CBFB (core-binding factor subunit beta)

Gene

• Entrez ID: 865
• Gene name: Core-binding factor subunit beta
• Gene symbol: CBFB
• Synonyms (NCBI Gene): CLCD2, PEBP2B
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000676	hsa-miR-145-5p	qRT-PCR, Luciferase reporter assay, Microarray	19915607
MIRT005217	hsa-miR-30a-5p	pSILAC	18668040
MIRT001562	hsa-miR-155-5p	pSILAC	18668040
MIRT005054	hsa-let-7b-5p	Microarray	17699775
MIRT003970	hsa-miR-125b-5p	Microarray	17891175
MIRT000676	hsa-miR-145-5p	Luciferase reporter assay	20737575
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21903586
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay	22689670
MIRT003970	hsa-miR-125b-5p	Luciferase reporter assay	22689670
MIRT020330	hsa-miR-130b-3p	Sequencing	20371350
MIRT001562	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT000676	hsa-miR-145-5p	Reporter assay;Other	19915607
MIRT005217	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT049318	hsa-miR-92a-3p	CLASH	23622248
MIRT039772	hsa-miR-615-3p	CLASH	23622248
MIRT195381	hsa-miR-153-3p	PAR-CLIP	21572407
MIRT558955	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT558954	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT558953	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT558952	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT558951	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT558950	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT558949	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT558948	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT075065	hsa-miR-5692a	PAR-CLIP	21572407
MIRT195380	hsa-miR-100-3p	PAR-CLIP	21572407
MIRT195385	hsa-miR-548ag	PAR-CLIP	21572407
MIRT195386	hsa-miR-548ai	PAR-CLIP	21572407
MIRT195387	hsa-miR-548ba	PAR-CLIP	21572407
MIRT195382	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT558947	hsa-miR-365a-3p	PAR-CLIP	21572407
MIRT558946	hsa-miR-365b-3p	PAR-CLIP	21572407
MIRT195383	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT195384	hsa-miR-4327	PAR-CLIP	21572407
MIRT558945	hsa-miR-448	PAR-CLIP	21572407
MIRT195381	hsa-miR-153-3p	PAR-CLIP	21572407
MIRT558955	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT558954	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT558953	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT558952	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT558951	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT558950	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT558949	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT558948	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT075065	hsa-miR-5692a	PAR-CLIP	21572407
MIRT195380	hsa-miR-100-3p	PAR-CLIP	21572407
MIRT195385	hsa-miR-548ag	PAR-CLIP	21572407
MIRT195386	hsa-miR-548ai	PAR-CLIP	21572407
MIRT195387	hsa-miR-548ba	PAR-CLIP	21572407
MIRT195382	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT558947	hsa-miR-365a-3p	PAR-CLIP	21572407
MIRT558946	hsa-miR-365b-3p	PAR-CLIP	21572407
MIRT195383	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT195384	hsa-miR-4327	PAR-CLIP	21572407
MIRT558945	hsa-miR-448	PAR-CLIP	21572407
MIRT865050	hsa-miR-1202	CLIP-seq
MIRT865051	hsa-miR-1266	CLIP-seq
MIRT865052	hsa-miR-1324	CLIP-seq
MIRT865053	hsa-miR-155	CLIP-seq
MIRT865054	hsa-miR-217	CLIP-seq
MIRT865055	hsa-miR-298	CLIP-seq
MIRT865056	hsa-miR-302a	CLIP-seq
MIRT865057	hsa-miR-302b	CLIP-seq
MIRT865058	hsa-miR-302c	CLIP-seq
MIRT865059	hsa-miR-302d	CLIP-seq
MIRT865060	hsa-miR-302e	CLIP-seq
MIRT865061	hsa-miR-30a	CLIP-seq
MIRT865062	hsa-miR-30b	CLIP-seq
MIRT865063	hsa-miR-30c	CLIP-seq
MIRT865064	hsa-miR-30d	CLIP-seq
MIRT865065	hsa-miR-30e	CLIP-seq
MIRT865066	hsa-miR-3146	CLIP-seq
MIRT865067	hsa-miR-3166	CLIP-seq
MIRT865068	hsa-miR-3194-5p	CLIP-seq
MIRT865069	hsa-miR-338-3p	CLIP-seq
MIRT865070	hsa-miR-3607-3p	CLIP-seq
MIRT865071	hsa-miR-365	CLIP-seq
MIRT865072	hsa-miR-3688-5p	CLIP-seq
MIRT865073	hsa-miR-372	CLIP-seq
MIRT865074	hsa-miR-373	CLIP-seq
MIRT865075	hsa-miR-3938	CLIP-seq
MIRT865076	hsa-miR-3972	CLIP-seq
MIRT865077	hsa-miR-4293	CLIP-seq
MIRT865078	hsa-miR-4307	CLIP-seq
MIRT865079	hsa-miR-4310	CLIP-seq
MIRT865080	hsa-miR-433	CLIP-seq
MIRT865081	hsa-miR-4418	CLIP-seq
MIRT865082	hsa-miR-4433	CLIP-seq
MIRT865083	hsa-miR-4436b-3p	CLIP-seq
MIRT865084	hsa-miR-4437	CLIP-seq
MIRT865085	hsa-miR-4459	CLIP-seq
MIRT865086	hsa-miR-4518	CLIP-seq
MIRT865087	hsa-miR-4722-5p	CLIP-seq
MIRT865088	hsa-miR-4755-3p	CLIP-seq
MIRT865089	hsa-miR-4761-3p	CLIP-seq
MIRT865090	hsa-miR-4772-3p	CLIP-seq
MIRT865091	hsa-miR-4773	CLIP-seq
MIRT865092	hsa-miR-509-3-5p	CLIP-seq
MIRT865093	hsa-miR-509-5p	CLIP-seq
MIRT865094	hsa-miR-515-5p	CLIP-seq
MIRT865095	hsa-miR-519a	CLIP-seq
MIRT865096	hsa-miR-519b-3p	CLIP-seq
MIRT865097	hsa-miR-519c-3p	CLIP-seq
MIRT865098	hsa-miR-520a-3p	CLIP-seq
MIRT865099	hsa-miR-520b	CLIP-seq
MIRT865100	hsa-miR-520c-3p	CLIP-seq
MIRT865101	hsa-miR-520d-3p	CLIP-seq
MIRT865102	hsa-miR-520e	CLIP-seq
MIRT865103	hsa-miR-548a-3p	CLIP-seq
MIRT865104	hsa-miR-548aa	CLIP-seq
MIRT865105	hsa-miR-548ac	CLIP-seq
MIRT865106	hsa-miR-548d-3p	CLIP-seq
MIRT865107	hsa-miR-548e	CLIP-seq
MIRT865108	hsa-miR-548f	CLIP-seq
MIRT865109	hsa-miR-548z	CLIP-seq
MIRT865110	hsa-miR-596	CLIP-seq
MIRT865111	hsa-miR-642a	CLIP-seq
MIRT865112	hsa-miR-665	CLIP-seq
MIRT865113	hsa-miR-891b	CLIP-seq
MIRT865114	hsa-miR-103a	CLIP-seq
MIRT865115	hsa-miR-107	CLIP-seq
MIRT865116	hsa-miR-1193	CLIP-seq
MIRT865050	hsa-miR-1202	CLIP-seq
MIRT865117	hsa-miR-124	CLIP-seq
MIRT865118	hsa-miR-1243	CLIP-seq
MIRT865119	hsa-miR-1244	CLIP-seq
MIRT865120	hsa-miR-1265	CLIP-seq
MIRT865121	hsa-miR-1276	CLIP-seq
MIRT865122	hsa-miR-128	CLIP-seq
MIRT865123	hsa-miR-1297	CLIP-seq
MIRT865124	hsa-miR-1305	CLIP-seq
MIRT865052	hsa-miR-1324	CLIP-seq
MIRT865125	hsa-miR-145	CLIP-seq
MIRT865053	hsa-miR-155	CLIP-seq
MIRT865126	hsa-miR-15a	CLIP-seq
MIRT865127	hsa-miR-15b	CLIP-seq
MIRT865128	hsa-miR-16	CLIP-seq
MIRT865129	hsa-miR-1910	CLIP-seq
MIRT865130	hsa-miR-193a-3p	CLIP-seq
MIRT865131	hsa-miR-193b	CLIP-seq
MIRT865132	hsa-miR-194	CLIP-seq
MIRT865133	hsa-miR-195	CLIP-seq
MIRT865134	hsa-miR-199a-3p	CLIP-seq
MIRT865135	hsa-miR-199b-3p	CLIP-seq
MIRT865136	hsa-miR-208a	CLIP-seq
MIRT865137	hsa-miR-208b	CLIP-seq
MIRT865138	hsa-miR-221	CLIP-seq
MIRT865139	hsa-miR-222	CLIP-seq
MIRT865140	hsa-miR-223	CLIP-seq
MIRT865141	hsa-miR-2392	CLIP-seq
MIRT865142	hsa-miR-26a	CLIP-seq
MIRT865143	hsa-miR-26b	CLIP-seq
MIRT865144	hsa-miR-27a	CLIP-seq
MIRT865145	hsa-miR-27b	CLIP-seq
MIRT865146	hsa-miR-2964a-5p	CLIP-seq
MIRT865147	hsa-miR-297	CLIP-seq
MIRT865061	hsa-miR-30a	CLIP-seq
MIRT865062	hsa-miR-30b	CLIP-seq
MIRT865063	hsa-miR-30c	CLIP-seq
MIRT865064	hsa-miR-30d	CLIP-seq
MIRT865065	hsa-miR-30e	CLIP-seq
MIRT865148	hsa-miR-3129-5p	CLIP-seq
MIRT865149	hsa-miR-3140-3p	CLIP-seq
MIRT865150	hsa-miR-3160-3p	CLIP-seq
MIRT865151	hsa-miR-3163	CLIP-seq
MIRT865152	hsa-miR-3192	CLIP-seq
MIRT865068	hsa-miR-3194-5p	CLIP-seq
MIRT865153	hsa-miR-323-3p	CLIP-seq
MIRT865154	hsa-miR-326	CLIP-seq
MIRT865155	hsa-miR-330-3p	CLIP-seq
MIRT865156	hsa-miR-330-5p	CLIP-seq
MIRT865069	hsa-miR-338-3p	CLIP-seq
MIRT865157	hsa-miR-3591-3p	CLIP-seq
MIRT865158	hsa-miR-3607-5p	CLIP-seq
MIRT865159	hsa-miR-3617	CLIP-seq
MIRT865160	hsa-miR-3620	CLIP-seq
MIRT865071	hsa-miR-365	CLIP-seq
MIRT865161	hsa-miR-3654	CLIP-seq
MIRT865162	hsa-miR-3659	CLIP-seq
MIRT865163	hsa-miR-3663-5p	CLIP-seq
MIRT865164	hsa-miR-3664-5p	CLIP-seq
MIRT865165	hsa-miR-3671	CLIP-seq
MIRT865166	hsa-miR-3689a-3p	CLIP-seq
MIRT865167	hsa-miR-3689c	CLIP-seq
MIRT865168	hsa-miR-3714	CLIP-seq
MIRT865169	hsa-miR-374c	CLIP-seq
MIRT865170	hsa-miR-380	CLIP-seq
MIRT865171	hsa-miR-3907	CLIP-seq
MIRT865172	hsa-miR-3908	CLIP-seq
MIRT865173	hsa-miR-3910	CLIP-seq
MIRT865174	hsa-miR-3925-3p	CLIP-seq
MIRT865076	hsa-miR-3972	CLIP-seq
MIRT865175	hsa-miR-3975	CLIP-seq
MIRT865176	hsa-miR-424	CLIP-seq
MIRT865177	hsa-miR-4275	CLIP-seq
MIRT865078	hsa-miR-4307	CLIP-seq
MIRT865079	hsa-miR-4310	CLIP-seq
MIRT865178	hsa-miR-4314	CLIP-seq
MIRT865179	hsa-miR-4328	CLIP-seq
MIRT865180	hsa-miR-4423-3p	CLIP-seq
MIRT865181	hsa-miR-4424	CLIP-seq
MIRT865082	hsa-miR-4433	CLIP-seq
MIRT865182	hsa-miR-4434	CLIP-seq
MIRT865083	hsa-miR-4436b-3p	CLIP-seq
MIRT865085	hsa-miR-4459	CLIP-seq
MIRT865183	hsa-miR-4465	CLIP-seq
MIRT865184	hsa-miR-4469	CLIP-seq
MIRT865185	hsa-miR-4487	CLIP-seq
MIRT865186	hsa-miR-4494	CLIP-seq
MIRT865187	hsa-miR-4495	CLIP-seq
MIRT865188	hsa-miR-4516	CLIP-seq
MIRT865189	hsa-miR-4531	CLIP-seq
MIRT865190	hsa-miR-455-3p	CLIP-seq
MIRT865191	hsa-miR-4646-5p	CLIP-seq
MIRT865192	hsa-miR-4658	CLIP-seq
MIRT865193	hsa-miR-4697-3p	CLIP-seq
MIRT865194	hsa-miR-4699-3p	CLIP-seq
MIRT865195	hsa-miR-4704-3p	CLIP-seq
MIRT865196	hsa-miR-4711-5p	CLIP-seq
MIRT865197	hsa-miR-4712-5p	CLIP-seq
MIRT865198	hsa-miR-4714-5p	CLIP-seq
MIRT865199	hsa-miR-4718	CLIP-seq
MIRT865200	hsa-miR-4720-3p	CLIP-seq
MIRT865087	hsa-miR-4722-5p	CLIP-seq
MIRT865201	hsa-miR-4727-5p	CLIP-seq
MIRT865202	hsa-miR-4728-5p	CLIP-seq
MIRT865088	hsa-miR-4755-3p	CLIP-seq
MIRT865203	hsa-miR-4769-3p	CLIP-seq
MIRT865204	hsa-miR-4786-5p	CLIP-seq
MIRT865205	hsa-miR-4794	CLIP-seq
MIRT865206	hsa-miR-4796-5p	CLIP-seq
MIRT865207	hsa-miR-4797-5p	CLIP-seq
MIRT865208	hsa-miR-4804-3p	CLIP-seq
MIRT865209	hsa-miR-486-5p	CLIP-seq
MIRT865210	hsa-miR-497	CLIP-seq
MIRT865211	hsa-miR-499-5p	CLIP-seq
MIRT865212	hsa-miR-499a-5p	CLIP-seq
MIRT865213	hsa-miR-506	CLIP-seq
MIRT865214	hsa-miR-5096	CLIP-seq
MIRT865215	hsa-miR-544	CLIP-seq
MIRT865103	hsa-miR-548a-3p	CLIP-seq
MIRT865104	hsa-miR-548aa	CLIP-seq
MIRT865216	hsa-miR-548ae	CLIP-seq
MIRT865217	hsa-miR-548aj	CLIP-seq
MIRT865218	hsa-miR-548am	CLIP-seq
MIRT865107	hsa-miR-548e	CLIP-seq
MIRT865108	hsa-miR-548f	CLIP-seq
MIRT865219	hsa-miR-548x	CLIP-seq
MIRT865220	hsa-miR-556-3p	CLIP-seq
MIRT865221	hsa-miR-558	CLIP-seq
MIRT865222	hsa-miR-567	CLIP-seq
MIRT865223	hsa-miR-574-5p	CLIP-seq
MIRT865224	hsa-miR-582-5p	CLIP-seq
MIRT865225	hsa-miR-607	CLIP-seq
MIRT865226	hsa-miR-624	CLIP-seq
MIRT865227	hsa-miR-633	CLIP-seq
MIRT865228	hsa-miR-641	CLIP-seq
MIRT865229	hsa-miR-651	CLIP-seq
MIRT865230	hsa-miR-655	CLIP-seq
MIRT865112	hsa-miR-665	CLIP-seq
MIRT865231	hsa-miR-770-5p	CLIP-seq
MIRT865232	hsa-miR-892b	CLIP-seq
MIRT865233	hsa-miR-936	CLIP-seq
MIRT865234	hsa-miR-940	CLIP-seq
MIRT865235	hsa-miR-944	CLIP-seq
MIRT865197	hsa-miR-4712-5p	CLIP-seq
MIRT865231	hsa-miR-770-5p	CLIP-seq
MIRT1956386	hsa-miR-1208	CLIP-seq
MIRT865117	hsa-miR-124	CLIP-seq
MIRT865122	hsa-miR-128	CLIP-seq
MIRT865124	hsa-miR-1305	CLIP-seq
MIRT1956387	hsa-miR-130a	CLIP-seq
MIRT1956388	hsa-miR-130b	CLIP-seq
MIRT1956389	hsa-miR-141	CLIP-seq
MIRT865125	hsa-miR-145	CLIP-seq
MIRT865132	hsa-miR-194	CLIP-seq
MIRT865134	hsa-miR-199a-3p	CLIP-seq
MIRT865135	hsa-miR-199b-3p	CLIP-seq
MIRT1956390	hsa-miR-19a	CLIP-seq
MIRT1956391	hsa-miR-19b	CLIP-seq
MIRT1956392	hsa-miR-200a	CLIP-seq
MIRT1956393	hsa-miR-214	CLIP-seq
MIRT865144	hsa-miR-27a	CLIP-seq
MIRT865145	hsa-miR-27b	CLIP-seq
MIRT865146	hsa-miR-2964a-5p	CLIP-seq
MIRT865147	hsa-miR-297	CLIP-seq
MIRT1956394	hsa-miR-300	CLIP-seq
MIRT1956395	hsa-miR-301a	CLIP-seq
MIRT1956396	hsa-miR-301b	CLIP-seq
MIRT865061	hsa-miR-30a	CLIP-seq
MIRT865062	hsa-miR-30b	CLIP-seq
MIRT865063	hsa-miR-30c	CLIP-seq
MIRT865064	hsa-miR-30d	CLIP-seq
MIRT865065	hsa-miR-30e	CLIP-seq
MIRT1956397	hsa-miR-3121-3p	CLIP-seq
MIRT865148	hsa-miR-3129-5p	CLIP-seq
MIRT865151	hsa-miR-3163	CLIP-seq
MIRT865152	hsa-miR-3192	CLIP-seq
MIRT865154	hsa-miR-326	CLIP-seq
MIRT865156	hsa-miR-330-5p	CLIP-seq
MIRT1956398	hsa-miR-34a	CLIP-seq
MIRT1956399	hsa-miR-34c-5p	CLIP-seq
MIRT865070	hsa-miR-3607-3p	CLIP-seq
MIRT1956400	hsa-miR-3619-5p	CLIP-seq
MIRT865163	hsa-miR-3663-5p	CLIP-seq
MIRT865164	hsa-miR-3664-5p	CLIP-seq
MIRT1956401	hsa-miR-3666	CLIP-seq
MIRT865165	hsa-miR-3671	CLIP-seq
MIRT1956402	hsa-miR-3674	CLIP-seq
MIRT865166	hsa-miR-3689a-3p	CLIP-seq
MIRT865167	hsa-miR-3689c	CLIP-seq
MIRT1956403	hsa-miR-3692	CLIP-seq
MIRT865168	hsa-miR-3714	CLIP-seq
MIRT865169	hsa-miR-374c	CLIP-seq
MIRT865170	hsa-miR-380	CLIP-seq
MIRT1956404	hsa-miR-381	CLIP-seq
MIRT865172	hsa-miR-3908	CLIP-seq
MIRT865173	hsa-miR-3910	CLIP-seq
MIRT865174	hsa-miR-3925-3p	CLIP-seq
MIRT865175	hsa-miR-3975	CLIP-seq
MIRT865177	hsa-miR-4275	CLIP-seq
MIRT1956405	hsa-miR-4291	CLIP-seq
MIRT865077	hsa-miR-4293	CLIP-seq
MIRT1956406	hsa-miR-4295	CLIP-seq
MIRT865178	hsa-miR-4314	CLIP-seq
MIRT865179	hsa-miR-4328	CLIP-seq
MIRT865180	hsa-miR-4423-3p	CLIP-seq
MIRT1956407	hsa-miR-4426	CLIP-seq
MIRT865082	hsa-miR-4433	CLIP-seq
MIRT865182	hsa-miR-4434	CLIP-seq
MIRT1956408	hsa-miR-4436b-5p	CLIP-seq
MIRT865085	hsa-miR-4459	CLIP-seq
MIRT865187	hsa-miR-4495	CLIP-seq
MIRT1956409	hsa-miR-449a	CLIP-seq
MIRT1956410	hsa-miR-449b	CLIP-seq
MIRT1956411	hsa-miR-450b-5p	CLIP-seq
MIRT865188	hsa-miR-4516	CLIP-seq
MIRT1956412	hsa-miR-452	CLIP-seq
MIRT865189	hsa-miR-4531	CLIP-seq
MIRT1956413	hsa-miR-454	CLIP-seq
MIRT1956414	hsa-miR-4540	CLIP-seq
MIRT865191	hsa-miR-4646-5p	CLIP-seq
MIRT1956415	hsa-miR-4647	CLIP-seq
MIRT1956416	hsa-miR-4662b	CLIP-seq
MIRT1956417	hsa-miR-4666-3p	CLIP-seq
MIRT1956418	hsa-miR-4671-3p	CLIP-seq
MIRT1956419	hsa-miR-4676-3p	CLIP-seq
MIRT865197	hsa-miR-4712-5p	CLIP-seq
MIRT865198	hsa-miR-4714-5p	CLIP-seq
MIRT865200	hsa-miR-4720-3p	CLIP-seq
MIRT865087	hsa-miR-4722-5p	CLIP-seq
MIRT865201	hsa-miR-4727-5p	CLIP-seq
MIRT865202	hsa-miR-4728-5p	CLIP-seq
MIRT1956420	hsa-miR-4742-3p	CLIP-seq
MIRT865088	hsa-miR-4755-3p	CLIP-seq
MIRT865203	hsa-miR-4769-3p	CLIP-seq
MIRT1956421	hsa-miR-4802-5p	CLIP-seq
MIRT1956422	hsa-miR-483-3p	CLIP-seq
MIRT865213	hsa-miR-506	CLIP-seq
MIRT1956423	hsa-miR-507	CLIP-seq
MIRT865094	hsa-miR-515-5p	CLIP-seq
MIRT1956424	hsa-miR-518a-5p	CLIP-seq
MIRT1956425	hsa-miR-527	CLIP-seq
MIRT1956426	hsa-miR-539	CLIP-seq
MIRT865215	hsa-miR-544	CLIP-seq
MIRT1956427	hsa-miR-548a-5p	CLIP-seq
MIRT865104	hsa-miR-548aa	CLIP-seq
MIRT1956428	hsa-miR-548ab	CLIP-seq
MIRT865216	hsa-miR-548ae	CLIP-seq
MIRT865217	hsa-miR-548aj	CLIP-seq
MIRT1956429	hsa-miR-548ak	CLIP-seq
MIRT865218	hsa-miR-548am	CLIP-seq
MIRT1956430	hsa-miR-548b-5p	CLIP-seq
MIRT1956431	hsa-miR-548c-5p	CLIP-seq
MIRT1956432	hsa-miR-548d-5p	CLIP-seq
MIRT1956433	hsa-miR-548h	CLIP-seq
MIRT1956434	hsa-miR-548i	CLIP-seq
MIRT1956435	hsa-miR-548j	CLIP-seq
MIRT1956436	hsa-miR-548w	CLIP-seq
MIRT865219	hsa-miR-548x	CLIP-seq
MIRT1956437	hsa-miR-548y	CLIP-seq
MIRT1956438	hsa-miR-557	CLIP-seq
MIRT1956439	hsa-miR-559	CLIP-seq
MIRT865222	hsa-miR-567	CLIP-seq
MIRT1956440	hsa-miR-587	CLIP-seq
MIRT865110	hsa-miR-596	CLIP-seq
MIRT1956441	hsa-miR-603	CLIP-seq
MIRT865225	hsa-miR-607	CLIP-seq
MIRT865227	hsa-miR-633	CLIP-seq
MIRT865230	hsa-miR-655	CLIP-seq
MIRT865112	hsa-miR-665	CLIP-seq
MIRT1956442	hsa-miR-7	CLIP-seq
MIRT1956443	hsa-miR-758	CLIP-seq
MIRT1956444	hsa-miR-761	CLIP-seq
MIRT1956445	hsa-miR-766	CLIP-seq
MIRT865231	hsa-miR-770-5p	CLIP-seq
MIRT1956446	hsa-miR-922	CLIP-seq
MIRT865233	hsa-miR-936	CLIP-seq
MIRT865234	hsa-miR-940	CLIP-seq
MIRT865235	hsa-miR-944	CLIP-seq
MIRT865116	hsa-miR-1193	CLIP-seq
MIRT1956386	hsa-miR-1208	CLIP-seq
MIRT865117	hsa-miR-124	CLIP-seq
MIRT865120	hsa-miR-1265	CLIP-seq
MIRT865122	hsa-miR-128	CLIP-seq
MIRT2193920	hsa-miR-129-3p	CLIP-seq
MIRT865123	hsa-miR-1297	CLIP-seq
MIRT865124	hsa-miR-1305	CLIP-seq
MIRT865052	hsa-miR-1324	CLIP-seq
MIRT865125	hsa-miR-145	CLIP-seq
MIRT865130	hsa-miR-193a-3p	CLIP-seq
MIRT865131	hsa-miR-193b	CLIP-seq
MIRT865134	hsa-miR-199a-3p	CLIP-seq
MIRT865135	hsa-miR-199b-3p	CLIP-seq
MIRT865138	hsa-miR-221	CLIP-seq
MIRT865139	hsa-miR-222	CLIP-seq
MIRT865141	hsa-miR-2392	CLIP-seq
MIRT865142	hsa-miR-26a	CLIP-seq
MIRT865143	hsa-miR-26b	CLIP-seq
MIRT865144	hsa-miR-27a	CLIP-seq
MIRT865145	hsa-miR-27b	CLIP-seq
MIRT865147	hsa-miR-297	CLIP-seq
MIRT2193921	hsa-miR-3125	CLIP-seq
MIRT865148	hsa-miR-3129-5p	CLIP-seq
MIRT865149	hsa-miR-3140-3p	CLIP-seq
MIRT865153	hsa-miR-323-3p	CLIP-seq
MIRT865157	hsa-miR-3591-3p	CLIP-seq
MIRT865071	hsa-miR-365	CLIP-seq
MIRT865163	hsa-miR-3663-5p	CLIP-seq
MIRT865164	hsa-miR-3664-5p	CLIP-seq
MIRT2193922	hsa-miR-3665	CLIP-seq
MIRT865165	hsa-miR-3671	CLIP-seq
MIRT865168	hsa-miR-3714	CLIP-seq
MIRT2193923	hsa-miR-374a	CLIP-seq
MIRT2193924	hsa-miR-374b	CLIP-seq
MIRT865169	hsa-miR-374c	CLIP-seq
MIRT865170	hsa-miR-380	CLIP-seq
MIRT865172	hsa-miR-3908	CLIP-seq
MIRT865173	hsa-miR-3910	CLIP-seq
MIRT2193925	hsa-miR-3916	CLIP-seq
MIRT865174	hsa-miR-3925-3p	CLIP-seq
MIRT865177	hsa-miR-4275	CLIP-seq
MIRT2193926	hsa-miR-4305	CLIP-seq
MIRT865079	hsa-miR-4310	CLIP-seq
MIRT865180	hsa-miR-4423-3p	CLIP-seq
MIRT865181	hsa-miR-4424	CLIP-seq
MIRT1956407	hsa-miR-4426	CLIP-seq
MIRT865083	hsa-miR-4436b-3p	CLIP-seq
MIRT865085	hsa-miR-4459	CLIP-seq
MIRT865183	hsa-miR-4465	CLIP-seq
MIRT865184	hsa-miR-4469	CLIP-seq
MIRT865187	hsa-miR-4495	CLIP-seq
MIRT2193927	hsa-miR-4517	CLIP-seq
MIRT2193928	hsa-miR-4643	CLIP-seq
MIRT1956415	hsa-miR-4647	CLIP-seq
MIRT2193929	hsa-miR-466	CLIP-seq
MIRT1956416	hsa-miR-4662b	CLIP-seq
MIRT2193930	hsa-miR-4678	CLIP-seq
MIRT865194	hsa-miR-4699-3p	CLIP-seq
MIRT865195	hsa-miR-4704-3p	CLIP-seq
MIRT865197	hsa-miR-4712-5p	CLIP-seq
MIRT865198	hsa-miR-4714-5p	CLIP-seq
MIRT865200	hsa-miR-4720-3p	CLIP-seq
MIRT865087	hsa-miR-4722-5p	CLIP-seq
MIRT865201	hsa-miR-4727-5p	CLIP-seq
MIRT2193931	hsa-miR-4728-3p	CLIP-seq
MIRT865089	hsa-miR-4761-3p	CLIP-seq
MIRT865203	hsa-miR-4769-3p	CLIP-seq
MIRT865091	hsa-miR-4773	CLIP-seq
MIRT2193932	hsa-miR-4789-3p	CLIP-seq
MIRT865205	hsa-miR-4794	CLIP-seq
MIRT865207	hsa-miR-4797-5p	CLIP-seq
MIRT2193933	hsa-miR-4800-5p	CLIP-seq
MIRT865208	hsa-miR-4804-3p	CLIP-seq
MIRT865213	hsa-miR-506	CLIP-seq
MIRT865215	hsa-miR-544	CLIP-seq
MIRT865220	hsa-miR-556-3p	CLIP-seq
MIRT865222	hsa-miR-567	CLIP-seq
MIRT865224	hsa-miR-582-5p	CLIP-seq
MIRT865225	hsa-miR-607	CLIP-seq
MIRT865226	hsa-miR-624	CLIP-seq
MIRT2193934	hsa-miR-646	CLIP-seq
MIRT865229	hsa-miR-651	CLIP-seq
MIRT865230	hsa-miR-655	CLIP-seq
MIRT2193935	hsa-miR-657	CLIP-seq
MIRT1956445	hsa-miR-766	CLIP-seq
MIRT865231	hsa-miR-770-5p	CLIP-seq
MIRT2193936	hsa-miR-877	CLIP-seq
MIRT2193937	hsa-miR-889	CLIP-seq
MIRT865232	hsa-miR-892b	CLIP-seq
MIRT865233	hsa-miR-936	CLIP-seq
MIRT2193938	hsa-miR-938	CLIP-seq
MIRT865234	hsa-miR-940	CLIP-seq
MIRT865235	hsa-miR-944	CLIP-seq
MIRT865116	hsa-miR-1193	CLIP-seq
MIRT865120	hsa-miR-1265	CLIP-seq
MIRT865132	hsa-miR-194	CLIP-seq
MIRT865141	hsa-miR-2392	CLIP-seq
MIRT865194	hsa-miR-4699-3p	CLIP-seq
MIRT865229	hsa-miR-651	CLIP-seq
MIRT2497292	hsa-miR-106a	CLIP-seq
MIRT2497293	hsa-miR-106b	CLIP-seq
MIRT865117	hsa-miR-124	CLIP-seq
MIRT2497294	hsa-miR-17	CLIP-seq
MIRT2497295	hsa-miR-20a	CLIP-seq
MIRT2497296	hsa-miR-20b	CLIP-seq
MIRT2497297	hsa-miR-28-5p	CLIP-seq
MIRT2497298	hsa-miR-3139	CLIP-seq
MIRT2497299	hsa-miR-3190	CLIP-seq
MIRT865152	hsa-miR-3192	CLIP-seq
MIRT865153	hsa-miR-323-3p	CLIP-seq
MIRT865154	hsa-miR-326	CLIP-seq
MIRT865156	hsa-miR-330-5p	CLIP-seq
MIRT2497300	hsa-miR-3609	CLIP-seq
MIRT865164	hsa-miR-3664-5p	CLIP-seq
MIRT865166	hsa-miR-3689a-3p	CLIP-seq
MIRT865167	hsa-miR-3689c	CLIP-seq
MIRT865168	hsa-miR-3714	CLIP-seq
MIRT2497301	hsa-miR-371-5p	CLIP-seq
MIRT2497302	hsa-miR-371b-5p	CLIP-seq
MIRT865173	hsa-miR-3910	CLIP-seq
MIRT865175	hsa-miR-3975	CLIP-seq
MIRT865178	hsa-miR-4314	CLIP-seq
MIRT865085	hsa-miR-4459	CLIP-seq
MIRT865191	hsa-miR-4646-5p	CLIP-seq
MIRT865198	hsa-miR-4714-5p	CLIP-seq
MIRT865087	hsa-miR-4722-5p	CLIP-seq
MIRT865202	hsa-miR-4728-5p	CLIP-seq
MIRT2497303	hsa-miR-4760-3p	CLIP-seq
MIRT2497304	hsa-miR-4796-3p	CLIP-seq
MIRT865213	hsa-miR-506	CLIP-seq
MIRT2497305	hsa-miR-519d	CLIP-seq
MIRT2497306	hsa-miR-548ah	CLIP-seq
MIRT865224	hsa-miR-582-5p	CLIP-seq
MIRT2497307	hsa-miR-600	CLIP-seq
MIRT1956442	hsa-miR-7	CLIP-seq
MIRT2497308	hsa-miR-708	CLIP-seq
MIRT2497309	hsa-miR-93	CLIP-seq
MIRT865234	hsa-miR-940	CLIP-seq
MIRT865153	hsa-miR-323-3p	CLIP-seq
MIRT2497301	hsa-miR-371-5p	CLIP-seq
MIRT2497302	hsa-miR-371b-5p	CLIP-seq
MIRT2677460	hsa-miR-4645-3p	CLIP-seq
MIRT2497303	hsa-miR-4760-3p	CLIP-seq
MIRT2497307	hsa-miR-600	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA1	Repression	19825991
MYC	Unknown	9064279
SP1	Unknown	9064279

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000209	Process	Protein polyubiquitination	IMP	22190036
GO:0001503	Process	Ossification	IEA
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	2845103, 10856244, 12217689, 17431401, 20195357, 22190034, 24402281, 25678665, 32296183, 33961781, 34591612, 35914814
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	8351518
GO:0016020	Component	Membrane	HDA	19946888
GO:0016513	Component	Core-binding factor complex	IBA
GO:0016513	Component	Core-binding factor complex	TAS	18258917
GO:0030098	Process	Lymphocyte differentiation	IEA
GO:0030099	Process	Myeloid cell differentiation	IEA
GO:0043371	Process	Negative regulation of CD4-positive, alpha-beta T cell differentiation	IEA
GO:0043371	Process	Negative regulation of CD4-positive, alpha-beta T cell differentiation	ISS
GO:0043378	Process	Positive regulation of CD8-positive, alpha-beta T cell differentiation	IEA
GO:0043378	Process	Positive regulation of CD8-positive, alpha-beta T cell differentiation	ISS
GO:0043565	Function	Sequence-specific DNA binding	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048469	Process	Cell maturation	IEA
GO:0060216	Process	Definitive hemopoiesis	IEA

Other IDs

• MIM: 121360
• HGNC: 1539
• e!Ensembl: ENSG00000067955

Protein

• UniProt ID: Q13951
• Protein name: Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
• Protein function: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or
• PDB: 1CL3, 1E50, 1H9D, 4N9F, 6NIL, 6P59, 6VGD, 6VGE, 6VGG, 8CX0, 8CX1, 8CX2, 8E40, 8FVI, 8FVJ, 8H0I, 8J62, 8SZK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02312	CBF_beta	1 → 168	Core binding factor beta subunit	Family

• Sequence:

  MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT
  GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD
  GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT
  RP

• Sequence length: 182

Pathways

Reactome:

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Transcriptional regulation by RUNX2
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX1 regulates transcription of genes involved in WNT signaling
Regulation of RUNX2 expression and activity
RUNX2 regulates osteoblast differentiation
RUNX2 regulates bone development
RUNX2 regulates genes involved in cell migration
RUNX2 regulates genes involved in differentiation of myeloid cells
Regulation of RUNX3 expression and activity
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates RUNX1-mediated transcription
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cleidocranial dysplasia 2	Pathogenic	rs2544397242	RCV002293960

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Uncertain significance	rs1961069899	RCV001196219
CBFB-related disorder	Uncertain significance; Likely benign	rs2544398133, rs377384370, rs774590494, rs755033312	RCV003414373 RCV003897222 RCV003944158 RCV003969451
Cholangiocarcinoma	Benign	rs8051487	RCV005918078

Associations from Text Mining
Disease Name	Relationship Type	References
Acute erythroleukemia	Associate	15224374
Adenocarcinoma	Associate	24390348
Alcohol Related Disorders	Associate	36241386
Breast Carcinoma In Situ	Associate	26643573, 31932682
Breast Neoplasms	Associate	27428424, 28027327, 30655324, 35732329
Carcinoma Hepatocellular	Associate	17094378
Carcinoma Lobular	Associate	26643573
Chromosome 16 trisomy	Associate	7858261
Chromosome Aberrations	Associate	22623292
Cleidocranial Dysplasia	Associate	10856244, 18166138, 36241386, 39894570
Colorectal Neoplasms	Associate	19156145
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	22722193
Developmental Disabilities	Associate	39894570
Disease	Associate	28089879
Dystonia 16	Associate	21275954, 23160462, 27843138, 35622005, 36011278, 9490670
Embryo Loss	Associate	16670269
Eosinophilia	Associate	15224374
Genetic Diseases Inborn	Associate	21198299
Glioma	Associate	36745477
Isodicentric Chromosome 15 Syndrome	Associate	15855281, 16917916, 16989659, 18024381, 18663147, 21638519, 22623292, 22875911, 23160462, 23878140, 24055056, 25266220, 30850577, 34010414, 34117074, 34730684, 35622005, 36011278, 7795233, 8142642, 9207416, 9490670, 9834241
Isodicentric Chromosome 15 Syndrome	Stimulate	17571080
Isodicentric Chromosome 15 Syndrome	Inhibit	26397705
Leiomyoma of vulva and esophagus	Associate	36745477
Leukemia	Associate	11742995, 12791658, 14736823, 16670269, 19825991, 19901261, 20060365, 23878140, 25079347, 26163765, 27428424, 29427994, 30742053, 30850577, 31896782, 8900225
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	28253536, 9207416
Leukemia Myeloid Acute	Associate	11369654, 12745661, 14736823, 15224374, 15226186, 15855281, 16630339, 18024381, 19463768, 19901261, 21198299, 21494256, 21638519, 22228403, 22915647, 23160462, 23236551, 23619823, 23878140, 25266220, 25715404, 25786458, 27843138, 28030795, 28253536, 29192243, 29427994, 29932212, 30809981, 30850577, 31896782, 31899799, 32092139, 32419364, 33836581, 34010414, 34117074, 34730684, 35622005, 35794567, 36011278, 36248800, 37904054, 38084551, 39361146, 7795233, 7858261, 7919348, 8739792, 9490670, 9584201, 9834241
Leukemia Myelomonocytic Acute	Associate	10590083, 9207416
Leukemia Myelomonocytic Chronic	Associate	7858261
Leukemia T Cell	Associate	16989659, 9207416
Myotonia with Skeletal Abnormalities and Mental Retardation	Associate	36241386
Nail Diseases	Associate	18166138
Neoplasms	Associate	19156145, 27428424, 28253536, 33004031, 33219256, 34480095, 36745477, 37145128
Neoplasms	Inhibit	30655324
Osteoarthritis	Associate	33573620
Osteogenesis Imperfecta	Associate	10856244
Osteoporosis	Associate	38364892
Osteosarcoma	Associate	31610798
Ovarian Neoplasms	Associate	36745477, 38084551
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	10856244, 11167739, 16989659, 18422993, 33971801, 9074414
Sarcoma Myeloid	Associate	36916780
Stomach Neoplasms	Associate	37493631
Uterine Cervical Neoplasms	Associate	25786458