Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8668
Gene name Gene Name - the full gene name approved by the HGNC.	Eukaryotic translation initiation factor 3 subunit I
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EIF3I
Synonyms (NCBI Gene) Gene synonyms aliases	EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p35.2

Show/Hide all(225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016316	hsa-miR-193b-3p	Proteomics	21512034
MIRT049001	hsa-miR-92a-3p	CLASH	23622248
MIRT046640	hsa-miR-222-3p	CLASH	23622248
MIRT045793	hsa-miR-191-5p	CLASH	23622248
MIRT016316	hsa-miR-193b-3p	CLASH	23622248
MIRT040929	hsa-miR-18a-3p	CLASH	23622248
MIRT037924	hsa-miR-532-3p	CLASH	23622248
MIRT035890	hsa-miR-1303	CLASH	23622248
MIRT957601	hsa-miR-4256	CLIP-seq
MIRT957602	hsa-miR-4729	CLIP-seq
MIRT957603	hsa-miR-4786-3p	CLIP-seq
MIRT957604	hsa-miR-556-3p	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT1983696	hsa-miR-1248	CLIP-seq
MIRT1983697	hsa-miR-1270	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT1983699	hsa-miR-1323	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT957601	hsa-miR-4256	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT1983706	hsa-miR-4531	CLIP-seq
MIRT1983707	hsa-miR-4659a-3p	CLIP-seq
MIRT1983708	hsa-miR-4659b-3p	CLIP-seq
MIRT1983709	hsa-miR-4683	CLIP-seq
MIRT1983710	hsa-miR-4695-3p	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT957602	hsa-miR-4729	CLIP-seq
MIRT1983712	hsa-miR-4778-3p	CLIP-seq
MIRT957603	hsa-miR-4786-3p	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT1983714	hsa-miR-548o	CLIP-seq
MIRT957604	hsa-miR-556-3p	CLIP-seq
MIRT1983715	hsa-miR-620	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT2218986	hsa-miR-1343	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT2218987	hsa-miR-3199	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT2448742	hsa-miR-1254	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT2218986	hsa-miR-1343	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT2448743	hsa-miR-3116	CLIP-seq
MIRT2448744	hsa-miR-3149	CLIP-seq
MIRT2218987	hsa-miR-3199	CLIP-seq
MIRT2448745	hsa-miR-411	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT2448746	hsa-miR-4715-3p	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT2448747	hsa-miR-4735-5p	CLIP-seq
MIRT2448748	hsa-miR-4775	CLIP-seq
MIRT2448749	hsa-miR-4794	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT2448750	hsa-miR-590-3p	CLIP-seq
MIRT2448751	hsa-miR-661	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT2448742	hsa-miR-1254	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT2218986	hsa-miR-1343	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT2448743	hsa-miR-3116	CLIP-seq
MIRT2448744	hsa-miR-3149	CLIP-seq
MIRT2448745	hsa-miR-411	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT2448746	hsa-miR-4715-3p	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT2448747	hsa-miR-4735-5p	CLIP-seq
MIRT2448748	hsa-miR-4775	CLIP-seq
MIRT2448749	hsa-miR-4794	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT2448750	hsa-miR-590-3p	CLIP-seq
MIRT2448751	hsa-miR-661	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT2522260	hsa-miR-122	CLIP-seq
MIRT2522261	hsa-miR-1227	CLIP-seq
MIRT2448742	hsa-miR-1254	CLIP-seq
MIRT2522262	hsa-miR-125a-3p	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT2522263	hsa-miR-130a	CLIP-seq
MIRT2522264	hsa-miR-130b	CLIP-seq
MIRT2218986	hsa-miR-1343	CLIP-seq
MIRT2522265	hsa-miR-136	CLIP-seq
MIRT2522266	hsa-miR-139-3p	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT2522267	hsa-miR-2392	CLIP-seq
MIRT2522268	hsa-miR-24	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT2522269	hsa-miR-301a	CLIP-seq
MIRT2522270	hsa-miR-301b	CLIP-seq
MIRT2448743	hsa-miR-3116	CLIP-seq
MIRT2448744	hsa-miR-3149	CLIP-seq
MIRT2522271	hsa-miR-3155	CLIP-seq
MIRT2522272	hsa-miR-3155b	CLIP-seq
MIRT2522273	hsa-miR-3186-5p	CLIP-seq
MIRT2218987	hsa-miR-3199	CLIP-seq
MIRT2522274	hsa-miR-3663-5p	CLIP-seq
MIRT2522275	hsa-miR-3664-3p	CLIP-seq
MIRT2522276	hsa-miR-3666	CLIP-seq
MIRT2522277	hsa-miR-3934	CLIP-seq
MIRT2448745	hsa-miR-411	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT2522278	hsa-miR-4284	CLIP-seq
MIRT2522279	hsa-miR-4295	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT2522280	hsa-miR-4438	CLIP-seq
MIRT2522281	hsa-miR-4454	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT2522282	hsa-miR-4474-3p	CLIP-seq
MIRT2522283	hsa-miR-4534	CLIP-seq
MIRT2522284	hsa-miR-454	CLIP-seq
MIRT2522285	hsa-miR-4654	CLIP-seq
MIRT1983709	hsa-miR-4683	CLIP-seq
MIRT1983710	hsa-miR-4695-3p	CLIP-seq
MIRT2448746	hsa-miR-4715-3p	CLIP-seq
MIRT2522286	hsa-miR-4716-5p	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT2522287	hsa-miR-4722-5p	CLIP-seq
MIRT2448747	hsa-miR-4735-5p	CLIP-seq
MIRT2522288	hsa-miR-4757-3p	CLIP-seq
MIRT2522289	hsa-miR-4763-5p	CLIP-seq
MIRT2522290	hsa-miR-4768-3p	CLIP-seq
MIRT2522291	hsa-miR-4769-5p	CLIP-seq
MIRT2522292	hsa-miR-4772-3p	CLIP-seq
MIRT2448748	hsa-miR-4775	CLIP-seq
MIRT2522293	hsa-miR-4781-3p	CLIP-seq
MIRT2448749	hsa-miR-4794	CLIP-seq
MIRT2522294	hsa-miR-4796-3p	CLIP-seq
MIRT2522295	hsa-miR-484	CLIP-seq
MIRT2522296	hsa-miR-5095	CLIP-seq
MIRT2522297	hsa-miR-515-5p	CLIP-seq
MIRT2522298	hsa-miR-541	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT2522299	hsa-miR-548t	CLIP-seq
MIRT2522300	hsa-miR-581	CLIP-seq
MIRT2448750	hsa-miR-590-3p	CLIP-seq
MIRT2522301	hsa-miR-654-5p	CLIP-seq
MIRT2448751	hsa-miR-661	CLIP-seq
MIRT2522302	hsa-miR-764	CLIP-seq
MIRT1983695	hsa-miR-1200	CLIP-seq
MIRT2522260	hsa-miR-122	CLIP-seq
MIRT2522261	hsa-miR-1227	CLIP-seq
MIRT2448742	hsa-miR-1254	CLIP-seq
MIRT2522262	hsa-miR-125a-3p	CLIP-seq
MIRT1983698	hsa-miR-1297	CLIP-seq
MIRT2522263	hsa-miR-130a	CLIP-seq
MIRT2522264	hsa-miR-130b	CLIP-seq
MIRT2218986	hsa-miR-1343	CLIP-seq
MIRT2522265	hsa-miR-136	CLIP-seq
MIRT2522266	hsa-miR-139-3p	CLIP-seq
MIRT1983700	hsa-miR-1976	CLIP-seq
MIRT2522267	hsa-miR-2392	CLIP-seq
MIRT2522268	hsa-miR-24	CLIP-seq
MIRT1983701	hsa-miR-26a	CLIP-seq
MIRT1983702	hsa-miR-26b	CLIP-seq
MIRT2522269	hsa-miR-301a	CLIP-seq
MIRT2522270	hsa-miR-301b	CLIP-seq
MIRT2448743	hsa-miR-3116	CLIP-seq
MIRT2448744	hsa-miR-3149	CLIP-seq
MIRT2522271	hsa-miR-3155	CLIP-seq
MIRT2522272	hsa-miR-3155b	CLIP-seq
MIRT2522273	hsa-miR-3186-5p	CLIP-seq
MIRT2218987	hsa-miR-3199	CLIP-seq
MIRT2522274	hsa-miR-3663-5p	CLIP-seq
MIRT2522275	hsa-miR-3664-3p	CLIP-seq
MIRT2522276	hsa-miR-3666	CLIP-seq
MIRT2522277	hsa-miR-3934	CLIP-seq
MIRT2448745	hsa-miR-411	CLIP-seq
MIRT1983703	hsa-miR-4279	CLIP-seq
MIRT2522278	hsa-miR-4284	CLIP-seq
MIRT2522279	hsa-miR-4295	CLIP-seq
MIRT1983704	hsa-miR-4324	CLIP-seq
MIRT2522280	hsa-miR-4438	CLIP-seq
MIRT2522281	hsa-miR-4454	CLIP-seq
MIRT1983705	hsa-miR-4465	CLIP-seq
MIRT2522282	hsa-miR-4474-3p	CLIP-seq
MIRT2522283	hsa-miR-4534	CLIP-seq
MIRT2522284	hsa-miR-454	CLIP-seq
MIRT2522285	hsa-miR-4654	CLIP-seq
MIRT1983710	hsa-miR-4695-3p	CLIP-seq
MIRT2448746	hsa-miR-4715-3p	CLIP-seq
MIRT2522286	hsa-miR-4716-5p	CLIP-seq
MIRT1983711	hsa-miR-4722-3p	CLIP-seq
MIRT2522287	hsa-miR-4722-5p	CLIP-seq
MIRT2448747	hsa-miR-4735-5p	CLIP-seq
MIRT2522288	hsa-miR-4757-3p	CLIP-seq
MIRT2522289	hsa-miR-4763-5p	CLIP-seq
MIRT2522290	hsa-miR-4768-3p	CLIP-seq
MIRT2522291	hsa-miR-4769-5p	CLIP-seq
MIRT2522292	hsa-miR-4772-3p	CLIP-seq
MIRT2448748	hsa-miR-4775	CLIP-seq
MIRT2522293	hsa-miR-4781-3p	CLIP-seq
MIRT2448749	hsa-miR-4794	CLIP-seq
MIRT2522294	hsa-miR-4796-3p	CLIP-seq
MIRT2522295	hsa-miR-484	CLIP-seq
MIRT2522296	hsa-miR-5095	CLIP-seq
MIRT2522297	hsa-miR-515-5p	CLIP-seq
MIRT2522298	hsa-miR-541	CLIP-seq
MIRT1983713	hsa-miR-544b	CLIP-seq
MIRT2522299	hsa-miR-548t	CLIP-seq
MIRT2522300	hsa-miR-581	CLIP-seq
MIRT2448750	hsa-miR-590-3p	CLIP-seq
MIRT2522301	hsa-miR-654-5p	CLIP-seq
MIRT2448751	hsa-miR-661	CLIP-seq
MIRT2522302	hsa-miR-764	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001732	Process	Formation of cytoplasmic translation initiation complex	IEA
GO:0002183	Process	Cytoplasmic translational initiation	IBA	21873635
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003743	Function	Translation initiation factor activity	IBA	21873635
GO:0003743	Function	Translation initiation factor activity	IC	17322308, 18599441
GO:0003743	Function	Translation initiation factor activity	IDA	17581632
GO:0003743	Function	Translation initiation factor activity	IDA	25849773
GO:0005515	Function	Protein binding	IPI	14688252, 17094969, 18599441, 18624398, 18628297, 24965446, 25959826, 28514442, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IDA	17322308, 17581632, 18599441, 25849773
GO:0006413	Process	Translational initiation	IC	17322308, 18599441
GO:0006413	Process	Translational initiation	IDA	17581632
GO:0006413	Process	Translational initiation	TAS
GO:0016282	Component	Eukaryotic 43S preinitiation complex	IEA
GO:0033290	Component	Eukaryotic 48S preinitiation complex	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071541	Component	Eukaryotic translation initiation factor 3 complex, eIF3m	IBA	21873635

MIM	HGNC	e!Ensembl
603911	3272	ENSG00000084623

Protein

UniProt ID

Q13347

Protein name

Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)

Protein function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40

PDB

6YBT , 6ZMW , 6ZON , 6ZP4 , 6ZVJ , 7A09 , 8OZ0 , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PJ5 , 8PJ6 , 8XXN , 9BLN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	3 → 37	WD domain, G-beta repeat	Repeat
PF00400	WD40	42 → 80	WD domain, G-beta repeat	Repeat
PF00400	WD40	275 → 312	WD domain, G-beta repeat	Repeat

Sequence

MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA

Sequence length

325

Interactions

View interactions

	Reactome
			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	24056964

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	31370342
Alzheimer Disease	Stimulate	33754896
Carcinogenesis	Stimulate	24056964
Carcinoma Hepatocellular	Associate	32100822
Colonic Neoplasms	Stimulate	24056964
Colorectal Neoplasms	Associate	24056964
Glioblastoma	Associate	31778600
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	31778600
Lung Neoplasms	Associate	36193788
Polyps	Stimulate	24056964
Prostatic Neoplasms	Stimulate	31778600

EIF3I (eukaryotic translation initiation factor 3 subunit I)