Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8653
Gene name Gene Name - the full gene name approved by the HGNC.
DEAD-box helicase 3 Y-linked
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DDX3Y
Synonyms (NCBI Gene) Gene synonyms aliases
DBY
Chromosome Chromosome number
Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Yq11.221
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023122 hsa-miR-124-3p Microarray 18668037
MIRT032055 hsa-miR-16-5p Proteomics 18668040
MIRT046978 hsa-miR-221-3p CLASH 23622248
MIRT052727 hsa-miR-1260b CLASH 23622248
MIRT558428 hsa-miR-203a-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding IBA 21873635
GO:0003724 Function RNA helicase activity IBA 21873635
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
400010 2699 ENSG00000067048
Protein
UniProt ID O15523
Protein name ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)
Protein function Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 202 390 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 424 534 Helicase conserved C-terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (
Sequence
MSHVVVKNDPELDQQLANLDLNSEKQSGGASTASKGRYIPPHLRNREASKGFHDKDSSGW
SCSKDKDAYSSFGSRDSRGKPGYFSERGSGSRGRFDDRGRSDYDGIGNRERPGFGRFERS
GHSRWCDKSVEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGSNCPPHIENF
SDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQI
YTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG
GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIR
RIVEQDTMPPKGVRHTMMFSATFPKEIQML
ARDFLDEYIFLAVGRVGSTSENITQKVVWV
EDLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREE
ALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVG
NLGLAT
SFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGRSKSNRFSGGFGARDY
RQSSGSSSSGFGASRGSSSRSGGGGYGNSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Sequence length 660
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Azoospermia Azoospermia rs200969445, rs144567652, rs765353898
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Non-obstructive azoospermia Non-obstructive azoospermia rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Oligospermia Oligospermia rs1602125411, rs377712900
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36928034
Azoospermia Associate 36997603
Carcinogenesis Inhibit 38217953
Carcinoma Squamous Cell Associate 30865384
Cerebral Infarction Associate 22365286
Depressive Disorder Major Associate 36928034
Esophageal Squamous Cell Carcinoma Associate 30865384
Glioblastoma Associate 40362575
Gonadoblastoma Associate 35481403
Graft vs Host Disease Associate 11929796, 14512314, 17085304