLS
GEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDR
CELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEIN
GVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPT
PPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQ
TEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKV
LESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSS
GDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPK
LPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPLLNVGSRRSQPGQRREPRKIITVSV
KEDVHLKKAENAWKPSQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGL
TVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNR
CQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELF
KLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIV
KERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTK
EKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSS
GGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKP
LPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRE
SAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVR
VGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYL
AELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREAD
LSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKAN
DEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYL
DSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNG
KGVALKSVTAFFTWLREAEEESEDN

Sequence length

1585

Interactions

View interactions

	KEGG		Reactome
	Viral myocarditis		ISG15 antiviral mechanism

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193921047	RCV000149098

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Infections	Inhibit	19855901
Lymphatic Metastasis	Associate	30082491
Lymphatic Metastasis	Stimulate	31257089
Stomach Neoplasms	Associate	31257089
Triple Negative Breast Neoplasms	Associate	30082491

EIF4G3 (eukaryotic translation initiation factor 4 gamma 3)